Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
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PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Dan R Robinson,
Shanker Kalyana-Sundaram,
Yi-Mi Wu,
Sunita Shankar,
Xuhong Cao,
Bushra Ateeq,
Irfan A Asangani,
Matthew Iyer,
Christopher A Maher,
Catherine S Grasso,
Robert J Lonigro,
Michael Quist,
Javed Siddiqui,
Rohit Mehra,
Xiaojun Jing,
Thomas J Giordano,
Michael S Sabel,
Celina G Kleer,
Nallasivam Palanisamy,
Rachael Natrajan,
Maryou B Lambros,
Jorge S Reis-Filho,
Chandan Kumar-Sinha and
Arul M Chinnaiyan
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
Abstract
We examined the spatial configuration of Hox clusters in embryonic mouse tissues where different Hox genes are active. When the cluster is transcriptionally inactive, Hox genes associate into a single 3D structure delimited from flanking regions. Once transcription starts, Hox clusters switch to a b...
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PMID: 21998387
PDF is available here.
Abstract
Terpenoids are the most diverse class of natural products. Recently, a series of terpenoids with novel structures have been isolated from actinomyces. Their biosynthetic gene clusters have been identified and characterized either by direct cloning or genomic mining, which promoted in...
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PMID: 21993283
PDF is available here.
Abstract
We analyzed the full genome of B. mori and identified five novel bombyxin families, V to Z. We characterized the genomic organization and chromosomal location of the novel bombyxin family genes. In contrast to previously identified bombyxin genes, bombyxin-V and -Z genes had intervening introns at a...
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PMID: 21801003
PDF is available here.
Abstract
We provide the first genome sequence for S. agalactiae isolated from a cow diagnosed with clinical mastitis (strain FSL S3-026). Comparison to eight S. agalactiae genomes obtained from human disease isolates revealed 183 genes specific to the bovine strain. Subsequent polymerase chain reaction (PCR)...
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PMID: 21536150
PDF is available here.
Abstract
We refer to as CC(R) domains. Here, we show that CC(R)-NB-LRR-encoding genes are present in the genomes of all higher plants surveyed, and that they comprise two distinct subgroups: one typified by the Nicotiana benthamiana N-required gene 1 (NRG1) protein and the other typified by the Arabidopsis a...
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PMID: 21501087
PDF is available here.
Abstract
• To adapt to waterlogging in soil, some gramineous plants, such as maize (Zea mays), form lysigenous aerenchyma in the root cortex. Ethylene, which is accumulated during waterlogging, promotes aerenchyma formation. However, the molecular mechanism of aerenchyma formation is not understood. • The...
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PMID: 21091694
PDF is available here.
Abstract
We present a structural and genetic analysis of the Y. pseudotuberculosis serotype O:1c OPS. Our results showed that this OPS has the same backbone as Y. pseudotuberculosis O:2b, but with a 3,6-dideoxy-D-ribo-hexofuranose (paratofuranose, Parf) side-branch instead of a 3,6-dideoxy-D-xylo-hexopyranos...
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PMID: 20418261
PDF is available here.
Abstract
We demonstrate that biologically relevant aspects of expression profiles may be captured by precision-reduced descriptions that are fully human readable, and that biologically relevant relationships may be captured by applying familiar pattern searching techniques to these precision-reduced descript...
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PMID: 21431551
PDF is available here.
Abstract
This study determined the molecular characteristics and clinical significance of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma (ARMS), an aggressive pediatric cancer with frequent PAX3-FOXO1 and PAX7-FOXO1 gene fusions.
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PMID: 21220470
PDF is available here.
Abstract
We examined the phylogenetic relationships of F-Box (FBX) genes, one of the largest and most polymorphic superfamilies known in the plant kingdom. FBX proteins comprise the target recognition subunit of SCF-type ubiquitin-protein ligases, where they individually recruit specific substrates for ubiqu...
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PMID: 21297981
PDF is available here.