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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Suppression, Genetic (0):
Recent article
Suppression, Genetic
Journal of Biological Chemistry (285)46 2010
Abstract
The deletion of phenylalanine 508 in the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator is directly associated with >90% of cystic fibrosis cases. This mutant protein fails to traffic out of the endoplasmic reticulum and is subsequently degraded by the pro...
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PMID: 20667826
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We carried out DNA microarray analysis after specific knockdown of EWS-Fli1 through transfection of synthetic siRNAs. EWS-Fli1 knockdown increased expression of genes such as DKK1 and p57 that are known to be repressed by EWS-Fli1 fusion protein. Among other potential EWS-Fli1 targets identified by...
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PMID: 20933505
PDF is available here.
PDF is available here.
Genes & Development (24)16 2010
Abstract
We characterize these opposing influences on gene expression in Caenorhabditis elegans olfactory neurons. Using transcriptional reporters that are expressed differentially in two olfactory neurons, AWC(ON) and AWC(OFF), we identify mutations that affect the long-term maintenance of appropriate chemo...
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PMID: 20713521
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We characterized a human H5N1 virus isolate (KAN-1) encoding a hemagglutinin (HA) with a K-to-E substitution at amino acid position 222 that was previously described to be selected in the lung of the infected patient. In mice, the growth of the HA(222E)-encoding virus was mainly confined to the lung...
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PMID: 20519408
PDF is available here.
PDF is available here.
Plant Physiology (153)3 2010
Abstract
The Arabidopsis (Arabidopsis thaliana) fatty acid biosynthesis1 (fab1) mutant grows as well as wild type at 22 degrees C, but after transfer to 2 degrees C fab1 plants cannot maintain photosynthetic function and die after 5 to 7 weeks at 2 degrees C. A fab1 suppressor line, S7, was isolated in a scr...
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PMID: 20488893
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
We have used cryoelectron tomography to investigate the morphotypes of this double mutant. Virions produced at the nonpermissive temperature do not assemble capsids, although Gag is processed normally; moreover, they are more variable in size than the wild type and have fewer glycoprotein spikes. At...
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PMID: 20427531
PDF is available here.
PDF is available here.
Abstract
We have developed an algorithm for the prediction of dual-targeting short interfering RNAs (siRNAs) in which both strands are deliberately designed to separately target different mRNA transcripts with complete complementarity. An advantage of this approach versus the use of two separate duplexes is...
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PMID: 20410240
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)11 2010
Abstract
We engineered Escherichia coli cells with a translation system orthogonal to the E. coli tyrosyl-tRNA synthetase (TyrRS)-tRNA(Tyr) pair, to use E. coli TyrRS variants for non-natural amino acids in the cells without interfering with tyrosine incorporation. We showed that the E. coli TyrRS-tRNA(Tyr)...
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PMID: 20159998
PDF is available here.
PDF is available here.
Abstract
We investigated the basis for these other phenotypes and found that they are dependent on the toxic biosynthetic intermediate homoserine. Moreover, homoserine is also toxic for Candida albicans thr1Delta mutants. Since increasing levels of threonine, but not other amino acids, overcome the homoserin...
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PMID: 20305002
PDF is available here.
PDF is available here.
Abstract
We used the yeast Saccharomyces cerevisiae as a model. Our genetic screening has revealed that a defect in MPT5/HTR1/UTH4/PUF5 led to an increased sensitivity to BrdU, and that overexpression of VHT1 or SDT1 led to resistance to BrdU. The increased sensitivity to BrdU caused by a defect in MPT5 was...
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PMID: 20352263
PDF is available here.
PDF is available here.
Microbiology (156)Pt 5 2010
Abstract
We recently showed that previous inactivation of pipX facilitates subsequent inactivation of the glnB gene. Here, we show that the three spontaneous pipX point mutations pipX-92delT, pipX160C>T and pipX194T>A, initially found in different glnB strains, are indeed suppressor mutations. When these mut...
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PMID: 20110304
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
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PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
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PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Methods in Molecular Biology (639)639 2010
Abstract
We describe mutagenesis by using ethyl methanesulfonate (EMS) and transfer (T)-DNA-mediated insertion or activation tagging as applied to the most widely used genetic plant model A. thaliana. Also, we demonstrate the utility of several genetic screening approaches to dissect adaptive responses to va...
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PMID: 20387043
PDF is available here.
PDF is available here.
Abstract
We isolated a gene (NtAn2) encoding a R2R3 MYB TF from developing tobacco flowers. NtAn2 shares high sequence homology with other known flavonoid-related MYB TFs and is mostly expressed in developing flowers. Constitutive ectopic expression of NtAn2 induces whole-plant anthocyanin production in toba...
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PMID: 20157728
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
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PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Virus Genes (40)2 2010
Abstract
We determined the phenotypic traits such as temperature sensitivity and growth kinetics of eight OPV isolates (six bi-recombinant and two non-recombinant). The growth phenotype of each isolate as well as of Sabin vaccine strains in Hep2 cell line at two different temperatures (37 and 40 degrees C) w...
|
PMID: 20091423
PDF is available here.
PDF is available here.
Abstract
Our findings show that organic PM(2.5) consist of toxic as well as bioactive components that can regulate the secretion of cytokines in BEAS-2B, which could modulate inflammatory response in the lung. Trace element analyses confirmed the presence of metals in organic extracts highlighting the relati...
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PMID: 20026096
PDF is available here.
PDF is available here.
Abstract
We have isolated 115 independent extragenic suppressors of four ram mutations: tao3, hym1, kic1 and sog2. Over 50% of the suppressors affect a single residue in Cbk1p (S745F), which is close to the phosphorylation site in the hydrophobic motif. Our results show that the CBK1-S745F allele leads to a...
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PMID: 19967545
PDF is available here.
PDF is available here.
Abstract
We studied cassava (Manihot esculenta) En/Spm-like transposons (Meens) with regard to genomic distribution, sequence diversity and methylation status. Cassava transposase fragments characteristic of En/Spm-like transposons were isolated, cloned and characterized. Sequence analysis showed that cassav...
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PMID: 20449796
PDF is available here.
PDF is available here.
Abstract
We have established a method to transfect siRNA into spheroid cells. Our current data indicate that the functions of HIF-1 or VEGF are independent of radiation sensitivity in spheroids under either normoxic or hypoxic conditions....
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PMID: 19959878
PDF is available here.
PDF is available here.
Abstract
We report that the use of rAAV2/5 vectors expressing shRNA targeting mutant IMPDH1 prevents photoreceptor degeneration, and preserves synaptic connectivity in a mouse model of RP10....
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PMID: 20238059
PDF is available here.
PDF is available here.
Abstract
We have shown that decreasing of eRF1 amount causes an impairment of NMD. Here we show that sup35 nonsense and missense mutations lead to accumulation of PTC-containing transcripts such as his7-1 mRNA and CYH2 pre-mRNA. Thus sup35 mutations do not only decrease translation fidelity but also influenc...
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PMID: 20198859
PDF is available here.
PDF is available here.
Abstract
Extension of an inverted repeat transgene cassette, containing partial nucleoprotein (N) gene sequences from four different tomato-infecting Tospovirus spp. with a partial N gene sequence from the tomato strain of Tomato yellow ring virus (TYRV-t), renders transgenic Nicotiana benthamiana plants add...
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PMID: 19737098
PDF is available here.
PDF is available here.
Abstract
Rice tungro disease (RTD) is caused by Rice tungro spherical virus (RTSV) and Rice tungro bacilliform virus (RTBV) transmitted by green leafhoppers. Rice cv. Utri Merah is highly resistant to RTD. To define the RTD resistance of Utri Merah, near-isogenic lines (NIL, BC(5) or BC(6)) developed from Ut...
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PMID: 19737100
PDF is available here.
PDF is available here.
Nature Methods (5)11 2009
Abstract
We have assembled an ordered, high-expression clone set of all of the essential genes from Escherichia coli and used it to systematically screen for suppressors of growth inhibitory compounds. Using this chemical genomic approach, we demonstrate that the targets of well-known antibiotics can be iden...
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PMID: 19783991
PDF is available here.
PDF is available here.
Analytical Biochemistry (396)2 2009
Abstract
The Renilla luciferase gene is commonly used as an internal control in luciferase-based reporter gene assays to normalize the values of the experimental reporter gene for variations that could be caused by transfection efficiency and sample handling. Various plasmids encoding Renilla...
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PMID: 19788887
PDF is available here.
PDF is available here.
Biochemical Journal (422)2 2009
Abstract
We found that MRFs (myogenic regulatory factors) regulated the expression of PGC-1alpha (peroxisome-proliferator-activated receptor gamma co-activator 1alpha) by targeting a short region, from nt -49 to +2 adjacent to the transcription initiation site, that contained two E-boxes. However, only the E...
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PMID: 19522704
PDF is available here.
PDF is available here.
Development (136)15 2009
Abstract
We show here that HAI2 is a potent regulator of protease-guided cellular responses, including motogenic activity and transepithelial resistance of epithelial monolayers. Furthermore, we show that inhibition of the transmembrane serine protease matriptase (encoded by St14) is an essential function of...
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PMID: 19592578
PDF is available here.
PDF is available here.
British Journal of Cancer (100)9 2009
Abstract
We have previously shown that WW domain-containing oxidoreductase (WWOX) has tumour-suppressing effects and that its expression is frequently reduced in pancreatic carcinoma. In this study, we examined WWOX expression in intraductal papillary mucinous neoplasm of the pancreas (IPMN) to assess the fu...
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PMID: 19352382
PDF is available here.
PDF is available here.
Abstract
We describe the ubiquitin-proteasome regulation of the Gcm protein and the consequence in gliogenesis without timely degradation of Gcm. Gcm binds to 2 F-box proteins, Supernumerary limbs (Slimb) and Archipelago (Ago), adaptors of SCF E3 ubiquitin ligases. Ubiquitination and proteasomal degradation...
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PMID: 19346490
PDF is available here.
PDF is available here.
Abstract
The expression of MMP-2 was inhibited and the inhibitory effects of different sequence varied. pGPU6-1 group had the most efficient inhibitory effect, followed by pGPU6-2 and pGPU6-3 groups. Invasiveness and adhesion were more significantly reduced in pGPU6-1, pGPU6-2 and pGPU6-3 groups as compared...
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PMID: 19266599
PDF is available here.
PDF is available here.
Abstract
We show that 26S proteasome activity and abundance attenuate with age, which is associated with the impaired assembly of the 26S proteasome with the 19S regulatory particle (RP) and the 20S proteasome. In a genetic gain-of-function screen, we characterized Rpn11, which encodes a subunit of the 19S R...
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PMID: 19075009
PDF is available here.
PDF is available here.
Journal of Molecular Biology (385)1 2009
Abstract
We determined the crystal structures of the p53 core domain incorporating the hot spot mutation R249S, the core domain incorporating R249S and a second-site suppressor mutation H168R (referred to as the double mutant R249S/H168R) and its sequence-specific complex with DNA and of the triple mutant R2...
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PMID: 18996393
PDF is available here.
PDF is available here.