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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Genome Components (16):
- Locus Control Region
- Genes
- Attachment Sites, Microbiological
- Tandem Repeat Sequences
- Silencer Elements, Transcriptional
- DNA, Intergenic
- Regulon
- Nucleolus Organizer Region
- CpG Islands
- Operon
- Insulator Elements
- Sequence Tagged Sites
- Isochores
- Interspersed Repetitive Sequences
- Replicon
- DNA Sequence, Unstable
Recent article
Genome Components
Eukaryotic Cell (9)3 2010
Abstract
We assessed the intraspecific variability of the NUMTs in this species by testing their presence/absence first in 28 strains, with 21 loci previously detected in the completely sequenced strain CBS 767(T), and second in a larger panel of 77 strains, with 8 most informative loci. We were able for the...
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PMID: 20048048
PDF is available here.
PDF is available here.
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Abstract
We have reconstructed a foot-and-mouth disease virus quasispecies with multiple, low-frequency, genetically distinguishable mutants that can escape neutralization by a monoclonal antibody. Some of the mutants included an amino acid substitution that affected an integrin recognition motif that overla...
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PMID: 18436553
PDF is available here.
PDF is available here.
Abstract
We have identified probably only few of the many potential functional mechanism and more investigation will be needed to comprehensively understand the complex nature and biology of mammalian RNAome. Here, we focus on various aspects of the diversity of the biological role of these nonprotein-coding...
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PMID: 18468878
PDF is available here.
PDF is available here.
Abstract
We would define the insulators and boundaries in the light of contemporary data. Rule 19 (a) (Boundaries)"Before the toss, the umpires shall agree the boundary of the field of play with both captains. The boundary shall, if possible, be marked along its whole length" Rules of Cricket....
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PMID: 18524562
PDF is available here.
PDF is available here.
Abstract
The molecular structure and transferability of Tn1546 in 143 vancomycin-resistant Enterococcus faecium (VREF) isolates obtained from patients (n = 49), surface water (n = 28), and urban and hospital sewage (n = 66) in Tehran, Iran, were investigated. Molecular characterization of Tn1546 elements in...
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PMID: 18192406
PDF is available here.
PDF is available here.
Abstract
Genome dose of active ribosome genes (ARG), average of nucleolus argyrophil structures in lymphocyte nuclei, levels of extracellular DNA (DNA(e)) concentrations and ratio of antibodies to total DNA (AB(DNA)) and ribosomal DNA (AB(DNA-rib)), and nuclease activity were determined in peripheral blood o...
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PMID: 19192541
PDF is available here.
PDF is available here.
Abstract
We employed a culture-independent metagenomic approach to analyse for the first time complete genomes in the halophage community and explored the in situ diversity by transmission electron microscopy and pulsed-field gel electrophoresis. We report the genomic sequence of a not yet isolated halophage...
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PMID: 17564605
PDF is available here.
PDF is available here.
Insect Molecular Biology (16)3 2007
Abstract
We report the complete cDNA sequence of the Anopheles gambiae voltage-gated sodium channel (VGSC) alpha-subunit isolated from mature adult mosquitoes. The genomic DNA contains 35 deduced exons with a predicted translation of
PDF is available here.
PDF is available here.
Abstract
We have used a PCR-based approach to identify breakpoint regions of rearranged structures in the human genome. In particular, we have identified intrachromosomal identical repeats that are located in reverse orientation, which may lead to chromosomal inversions. A bioinformatic workflow pathway to s...
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PMID: 17389356
PDF is available here.
PDF is available here.
Abstract
We report the discovery and characterization of retroviral sequences belonging to a new lentiviral subgroup from the European rabbit (Oryctolagus cuniculus). These viruses, the first endogenous examples described, are >7 million years old and thus provide the first evidence for an ancient origin of...
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PMID: 17384150
PDF is available here.
PDF is available here.
Abstract
We have previously distinguished essential and non-essential genes by evaluating the growth and enzyme-producing properties of strains of B. subtilis in which about 3000 genes (except 271 essential genes) have been disrupted or deleted singly, and have successfully utilized the findings from these s...
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PMID: 17115975
PDF is available here.
PDF is available here.
Abstract
Research programmes for constructing a 'cell factory' have been funded in several countries. In Japan, the 'Minimum genome factory' (MGF) project was launched in 2001. In this project, several model microbes have been genetically reconstructed to obtain a cell with fewer genes on a chromosome of red...
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PMID: 17300222
PDF is available here.
PDF is available here.
Abstract
We show that the need for an appropriate phenotypic variability induces a relationship between the deleteriousness of gene mutations and the quantity of non-coding sequences maintained in the genome. The more deleterious the gene mutations, the shorter the intergenic sequences. Indeed, in a shorter...
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PMID: 17055537
PDF is available here.
PDF is available here.
BMC Bioinformatics (8)1 2007
Abstract
Tracembler takes one or multiple DNA or protein sequence(s) as input to the NCBI Trace Archive BLAST engine to identify matching sequence reads from a species of interest. The BLAST searches are carried out recursively such that BLAST matching sequences identified in previous rounds of searches are...
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PMID: 17490482
PDF is available here.
PDF is available here.
Genome Biology (8)10 2007
Abstract
We constructed a microarray based on the complete genome sequence of Xcc strain 8004 and investigated the genetic diversity and host specificity of Xcc by array-based comparative genome hybridization analyses of 18 virulent strains. The results demonstrate that a genetic core comprising 3,405 of the...
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PMID: 17927820
PDF is available here.
PDF is available here.
Bioinformatics (23)1 2007
Abstract
We have created a database of evolutionary conserved regions (ECRs) in vertebrate genomes, entitled ECRbase, which is constructed from a collection of whole-genome alignments produced by the ECR Browser. ECRbase features a database of syntenic blocks that recapitulate the evolution of rearrangements...
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PMID: 17090579
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (110)45 2006
Abstract
We analyze publicly available data on Affymetrix microarray spike-in experiments on the human HGU133 chipset in which sequences are added in solution at known concentrations. The spike-in set contains sequences of bacterial, human, and artificial origin. Our analysis is based on a recently introduce...
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PMID: 17092029
PDF is available here.
PDF is available here.
Molecular Diversity (10)4 2006
Abstract
Sialic acids are a family of acidic sugars with a 9-carbon backbone, prominently expressed in animals of deuterostome lineage. Siglecs are the largest family of vertebrate endogenous receptors that recognize glycoconjugates containing sialic acids. Although a few Siglecs are well-conserved throughou...
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PMID: 16972014
PDF is available here.
PDF is available here.
Abstract
We constructed libraries by direct PCR amplification and cloning of 16S rRNA genes. Almost half of the sequences of the 16S rRNA gene libraries clustered with uncultured archaeal groups. In an effort to access genomic information from uncultured archaeal members we further constructed a fosmid libra...
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PMID: 16907759
PDF is available here.
PDF is available here.
Abstract
We characterized the genomic structure and transcriptional regulation of CYSLTR1 and examined associations between CYSLTR1 polymorphisms and asthma/rhinitis. The experiment of rapid amplification of cDNA end revealed that CYSLTR1 contains three exons and that the entire open reading frame is located...
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PMID: 16771777
PDF is available here.
PDF is available here.
Postgraduate Medicine (119)2 2006
Abstract
Genomic profiling is a significant addition to the clinician's armamentarium, enabling more specific diagnosis and targeted treatment of a wide range of diseases, including cancer. Although not yet widely used in a clinical setting, the new technology is providing detailed information about the part...
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PMID: 16961053
PDF is available here.
PDF is available here.
Abstract
Previous research reveals that the genome structures of rhizobial type strains and reference strains can reflect their phylogenetic relationships. In order to further explore the potential application of genome structure as a phylogenetic marker in rhizobial natural taxonomy, this study analyzed the...
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PMID: 17294652
PDF is available here.
PDF is available here.
Periodontology 2000 (42) 2006
Abstract
Abstract
We present an algorithm for pathway mapping across microbial genomes. The algorithm takes into account both sequence similarity and genomic structure information such as operons and regulons. One basic premise of our approach is that a microbial pathway could generally be decomposed into a few opero...
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PMID: 16373500
PDF is available here.
PDF is available here.
Abstract
We present the complete genome sequence of c-st, a representative of BoNTX/C1-converting phages. The genome is a linear double-stranded DNA of 185,682 bp with 404-bp terminal direct repeats, the largest known temperate phage genome. We identified 198 potential protein-coding regions, including the g...
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PMID: 16287978
PDF is available here.
PDF is available here.
Orvosi Hetilap (146)43 2005
Abstract
The resolution of complete genome sequences of many pathogens has dramatically expanded our perspectives in developing novel vaccines by increasing both the speed and scale of target identification. Genomics-based technologies with their significant advantages can be applied to most pathogens and ha...
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PMID: 16323567
PDF is available here.
PDF is available here.
Abstract
Until recently the study of individual DNA sequences and of total DNA content (the C-value) sat at opposite ends of the spectrum in genome biology. For gene sequencers, the vast stretches of non-coding DNA found in eukaryotic genomes were largely considered to be an annoyance, whereas genome-size re...
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PMID: 16151375
PDF is available here.
PDF is available here.
Abstract
We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-kappaB-like transcription factor orthologous to Drosophila Relish. Through alternative splicing, REL2 produces a full-length (REL2-F) and a shorter (REL2-S) protein isoform lacking the inhibit...
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PMID: 16076953
PDF is available here.
PDF is available here.
Forensic Science International (151)2-3 2005
Abstract
The genomic matching technique (GMT) targets duplicated polymorphic sequences within genomic blocks in the human major histocompatibility complex (MHC), differentiating between individuals at the DNA level using a single primer pair per block. The GMT is currently used to supplement human leukocyte...
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PMID: 15939159
PDF is available here.
PDF is available here.
Abstract
Synthetic biologists come in two broad classes. One uses unnatural molecules to reproduce emergent behaviours from natural biology, with the goal of creating artificial life. The other seeks interchangeable parts from natural biology to assemble into systems that function unnaturally. Either way, a...
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PMID: 15995697
PDF is available here.
PDF is available here.
Folia Parasitologica (52)1-2 2005
Abstract
Microsporidia have been known for some time to possess among the smallest genomes of any eukaryote. There is now a completely sequenced microsporidian genome, as well as several other large-scale sequencing efforts, so the nature of these genomes is becoming apparent. This paper reviews some of the...
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PMID: 16004359
PDF is available here.
PDF is available here.
Folia Parasitologica (52)1-2 2005
Abstract
The genome sequence of the microsporidian parasite Encephalitozoon cuniculi Levaditi, Nicolau et Schoen, 1923 contains about 2,000 genes that are representative of a non-redundant potential proteome composed of 1,909 protein chains. The purpose of this review is to relate some advances in the charac...
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PMID: 16004360
PDF is available here.
PDF is available here.
Current Biology (15)7 2005
Abstract
Insect Molecular Biology (14)2 2005
Abstract
Genome sizes and the organization of repetitive DNA were determined in the hard ticks Ixodes scapularis and Boophilus microplus using reassociation kinetics. The I. scapularis genome contains approximately 2.15 pg (2.1x10(3) Mbp) of DNA and consists of no foldback (FB), 27% highly repetitive (HR), 3...
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PMID: 15796755
PDF is available here.
PDF is available here.
Abstract
Plasma insulin and glucose concentrations are important quantitative phenotypes related to diabetes and the metabolic syndrome. Reports purporting to identify quantitative trait loci (QTLs) that contribute to the variation in fasting insulin and glucose concentrations are discrepant. As part of the...
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PMID: 15616041
PDF is available here.
PDF is available here.
Nature Genetics (37)1 2005
Abstract
Abstract
We have identified and characterized five novel truncated forms of the TFIID subunit TAF4 (TAF(II)135). Analysis of the mouse gene structure revealed that all truncations were the results of alternative splicing and resulted in the loss of domains or parts of domains implicated in TAF4 functional in...
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PMID: 15530431
PDF is available here.
PDF is available here.
Abstract
We report the identification and the characterization of cng-3, a new CNG channel gene, found in C. elegans. CNG-3 contains six putative transmembrane regions and a cyclic nucleotide-binding domain that show high homology with CNG channels of higher animals as well as TAX-4. The expression of cng-3...
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PMID: 15530424
PDF is available here.
PDF is available here.
Abstract
We also describe examples where mechanisms of genome evolution have acted in the adaptation of bacterial species to particular niches....
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PMID: 15568993
PDF is available here.
PDF is available here.
Nature Genetics (36)12 2004
Abstract
Salmonella enterica serovars often have a broad host range, and some cause both gastrointestinal and systemic disease. But the serovars Paratyphi A and Typhi are restricted to humans and cause only systemic disease. It has been estimated that Typhi arose in the last few thousand years. The sequence...
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PMID: 15531882
PDF is available here.
PDF is available here.
Abstract
Abstract
An analysis of dinucleotide frequencies was carried out on DNAs from insects and mammals, as well as on large DNA sequences from the genomes of Drosophila melanogaster, Anopheles gambiae, puffer fish (Takifugu rubripes), zebra fish (Danio rerio) and human. These organisms were chosen because Drosoph...
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PMID: 15177689
PDF is available here.
PDF is available here.
Abstract
We developed an affinity method to isolate human genomic fragments containing binding sites for PPARs and to identify novel PPAR target genes. For this, an antibody raised against all PPAR subtypes was used. Immunoselected fragments were amplified and sequenced and one of them, ISF5148, was found to...
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PMID: 15177567
PDF is available here.
PDF is available here.
Abstract
The past decade has witnessed a tremendous expansion of our knowledge-base of genetics of inflammatory bowel disease. To a large extent, this progress reflects the scientific innovation and impact of the human genome project, which has fueled many laboratory-based studies focusing on the molecular g...
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PMID: 15157826
PDF is available here.
PDF is available here.
Sleep Medicine (5)3 2004
Abstract
Several studies on Restless legs syndrome (RLS) have suggested a substantial genetic contribution in the etiology of this sleep disorder. Clinical surveys of idiopathic RLS patients have shown that up to 60% report a positive family history. Investigations of single families with RLS have suggested...
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PMID: 15165539
PDF is available here.
PDF is available here.
Abstract
The genome sizes of seven strains of oral treponemes were determined using pulsed-field gel electrophoresis (PFGE). These strains represent members from six of the currently known cultivable oral treponeme groups. The PFGE fragments were digitally recorded and then quantitated using GIMP v 1.2, an i...
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PMID: 14871355
PDF is available here.
PDF is available here.
Trends in Microbiology (12)4 2004
Abstract
Biochemical Journal (378)Pt 3 2004
Abstract
Porcine taurochenodeoxycholic acid 6alpha-hydroxylase, cytochrome P450 4A21 (CYP4A21), differs from other members of the CYP4A subfamily in terms of structural features and catalytic activity. CYP4A21 participates in the formation of hyocholic acid, a species-specific primary bile acid in the pig. T...
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PMID: 14641109
PDF is available here.
PDF is available here.
Survey of Ophthalmology (49)2 2004
Abstract
Over the past decade, there has been an exponential increase in our knowledge of heritable eye conditions. Coincidentally, our ability to provide accurate genetic diagnoses has allowed appropriate counseling to patients and families. A summary of our current understanding of ocular genetics will pro...
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PMID: 14998691
PDF is available here.
PDF is available here.
Abstract
The role played by active oxygen forms in damaging the human genome by environmental factors as well as the application of antioxidants to keep the oncology statistics among the hazardous-area residents low are under discussion. According to the independent results, there are essential differences b...
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PMID: 15108371
PDF is available here.
PDF is available here.
Bioinformatics (19)13 2003
Abstract
FindGDPs is a program that uses a greedy algorithm to quickly identify a set of genome-directed primers that specifically anneal to all of the open reading frames ina genome and that do not exhibit full-length complementarity to the members of another user-supplied set of nucleotide sequences.
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PMID: 15593406
PDF is available here.
PDF is available here.
Abstract
We present the first report of reciprocal chromosome painting between humans and a rodent. Gene mapping and sequencing data lead to the generalization that rodent genomes are highly rearranged. In contrast, our results show a surprising conservation of genome structure between humans and squirrels....
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PMID: 12837274
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)26 2003
Abstract
We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demon...
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PMID: 12716890
PDF is available here.
PDF is available here.
Cancer Letters (194)2 2003
Abstract
Telomeres, the ends of linear chromosomes, play a major role in the maintenance of genome integrity. Telomerase or alternative lengthening of telomeres (ALT) mechanisms exist in most cancer cells in order to stabilize telomere length by the addition of telomeric repeats. Telomere loss can be dramati...
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PMID: 12757975
PDF is available here.
PDF is available here.
Genetic Epidemiology (24)4 2003
Abstract
We examine this idea in depth, and show that it can be interpreted as a computational device for locating the posterior mode without necessarily implying that the original random effects structure is incorrect. We illustrate the application of this technique to mixed models for familial data.
Copyri...
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PMID: 12687647
PDF is available here.
PDF is available here.
Abstract
These results suggest that expression of ASK 2 is regulated by multiple mechanisms....
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PMID: 12708028
PDF is available here.
PDF is available here.
Abstract
Abstract
To screen genes involved in P15(INK4b) regulation during cell cycle, differential display method was applied to compare mRNAs from G(1) synchronized cells of MLIK6, which overexpressed P15(INK4b) gene, and its control MLC2. By using this approach, 15 cDNA fragments that were preferentially expressed...
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PMID: 12470661
PDF is available here.
PDF is available here.