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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Genes, Homeobox (0):
Recent article
Genes, Homeobox
Abstract
We examined the spatial configuration of Hox clusters in embryonic mouse tissues where different Hox genes are active. When the cluster is transcriptionally inactive, Hox genes associate into a single 3D structure delimited from flanking regions. Once transcription starts, Hox clusters switch to a b...
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PMID: 21998387
PDF is available here.
PDF is available here.
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Abstract
We investigated whether differentiation of endothelial cells (ECs) from mouse ESCs was accompanied by activation of distinct Hox gene expression profiles. Differentiation was observed within 3 days, as indicated by the appearance of cells expressing specific endothelial marker genes (Flk-1+ /VE-Cadh...
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PMID: 21200152
PDF is available here.
PDF is available here.
Abstract
We investigated whether differentiation of endothelial cells (ECs) from mouse ESCs was accompanied by activation of distinct Hox gene expression profiles. Differentiation was observed within 3 days, as indicated by the appearance of cells expressing specific endothelial marker genes (Flk-1+ /VE-Cadh...
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PMID: 21200152
PDF is available here.
PDF is available here.
Abstract
We have carried out two cDNA sequencing projects to characterize the mRNA transcripts that are present during development of this embryo. These efforts have generated 480 megabases of new sequence, which have been assembled into transcript contigs and represent thousands of newly identified Ilyanass...
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PMID: 21558239
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We have rescued the developmental defect of a strong toy mutant allele and analyzed so expression in the ocelli primordium of toy loss-of-function eye-antennal discs during third instar larva. The results show that so expression is only marginally affected in the absence of Toy transcriptional activ...
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PMID: 20580700
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We review recent novel insight into the modalities of Hox protein function in imparting specific identity to anatomical regions of the vertebral column, and in controlling the emergence of these tissues concomitantly with providing them with axial identity. The control of these functions must have b...
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PMID: 20435029
PDF is available here.
PDF is available here.
Abstract
We tested the effect of miR-221 on GAX expression. miR-221 strongly upregulated GAX, suggesting that miR-221 downregulates a repressor of GAX. We next expressed miR-221 in ECs and identified ZEB2, a modulator of the epithelial-mesenchymal transition, as being strongly downregulated by miR-221. Using...
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PMID: 20516212
PDF is available here.
PDF is available here.
Abstract
We report a mouse embryonic node gene, which we named Pitchfork (Pifo). Pifo associates with ciliary targeting complexes and accumulates at the basal body during cilia disassembly. Haploinsufficiency causes a unique node cilia duplication phenotype, left-right asymmetry defects, and heart failure. T...
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PMID: 20643351
PDF is available here.
PDF is available here.
Abstract
We have studied the spatial and temporal expression of the two homeobox genes OTX2 and OTX1 in human fetal brains from 7 to 14 weeks postconception by in situ hybridization and immunohistochemistry. OTX2 was expressed in the diencephalon, mesencephalon, and choroid plexus, with a minor expression in...
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PMID: 20354145
PDF is available here.
PDF is available here.
Development (137)14 2010
Abstract
We derive gene interaction networks for anterior-posterior (AP) patterning under two developmental paradigms. For patterning during growth (paradigm I), which is appropriate for vertebrates and short germ-band insects, the algorithm creates gene expression patterns reminiscent of Hox gene expression...
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PMID: 20570938
PDF is available here.
PDF is available here.
Abstract
We aim at tackling the problem of how the bilaterian anterior-posterior (AP) axis is organized, and how this axis have been established over evolutionary time. To this purpose we have studied the role of some key regulatory genes involved in the control of the AP axis, the Hox family of transcriptio...
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PMID: 20565536
PDF is available here.
PDF is available here.
Developmental Biology (340)2 2010
Abstract
We used sequence conservation around the Hox4 genes to analyze all fish:human conserved non-coding sequences by reporter assays in stable zebrafish transgenesis. Thirty-four elements were functionally tested in GFP reporter gene constructs and more than 100 F1 lines were analyzed to establish a corr...
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PMID: 20144609
PDF is available here.
PDF is available here.
Abstract
We studied LSCs in mouse models of acute myelogenous leukemia (AML) induced either by coexpression of the Hoxa9 and Meis1a oncogenes or by the fusion oncoprotein MLL-AF9. We show that the Wnt/beta-catenin signaling pathway is required for self-renewal of LSCs that are derived from either hematopoiet...
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PMID: 20339075
PDF is available here.
PDF is available here.
Abstract
Our data provide evidence that at least 34 distinct Hox genes exist in the Japanese eel genome and that they represent eight Hox clusters. Duplication of Hox genes in the Japanese eel appears to be the result of the fish-specific genome duplication (FSGD) event. The Japanese eel shared the FSGD even...
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PMID: 19670462
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. The amino acid sequences of Duxbl homeodomains are most similar to those of human DUX4 protein, associated with facioscapu...
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PMID: 20063414
PDF is available here.
PDF is available here.
Abstract
The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox tra...
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PMID: 19461655
PDF is available here.
PDF is available here.
Abstract
We show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basa...
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PMID: 20080660
PDF is available here.
PDF is available here.
Abstract
Lhx3 genes are members of one of the six subfamilies of the LIM class homeobox genes. In ascidians, Lhx3 is known to play a critical role in endoderm differentiation, while in vertebrates Lhx3 is involved in the development of pituitary and subsets of motor neurons. It has been shown recently, using...
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PMID: 20123132
PDF is available here.
PDF is available here.
Abstract
We here report an algorithm for the identification of such motifs and subsequent genome-wide scans for their conglomerations at loci other than these provided as input sequences, for which we usually select promoter regions of coexpressed genes. The initial testing of the software implementing this...
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PMID: 20865483
PDF is available here.
PDF is available here.
Abstract
The unusual pattern of evolution suggests that the ARGFX gene may encode a functional RNA or alternatively it may have 'flickered' between functional and non-functional states in the evolutionary history of mammals, particularly in the period when many mammalian lineages diverged within a relatively...
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PMID: 20565723
PDF is available here.
PDF is available here.
Abstract
In Gibbula varia the ParaHox genes are expressed during anterior-posterior patterning of the digestive system. This colinearity is not easy to spot during early larval stages because the differentiated endothelial cells within the yolk permanently migrate to their destinations in the gut. After tors...
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PMID: 20624311
PDF is available here.
PDF is available here.
Abstract
We show that the retinoid receptor antagonist AGN193109 causes a posterior hindbrain defect in Xenopus, comparable to that seen in other vertebrates. We show that this defect arises during gastrulation. Blocking endogenous retinoid activity during gastrulation causes downregulation of the most 3' Ho...
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PMID: 20209433
PDF is available here.
PDF is available here.
Abstract
We highlight three tributaries of Michaels contribution to evolutionary developmental biology. First, he has made major contributions to our understanding of development of the fruit fly, Drosophila melanogaster. Second, he has maintained a consistent focus on several key problems in evolutionary de...
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PMID: 20209429
PDF is available here.
PDF is available here.
Cell Cycle (8)24 2009
Abstract
We have studied the effects of high levels of Polyhomeotic (PH) protein, a member of the Polycomb Group (PcG), during the proliferation of the imaginal discs in Drosophila. Overexpression of PH protein causes induction of proliferation, accompanied with induction of JNK-dependent apoptosis. As a res...
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PMID: 19923887
PDF is available here.
PDF is available here.
Abstract
We propose that during development, dissociation of the Hox- and segmentation-clock-dependent vertebral patterning systems explains the enormous diversity of vertebral formulae observed in vertebrates....
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PMID: 19621429
PDF is available here.
PDF is available here.
Abstract
Homeobox (Hox) genes encode transcription factors that act as critical regulators of growth and differentiation during embryogenesis. While many studies have identified increased expression of Hox genes in tumors, much less is known about the mechanistic basis by which Hox genes facilitate tumor dev...
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PMID: 19726879
PDF is available here.
PDF is available here.
Abstract
We used single nucleotide polymorphism array analysis to analyze paired diagnostic and relapsed T-ALL samples to identify recurrent genetic alterations in T-ALL. This analysis showed that diagnosis and relapsed cases have common genetic alterations, but also that relapsed samples frequently lose chr...
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PMID: 19494353
PDF is available here.
PDF is available here.
Annals of Botany (104)3 2009
Abstract
The four DEF paralogues shaped floral diversity in orchids in a dramatic way by modularizing the floral perianth based on a complex series of sub- and neo-functionalization events. These genes may have eliminated constraints, so that different kinds of perianth organs could then evolve individually...
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PMID: 19141602
PDF is available here.
PDF is available here.
Endocrinology (150)7 2009
Abstract
We hypothesized that an epigenetic mechanism underlies DES-mediated alterations in HOXA10 expression. We analyzed the expression pattern and methylation profile of HOXA10 after DES exposure. Expression of HOXA10 is increased in human endometrial cells after DES exposure, whereas Hoxa10 expression is...
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PMID: 19299448
PDF is available here.
PDF is available here.
Abstract
Bleeding or inflammation in early pregnancy may result in pregnancy loss or defective implantation. Their effect on HOX gene expression in first trimester decidua is unknown. Bleeding results in thrombin generation, although infection or inflammation results in production of cytokines typified by In...
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PMID: 19389728
PDF is available here.
PDF is available here.
Development (136)14 2009
Abstract
We demonstrate through loss-of-function studies in mice that the Cut homeodomain transcription factor Cux2 (Cutl2) plays an important role in regulating the formation of dorsal spinal cord interneurons. Furthermore, we show that Notch regulates Cux2 expression. Although Notch signaling can be inhibi...
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PMID: 19542352
PDF is available here.
PDF is available here.
Biology of Reproduction (80)5 2009
Abstract
These results indicate that GV- and MII-oocyte extracts have different roles on nuclear reprogramming. Furthermore, both oocyte extracts induced site-specific demethylation in the upstream region of NANOG. These results indicate that cell-free extracts derived from GV- and MII-oocytes could be usefu...
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PMID: 19164171
PDF is available here.
PDF is available here.
Developmental Biology (329)1 2009
Abstract
We performed a functional analysis of Sex combs reduced (Scr) during post-embryonic development in Oncopeltus fasciatus. The main effect was observed in prothorax of Scr-RNAi adults, and ranged from significant alterations in its size and shape to a near complete transformation of its posterior half...
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PMID: 19382295
PDF is available here.
PDF is available here.
Abstract
Male fetal mortality in group A, B, C, D, and E were 3.57%, 6.90%, 12.00%, 19.23% and 36.36%, respectively, which showed a dose-effect relationship between DES and the male fatal mortality (r=0.999, P<0.01). DTA in group B, C, D and E were (23.7+/-1.7) U, (38.8+/-1.9) U, (49.3+/-1.8) U and (58.6+/-2...
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PMID: 19534997
PDF is available here.
PDF is available here.
Human Genomics (3)3 2009
Abstract
Human Genomics (3)3 2009
Abstract
We analyse these results and show that the biophysical model explains them successfully....
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PMID: 19403461
PDF is available here.
PDF is available here.
Abstract
We analyzed the dynamic association of MLL and H3K4 trimethylation at different stages of the cell cycle. Interestingly, MLL1, which is normally associated with transcriptionally active chromatins (G1 phase), dissociates from condensed mitotic chromatin and returns at the end of telophase when the n...
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PMID: 19220463
PDF is available here.
PDF is available here.
Cell Cycle (8)5 2009
Abstract
We offer a comprehensive coverage of currently-available in vitro and in vivo models of human epithelial ovarian cancer, focusing on latest updates of genetically-modified rodent and human models and the valuable information conveyed by them....
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PMID: 19221485
PDF is available here.
PDF is available here.
Cell Cycle (8)5 2009
Abstract
We offer a comprehensive coverage of currently-available in vitro and in vivo models of human epithelial ovarian cancer, focusing on latest updates of genetically-modified rodent and human models and the valuable information conveyed by them....
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PMID: 19221485
PDF is available here.
PDF is available here.
Abstract
In cultured prostate cancer cells cAMP blocks proliferation and induces neuroendocrine differentiation. Pyk2 expression inversely correlates with malignancy of prostate cancer. The aim of this study was to investigate the interaction between cAMP and Pyk2 in the prostate. EPN cells, a line derived f...
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PMID: 19106639
PDF is available here.
PDF is available here.
Abstract
We will focus on the role of short ncRNAs that repress Hox genes in Drosophila and mammals by RNA interference (RNAi), on long ncRNAs that may repress a Hox in cis in Drosophila by transcriptional interference, and on a novel long ncRNA that functions in trans to regulate Hox genes mammals....
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PMID: 19234521
PDF is available here.
PDF is available here.
Abstract
We analyzed HOX genes through profiling with multiplex RT-PCR. The results showed that the expression patterns of four HOX genes, HOXA7, HOXB3, HOXA3, and HOXB13, significantly changed during angiogenesis. The expression levels of HOXA7 and HOXB3 were dramatically increased, whereas those of HOXA3 a...
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PMID: 17972163
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
We used transgenic mice with a knock-in for Msx1 or Msx2. Msx expression was analyzed on whole-mount experiments on heterozygous mice. The results were confirmed by quantitative RT-PCR on mandible and tibia samples. Steady-state levels of Msx2 mRNA were determined at 2 ages, at postnatal day 14 and...
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PMID: 18769023
PDF is available here.
PDF is available here.
Abstract
We identified in silico the putative full complement of Irx genes in the sequenced genomes of 36 different species representative of the main metazoan lineages, including non bilaterian species, several arthropods, non vertebrate chordates, and a basal vertebrate, the sea lamprey. We performed exten...
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PMID: 19368711
PDF is available here.
PDF is available here.
Abstract
The DEF-like genes from Orchidaceae form four well-supported, ancient clades of orthologues. In contrast, orchid GLO-like genes form a single clade of ancient orthologues and recent paralogues. DEF-like genes from orchid clade 2 (OMADS3-like genes) are under less stringent purifying selection than t...
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PMID: 19383167
PDF is available here.
PDF is available here.
Abstract
We summarize recent progress in understanding the pathology and biology of this disease and in development of models for preclinical research. Our new understanding of this disease suggests new targets for therapeutic intervention and novel markers for early detection of disease....
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PMID: 19273186
PDF is available here.
PDF is available here.
Abstract
We summarize the current understanding of how Hox gene clusters have been modified from basal lineages of deuterostomes to diverse taxa of vertebrates. Our parsimony reconstruction of Hox cluster architecture at various stages of vertebrate evolution highlights that the variation in Hox cluster stru...
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PMID: 19557682
PDF is available here.
PDF is available here.
Abstract
I interviewed Cliff on the 3rd October, 2007, in his office at Harvard....
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PMID: 19557679
PDF is available here.
PDF is available here.
Abstract
Denis Duboule is one of the most influential and highly-cited scientists in developmental biology. Born in Geneva in 1955, he holds dual Swiss and French nationality. His undergraduate studies in biology at the University of Geneva included research on mouse embryology. He later learned molecular te...
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PMID: 19557678
PDF is available here.
PDF is available here.
Abstract
We define a gene regulatory network for Hoxa2, responsible for temporal and spatial expression in hindbrain development. Hoxa2 plays an important role in regulating the regional identity of rhombomere 2 (r2) and is the only Hox gene expressed in this segment. In this study, we found that a Hoxa2 cis...
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PMID: 19104046
PDF is available here.
PDF is available here.
Developmental Biology (324)2 2008
Abstract
We have generated Six3+/- ;Hesx1Cre/+ double heterozygous mice. Strikingly, these mice show marked dwarfism, which is first detectable around weaning, and die by the 5th-6th week of age. Thyroid and gonad development is also impaired in these animals. Analysis of Six3+/- ;Hesx1Cre/+ compound embryos...
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PMID: 18775421
PDF is available here.
PDF is available here.
Collegium Antropologicum (32)4 2008
Abstract
The 2nd to 4th digit ratio (2D:4D) is a sexually dimorphic biometric marker, related to prenatal estrogen and testosterone levels in utero, and determined genetically by the HOX genes. 2D:4D presents a population variation, which seems to be dependent on geographical position or ethnicity, and may r...
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PMID: 19149213
PDF is available here.
PDF is available here.
Genome Research (18)12 2008
Abstract
We made such predictions across the large, complex ceh-13/lin-39 locus and tested them transgenically. We also examined how prediction quality varied with different genomes and parameters in our comparisons. Specifically, we sequenced approximately 0.5% of the C. brenneri and C. sp. 3 PS1010 genomes...
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PMID: 18981268
PDF is available here.
PDF is available here.
Abstract
We have identified 102 homeobox genes in the typical insect of Lepidoptera, Bombyx mori, based on the newly assembled genome sequence with 9X coverage. These identified homeobox genes were categorized into nine classes including at least 74 families. The available ESTs and microarray data at present...
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PMID: 19280701
PDF is available here.
PDF is available here.
Abstract
We report here on the current knowledge of the role played by homeobox genes in normal and abnormal vasculogenesis and postulate a common molecular mechanism accounting for the involvement of homeobox genes in the regulation of the nuclear export of specific transcripts potentially capable of genera...
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PMID: 19013779
PDF is available here.
PDF is available here.
Abstract
We show that S and AN, which encode a homeobox transcription factor and an F-box protein, respectively, control inflorescence architecture by promoting successive stages in the progression of an inflorescence meristem to floral specification. S and AN are sequentially expressed during this gradual p...
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PMID: 19018664
PDF is available here.
PDF is available here.
Abstract
We conducted cDNA sequencing in diverse early vertebrates for members of homeobox-containing (Dlx and ParaHox) and other gene families that would serve as landmarks for genome duplications. Including these new sequences, we performed a molecular phylogenetic census using the maximum likelihood metho...
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PMID: 18842688
PDF is available here.
PDF is available here.
Genome Research (18)10 2008
Abstract
We used tiled microarrays to identify stable nucleosome positions along the HOX gene clusters in human cell lines. We show that nucleosome positions exhibit sequence properties and long-range organization that are different from those characterized in other organisms. Despite overall variability of...
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PMID: 18723689
PDF is available here.
PDF is available here.
Abstract
We focus on the role of Hox genes in shaping segmental morphologies along the AP axis in Drosophila, discuss some of the conclusions drawn from analyses of large target gene sets and highlight methods that could be used to gain a more thorough understanding of Hox molecular function. In addition, th...
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PMID: 18798525
PDF is available here.
PDF is available here.
Zoological Science (25)10 2008
Abstract
We carry out a comparative review of ParaHox gene cluster organization among the deuterostomes, and discuss how the recently published hagfish ParaHox clusters fit into current theories about the evolution of this group of genes....
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PMID: 19267630
PDF is available here.
PDF is available here.