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Vitreoretinopathy, Proliferative (0):
Recent article
Vitreoretinopathy, Proliferative
Nippon Ganka Gakkai zasshi (114)11 2010
Abstract
We elucidated the critical role of transforming growth factor-beta (TGF-beta) in the contractile effect and its underlying mechanisms mediating cicatricial contraction in proliferative vitreoretinal diseases at least in part. Fasudil, a potent and selective Rho-kinase (ROCK) inhibitor, almost comple...
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PMID: 21141072
PDF is available here.
PDF is available here.
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Abstract
Abstract
Proliferative vitreoretinopathy (PVR) is the most important complication of retinal detachment and vitreoretinal surgery. PVR is considered to represent a maladapted retinal wound repair process; proliferation of retinal and immune cells induces the formation of epiretinal membranes which cause trac...
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PMID: 20234978
PDF is available here.
PDF is available here.
Abstract
Nippon Ganka Gakkai zasshi (114)2 2010
Abstract
Pathobiology (77)2 2010
Abstract
We found that a higher level integrin-alpha(5) was present at the RPE cell surface in PVR compared with normal retina. EGF could dose dependently increase integrin-alpha(5) mRNA and protein levels in vitro. EGF promoted ARPE-19 cell proliferation and migration. Neutralizing integrin-alpha(5) by spec...
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PMID: 20332668
PDF is available here.
PDF is available here.
Abstract
Eighty-seven patients had PVR and 27 received PDRR (mean age: 66.6 years; mean follow-up: 2.3 years). Ten patients had grade B PVR, 8 had CP1 to CP6, and 7 had CA2 to CA6. Twenty-four (89%) patients achieved a reattached retina without silicone oil. Mean logarithm of the minimum angle of resolution...
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PMID: 20128567
PDF is available here.
PDF is available here.
Vestnik oftalmologii (126)1 2010
Abstract
The investigation was undertaken to study changes in the structure of the vitreoretinal complex in experimental chlamydial infection. Six rabbits were inoculated with Ch. pneumonia (6 eyes) and Ch. trachomatis (6 eyes) via instillations, subconjunctivally and intravitreally. Clinical and pathomorpho...
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PMID: 20645572
PDF is available here.
PDF is available here.
Abstract
Results from this review indicate that there is inconsistent evidence from two studies on patients at different risk of PVR on the effect of LMWH and 5-FU used during vitrectomy to prevent PVR. Future research should be conducted on high risk patients only, until a benefit is confirmed at least in t...
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PMID: 20614445
PDF is available here.
PDF is available here.
Abstract
Early diagnosis, prompt systemic and ocular treatment, as well as close ophthalmic examination are essential in such cases....
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PMID: 19882533
PDF is available here.
PDF is available here.
Abstract
The intravitreous injectable lipid prodrugs of AraG and 5-fluoro-2'-deoxyuridine could be long-lasting, slow-release, antiproliferative compounds to treat unwanted intraocular proliferation....
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PMID: 19696179
PDF is available here.
PDF is available here.
Abstract
EphB4 and EphrinB2 are expressed in RPE cells and PVR membranes. sEphB4 inhibits PDGF-induced RPE cell attachment, proliferation, and migration. This effect may result from the inhibition of FAK and MAPK phosphorylation....
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PMID: 19696168
PDF is available here.
PDF is available here.
Abstract
Intravitreal bevacizumab injection with PRP resulted in marked regression of neovascularization compared with PRP alone. One serious side effect, BRAO, was noted in this study. Further studies are needed to determine the effect of repeated intravitreal bevacizumab injections and the proper number of...
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PMID: 20046686
PDF is available here.
PDF is available here.
Abstract
We failed to prove that tramadol is effective for pain relief because of the small sample size. However, tramadol was effective for the relief of more severe pain. It was also found to stabilize vital sign changes, such as systolic blood pressure during PRP....
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PMID: 20046687
PDF is available here.
PDF is available here.
Georgian medical news ()175 2009
Abstract
Proliferative vitreoretinopathy (PVR) appears to be one of the main reasons of functional and sometimes also anatomical death of the eye after its damages and diseases as well as is one of the heavy complications of the post operation period at vitreoretinal surgery. PVR is characterized by the occu...
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PMID: 19893117
PDF is available here.
PDF is available here.
Abstract
Proliferative vitreoretinopathy in the inferior retina remains clinically challenging. Heavier-than-water intraocular tamponades have been developed to improve inferior tamponading properties. The parameters of an optimal intraocular tamponade are defined and the influences of the specific gravity,...
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PMID: 19750417
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe the advantages of the heavy silicone oil endotamponade and our own clinical experiences with Densiron(R) 68. The use of heavy silicone oils turned out to be quite convenient, leading for example to shorter tamponade times, easy handling of the oil, no need for uncomfortable prone-positio...
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PMID: 19750418
PDF is available here.
PDF is available here.
Abstract
Abstract
In macular hole surgery, good to excellent anatomic and functional results have been reported using heavy tamponades with primary closure rates of up to 100 % of the cases. In reoperations of reopened macular holes, the reported success rates were between 60 % and 100 %. In the group of patients wit...
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PMID: 19750421
PDF is available here.
PDF is available here.
Abstract
Despite major improvements of vitreo-retinal surgical techniques proliferative vitreoretinopathy (PVR) remains a major challenge. Surgical therapy alone may not be sufficient in complicated cases of PVR. A combination of standard techniques such as pars plana vitrectomy with a vitreous substitute an...
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PMID: 19750422
PDF is available here.
PDF is available here.
Abstract
The anatomic success rate after surgery with HSO (Oxane HD) was relatively low; however, only complex cases bearing a higher risk of retinal re-detachment received HSO in this study. Oxane HD does not appear to have major advantages compared to conventional silicone oil or other new-generation heavy...
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PMID: 19750420
PDF is available here.
PDF is available here.
Abstract
Preoperative CRA parameters and LogMAR VAs (pre-, and postoperative 8 months) were influenced by preoperative RD duration in both no PVR and PVR. Preoperative CRA parameters were correlated with LogMAR VAs (pre-, postoperative 8 months, and the difference) only in PVR. Postoperative 8 months and pre...
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PMID: 19156435
PDF is available here.
PDF is available here.
Der Ophthalmologe (106)4 2009
Abstract
The retinal pigment epithelium (RPE) is a cellular monolayer between the choriocapillaris and the photoreceptors which controls the uptake of nutrients by the retina and the disposal of shed photoreceptor outer segments from the retina. The RPE is responsible for a continuous supply of rhodopsin by...
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PMID: 19343351
PDF is available here.
PDF is available here.
Der Ophthalmologe (106)4 2009
Abstract
The retinal pigment epithelium (RPE) serves a variety of different functions and impairment of these functions can lead to a multitude of different diseases of the posterior segment of the eye. The RPE plays an important role as an ion and fluid pump for the reabsorption of subretinal fluid in retin...
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PMID: 19340431
PDF is available here.
PDF is available here.
Der Ophthalmologe (106)4 2009
Abstract
Patients were 59.1 (+/-18.1) years old, male:female =48:32, R:L=40:40. Fifty-six patients (70%) had previous unsuccessful retinal surgery, and 24 (30%) received heavy silicone oil at their first procedure. The extent of the detachments was 2.46 quadrants (+/-0.83) with macular involvement in 49 case...
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PMID: 18636266
PDF is available here.
PDF is available here.
Abstract
We determined whether the PDGFRs in epiretinal membranes isolated from PVR patient donors were activated. Indeed, immunohistochemical staining (using pan- and phospho-PDGFR antibodies) revealed that both PDGFR subunits were activated. Quantification of these data demonstrated that a greater percenta...
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PMID: 19032953
PDF is available here.
PDF is available here.
Abstract
Unique vitreomacular features exist in diabetic fibrovascular proliferation and MH. Internal limiting membrane peeling does not seem to significantly affect MH closure in cases with moderate or high macular detachment. Final vision may be associated with preoperative visual acuity and degree of macu...
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PMID: 18997639
PDF is available here.
PDF is available here.
Abstract
It appears that, in addition to VEGF, PDGF-AA, -AB, and -BB in the vitreous are also correlated with PDR....
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PMID: 19219687
PDF is available here.
PDF is available here.
Abstract
We present general guidelines to help us with the treatment of diabetic retinopathy (DR) at a time when numerous therapeutic alternatives have been developed although their role has not yet been adequately defined. This protocol is not directed at experienced retinologists but rather at general opht...
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PMID: 19253176
PDF is available here.
PDF is available here.
Abstract
There is a local reduction in retinal function in the area of retained subretinal PFCL. There may be partial recovery of retinal function in an area vacated by the subretinal PFCL. Subretinal PFCL beneath the fovea or at risk for migration beneath the fovea should be considered for removal....
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PMID: 18854788
PDF is available here.
PDF is available here.
Molecular Vision (15) 2009
Abstract
Principal component analysis (PCA) showed a wide dispersal of the different clinical conditions. Partial least squares discriminant analysis (PLS-DA) was used to define differences between lens-induced uveitis (LIU) and chronic uveitis (CU) and could distinguish between these conditions with a sensi...
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PMID: 19536306
PDF is available here.
PDF is available here.
Vestnik oftalmologii (125)5 2009
Abstract
IgM, IgG, IgA, and IgE in the subretinal fluid (SRF) of the subpopulational composition of peripheral blood T lymphocytes and the parameters of a leukocyte migration inhibition test (LMIT) were comparatively studied in patients with posttraumatic and regmatogenic retinal detachments (RD) complicated...
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PMID: 19916335
PDF is available here.
PDF is available here.
Abstract
The trauma model with dispase and retinal diathermy produces vitreoretinal membranes. Hypericin was considered effective in PVR emergence and progression decrease....
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PMID: 20027403
PDF is available here.
PDF is available here.
Abstract
Familial exudative vitreoretinopathy (FEVR) is an inherited blinding condition characterized by abnormal development of the retinal vasculature. The authors describe a rare case of the disease associated with severe infantile osteoporosis in a young female patient. The patient was submitted to multi...
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PMID: 19466342
PDF is available here.
PDF is available here.
Abstract
Abstract
Postoperative follow-up time was between 6 and 63 months (mean: 18 months). 1) Combined surgery: Preoperative best-corrected visual acuity (BCVA) ranged from 20/200 to hand motions, and postoperative BCVA ranged from 20/30 to hand motions. BCVA improved in 17 eyes (60.7%), while in 7 (25%) eyes ther...
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PMID: 19173136
PDF is available here.
PDF is available here.
Abstract
Proliferative Vitreoretinopathy (PVR) refers to the migration and proliferation of cells into the subretinal space, vitreous cavity, and onto the retinal surface and undersurface. Subsequent collagen production and cell-mediated contraction of the collagenous scar leads to retinal detachment and los...
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PMID: 19899548
PDF is available here.
PDF is available here.
Der Ophthalmologe (106)1 2009
Abstract
Abstract
Twenty-three gauge instrumentation seems to be feasible, effective and safe for vitrectomy with SO injection in DTRD and PVR, and can be considered in the surgical management of these complex vitreoretinal diseases....
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PMID: 19237782
PDF is available here.
PDF is available here.
Annals of Saudi Medicine (29)5 2009
Abstract
Twenty patients were included in the study, accounting for 9.4% of all retinal detachment surgery cases performed over a period of 3 years (January 2006 to December 2008). The median age was 11.0 years, (range, birth to 18 years). Trauma, (45%) myopia/vitreoretinal degeneration (10%) and prior ocula...
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PMID: 19700893
PDF is available here.
PDF is available here.
Abstract
The most common conditions predisposing to rhegmatogenous retinal detachment were peripheral retinal degeneration and trauma. Rhegmatogenous retinal detachments secondary to iridofundal coloboma may be more common than previously reported. A combination of buckling and vitreoretinal techniques helpe...
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PMID: 18835797
PDF is available here.
PDF is available here.
Abstract
We conclude that targeting of ILK with a small interfering RNA not only inhibits human RPE cell attachment, spreading, migration and proliferation in vitro, but also effectively suppresses development of proliferative vitreoretinopathy in a rabbit model. This may be a potential therapeutic usefulnes...
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PMID: 18926819
PDF is available here.
PDF is available here.
Abstract
Successful removal of subretinal perfluorocarbon liquid was achieved in all cases with no complications. Visual acuity improved in all patients. CONCLUSION: With the technique presented, retained subretinal perfluorocarbon liquid can be successfully removed with minimal trauma to adjacent tissues....
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PMID: 19029164
PDF is available here.
PDF is available here.
Bioscience Reports (28)6 2008
Abstract
We examined the molecular signalling involved in thrombin-induced RPE cell proliferation, using rat RPE cells in culture as a model system for PVR pathogenesis. Our results showed that thrombin activation of PAR-1 induces RPE cell proliferation through Ras-independent activation of the Raf/MEK/ERK1/...
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PMID: 18636965
PDF is available here.
PDF is available here.
Ophthalmology (115)12 2008
Abstract
The incidence of endophthalmitis was 0.03% for both 20-G and 25-G vitrectomies. This is the first data set to demonstrate no statistically significant difference between endophthalmitis rates in 20-G and 25-G vitrectomy. At the completion of 25-G vitrectomy, the ocular surface irrigation fluid and v...
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PMID: 18930557
PDF is available here.
PDF is available here.
Abstract
These results elucidate the critical role of TGF-β in mediating cicatricial contraction in proliferative vitreoretinal diseases. ROCK, a key downstream mediator of TGF-β and other factors might become a unique therapeutic target in the treatment of proliferative vitreoretinal diseases....
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PMID: 18952846
PDF is available here.
PDF is available here.
Molecular Biotechnology (40)3 2008
Abstract
We investigate HBP21, a novel human protein of unknown function having three tandem TPR motifs predicted by computational sequence analysis. We confirmed the high expression of HBP21 in breast cancer and proliferative vitreoretinopathy (PVR) proliferative membrane and examined whether HBP21 could in...
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PMID: 18587674
PDF is available here.
PDF is available here.
Abstract
We present an interventional consecutive case series to describe our experience of transvitreal endoresection (TVE) for vasoproliferative retinal tumours (VPRTs). Three patients with VPRTs refractory to conventional treatment modalities of cryotherapy, plaque radiotherapy and anti-VEGF presented wit...
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PMID: 19128373
PDF is available here.
PDF is available here.
Abstract
A total of 103 patients were recruited, 70 men and 32 women, mean age 56.7 years, with 57 left eyes. Mean duration of follow up was 9.2 months. Nineteen patients (18.4%) had BvRPE, and 20 had RPE clusters off blood vessels (nine had both). In those with the sign of BvRPE the mean number of RPE clust...
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PMID: 19128379
PDF is available here.
PDF is available here.
Abstract
LOX activity showed a statistically significant decrease in the vitreous of PDR and RRD relative to control specimens. This effect can contribute to the inadequate collagen cross-linking that causes the ECM changes that occur in these diseases....
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PMID: 18566459
PDF is available here.
PDF is available here.
Abstract
PURPOSE. To better understand the mechanism underlying the anti-apoptotic activity of {alpha}B-crystallin in RPE cells. METHODS. Cells of the human retinal pigment epithelial line ARPE-19 were treated with a histone deacetylase inhibitor (HDACI), suberoylanilide hydroxamic acid (SAHA), with or witho...
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PMID: 18552382
PDF is available here.
PDF is available here.
Abstract
Statins might have therapeutic potential in the prevention of PVDs....
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PMID: 18599521
PDF is available here.
PDF is available here.
Abstract
Twenty-seven patients were operated on with a mean follow-up of 57.5 weeks. Twenty-three patients presented a posterior PVR > CP6 and 26 patients an anterior PVR > CA5. Heavy silicone oil was removed in 19 patients after a mean follow-up of 14 weeks. At the 4-week follow-up visit, only one retinecto...
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PMID: 18587596
PDF is available here.
PDF is available here.
Abstract
Fifty patients (50 eyes) underwent vitrectomy with silicone oil intraocular tamponade for RD with proliferative vitreoretinopathy. The mean duration of intraocular silicone oil tamponade was 4.5 months (1-15 months). Seventeen patients had complementary procedures such as phacoemulsification, epimac...
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PMID: 19107043
PDF is available here.
PDF is available here.
Der Ophthalmologe (105)10 2008
Abstract
In spite of the technical progress in vitreoretinal surgery, the anatomical and functional results of severe ocular injuries involving the posterior segment are still discouraging. Perforating injuries and ruptures that extend posterior to the muscle insertions have the worst outcomes. When the seco...
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PMID: 18830604
PDF is available here.
PDF is available here.
Der Ophthalmologe (105)10 2008
Abstract
Due to its function of light perception, the eye is exposed to high levels of radiation of the optical spectrum. Most of the ultraviolet and infrared radiation is absorbed in the cornea and lens, and mostly only radiation of the visible spectrum can reach the retina. Visible light can cause retinal...
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PMID: 18815792
PDF is available here.
PDF is available here.
Abstract
Postoperative administration with oral moderate dosage of RA for eight weeks appears to maintain retinal attachment, decrease the macular pucker, and improve vision after surgical repair for eyes with PVR....
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PMID: 18599016
PDF is available here.
PDF is available here.
Abstract
Proliferative vitreoretinopathy (PVR) is the most common cause of anatomic failure in retinal detachment surgery. To understand the molecular mechanisms, vitreous proteomes of patients with PVR were investigated by two-dimensional-nano-liquid chromatography coupled with tandem mass spectrometry. Vit...
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PMID: 18752205
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (112)9 2008
Abstract
To survey the use of silicone oil in clinical ophthalmology in Japan.
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PMID: 18833943
PDF is available here.
PDF is available here.