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Genes, Switch (0):
Recent article
Genes, Switch
Nature Genetics (42)9 2010
Abstract
The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and t...
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PMID: 20802474
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We show that an LTR retrotransposon of ERV-9 human endogenous retrovirus located 40-70 kb upstream of the human fetal gamma- and adult beta-globin genes serves a long-range, host function. The ERV-9 LTR contains multiple CCAAT and GATA motifs and competitively recruits a high concentration of NF-Y a...
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PMID: 20615953
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We show with a computational systems biology model that coupling of the two feedback loops at the Blimp-1 node, through parallel inhibition of Blimp-1 gene activation by Bcl-6 and repression of Blimp-1 gene deactivation by Pax5, can generate a bistable switch capable of directing B cells to differen...
|
PMID: 20123757
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
We demonstrate molecular events among BMP2-induced transcription factors that constitute a network of molecular switches on promoters of bone-related genes to coordinate their temporal expression during cellular differentiation. Our studies provide evidence for (1) selective association of HOXA10, M...
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PMID: 18701816
PDF is available here.
PDF is available here.
Iubmb Life (60)12 2008
Abstract
We discuss the significance of ACH formation, provide an overview of the proteins implicated in chromatin looping at the beta-globin locus, and evaluate the relationship between nuclear organization and beta-globin gene expression.
(c) 2008 IUBMB....
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PMID: 18767169
PDF is available here.
PDF is available here.
Abstract
ATP-dependent chromatin remodeling by the mating type switching/sucrose non-fermenting (SWI/SNF) complex is a basic biological event in the body, which is required for all the key processes involved in DNA metabolism such as gene expression, DNA replication, repair, chromosomal recombination and mit...
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PMID: 19157109
PDF is available here.
PDF is available here.
Abstract
We have studied two indicator genes that change their expression oppositely in mouse binucleate ventricular cardiomyocytes during development and in response to cardiac hypertrophy. One is a single-copy transgene controlled by an alpha-myosin heavy chain (aMHC) promoter and coding for CFP. The other...
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PMID: 18755891
PDF is available here.
PDF is available here.
Abstract
We show that the Rice Indeterminate 1 (RID1) gene acts as the master switch for the transition from the vegetative to reproductive phase. RID1 encodes a Cys-2/His-2-type zinc finger transcription factor that does not have an ortholog in Arabidopsis spp. A RID1 knockout (rid1), mutated by T-DNA inser...
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PMID: 18725639
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that the transcription factor Ikaros plays a major role in the formation of the beta-globin ACH, and in haemoglobin switching. In Plastic mice, where the DNA-binding region of Ikaros is disrupted by a point mutation, there is concomitant marked down-regulation of HBB, and up-regulation of HB...
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PMID: 18318763
PDF is available here.
PDF is available here.
Biophysical Journal (94)9 2008
Abstract
We present a detailed analysis, based on the forward flux sampling simulation method, of the switching dynamics and stability of two models of genetic toggle switches, consisting of two mutually repressing genes encoding transcription factors (TFs); in one model (the exclusive switch), the two trans...
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PMID: 18222998
PDF is available here.
PDF is available here.
Biological Chemistry (389)5 2008
Abstract
A large variety of RNA-based mechanisms have been uncovered in all living organisms to regulate gene expression in response to internal and external changes, and to rapidly adapt cell growth in response to these signals. In bacteria, structural elements in the 5' leader regions of mRNAs have direct...
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PMID: 18953726
PDF is available here.
PDF is available here.
EMBO Journal (27)7 2008
Abstract
We show that the switch complex associates with the membrane-bound respiratory protein fumarate reductase (FRD). We provide evidence that FRD binds to preparations of isolated switch complexes, forms a 1:1 complex with the switch protein FliG, and that this interaction is required for both flagellar...
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PMID: 18337747
PDF is available here.
PDF is available here.