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Down-Regulation (0):
Recent article
Down-Regulation
Abstract
We show that inhibition of Bcr-Abl oncogene by imatinib induces down-regulation of Jab1 in Bcr-Abl-positive K562, Ku812, and MEG01 leukemia cells suggesting Bcr-Abl may regulate Jab1 expression. Promoter deletion and mutation analysis indicate the Tcf-4/β-catenin and STAT1 binding sites located bet...
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PMID: 21935931
PDF is available here.
PDF is available here.
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Journal of Virology (85)21 2011
Abstract
Persistent infections with human papillomavirus type 16 (HPV16), HPV18, or HPV31 are necessary for the development of cervical cancer, implying that HPVs have evolved immunoevasive mechanisms. Recent global transcriptome analyses indicated that these HPV types downregulate the consti...
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PMID: 21849431
PDF is available here.
PDF is available here.
Abstract
We used a foamy virus vector to express the miRNAs in human hematopoietic progenitors and performed immune reconstitutions in NOD/LtSz-scid IL2Rγ(null) mice. We found that ectopic expression of miR-K12-11 or miR-155 leads to a significant expansion of the CD19(+) B-cell population in the spleen. Su...
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PMID: 21813606
PDF is available here.
PDF is available here.
Life Sciences (89)11-12 2011
Abstract
We used activated EL-4 murine T-lymphoma cells, which produce interleukin (IL)-4 and IL-5, but not interferon (IFN)-γ, as T(H)2 cell-like cells and treated them with PMA+cAMP to investigate the effects of shikonin on T(H)2 cytokines, transcriptional factors, and the related mitogen-activated protei...
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PMID: 21806999
PDF is available here.
PDF is available here.
Developmental Cell (21)3 2011
Abstract
We report a role of Lgl1, the mammalian homolog of Drosophila tumor suppressor Lethal giant larvae, in controlling membrane trafficking underlying axonal growth. We find that Lgl1 is associated with plasmalemmal precursor vesicles and enriched in developing axons. Lgl1 upregulation promoted axonal g...
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PMID: 21856246
PDF is available here.
PDF is available here.
Brain research (1411) 2011
Abstract
We show MMP-9 overexpression conferred a poor prognosis in 163 GBM patients. Furthermore, MMP-9 specific miRNA expression profile (14 positively and 31 negatively correlated miRNAs with MMP-9) was established via miRNA microarrays in 60 GBM samples. Among them, two miRNAs: miR-885-5p and miR-491-5p,...
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PMID: 21831363
PDF is available here.
PDF is available here.
British Journal of Cancer (105)6 2011
Abstract
We found that miR-874 was significantly reduced in cancer cells. We focused on the functional significance of miR-874 in cancer cells and identification of miR-874-regulated novel cancer networks in MSSCC.
We used PCR-based methods to investigate the downregulated miRNAs in clinical...
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PMID: 21847129
PDF is available here.
PDF is available here.
Abstract
We present evidence that Nedd4-2 coimmunoprecipitated with NCC and stimulated NCC ubiquitylation at the surface of transfected HEK293 cells. In Xenopus laevis oocytes, coexpression of NCC with wild-type Nedd4-2, but not its catalytically inactive mutant, strongly decreased NCC activity and surface e...
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PMID: 21852580
PDF is available here.
PDF is available here.
Abstract
We previously reported that it also plays a key role in the tumorigenesis and metastasis of human osteosarcoma. In the present study, we constructed a recombinant encoding BLCAP cDNA. Overexpression of BLCAP resulted in growth inhibition and induced apoptosis of human TC-135 Ewing's sarcoma cells in...
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PMID: 21844121
PDF is available here.
PDF is available here.
Abstract
Macrolide antibiotics have been used to treat acute and chronic inflammation in the respiratory tract based on their antibacterial activity. Now it is well known that macrolides down-regulate damaging prolonged inflammation as well as increase mucous clearance and decrease bacterial...
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PMID: 21991841
PDF is available here.
PDF is available here.
Abstract
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to modulate multiple cellular processes, including apoptosis. The aim of this study was to assess the effects of HCV NS5A on apoptosis induced by Toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS)....
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PMID: 21844306
PDF is available here.
PDF is available here.
Genes & Development (25)16 2011
Abstract
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mitochon...
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PMID: 21852532
PDF is available here.
PDF is available here.
Abstract
We found that it also acts as a polarizing factor for axon/dendrite development in cultured hippocampal neurons. Exposure of the undifferentiated neurite to localized Sema3A suppressed its differentiation into axon and promoted dendrite formation, resulting in axon formation away from the Sema3A sou...
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PMID: 21835341
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)32 2011
Abstract
We show that PS impairs the morphological and functional maturation of hippocampal granule cells in adult offspring via the downregulated expression of mineralocorticoid receptors. PS reduced the dendritic complexity and spine density of neonatal-generated granule cells, which persists into adulthoo...
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PMID: 21832180
PDF is available here.
PDF is available here.
Abstract
The C57BL/6 mice were subjected to a chronic combined stress which resulted in the induction of a depressive-like state. The occurrence of a depressive-like state was defined by a decrease in sensitivity to the reward determined by the diminished preference of sweetened solutions ove...
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PMID: 21961309
PDF is available here.
PDF is available here.
Abstract
We showed that low testosterone increases the risk of mortality. We here studied plausible links among testosterone levels, vascular derangements, and cardiovascular events in nondialysis CKD men. Design, setting, participants, & methods This was a cross-sectional analysis in which flow-mediated dil...
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PMID: 21700826
PDF is available here.
PDF is available here.
Abstract
We describe a human syndrome featuring craniosynostosis, maxillary hypoplasia, delayed tooth eruption, and supernumerary teeth. We performed homozygosity mapping in three unrelated consanguineous Pakistani families and localized the syndrome to a region in chromosome 9. Mutational analysis of candid...
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PMID: 21741611
PDF is available here.
PDF is available here.
Abstract
Aim for this study was to investigate the effect of long-acting beta2-adrenoceptor agonist formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice.
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PMID: 21780541
PDF is available here.
PDF is available here.
Oral Oncology (47)9 2011
Abstract
We showed that some growth factors are produced in higher levels by tumor-associated myofibroblasts compared to tumor-associated fibroblasts, including activin A. Myofibroblast-conditioned media containing activin A significantly increased OSCC cell proliferation and tumor volume, whereas down-regul...
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PMID: 21727023
PDF is available here.
PDF is available here.
Oral Oncology (47)9 2011
Abstract
The HIV/SIV accessory protein Nef is known to down-modulate cell surface receptors that are required for virus entry such as CD4, CCR5 and CXCR4 to block lethal viral superinfection of the infected cell. The chemokine receptor CXCR4 also plays an important role in promoting cell proliferation, metast...
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PMID: 21763177
PDF is available here.
PDF is available here.
Abstract
To evaluate the effect of RNA interference (RNAi) mediated silence of signal transduction and activation of transcription (STAT)3 on the growth of human pancreatic cancer cells both in vitro and in vivo.
STAT3 specific shRNA was used to silence the expression of STAT3...
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PMID: 21799645
PDF is available here.
PDF is available here.
Abstract
We tested whether integrin β1 and FAK-Src signaling are abnormally regulated in autism and whether abnormal FAK-Src signaling leads to defects in B-lymphoblast adhesion, migration, proliferation, and IgG production. To our knowledge, for the first time, we show that protein expression levels of bot...
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PMID: 21703394
PDF is available here.
PDF is available here.
Abstract
We identified a heterozygous SMAC/DIABLO mutation, c.377C>T (p.Ser126Leu, refers to p.Ser71Leu in the mature protein) in a six-generation Chinese kindred characterized by dominant progressive nonsyndromic hearing loss, designated as DFNA64. SMAC/DIABLO is highly expressed in human embryonic ears and...
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PMID: 21722859
PDF is available here.
PDF is available here.
Oral Oncology (47)7 2011
Abstract
We explored the expression of CHD5 in 65 patients with laryngeal squamous cell carcinoma (LSCC) using real-time PCR, immunohistochemistry and Western blotting. DNA methylation was detected using bisulfate-specific sequencing. The potential function of CHD5 was determined using MTT, apoptosis and tra...
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PMID: 21636313
PDF is available here.
PDF is available here.
Abstract
We have reported that excessive amounts of IL-13 are produced by peripheral blood effector CD8+ T cells from patients with diffuse cutaneous SSc (dcSSc). The aim of the present study was to establish the molecular basis of IL-13 dysregulation in the pathogenesis of SSc....
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PMID: 21638273
PDF is available here.
PDF is available here.
Abstract
Our results indicated that occludin small-interfering RNA (siRNA) transfection causes an increase in transepithelial flux of various-sized probes, including urea, mannitol, inulin, and dextran, across the Caco-2 monolayers, without affecting the transepithelial resistance. The increase in relative f...
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PMID: 21415414
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)6 2011
Abstract
We employed in vivo approach to explore if endogenous PTEN participates in EMT (Epithelial-mesenchymal transition) in early chick embryo. PTEN was initially detected to highly express in primitive streak during chick gastrulation, in which EMT occurs, and subsequently mesoderm structure such as somi...
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PMID: 21684867
PDF is available here.
PDF is available here.
Abstract
First, we found that exposure of normal mice to DEP consisting of standard reference material (SRM) 2975 via intratracheal installation can downregulate NEP expression in a concentration-dependent manner. The changes were accompanied by increases in the number of macrophages and epithelial cells, as...
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PMID: 21877416
PDF is available here.
PDF is available here.
Abstract
We reported that CIDEA and CIDEC are differentially regulated by insulin and contribute separately to insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. However, the upstream signals of CIDE proteins remain unclear. Here, we investigated the signaling molecules involved...
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PMID: 21636835
PDF is available here.
PDF is available here.
Abstract
We now reveal a novel role of IL-28 cytokines in inducing type 1 immunity and protection from allergic airway disease. Treatment of wild-type mice with recombinant or adenovirally expressed IL-28A ameliorated allergic airway disease, suppressed Th2 and Th17 responses and induced IFN-γ. Moreover, ab...
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PMID: 21538995
PDF is available here.
PDF is available here.
Cancer Epidemiology (35)3 2011
Abstract
We evaluated the effect of sulforaphane alone or in combination with gemcitabine on HeLa cells by cell viability assay and confirmed the results by apoptosis assay. Further we analyzed the effect of sulforaphane on the expression of Bcl-2, COX-2 and IL-1β by RT-PCR on HeLa cells.
In...
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PMID: 20956097
PDF is available here.
PDF is available here.
Abstract
preoperatively, plasma esterase activity was significantly lower in patients who developed delirium compared with the remaining subjects. Following surgery BuChE activity was lower in the delirium group but this difference disappeared after controlling for preoperative values. Plasma cholinesterase...
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PMID: 21576115
PDF is available here.
PDF is available here.
Abstract
We observed that IL-12 initially activates NK cells, but prolonged IL-12 treatment specifically down-regulates IL-12 signaling and induces NK cell apoptosis associated with a significant reduction in cytolytic activity and IFN-γ production in response to further IL-12 stimulation. Further results d...
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PMID: 21543583
PDF is available here.
PDF is available here.
Abstract
We found that NMDA receptor activity and Ca(2+) influx caused the dephosphorylation of Ser940 in dissociated rat neurons, leading to a loss of KCC2 function that lasted longer than 20 min. Protein phosphatase 1 mediated the dephosphorylation events of Ser940 that coincided with a deficit in hyperpol...
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PMID: 21532577
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)12 2011
Abstract
In our series, Id1 levels showed an independent prognostic value in patients with adenocarcinoma, regardless of the stage. Id1 silencing may sensitize adenocarcinoma cells to radiotherapy and chemotherapy....
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PMID: 21540238
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)12 2011
Abstract
MMP1 and MMP2 may be useful biomarkers that can help risk stratify patients at higher risk of developing recurrence in colorectal cancer, and guide individualized treatment decisions to achieve better outcomes....
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PMID: 21531813
PDF is available here.
PDF is available here.
Cell Metabolism (13)5 2011
Abstract
We report that knockdown of NPY expression in the DMH by adeno-associated virus-mediated RNAi reduced fat depots in rats fed regular chow and ameliorated high-fat diet-induced hyperphagia and obesity. DMH NPY knockdown resulted in development of brown adipocytes in inguinal white adipose tissue thro...
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PMID: 21531339
PDF is available here.
PDF is available here.
Abstract
We combine metabolic labeling of RNA at high temporal resolution with advanced RNA quantification and computational modeling to estimate RNA transcription and degradation rates during the response of mouse dendritic cells to lipopolysaccharide. We find that changes in transcription rates determine t...
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PMID: 21516085
PDF is available here.
PDF is available here.
Abstract
Down-regulating human telomerase reverse transcriptase (hTERT) expression will significantly suppress the cell viability of laryngeal squamous cell carcinoma Hep-2, which was mainly due to the inhibition of cyclin D1 and thus G1/S phase transition.
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PMID: 21492065
PDF is available here.
PDF is available here.
Abstract
We investigated the functions of two fatty acid biosynthesis genes; pod-2, encoding acetyl-CoA carboxylase, and fasn-1, encoding fatty acid synthase, in the C. elegans molting process. Although both the pod-2 and fasn-1 genes were expressed at constant levels throughout C. elegans development, knock...
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PMID: 21524356
PDF is available here.
PDF is available here.
Abstract
We hypothesize that dysregulation of immune-related genes modifies synaptic functions and stability in this region....
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PMID: 21091092
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)4 2011
Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.
Abstract
We test our hypothesis that the Hypocretin system is regulated by TNF-α. Prepro-Hypocretin and Hypocretin receptor 2 (HcrtR2) can be detected at a very low level in rat B35 neuroblastoma cells. In response to TNF-α, Prepro-Hypocretin mRNA and protein levels are down-regulated, and also HcrtR2 prot...
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PMID: 21094253
PDF is available here.
PDF is available here.
Abstract
To determine the effect of Legalon-SIL (LS) on hepatitis C virus (HCV) core and NS5A expression and on heme oxygenase-1 (HMOX-1) and its transcriptional regulators in human hepatoma cells expressing full length HCV genotype 1b.
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PMID: 21483629
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)3 2011
Abstract
We investigated the molecular mechanism of the effects of this combination therapy on melanoma tumor growth. In B16 tumor-bearing mice, the addition of IFN-α to DTIC treatment significantly reduced tumor volume, compared with control or DTIC alone. Consistently, Digital Radiography data showed less...
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PMID: 21389866
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We analyzed altered protein expressions in various tissues, namely, brain, lung, spleen, and intestine, from 1 Gy-irradiated mice by employing 2-DE analysis. MALDI-TOF MS and peptide mapping identified 25 proteins that showed greater than twofold expressional changes. In order to confirm signific...
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PMID: 21319302
PDF is available here.
PDF is available here.
Brain research (1382) 2011
Abstract
We report that either deafferentation or reduction of sensory input by nares occlusion significantly reduced GAD67 protein and the number of SA cells expressing GAD67. However, neither manipulation altered GAD65 protein or the number of GAD65 PG cells. These findings show that sensory experience str...
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PMID: 21276774
PDF is available here.
PDF is available here.
Abstract
We used three independent experimental approaches to determine the role of ADK as a molecular target for predicting the brain's susceptibility to ischemic stroke. First, when subjected to a middle cerebral artery occlusion model of focal cerebral ischemia, transgenic fb-Adk-def mice, which have incr...
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PMID: 21427729
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to determine whether lower expression levels of DICER1 are associated with disease recurrence in patients with endometrioid endometrial cancer. The authors also explored DNA methylation and haploinsufficiency as potential mechanisms related to altered DICER1 expression...
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PMID: 21425145
PDF is available here.
PDF is available here.
Abstract
We sought to determine the mechanism by which BMP4 is down-regulated in CNV. BMP4 expression was decreased within laser-induced CNV lesions in mice at a time when tumor necrosis factor (TNF) expression was high (7 d postlaser) and was reexpressed in RPE when TNF levels declined (14 d postlaser). We...
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PMID: 21411747
PDF is available here.
PDF is available here.
Abstract
We investigated whether HDB would inhibit the ODC pathway to enhance apoptosis in human promyelocytic leukemia HL-60 cells. We found ODC enzyme activity was reduced during HDB treatment. Overexpression of ODC in HL-60 parental cells could reduce HDB-induced apoptosis, which leads to loss of mitochon...
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PMID: 21372632
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
Carcinoma-associated fibroblasts (CAFs) in tumor stroma play an important role in tumor progression and have been associated with a poor prognosis in oral squamous cell carcinoma (OSCC). However, how CAFs influence OSCC malignancy and whether normalizing CAFs inhibits cancer progression remain unclea...
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PMID: 21385934
PDF is available here.
PDF is available here.
Abstract
We studied the process of folate transport and the expression of folate transporters in the rat intestine after folate oversupplementation. Rats were oversupplemented with tenfold the normal requirement of folic acid for periods of 10 and 60 d. Folate uptake in intestinal brush-border membrane vesic...
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PMID: 21092376
PDF is available here.
PDF is available here.
Abstract
The investigators' laboratory has demonstrated that the Notch1 signaling pathway acts as a tumor suppressor in carcinoid tumors. The aim of this study was to examine hesperetin, a flavonoid, as a potential Notch1 activator and carcinoid tumor suppressor.
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PMID: 21367373
PDF is available here.
PDF is available here.
Abstract
OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance.
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PMID: 21404460
PDF is available here.
PDF is available here.
Abstract
We have utilized a spliceoform-specific microarray and polymerase chain reaction to evaluate all known splice variants in human pancreatic cancer cell lines representing a spectrum of differentiation, from near-normal HPDE6 to Capan-1 and poorly differentiated MiaPaCa2 cells. Validation of altered s...
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PMID: 21178653
PDF is available here.
PDF is available here.
Abstract
To explore the mechanism of retinoic acid (RA) protection against hyperoxia-induced lung injury.
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PMID: 21426648
PDF is available here.
PDF is available here.
Abstract
To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma.
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PMID: 21448356
PDF is available here.
PDF is available here.
Abstract
To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, to repair the intestinal epithelium barrier dis...
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PMID: 21359923
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether loss of JPH2 expression is noted among patients with HCM and whether expression silencing might perturb Ca(2+) handling in a prohypertrophic manner.
JPH2 expression was reduced in flash-frozen human cardiac tissue procured from patients with HCM compare...
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PMID: 21216834
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether loss of JPH2 expression is noted among patients with HCM and whether expression silencing might perturb Ca(2+) handling in a prohypertrophic manner.
JPH2 expression was reduced in flash-frozen human cardiac tissue procured from patients with HCM compare...
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PMID: 21216834
PDF is available here.
PDF is available here.