Author(s) unavailable
Abstract
The earlier identified gene RAD31 was mapped on the right arm of chromosome II in the region of gene MEC1 localization. Epistatic analysis demonstrated that the rad31 mutation is an allele of the MEC1 gene, which allows further designation of the rad31 mutation as mec1-212. Mutation mec1-212, similar...
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PMID: 21786666
PDF is available here.
Abstract
There is substantial evidence that mitochondria are involved in the aging process. Mitochondrial function requires the coordinated expression of hundreds of nuclear genes and a few dozen mitochondrial genes, many of which have been associated with either extended or shortened life sp...
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PMID: 20601194
PDF is available here.
Abstract
We provide evidence of a rugged molecular fitness landscape arising during an evolution experiment in an asexual population of Saccharomyces cerevisiae. We identify the mutations that arose during the evolution using whole-genome sequencing and use competitive fitness assays to describe the mutation...
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PMID: 21552329
PDF is available here.
Abstract
We reviewed these strategies and methods, as well as their difficulty and challenge. Meanwhile, we presented a brief framework of GWAS next step to readers....
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PMID: 21377965
PDF is available here.
Abstract
We propose a Robust Multifactor Dimensionality Reduction (RMDR) method that performs constructive induction using a Fisher's Exact Test rather than a predetermined threshold. The advantage of this approach is that only statistically significant genotype combinations are considered in the MDR analysi...
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PMID: 21091664
PDF is available here.
Abstract
We aim to provide a comprehensive review of recent studies on the genetics of SSc, including genes associated with autoimmunity, fibrosis, and vascular disease. We also discuss the most relevant data obtained in genetic association studies of large populations that included a replication strategy, o...
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PMID: 21586222
PDF is available here.
Anna A Latiano,
Orazio O Palmieri,
Tiziana T Latiano,
Giuseppe G Corritore,
Fabrizio F Bossa,
Giuseppina G Martino,
Giuseppe G Biscaglia,
Daniela D Scimeca,
Maria Rosa MR Valvano,
Maria M Pastore,
Antonio A Marseglia,
Renata R D'Incà,
Angelo A Andriulli and
Vito V Annese
Abstract
We aimed to investigate the influence of SNPs tagging the genes/loci PTGER4, TNFSF15, NKX2-3, ZNF365, IFNG, PTPN2, PSMG1, and HLA in a large pediatric- and adult-onset IBD Italian cohort.
Eight SNPs were assessed in 1,070 Crohn's disease (CD), 1,213 ulcerative colitis (UC), 557 of wh...
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PMID: 21818367
PDF is available here.
Abstract
We designed a new approach that integrates epistatic association analysis in crop cultivars with breeding by design. First, we proposed an epistatic association mapping (EAM) approach in homozygous crop cultivars. The phenotypic values of complex traits, along with molecular marker information, were...
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PMID: 21423630
PDF is available here.
Abstract
We asked whether the PHO pathway was the same in the distantly related fission yeast, Schizosaccharomyces pombe. We screened a deletion collection for mutants aberrant in phosphatase activity, which is primarily a consequence of pho1(+) transcription. We identified a novel zinc finger-containing pro...
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PMID: 21169418
PDF is available here.
Abstract
We evaluated genetic variation in their candidate genes to obtain a better understanding of their association with colon and rectal cancer. We used data from two population-based case-control studies of colon (n=1574 cases, 1940 controls) and rectal (n=791 cases, 999 controls) cancer. We observed ge...
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PMID: 21035469
PDF is available here.
Abstract
Multiple statistically significant multilocus associations existed. IL2RA rs4749926 and TLR2 rs4696480 associated with IgE in both age groups tested (1-2 and 6-8 years). TGFBR2 polymorphisms associated with total and specific IgE in both age groups and with asthma. TGFBR2 rs9831477 associated with s...
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PMID: 20599261
PDF is available here.
Abstract
We evaluate the common perception that stress increases selection. We consider various conceptual paradigms for thinking about selection and stress, and then review the empirical data. We reject the notion that stress typically increases selection. Instead, we find that different types of stresses a...
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PMID: 20538366
PDF is available here.
Abstract
Our results could be helpful in further understanding the genetic interaction between candidate genes contributing to phenotypic variation of abdominal fat content in broilers....
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PMID: 20816383
PDF is available here.
Abstract
We decided to pursue the question of whether polymorphic variants of genes encoding enzymes involved in choline metabolism might be associated with the maternal risk of having a baby with NCL/P. Analysis of 18 single nucleotide polymorphisms (SNPs) of betaine-homocysteine methyltransferase (BHMT), b...
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PMID: 20662904
PDF is available here.
Abstract
We propose a two-phase procedure based on penalized likelihood techniques and extended Bayes information criterion (EBIC) for QTL mapping. The procedure consists of a screening phase and a selection phase. In the screening phase, the main and interaction features are alternatively screened by a pena...
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PMID: 20336448
PDF is available here.
Abstract
We have mutated core modifiable residues that are conserved in Saccharomyces cerevisiae histone H2B and characterized the effects of the mutants on yeast silencing, gene expression, and the DNA damage response. We identified three histone H2B core modifiable residues as functionally important. We fi...
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PMID: 20479120
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
|
PMID: 20487315
PDF is available here.
Abstract
SUMMARY: This study describes the quantitative trait locus (QTL) analysis of cadmium (Cd), zinc (Zn), iron (Fe), potassium (K), magnesium (Mg) and calcium (Ca) accumulation in the pseudometallophyte Arabidopsis halleri under conditions of Cd excess using an interspecific A. halleri x...
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PMID: 20487315
PDF is available here.
Abstract
The present study focused on the identification of epistatic QTL pairs for body composition traits (carcass cut, lean tissue, and fat tissue weights) measured at slaughter weight (140 kg of BW) in a 3-generation full-sib population developed by crossing Pietrain sires with a crossbre...
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PMID: 20228239
PDF is available here.
Abstract
We presented a QTL mapping result in rice (Oryza sativa) as an example to describe the features of QTLNetworkR....
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PMID: 20593516
PDF is available here.
Abstract
Peroxiredoxins are redox-sensing enzymes with multiple cellular functions. Previously, we reported on the potent antioxidant function of Drosophila peroxiredoxin 5 (dPrx5). Studies with mammalian and human cells suggest that peroxiredoxins can modulate immune-related signaling.
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PMID: 20600624
PDF is available here.
Abstract
Variation in leaf development caused by water deficit was analysed in 120 recombinant inbred lines derived from two Arabidopsis thaliana accessions, Ler and An-1. Main effect quantitative trait loci (QTLs) and QTLs in epistatic interactions were mapped for the responses of rosette area, leaf number...
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PMID: 20545881
PDF is available here.
Abstract
MicroRNAs are small non-coding RNAs which regulate gene expression in a post-transcriptional manner. Although the first study was published about 15 years ago, knowledge about their role in regulation of cell proliferation, differentiation, apoptosis and immunity has been greatly adv...
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PMID: 20621017
PDF is available here.
Abstract
MicroRNAs are small non-coding RNAs which regulate gene expression in a post-transcriptional manner. Although the first study was published about 15 years ago, knowledge about their role in regulation of cell proliferation, differentiation, apoptosis and immunity has been greatly adv...
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PMID: 20621017
PDF is available here.
Abstract
I was generally better than RBF II, and was able to identify relevant SNPs in the toy example....
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PMID: 20667165
PDF is available here.
Abstract
We found that the COMT x MAOA interaction significantly predicted full scale (FSIQ) and performance (PIQ) IQ scores (P = 0.039, 0.011); the MAOA-uVNTR significantly predicted FSIQ, PIQ and verbal IQ (VIQ) (P = 0.009, 0.019, 0.038); COMT Val158Met independently had no effect on any of the IQ scores....
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PMID: 19941049
PDF is available here.
Abstract
We consider many-site mutation-recombination models of molecular evolution, where fitness is a function of a Hamming distance from one (one-dimensional case) or two (two-dimensional case) sequences. For the one-dimensional case, we calculate the population distribution dynamics for a model with zero...
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PMID: 20866270
PDF is available here.