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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Epigenesis, Genetic (4):
Recent article
Epigenesis, Genetic
Abstract
We will discuss recent advances gleaned from application of global "omics" techniques to dissect the molecular mechanisms that define the pluripotent state. Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 12 is August 30, 2011. Please see http://www...
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PMID: 21801025
PDF is available here.
PDF is available here.
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Abstract
Our results indicated that there were 23 combinatorial patterns for 12 histone modifications investigated when a general Bayesian network was constructed. Meanwhile, different networks were also constructed for the genes with high transcript levels (H-network) and low transcript levels (L-network),...
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PMID: 21815215
PDF is available here.
PDF is available here.
Abstract
We show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs. We improved the Sendai virus vectors by introducing temperature-sensitive mutations so that the vectors could be easily...
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PMID: 21821793
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1816)1 2011
Abstract
We present a compilation of multiple types of information on each HNSCC linked miRNA including their expression status in tumors, their molecular targets relevant to cancer, results of gene manipulation studies and association with clinical outcome. Further, we use this information to devise a new s...
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PMID: 21549178
PDF is available here.
PDF is available here.
Abstract
Histone deacetylases inhibitors (HDACi) represent a new epigenetic targeting therapy class, which is widely investigated in fundamental research and clinical trials. They are able to restore and increase tumor suppressor genes expression and to play an anti-tumoral activity through numerous targets,...
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PMID: 21827981
PDF is available here.
PDF is available here.
Nature Cell Biology (13)8 2011
Abstract
How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Sta...
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PMID: 21808242
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)26 2011
Abstract
Abstract
We discuss proven and proposed ways risk genes can be used to enhance the development and discovery of treatments for schizophrenia and highlight key studies in these approaches....
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PMID: 21093417
PDF is available here.
PDF is available here.
Abstract
We will describe the different methods of reprogramming somatic cells....
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PMID: 21702219
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)6 2011
Abstract
Inheritable variation induced by plant grafting is a universal phenomenon; however, its mechanism has always been a controversial subject. In recent years, research on horizontal transfer of genetic materials between stock and scion has made great progress. The latest studies have found that genetic...
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PMID: 21684863
PDF is available here.
PDF is available here.
Abstract
Epigenetic modifications of N-terminal histone tails, especially histone H3, are important for the regulation of the target genes in chromatin. Specific methods for detection of these modifications in histone H3 N-terminal peptides are valuable tools for diagnostic and therapeutic...
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PMID: 21749292
PDF is available here.
PDF is available here.
Abstract
We will discuss recent approaches to PKD therapy. It provides important information regarding potential targets for PKD. [BMB reports 2011; 44(6): 359-368]....
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PMID: 21699747
PDF is available here.
PDF is available here.
Abstract
Without any alteration of DNA sequence, heritable changes in gene expression, caused by epigenetic pathways, are gaining a spotlight in research of diseases, and in particular, cancer. Although the dominant paradigm in cancer research, proposed by Vogelstein, suggested that cancer progression was ca...
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PMID: 21318291
PDF is available here.
PDF is available here.
Plant Biology (62)1 2011
Abstract
The epigenomic regulation of chromatin structure and genome stability is essential for the interpretation of genetic information and ultimately the determination of phenotype. High-resolution maps of plant epigenomes have been obtained through a combination of chromatin technologies...
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PMID: 21438682
PDF is available here.
PDF is available here.
Plant Biology (62)1 2011
Abstract
The flowering plant germline is produced during the haploid gametophytic stage. Defining the germline is complicated by the extreme reduction of the male and female gametophytes, also referred to as pollen and embryo sac, respectively. Both male and female gamete progenitors are segr...
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PMID: 21332359
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)8 2011
Abstract
We summarize the roles of siRNA-mediated chromatin modification in various biological processes of A. thaliana, and present some speculation on the functions and interactions of silencing factors that, while not yet assigned to defined biochemical activities, have been loosely assigned to specific e...
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PMID: 21605714
PDF is available here.
PDF is available here.
Abstract
We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epithelial-mesenchymal transition (EMT). Here, we show that MAP3K4 controls the activity of the histone acetyltransferase CBP, and that acetylation of histones H2A and H2B...
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PMID: 21549327
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)5 2011
Abstract
The low efficiency of somatic cell nuclear transfer (SCNT) is a significant barrier to the production of highly valuable transgenic livestock. It is generally believed that the principal cause of the low SCNT efficiency is the aberrant nuclear epigenetic reprogramming of donor somatic cell. DNA methy...
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PMID: 21586401
PDF is available here.
PDF is available here.
Abstract
We further confirmed that the mRNA expression of six of these 25 genes, namely family with sequence similarity 178, member A (FAM178A), retinoic acid receptor responder (tazarotene induced) (RARRES1), ubiquitin specific peptidase 28 (USP28), Scm-like with four mbt domains 2 (SFMBT2), family with seq...
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PMID: 21756782
PDF is available here.
PDF is available here.
Abstract
We report the validation of a fast and sensitive method for the quantification of global 5-hydroxymethyl-2'-deoxycytidine (5 hmdC) in DNA. The method is based on a procedure consisting of fluorescence labeling of deoxyribonucleotides and analysis by capillary electrophoresis with laser-induced fluor...
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PMID: 21593596
PDF is available here.
PDF is available here.
Abstract
Triple-negative breast cancer (TNBC) occurs in approximately 15% of all breast cancer patients, and the incidence of TNBC is greatly increased in BRCA1 mutation carriers. This study aimed to assess the impact of BRCA1 promoter methylation with respect to breast cancer subtypes in spo...
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PMID: 21593597
PDF is available here.
PDF is available here.
Abstract
We review recent studies exploring the role of DNA methylation in these critical processes. Further, we suggest that, perhaps, the adult brain controls and utilizes the mechanism of DNA methylation in non-traditional ways that are waiting to be explored....
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PMID: 21527830
PDF is available here.
PDF is available here.
Abstract
Sponsored by the New York Academy of Sciences, the Warren Alpert Medical School of Brown University and the University of Massachusetts Boston, "Behavioral Epigenetics" was held on October 29-30, 2010 at the University of Massachusetts Boston Campus Center, Boston, Massachusetts. This meeting feature...
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PMID: 21615751
PDF is available here.
PDF is available here.
Abstract
We have recently demonstrated that exposure to a suboptimal diet during early development leads to abnormal epigenetic regulation of a promoter-enhancer interaction at the gene encoding HNF-4α, a key transcription factor required for pancreatic β-cell differentiation and glucose homeostasis. In ad...
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PMID: 21623004
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)8 2011
Abstract
A relatively high degree of nuclear DNA (nDNA) methylation is a specific feature of plant genomes. Targets for cytosine DNA methylation in plant genomes are CG, CHG and CHH (H is A, T, C) sequences. More than 30% total m(5)C in plant DNA is located in non-CG sites. DNA methylation in plants is specie...
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PMID: 21549230
PDF is available here.
PDF is available here.
Abstract
We addressed the question of the influence of the locus structure and epigenetic modifications of the target locus on its susceptibility for being paramutated by trans-acting small RNA molecules. Silencing was induced by crossing a 35S promoter silencer locus 271 with two different 35S-driven transg...
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PMID: 21521939
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)4 2011
Abstract
As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biological processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effec...
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PMID: 21482516
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)4 2011
Abstract
We described that active DNA demethylation take place in a spatial- and temporal-specific way on the basis of recent literatures. Moreover, several candidate pathways such as oxygenation and deamination of 5-methyl cytosine and DNA repair pathways, which may be responsible for the active process wer...
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PMID: 21482518
PDF is available here.
PDF is available here.
Abstract
In plant cells, DNA is packaged into chromatin by wrapping around histone octamers. Pathways that lead to cytosine DNA methylation, posttranslational histone modifications and certain components of the RNA interfering (RNAi) pathway are critically important in modulating chromatin structure, thereby...
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PMID: 21470901
PDF is available here.
PDF is available here.
Epigenetics (6)4 2011
Abstract
We have investigated promoter methylation of the Insr, Igf1 and Igf1r genes in skeletal and cardiac muscles of normal and diabetic db/db mice. No differences in Insr promoter methylation were found in the heart and skeletal muscles and no methylation was detected in the Igf1 promoter in skeletal mus...
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PMID: 21474992
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)8 2011
Abstract
The finely regulated series of events that span from the birth of a cell to the production of two new born cells encompass the cell cycle. Cell cycle progression occurs in a unidirectional manner and requires passing through a number of stages in response to cellular, developmental and environmental...
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PMID: 21453801
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)8 2011
Abstract
Histone methylation plays an important role in epigenetic regulation of gene expression. Reversible methylation/demethylation of several histone lysine residues is mediated by distinct histone methyltransferases and histone demethylases. Jumonji proteins have been characterized to be involved in hist...
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PMID: 21419882
PDF is available here.
PDF is available here.
Abstract
In some plant species, prolonged exposure to low temperature during the winter season is necessary to acquire the competence to flower in the following spring. This process, known as vernalization, is an epigenetic change in that a mitotically stable change of the developmental poten...
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PMID: 21406964
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
To analyze the role and translational potential for hypermethylation of CpG islands and shores in the regulation of small RNAs within urothelial cell carcinoma (UCC). To examine microRNAs (miR) and mirtrons, a new class of RNA located within gene introns and processed in a Drosha-independent manner....
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PMID: 21138856
PDF is available here.
PDF is available here.
Abstract
Basic tenets of Mendelian inheritance are violated by paramutations in which trans-homolog interactions lead to heritable changes in gene regulation and phenotype. First described in plants, similar behaviors have now been noted in diverse eukaryotes. Genetic and molecular studies of paramutations oc...
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PMID: 21420347
PDF is available here.
PDF is available here.
Abstract
DNA methylation is an important epigenetic mechanism for silencing transposons and other repetitive elements, and for stable repression of specific transgenes and endogenous genes. Plants can utilize small interfering RNAs (siRNAs) to guide de novo DNA methyltransferases for the establishment of sequ...
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PMID: 21420348
PDF is available here.
PDF is available here.
Abstract
We resequenced 300 genes in matched diagnosis and relapse samples from 23 patients with ALL. This identified 52 somatic non-synonymous mutations in 32 genes, many of which were novel, including the transcriptional coactivators CREBBP and NCOR1, the transcription factors ERG, SPI1, TCF4 and TCF7L2, c...
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PMID: 21390130
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)7 2011
Abstract
To address the association between sequence variants within the MGMT (O(6)-methylguanine-DNA methyltransferase) promoter-enhancer region and methylation of MGMT in premalignant lesions from smokers and lung adenocarcinomas, their biological effects on gene regulation, and targeting MGMT for therapy....
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PMID: 21355081
PDF is available here.
PDF is available here.
Neuroinformatics (9)1 2011
Abstract
We report the development and implementation of an open access database (BTECH), a community resource for the deposition of a wide range of molecular data derived from brain tumor studies. This comprehensive database integrates multiple datasets, including transcript profiles, epigenomic CpG methyla...
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PMID: 21210251
PDF is available here.
PDF is available here.
Birth Defects Research (93)1 2011
Abstract
Considerable epidemiological, experimental and clinical data have amassed showing that the risk of developing disease in later life is dependent on early life conditions, mainly operating within the normative range of developmental exposures. This relationship reflects plastic respon...
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PMID: 21425438
PDF is available here.
PDF is available here.
Abstract
We present a model for the assembly and deposition of centromeric nucleosomes that couples these processes to the cell cycle. This model reconciles divergent data for CENP-A-containing nucleosomes and provides a basis for how centromere identity is stably inherited.
Copyright © 2011...
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PMID: 21335232
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)7 2011
Abstract
Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management.
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PMID: 21325292
PDF is available here.
PDF is available here.
Abstract
We discuss potential mechanisms for how Myc establishes and maintains the pluripotent state and incorporate proteomics data that supports a model where Myc acts as part of a regulatory network with epigenetic modifiers....
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PMID: 21293186
PDF is available here.
PDF is available here.
Trends in Genetics (27)4 2011
Abstract
The emerging field of epigenomics has the potential to bridge the gap between static genomic sequences and complex phenotypes that arise from multigenic, nonlinear and often context-dependent interactions. However, this goal can only be achieved if easily manageable experimental systems are available...
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PMID: 21288591
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
The importance of genetic and epigenetic alterations maybe in their aggregate role in altering core pathways in tumorigenesis.
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PMID: 21278247
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
This phase I study evaluated the safety, tolerability, pharmacokinetics, and preliminary efficacy of the combination of decitabine with vorinostat. Patients and Methods: Patients with advanced solid tumors or non-Hodgkin's lymphomas were eligible. Sequential and concurrent schedules were studied.
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PMID: 21278245
PDF is available here.
PDF is available here.
Abstract
I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases....
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PMID: 21270506
PDF is available here.
PDF is available here.
Abstract
We discuss how parent-of-origin effects and genomic imprinting may play a role in autoimmunity and speculate how imprinted miRNAs may influence the expression of many target autoimmune associated genes....
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PMID: 21627045
PDF is available here.
PDF is available here.
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques (67) 2011
Abstract
Acute leukemia is characterized by clonal expansion of hematopoietic stem and progenitor cells with blocked differentiation. Clinical and experimental evidences suggest that acute myeloid leukemia (AML) is the product of several functionally cooperating genetic alterations including chromosomal tran...
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PMID: 21141731
PDF is available here.
PDF is available here.
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques (67) 2011
Abstract
We review the most recent advances in the field of epigenetic mechanisms of mental retardation. In particular, we focus on animal models of the human diseases and the mechanism of transcriptional deregulation associated with changes in the cell epigenome....
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PMID: 21141728
PDF is available here.
PDF is available here.
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques (67) 2011
Abstract
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques (67) 2011
Abstract
We will briefly summarize our current knowledge of the epigenetic patterns and mechanisms of gene regulation in healthy tissues and relate this to what is known for cancer genomes. Our focus will be on DNA methylation. We will review the current standing of technologies that have been developed over...
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PMID: 21141723
PDF is available here.
PDF is available here.
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques (67) 2011
Abstract
We will review recent studies of small molecules in controlling cell fate....
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PMID: 21141734
PDF is available here.
PDF is available here.
Abstract
We are now at the stage where we can exploit this knowledge to address questions of how deregulated gene expression and aberrant chromatin programming contributes to disease processes. This chapter will give a basic introduction into the principles of epigenetics and the determinants of chromatin st...
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PMID: 21627039
PDF is available here.
PDF is available here.
Abstract
We first present a background on the occurrence of nickel in the environment, human exposure, and human health effects....
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PMID: 21905451
PDF is available here.
PDF is available here.
Abstract
We opted to release this communication to contribute to exploration of these issues. By using a questionnaire, containing residential history and activities that may have led to exposure to war contaminants, retrospective reproductive history of four polygamous Fallujah families were documented. Our...
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PMID: 21318016
PDF is available here.
PDF is available here.
Abstract
We have identified and studied an LHP1-Interacting Factor2 (LIF2). LIF2 protein has RNA recognition motifs and belongs to the large hnRNP protein family, which is involved in RNA processing. LIF2 interacts in vivo, in the cell nucleus, with the LHP1 chromo shadow domain. Expression of LIF2 was detec...
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PMID: 21304947
PDF is available here.
PDF is available here.
Abstract
We will discuss the contribution of 'omics' approaches to these discoveries as well as the possible impact that they are expected to have in the future....
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PMID: 21836626
PDF is available here.
PDF is available here.
Abstract
We performed parallel quantitative proteomic and phosphoproteomic analyses of hESCs during differentiation initiated by a diacylglycerol analog or transfer to media that had not been conditioned by feeder cells. We profiled 6521 proteins and 23,522 phosphorylation sites, of which almost 50% displaye...
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PMID: 21406692
PDF is available here.
PDF is available here.