Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Transcriptional Activation (0):
Recent article
Transcriptional Activation
Abstract
We examined the spatial configuration of Hox clusters in embryonic mouse tissues where different Hox genes are active. When the cluster is transcriptionally inactive, Hox genes associate into a single 3D structure delimited from flanking regions. Once transcription starts, Hox clusters switch to a b...
|
PMID: 21998387
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We demonstrated that overexpressed HO-1 promotes the survival of renal cancer cells by inhibiting cellular apoptosis; we also showed that the proto-oncogene H-Ras becomes activated in these cells under stress following treatment with immunosuppressive agents. However, it is not known if there is an...
|
PMID: 21808062
PDF is available here.
PDF is available here.
Systems Biology, IET (5)5 2011
Abstract
Qualitative models allow understanding the relation between the structure and the dynamics of gene regulatory networks. The dynamical properties of these models can be automatically analysed by means of formal verification methods, like model checking. This facilitates the model-vali...
|
PMID: 22010757
PDF is available here.
PDF is available here.
Abstract
Atherosclerotic vascular disease, diabetes mellitus (DM) and dementia are major global health problems. Both endogenous and exogenous factors activate genes functioning in biological processes. This review article focuses on gene-activation mechanisms that regress atherosclerosis, el...
|
PMID: 21568932
PDF is available here.
PDF is available here.
Abstract
Hematopoietic stem cells (HSCs) differentiate into mature lineage restricted blood cells under the influence of a complex network of hematopoietic cytokines, cytokine-mediated transcriptional regulators, and manifold intercellular signaling pathways. The classical model of hematopoie...
|
PMID: 21426948
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We show that Saccharomyces cerevisiae NMD mutants accumulate 5'-extended RNAs (CD-CUTs) of many subtelomeric genes. Using the subtelomeric ZRT1 and FIT3 genes activated in response to zinc and iron deficiency, respectively, we show that transcription of these CD-CUTs mediates repression at the bona...
|
PMID: 21738494
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)9 2011
Abstract
We review the available data and integrate the results with structural and biochemical studies of related enzymes to derive a model for Mot1's catalytic action consistent with the broad literature on enzymes in this family. We propose that the Mot1 ATPase domain is tethered to TBP by a flexible, spr...
|
PMID: 21658482
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (36)5 2011
Abstract
We studied MR gene haplotypes constituted by the two single nucleotide polymorphisms MR-2G/C (rs2070951) and MRI180V (rs5522). The haplotypes showed differences in cortisol-induced gene transcription and protein expression while the structural variant MRI180V did not affect ligand binding. Moreover,...
|
PMID: 21095064
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We investigate the mechanisms by which ETS fusions mediate their effects, and find that the product of the predominant ETS gene fusion, TMPRSS2:ERG, interacts in a DNA-independent manner with the enzyme poly (ADP-ribose) polymerase 1 (PARP1) and the catalytic subunit of DNA protein kinase (DNA-PKcs)...
|
PMID: 21575865
PDF is available here.
PDF is available here.
Abstract
We replaced conserved residues at the dimer interface to design a heterodimer with increased stability. One E2R mutant in which histidine was replaced by a glutamate residue showed preferential heterodimer formation in vitro, as well as an increase in plasticity at the interface, as a result of hist...
|
PMID: 21482558
PDF is available here.
PDF is available here.
Abstract
We show that Drosophila STAT (STAT92E) functions as a general transcription factor that, together with the transcription factor Zelda, induces transcription of a large number of early-transcribed zygotic genes during the MZT. STAT92E is present in the early embryo as a maternal product and is active...
|
PMID: 21637778
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We describe the molecular mechanisms regulating the ubiquitin proteasome system, thereby focussing on Nrf2 as well as on the recently identified transcription factor (TF) TCF11. In response to proteasome inhibition TCF11 plays a central role in upregulating the proteasome system via an ERAD-dependen...
|
PMID: 21412055
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
The ATM substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ, also known as ATMIN and ZNF822) has previously been reported to be important for the repair of methylating and oxidative DNA damage, and it has also been proposed to regulate the stability and DNA damage-independent act...
|
PMID: 21415597
PDF is available here.
PDF is available here.
Abstract
We describe in this report functional consequences of Aurora-A phosphorylation of p53 tumor suppressor protein on its subcellular distribution and binding with ERα that may be important in downregulating the transcription of p53-responsive growth inhibitory genes and development of resistance to DN...
|
PMID: 21761334
PDF is available here.
PDF is available here.
Abstract
We examined the effects of cadmium chloride (CdCl₂) exposure on the expression and phosphorylation status of members of the Fos family, components of the activator protein-1 transcription factor, in HK-2 human renal proximal tubular cells. Following the exposure to CdCl₂, the expression of c-fos...
|
PMID: 21219922
PDF is available here.
PDF is available here.
Abstract
We examined the effects of cadmium chloride (CdCl₂) exposure on the expression and phosphorylation status of members of the Fos family, components of the activator protein-1 transcription factor, in HK-2 human renal proximal tubular cells. Following the exposure to CdCl₂, the expression of c-fos...
|
PMID: 21219922
PDF is available here.
PDF is available here.
Cell Host & Microbe (9)3 2011
Abstract
We have determined that Gat201 controls the mRNA levels of ∼1100 genes (16% of the genome) and binds the upstream regions of ∼130 genes. Seven Gat201-bound genes encode for putative and known transcription factors--including two previously implicated in virulence--suggesting an extensive regulat...
|
PMID: 21402362
PDF is available here.
PDF is available here.
Scientific American (304)2 2011
Abstract
Oligonucleotides (21)1 2011
Abstract
Recently, it has been reported that, in several tumor cell lines, short double-stranded RNAs tailored for promoter regions of specific genes are able to activate their transcription. Such molecules (named RNA activators) act opposite to other double-stranded RNA molecules (named RNA...
|
PMID: 21241187
PDF is available here.
PDF is available here.
Cell Cycle (10)3 2011
Abstract
We have recently found that targeting is regulated through the cell cycle. Immediately following the initiation of DNA replication, active genes lose peripheral localization for ~30 minutes. This regulation is mediated by cyclic phosphorylation of a nucleoporin by Cdk1. Some genes that are targeted...
|
PMID: 21228627
PDF is available here.
PDF is available here.
Abstract
Hedgehog (Hh) signaling pathway is involved in regulation of many tissues development and oncogenesis. Recently, Hh signaling has been identified as a required functional pathway for leukemia stem cells(LSCs), and loss of this pathway impairs leukemia progression.
|
PMID: 21235817
PDF is available here.
PDF is available here.
Abstract
We show that E2F1 is capable of inducing growth by regulating mTORC1 activity. The activation of cell growth and mTORC1 by E2F1 is dependent on both E2F1's ability to bind DNA and to regulate gene transcription, demonstrating that a gene induction expression program is required in this process. Unli...
|
PMID: 21283628
PDF is available here.
PDF is available here.
Abstract
We show that presence of the P. aeruginosa derived biosurfactant rhamnolipid was indispensable for flagellin-induced psoriasin expression in human skin, contrary to in vitro conditions. The importance of the bacterial virulence factor flagellin as the major inducing factor of psoriasin expression in...
|
PMID: 21283546
PDF is available here.
PDF is available here.
Abstract
Argonaute (AGO) proteins bind to small-interfering (si)RNAs and micro (mi)RNAs to target RNA silencing against viruses, transgenes and in regulation of mRNAs. Plants encode multiple AGO proteins but, in Arabidopsis, only AGO1 is known to have an antiviral role.
|
PMID: 21305057
PDF is available here.
PDF is available here.
Abstract
We report evidence that ALKBH5 is probably unique amongst the ALKBH genes in being a direct transcriptional target of hypoxia inducible factor-1 (HIF-1) and is induced by hypoxia in a range of cell types. We show that purified recombinant ALKBH5 is a bona fide 2OG oxygenase that catalyses the decarb...
|
PMID: 21264265
PDF is available here.
PDF is available here.
Abstract
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied transcriptional programs. Consequently, NF-κB-dependent transcription is not only t...
|
PMID: 21772278
PDF is available here.
PDF is available here.
Abstract
Activator protein-1 (AP-1) is a mediator of BMP or FGF signaling during Xenopus embryogenesis. However, specific role of AP-1 in activin signaling has not been elucidated during vertebrate development.
|
PMID: 21829441
PDF is available here.
PDF is available here.
British Journal of Nutrition (105)2 2011
Abstract
We tested curcumin for its ability to induce PON1 in Huh7 hepatocytes in culture. Curcumin ( ≥ 10 μmol/l) dose-dependently induced PON1 transactivation in Huh7 cells. However, dietary supplementation of female B6C3F1 mice with curcumin (500 mg/kg diet) for 2 weeks did not increase the hepatic PON...
|
PMID: 21078213
PDF is available here.
PDF is available here.
Cellular Immunology (271)2 2011
Abstract
We observed that the phytol-derived immunostimulant, PHIS-01 (phytanol), is a nontoxic oil-in-water adjuvant which is superior to most commercial adjuvants. In contrast, the parent diterpene alcohol phytol, though highly effective as an adjuvant, is relatively toxic. To assess the importance of the...
|
PMID: 21813116
PDF is available here.
PDF is available here.
Abstract
We review recent advances in our understanding of the architecture of the regulatory regions within KIR genes and discuss a potential role for non-coding RNA in KIR transcriptional regulation during NK cell development. Understanding the molecular mechanisms that underlie KIR expression may help gui...
|
PMID: 21411970
PDF is available here.
PDF is available here.
Abstract
We review how cell cycle regulators affect lymphoid system development and homeostasis and discuss recent evidence implicating the cell cycle inhibitor Geminin in this process. Geminin has been shown to coordinate proliferation and differentiation by regulating cell cycle progression, chromatin orga...
|
PMID: 21740351
PDF is available here.
PDF is available here.
Abstract
We attempted to demonstrate the possible functional expression of GABAergic signaling machineries by adipocytes.
GABA(B) receptor 1 (GABA(B)R1) subunit was constitutively expressed by mouse embryonic fibroblasts differentiated into adipocytes and adipocytic 3T3-L1 cells in culture, a...
|
PMID: 21655283
PDF is available here.
PDF is available here.
Abstract
We show that cigarette smoke is a selective adjuvant that augments in vitro and in vivo Th17, but not Th1, cell differentiation via the aryl hydrocarbon receptor. Smoke exposed IL-17RA(-/-) mice failed to induce CCL2 and MMP12 compared to WT mice. Remarkably, in contrast to WT mice, IL-17RA(-/-) mic...
|
PMID: 21647421
PDF is available here.
PDF is available here.
American Surgeon (11) 2011
Abstract
Abstract
We report here that in addition to MGA2's role in regulation of unsaturated fatty acids, MGA2 is required for full basal expression of ERG1. Mga2p was found to be controlled by a novel regulator in its activation of ERG1, as neither unsaturated fatty acids nor cobalt affected ERG1 expression, as had...
|
PMID: 21075079
PDF is available here.
PDF is available here.
Abstract
We investigated the role of the Osx gene using the clonal mouse embryonic cell line ATDC5, which retains the properties of the chondroprogenitor. ATDC5 cells express Osx; therefore, the effects of Osx gene silencing with shRNA lentiviral particles on chondrocyte marker gene expression and alkaline p...
|
PMID: 21075078
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)3 2011
Abstract
These findings suggest that FOXO1 is a direct target of progestin, implicating novel molecular mechanisms of progestin to eradicate endometrial neoplasia....
|
PMID: 21131554
PDF is available here.
PDF is available here.
Abstract
Signaling crosstalk between the β-catenin and NF-κB pathways represents a functional network. To test whether the crosstalk also occurs on their common target genes, the cyclin D1 promoter was used as a model because it contains binding sites for both proteins. β-catenin activated transcription f...
|
PMID: 21056029
PDF is available here.
PDF is available here.
Abstract
Luciferase reporter constructs and transient co-transfection approaches demonstrate that elevated expression of RORalpha1 augments 17-beta-estradiol (E(2))-induced transcriptional activation of the full-length ERalpha, but not truncated ERalpha constructs (ABCD or CDEF), in MCF-7 breast cancer and H...
|
PMID: 20558189
PDF is available here.
PDF is available here.
Abstract
We demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation r...
|
PMID: 20890087
PDF is available here.
PDF is available here.
Abstract
We first studied homologous genes to OAF1 and PIP2 of Saccharomyces cerevisiae, but their disruption did not change growth on oleic acid at all. We next characterized a Y. lipolytica gene, POR1 (primary oleate regulator 1), an ortholog of farA encoding a transcriptional activator that regulates fatt...
|
PMID: 20977884
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of eccentric cleavage products of β-carotene, i.e. β-apocarotenoids (BACs), on retinoid X receptor alpha (RXRα) signaling. Transactivation assays were performed to test whether BACs activate or antagonize RXRα. Reporter gene constructs (RXRE-Luc, pRL-tk) and RXRα wer...
|
PMID: 20678466
PDF is available here.
PDF is available here.
EMBO Journal (29)23 2010
Abstract
We show that for transcription activation the PHD of TAF3 can be replaced by PHDs of other high-affinity H3K4me3 binders. Interestingly, H3K4me3 binding of TFIID and the TAF3-PHD is decreased by phosphorylation of the adjacent threonine residue (H3T3), which coincides with mitotic inhibition of tran...
|
PMID: 20953165
PDF is available here.
PDF is available here.
Abstract
We have shown, that PPARγ activates ABCA1 gene transcription in human hepatoma cells HepG2 through increasing of LXRβ binding with promoter region of ABCA1 gene. Treatment of HepG2 cells with PPARγ agonist GW1929 leads to dissociation of LXRβ from ABCA1/LXRβ complex and to nuclear translocation...
|
PMID: 20951680
PDF is available here.
PDF is available here.
Abstract
We examined the role of each kind of FFA on renal tubular damage in vitro and tried to identify its molecular mechanism. In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-i...
|
PMID: 20937260
PDF is available here.
PDF is available here.
Abstract
We examined the role of each kind of FFA on renal tubular damage in vitro and tried to identify its molecular mechanism. In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-i...
|
PMID: 20937260
PDF is available here.
PDF is available here.
Abstract
We examined the role of each kind of FFA on renal tubular damage in vitro and tried to identify its molecular mechanism. In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-i...
|
PMID: 20937260
PDF is available here.
PDF is available here.
Journal of Virology (84)21 2010
Abstract
We have now discovered that the recently identified type III IFNs (IFN-λ) constitute the major response to intranasal infection with this virus. Type III IFNs were present at much higher levels than type I IFNs in the lungs of infected mice, and the enhanced susceptibility of STAT2-/- animals demon...
|
PMID: 20739515
PDF is available here.
PDF is available here.
Abstract
Abstract
We report the reciprocal effect on keratin expression of ΔNp63, pivotal in normal epidermal morphogenesis and maintenance, and Skn-1a/Oct-11, a POU transcription factor that triggers and regulates the differentiation of keratinocytes. The expression of Skn-1a markedly downregulated ΔNp63-driven K1...
|
PMID: 20888799
PDF is available here.
PDF is available here.
Abstract
We show that TAp63, a p53 family member, suppresses tumorigenesis and metastasis, and coordinately regulates Dicer and miR-130b to suppress metastasis. Metastatic mouse and human tumours deficient in TAp63 express Dicer at very low levels, and we found that modulation of expression of Dicer and miR-...
|
PMID: 20962848
PDF is available here.
PDF is available here.
Developmental Cell (19)4 2010
Abstract
We show that pericentric satellites undergo a transient peak in expression precisely at the time of chromocenter formation. This transcription is regulated in a strand-specific manner in time and space and is strongly biased by the parental asymmetry. The transcriptional upregulation follows a devel...
|
PMID: 20951352
PDF is available here.
PDF is available here.
British Journal of Cancer (103)8 2010
Abstract
The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about ep...
|
PMID: 20823885
PDF is available here.
PDF is available here.
Abstract
We characterized the functional domains of BFV BTas. BTas contains two major functional domains: the N-terminal DNA-binding domain (residues 1-133) and the C-terminal activation domain (residues 198-249). The complete BTas responsive regions were mapped to the positions -380/-140 of LTR and 9205/927...
|
PMID: 20615521
PDF is available here.
PDF is available here.
Current Genetics (56)5 2010
Abstract
We suggest that decreased stability of Tra1-L3733A accounts for the phenotypes since intragenic suppressors of tra1-L3733A restored Tra1 levels, and reducing wild-type Tra1 led to comparable growth defects. Also supporting a key role for the FATC domain in the structure/function of Tra1, addition of...
|
PMID: 20635087
PDF is available here.
PDF is available here.
Cell Cycle (9)18 2010
Abstract
We studied the effects of hypoxia on PTHrP expression. We found that PTHrP is transcriptionally induced by prolonged (48 h) hypoxia in multiple human cancer and endothelial cell lines. Pharmacological up or downregulation of hypoxia-inducible factor (HIF) resulted in induction or reduction of PTHrP...
|
PMID: 20890122
PDF is available here.
PDF is available here.
Human Molecular Genetics (19)18 2010
Abstract
We report the identification of the Krüppel-like ZF protein, ZNF224, as a novel human WT1-associating protein and demonstrate that ZNF224 and its isoform ZNF255 show a specific pattern of interaction with the WT1 splicing variants WT1(-KTS) and WT1(+KTS). These interactions occur in different subce...
|
PMID: 20591825
PDF is available here.
PDF is available here.
Chemico-Biological Interactions (187)1-3 2010
Abstract
We examined the effects of heat shock on the transcription and protein assembly of AChE(T) in cultured NG108-15 cells. The transcription of AChE(T) was rapidly induced by heat shock at 40 degrees C, reaching a 15-fold increase in 3h and decreasing thereafter. On the other hand, the level of PRiMA mR...
|
PMID: 20176004
PDF is available here.
PDF is available here.
Molecular Cell (39)4 2010
Abstract
We identify differentially regulated microRNAs important for this switch and putative transcription factor binding sites in their promoters. STAT3, a transcription factor activated by IL-6, directly activates miR-21 and miR-181b-1. Remarkably, transient expression of either microRNA induces the epig...
|
PMID: 20797623
PDF is available here.
PDF is available here.