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Genes, araC (0):
Recent article
Genes, araC
In Silico Biology (7)4-5 2007
Abstract
We detected a total of 45 AraC/XylS family transcription regulators in the genome of the Gram-negative pathogen, Burkholderia pseudomallei. Further in silico analysis of each detected AraC/XylS family transcription regulatory protein and its neighboring genes allowed us to make a first-order guess o...
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PMID: 18391231
PDF is available here.
PDF is available here.
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Microbiology (152)Pt 10 2006
Abstract
These results suggested the dual regulation of the pegBCDAE operon through the pegB promoter by an AraC-type regulator, PegR (PEG-independent), and through the pegA and pegR promoters by a GalR/LacI-type regulator together with HU (PEG-dependent)....
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PMID: 17005983
PDF is available here.
PDF is available here.
Molecular Microbiology (58)2 2005
Abstract
We have identified a 32 bp conserved sequence element (PchR-box) in promoter regions of pyochelin-controlled genes and we show that the PchR-box in the pchR-pchDCBA intergenic region is essential for the induction of the pyochelin biosynthetic operon pchDCBA and the repression of the divergently tra...
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PMID: 16194235
PDF is available here.
PDF is available here.
Abstract
We constructed synthetic operons that express three key enzymes for biosynthesis of these precursors: (1). DXS,1-deoxy-d-xylulose-5-phosphate synthase; (2). IPPHp, IPP isomerase from Haematococcus pluvialis; and (3). one of two variants of IspA, FPP synthase that produces either GPP or GGPP. The rep...
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PMID: 15236249
PDF is available here.
PDF is available here.
Molecular Microbiology (53)2 2004
Abstract
I and II sites, but others required only a single type I or type II site. AdpA bound mutated type I sites with various distances between the two consensus sequences with significant affinities, although the optimal distances for AdpA to bind were 13-14 bp and 2 bp. The DNA-binding domain is therefor...
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PMID: 15228534
PDF is available here.
PDF is available here.
Journal of Bacteriology (184)16 2002
Abstract
We characterized the virulence phenotype of a nonpolar mxiE mutant and found that this mutant retained the ability to invade mammalian cells in tissue culture and secrete Ipas (type III effectors required for host cell invasion), although it was less efficient than wild-type Shigella at cell-to-cell...
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PMID: 12142411
PDF is available here.
PDF is available here.
Molecular Microbiology (40)6 2001
Abstract
We show that HilC and HilD bind directly to the hilA promoter region in vitro. We also provide evidence that HilC and HilD bind to the same or overlapping sites within the URS. Our data are consistent with a model in which HilC and HilD derepress hilA expression by binding directly to the URS and co...
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PMID: 11442828
PDF is available here.
PDF is available here.
Microbiology (147)Pt 5 2001
Abstract
Expression of the gap gene encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is developmentally regulated, and induced by glucose in Streptomyces aureofaciens. A gene, gapR, encoding a protein similar to the AraC/XylS family of bacterial transcriptional regulators was identified upstream of...
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PMID: 11320132
PDF is available here.
PDF is available here.
Abstract
The AraC family of bacterial transcriptional activators regulate diverse genetic systems. Recent X-ray diffraction studies show that the monomeric MarA and Rob activators bind to their asymmetric degenerate DNA sites via two different helix-turn-helix elements. Activation by MarA, SoxS or Rob requir...
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PMID: 11282467
PDF is available here.
PDF is available here.
Journal of Bacteriology (181)10 1999
Abstract
We postulate that HilA-independent activation of inv expression is important for efficient assembly and function of the SPI1 TTSS....
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PMID: 10322010
PDF is available here.
PDF is available here.
Abstract
We describe the development and analysis of broad-host-range (BHR) cloning vectors that carry the araC-PBAD controlled expression cassette from Escherichia coli. These plasmids are designed to facilitate l-arabinose-responsive control of target genes in a variety of Gram-negative bacterial hosts. BH...
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PMID: 10023058
PDF is available here.
PDF is available here.
Abstract
The ArC/XylS family of prokaryotic positive transcriptional regulators includes more than 100 proteins and polypeptides derived from open reading frames translated from DNA sequences. Members of this family are widely distributed and have been found in the gamma subgroup of the proteobacteria, low-...
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PMID: 9409145
PDF is available here.
PDF is available here.
Journal of Bacteriology (179)5 1997
Abstract
We report the cloning and sequencing of the araC locus. This region comprises two open reading frames with divergently arranged promoters, the regulatory gene, araC, encoding a 41-kDa polypeptide, and a partially cloned gene, termed araE, which most probably codes for a permease involved in the tran...
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PMID: 9045819
PDF is available here.
PDF is available here.
Abstract
These results are consistent with published reports on PAP. While the CHO cells were slightly more resistant to the toxic effects of PAP, the dose levels used in the two cell lines did not differ by more than 2-fold. At equivalent survival levels, PAP induced a significant (up to 20% aberrant cells)...
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PMID: 7556113
PDF is available here.
PDF is available here.
Abstract
We report here the spontaneous mutation spectrum at the hprt locus in 64 independently isolated mutants of Chinese hamster ovary (CHO) cells. All nine hprt exons were simultaneously analyzed via multiplex polymerase chain reaction (PCR) for rapid detection of gene deletions or insertions. Structural...
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PMID: 7556109
PDF is available here.
PDF is available here.
EMBO Journal (13)21 1994
Abstract
We have used classic fluctuation tests to show that cells capable of producing a clone of descendants that are phenotypically Ara-Lac+ do, indeed, arise in stationary phase cultures kept starving in depleted minimal medium. We found that Ara-Lac+ progenitors arise rapidly under these conditions, in...
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PMID: 7957089
PDF is available here.
PDF is available here.
Abstract
We propose that the Ara forward mutation test carried out in the set of over-producing bacteria constructed in the genetic background of TA98 might play a role for routine testing of large number of samples. The isogenic defective strains could be used in cases of uncertain results with the correspo...
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PMID: 8013475
PDF is available here.
PDF is available here.
Abstract
Abstract
We have generated a set of overlapping deletions from the proximal end of the araC gene. We found that the removal of up to nearly 60% of the coding sequence of this protein still allows transcriptional activation of the ara operons in vivo, up to 27% that of the wild type. These truncated proteins,...
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PMID: 2140192
PDF is available here.
PDF is available here.
Journal of Molecular Biology (209)4 1989
Abstract
Depurination/depyrimidation binding-interference experiments (missing contact probing) identified specific candidate residue-base interactions lost by mutants of Escherichia coli L-arabinose operon regulatory protein, AraC, to one of its binding sites, araI. These candidates were then checked more r...
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PMID: 2531226
PDF is available here.
PDF is available here.
Abstract
Journal of Bacteriology (171)2 1989
Abstract
We found that a 3-base-pair substitution resulted in a 30% reduction in araBAD expression, whereas a 6-base-pair substitution resulted in an 80% reduction. Both of these substitution mutations reduced araC expression threefold. We conclude that CRP bound to this site regulates expression in both dir...
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PMID: 2521619
PDF is available here.
PDF is available here.
Immunology (7) 1989
Abstract
Journal of Bacteriology (170)9 1988
Abstract
We describe a systematic analysis of the effect of mutations within the known regulatory binding sites for araBAD and araC transcription on araC expression. Our results suggest that the novel activation of araC expression requires the AraC activator-binding site, araI, and the cyclic AMP receptor pr...
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PMID: 2970455
PDF is available here.
PDF is available here.
Abstract
We examined the recognition of the araBAD promoter by the AraC protein in the Escherichia coli arabinose operon. A mutant promoter, with base substitutions at positions contacted by AraC, was used to isolate suppressor mutations in araC by direct selection. Two hydroxylamine-induced araC mutations w...
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PMID: 2831229
PDF is available here.
PDF is available here.
Abstract
Abstract
In Escherichia coli the levels of numerous enzymes associated with aerobic metabolism are decreased during anaerobic growth. In an arcA mutant the anaerobic levels of these enzymes are increased. The enzymes, which are encoded by different regulons, include members that belong to the tricarboxylic a...
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PMID: 2964639
PDF is available here.
PDF is available here.
Abstract
We propose that araI2 occupancy by AraC protein leads to RNA polymerase recognition of the araBAD promoter and that araI1 acts as a switch mechanism allowing both the repressor and the activator forms of AraC protein to regulate the araBAD promoter....
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PMID: 2962192
PDF is available here.
PDF is available here.
Abstract
The araC gene of Citrobacter freundii was cloned into plasmid pBR322 and expressed in Escherichia coli and Salmonella typhimurium. The nucleotide sequence and the predicted translational product were determined and compared to those of E. coli, S. typhimurium and Erwinia carotovora. The predicted tr...
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PMID: 2965663
PDF is available here.
PDF is available here.