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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Gene Expression (2):
Recent article
Gene Expression
Abstract
We chose bicistronic lentiviral vectors coexpressing fluorescent reporters (eGFP, dTomato, Cerulean, or Venus) along with the canonical RFs to transduce a bulk of murine embryonic fibroblasts (MEFs). Using a flow cytometric approach, we were able to independently and proportionally quantify all fluo...
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PMID: 21548079
PDF is available here.
PDF is available here.
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Abstract
Bioluminescence imaging is a powerful technique to visualize and monitor biological processes in numerous systems. This unit describes two strategies for bioluminescence imaging that can be used to study bacterial infection in mice. One method is to express a luciferase gene in the b...
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PMID: 21538305
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Infectious HCV pseudoparticles (HCVpp) can be assembled by display of unmodified and functional HCV glycoproteins on retroviral and lentiviral core particles. HCVpp have been shown to mimic the early infection steps of parental HCV. The presence of a marker gene packaged within these HCV pseudoparti...
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PMID: 19009280
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
The analysis of transgene inheritance is an important step in the molecular and genetic characterization of transgenes. In this manuscript, two approaches to characterize the inheritance of transgenes are described. The first approach is based on the expression of the transgene phenotype and the sec...
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PMID: 19378007
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We will describe the construction of a fusion protein with the SUMO-tag, its expression in Escherichia coli, and its purification followed by the removal of the SUMO-tag by a SUMO-specific protease in vitro....
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PMID: 19107426
PDF is available here.
PDF is available here.
Abstract
We tried to read the biological clock in tissues from dead bodies to estimate the time of death using molecular biological techniques. At first, we examined real-time RT-PCR analysis of gene expression for mPer2 and mBmal1, which constitutes a feedback loop in the oscillation system, in the kidney,...
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PMID: 21069371
PDF is available here.
PDF is available here.
DNA Repair (10)5 2011
Abstract
We examined the consequences of overexpressing SRS2 as well as two helicase-dead mutants, srs2-K41A and srs2-K41R, in the collection of 4827 yeast haploid deletion mutants. We identified 274 genes affecting a large variety of cellular functions that are required for cell growth when SRS2 or its muta...
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PMID: 21459050
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2011)5 2011
Abstract
Engineering effective vectors has been crucial to the efficient delivery and expression of therapeutic gene products in vivo. Among these, HSV-1 represents an excellent candidate vector for delivery to the peripheral and central nervous systems. The natural biology of HSV-1 includes the establishmen...
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PMID: 21536761
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)5 2011
Abstract
We discussed the three points for promoting the industrialization of animal transgenic breeding....
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PMID: 21586397
PDF is available here.
PDF is available here.
Abstract
We investigated the possible prognostic role of HIPK2 on a retrospective series of 80 colon cancer cases by setting up a multiplexed cytometric approach capable of exploring correlative protein expression at the single tumor cell level on TMA. Crossing the data with quantitative PCR and p53 gene seq...
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PMID: 21514416
PDF is available here.
PDF is available here.
Abstract
Hypertrophy occurs in urinary bladder wall smooth muscle (BSM) in men with partial bladder outlet obstruction (PBOO) caused by benign prostatic hyperplasia (BPH) and in animal models of PBOO. Hypertrophied BSM from the rabbit model exhibits down-regulation of caveolin-1, a structural and functional p...
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PMID: 21514437
PDF is available here.
PDF is available here.
Abstract
We demonstrate that plating GI-101A human breast cancer cells on hard (0.9%) agar selects for the subpopulation of metastasis-initiating cells. The agar-selected cells, designated GI-AGR, were homogeneous for CD44(+) and CD133(+) and five times more invasive than the parental GI-101A cells. Moreover...
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PMID: 21514446
PDF is available here.
PDF is available here.
Abstract
The ability of the rodent testis to tolerate graft alloantigens and spermatogenic cell autoantigens is well known. The mechanisms underlying this "immune privilege" are poorly understood, but the numerous resident TMs have been implicated. Although it has been assumed that TMs display a phenotype con...
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PMID: 21498587
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We report that BMI1 contains a functional recognition motif for the F box protein βTrCP, which regulates ubiquitination and proteasome-mediated degradation of various proteins. We show that overexpression of wild-type βTrCP but not the ΔF mutant of it promotes BMI1 ubiquitination and degradation,...
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PMID: 21430439
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
The ATM substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ, also known as ATMIN and ZNF822) has previously been reported to be important for the repair of methylating and oxidative DNA damage, and it has also been proposed to regulate the stability and DNA damage-independent act...
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PMID: 21415597
PDF is available here.
PDF is available here.
Abstract
There were no effects of drug or dose (0, 50, 100 or 150 mg/kg bwt) on any of the physical or neurological examination, behaviour factors, electrocardiogram or clinical pathological results collected from any of the horses. All parameters measured remained within the normal reference range. There...
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PMID: 21492212
PDF is available here.
PDF is available here.
Abstract
We have generated premeiotic Stra8-positive cells from C2C12 myoblasts following treatment with 10 μM all-trans-RA for 8 days. The differentiated C2C12 cells exhibited spherical morphology similar to spermatogonia, and they expressed gene markers of premeiosis, meiosis and postmeiosis. In addition,...
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PMID: 21091440
PDF is available here.
PDF is available here.
Abstract
We report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a significant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner. The inhibition entails a significant shortening of telomeres and compromised prolife...
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PMID: 21574023
PDF is available here.
PDF is available here.
Kidney International (79)8 2011
Abstract
We tested whether it directly regulates renal cell survival and organ function in a model of transient renal ischemia using Hsp70 knockout, heterozygous, and wild-type mice. The kidney cortical Hsp70 content inversely correlated with tubular injury, apoptosis, and organ dysfunction after injury. In...
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PMID: 21270764
PDF is available here.
PDF is available here.
Kidney International (79)8 2011
Abstract
We tested whether it directly regulates renal cell survival and organ function in a model of transient renal ischemia using Hsp70 knockout, heterozygous, and wild-type mice. The kidney cortical Hsp70 content inversely correlated with tubular injury, apoptosis, and organ dysfunction after injury. In...
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PMID: 21270764
PDF is available here.
PDF is available here.
Kidney International (79)8 2011
Abstract
We tested whether it directly regulates renal cell survival and organ function in a model of transient renal ischemia using Hsp70 knockout, heterozygous, and wild-type mice. The kidney cortical Hsp70 content inversely correlated with tubular injury, apoptosis, and organ dysfunction after injury. In...
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PMID: 21270764
PDF is available here.
PDF is available here.
Abstract
The extracellular protein collagen triple helix repeat containing 1 (CTHRC1) is aberrantly upregulated in melanoma and most human solid cancers. However, its role in cancer remains unknown.
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PMID: 21477558
PDF is available here.
PDF is available here.
Nature Immunology (12)4 2011
Abstract
We show that transforming growth factor-β (TGF-β) controls the development of TCRαβ+CD8αα+ IELs. Mice with either a null mutation in the gene encoding TGF-β1 or T cell-specific deletion of TGF-β receptor I lacked TCRαβ+CD8αα+ IELs, whereas mice with transgenic overexpression of TGF-β1 h...
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PMID: 21297643
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)3 2011
Abstract
We investigated the molecular mechanism of the effects of this combination therapy on melanoma tumor growth. In B16 tumor-bearing mice, the addition of IFN-α to DTIC treatment significantly reduced tumor volume, compared with control or DTIC alone. Consistently, Digital Radiography data showed less...
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PMID: 21389866
PDF is available here.
PDF is available here.
Integrative Biology (3)4 2011
Abstract
We recently reported that apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor growth and improve survival in a mouse model of ovarian cancer. The current study was designed to examine whether inhibition of angiogenesis is one of the mechanisms for the observed anti-tumorigenic effe...
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PMID: 21283904
PDF is available here.
PDF is available here.