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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Genome (14):
Recent article
Genome
Abstract
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Abstract
We present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 sequencing of shotgun and paired-end librar...
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PMID: 21832995
PDF is available here.
PDF is available here.
Eukaryotic Cell (10)9 2011
Abstract
Algae are a large group of aquatic, typically photosynthetic, eukaryotes that include species from very diverse phylogenetic lineages, from those similar to land plants to those related to protist parasites. The recent sequencing of several algal genomes has provided insights into th...
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PMID: 21803865
PDF is available here.
PDF is available here.
Nature Reviews: Genetics (12)9 2011
Abstract
RNA structure is crucial for gene regulation and function. In the past, transcriptomes have largely been parsed by primary sequences and expression levels, but it is now becoming feasible to annotate and compare transcriptomes based on RNA structure. In addition to computational pred...
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PMID: 21850044
PDF is available here.
PDF is available here.
Developmental Cell (21)2 2011
Abstract
We conducted two genome-wide RNAi screens identifying genes required for intoxication and demonstrating that requirements are strikingly different between PE and Ricin, with only 13% overlap. Yet factors required by both toxins are present from the endosomes to the ER, and, at the morphological leve...
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PMID: 21782526
PDF is available here.
PDF is available here.
Abstract
The C57BL/6 mice were subjected to a chronic combined stress which resulted in the induction of a depressive-like state. The occurrence of a depressive-like state was defined by a decrease in sensitivity to the reward determined by the diminished preference of sweetened solutions ove...
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PMID: 21961309
PDF is available here.
PDF is available here.
Systems Biology, IET (5)4 2011
Abstract
The gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. K...
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PMID: 21823758
PDF is available here.
PDF is available here.
Trends in Genetics (27)6 2011
Abstract
Fuelled by new sequencing technologies, epigenome mapping projects are revealing epigenomic variation at all levels of biological complexity, from species to cells. Comparisons of methylation profiles among species reveal evolutionary conservation of gene body methylation patterns, pointing to the fu...
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PMID: 21507501
PDF is available here.
PDF is available here.
Abstract
We have recently demonstrated that Tet1 is specifically expressed in murine embryonic stem (ES) cells and is required for ES cell maintenance. Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, here we show in mouse ES cells that Tet1 is preferentially bound to CpG-rich...
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PMID: 21451524
PDF is available here.
PDF is available here.
Abstract
We further confirmed that the mRNA expression of six of these 25 genes, namely family with sequence similarity 178, member A (FAM178A), retinoic acid receptor responder (tazarotene induced) (RARRES1), ubiquitin specific peptidase 28 (USP28), Scm-like with four mbt domains 2 (SFMBT2), family with seq...
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PMID: 21756782
PDF is available here.
PDF is available here.
Abstract
We studied the biological and genetic characteristics of such cells in CRC cell lines and primary tumors. Three CRC cell lines were sorted in CD133 positive and negative fractions. The respective genetic aberration profiles were studied using array comparative genomic hybridization (aCGH) and expres...
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PMID: 21435437
PDF is available here.
PDF is available here.
Abstract
We review recent data and theory that support gene duplication as a theoretically predicted and experimentally supported means of resolving intralocus sexual antagonism. We believe that this role is probably the consequence of sexual conflict for housekeeping genes that are required in males and fem...
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PMID: 21397976
PDF is available here.
PDF is available here.
Abstract
We show that mammalian Dpy-30, a core subunit of the SET1/MLL histone methyltransferase complexes, modulates H3K4 methylation in vitro, and directly regulates chromosomal H3K4 trimethylation (H3K4me3) throughout the mammalian genome. Depletion of Dpy-30 does not affect ESC self-renewal, but signific...
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PMID: 21335234
PDF is available here.
PDF is available here.
Trends in Genetics (27)4 2011
Abstract
Horizontal gene transfer is increasingly described between bacteria and animals. Such transfers that are vertically inherited have the potential to influence the evolution of animals. One classic example is the transfer of DNA from mitochondria and chloroplasts to the nucleus after the acquisition of...
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PMID: 21334091
PDF is available here.
PDF is available here.
Abstract
We propose that 'speciation gene' be defined as any gene contributing to the evolution of reproductive isolation. Characterizing a speciation gene involves establishing that the gene affects a component of reproductive isolation; demonstrating that divergence at the locus occurred before completion...
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PMID: 21310503
PDF is available here.
PDF is available here.
Abstract
We present a Sumatran orang-utan draft genome assembly and short read sequence data from five Sumatran and five Bornean orang-utan genomes. Our analyses reveal that, compared to other primates, the orang-utan genome has many unique features. Structural evolution of the orang-utan genome has proceede...
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PMID: 21270892
PDF is available here.
PDF is available here.
Abstract
We cloned the cDNAs of these genes and examined their expression in untreated tadpoles and in tadpoles exposed to waterborne aryl hydrocarbon receptor agonists, 3,3',4,4',5-pentachlorobiphenyl (PCB126), β-naphthoflavone (βNF), or indigo. We also examined the effects of PCB126 on expression of gene...
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PMID: 20965207
PDF is available here.
PDF is available here.
British Journal of Nutrition (105)1 2011
Abstract
Inter-individual response differences to vitamin D and Ca supplementation may be under genetic control through vitamin D and oestrogen receptor genes, which may influence their absorption and/or metabolism. Metabolomic studies on blood and urine from subjects supplemented with Ca and vitamin D revea...
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PMID: 20727239
PDF is available here.
PDF is available here.
Abstract
We present the readDepth package for R, which can detect these aberrations by measuring the depth of coverage obtained by massively parallel sequencing of the genome. In addition to achieving higher accuracy than existing packages, our tool runs much faster by utilizing multi-core architectures to p...
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PMID: 21305028
PDF is available here.
PDF is available here.
Abstract
We used the fluorescence-labeled methylation-sensitive amplified polymorphism (F-MSAP) method to assess the extent and pattern of cytosine methylation in muscle, heart, liver, spleen, lung, kidney and stomach from the swine strain Laiwu, and we also examined specific methylation patterns in the seve...
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PMID: 21283691
PDF is available here.
PDF is available here.
Abstract
Among vertebrates, teleost fish exhibit a considerably wide range of sex determination patterns that may be influenced by extrinsic parameters. However even for model fish species like the zebrafish Danio rerio the precise mechanisms involved in primary sex determination have not been studied extensi...
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PMID: 21304996
PDF is available here.
PDF is available here.
Abstract
We demonstrate in vivo movement of a restriction-modification system within a genome under a laboratory condition. After blocking replication of a temperature-sensitive plasmid carrying a PaeR7I restriction-modification system in Escherichia coli cells, the plasmid was found integrated into the chro...
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PMID: 21305031
PDF is available here.
PDF is available here.
Abstract
We provide evidence that human genes are currently not operating at their maximum capacity in terms of gene regulation. We analyse genes spanning the full spectrum of eukaryote evolution, from primate-specific genes to genes present in the eukaryote ancestor, and show that older genes tend to be bou...
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PMID: 21398425
PDF is available here.
PDF is available here.
Abstract
Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, wh...
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PMID: 21395512
PDF is available here.
PDF is available here.
Abstract
We examined piebald, a pigmentation phenotype in both human and Merino sheep, by analysing multiple data types using a systems approach. First, a case control analysis of 49,034 ovine SNP was performed which confirmed a multigenic basis for the condition. We combined these results with gene expressi...
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PMID: 21701676
PDF is available here.
PDF is available here.
Biology Direct (6) 2011
Abstract
We now have a tremendous opportunity to better understand which genes are the most variable or conserved, and what their particular functions and evolutionary dynamics are, through comparative genomics.
We chose human and eleven other high-coverage mammalian genome data-as well as an...
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PMID: 21342519
PDF is available here.
PDF is available here.
Abstract
We have applied the metagenome approach employing the barcoding target gene coi as a model sequence in catch from four very different fish assemblages exploited by fisheries: freshwater communities from the Amazon River and northern Spanish rivers, and marine communities from the Cantabric and Medit...
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PMID: 21829636
PDF is available here.
PDF is available here.
Abstract
We report the functional annotation and comparative analyses of transcriptome data sets for two eastern African cichlid species, Astatotilapia burtoni and Ophthalmotilapia ventralis, representatives of the modern haplochromines and ectodines, respectively. Nearly 647,000 expressed sequence tags were...
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PMID: 21617250
PDF is available here.
PDF is available here.
Abstract
MicroRNAs are a family of ~22 nt small RNAs that can regulate gene expression at the post-transcriptional level. Identification of these molecules and their targets can aid understanding of regulatory processes. Recently, HTS has become a common identification method but there are two major limitatio...
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PMID: 21504621
PDF is available here.
PDF is available here.
Abstract
The throughput of commercially available sequencers has recently significantly increased. It has reached the point where measuring the RNA expression by the depth of coverage has become feasible even for largest genomes. The development of software tools is constantly following the progress of biolog...
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PMID: 21612622
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)53 2010
Abstract
We show a novel interaction between the transcription elongation factor Bur1-Bur2 and replication protein A (RPA), the eukaryotic single-stranded DNA-binding protein with functions in DNA repair, recombination, and replication. Bur1 interacted via its C-terminal domain with RPA, and bur1-ΔC mutants...
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PMID: 21075850
PDF is available here.
PDF is available here.
Abstract
Cytogenetic and Genome Research (132)1-2 2011
Abstract
We have established the first genome-wide comparative chromosome map between human and the 6-banded armadillo (Euphractussexcinctus, 2n = 58), a basal species on the Xenarthra branch, by reciprocal cross-species chromosome painting. In total, 22 human autosomal paints revealed 41 homologous segments...
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PMID: 20720395
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (132)1-2 2011
Abstract
We have established the first genome-wide chromosomal homologies between human and the Forrest's pika (Ochotona forresti, 2n = 54) by cross-species chromosome painting. Integration of our map with the published comparative chromosome map between human and rabbit has enabled the establishment of an i...
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PMID: 20664243
PDF is available here.
PDF is available here.
Abstract
We have shown previously that immunoglobulin fragment-fused GLP-1 (GLP-1/Fc) is a structurally stable GLP-1 analog. Here, we report a non-viral GLP-1/Fc gene therapy strategy utilizing a REP78-in-trans and REB-in-cis element system to achieve a site-specific genomic integration. For this purpose, th...
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PMID: 21070745
PDF is available here.
PDF is available here.
Abstract
Abstract
We use inferred domain architectures of ancestral genomes to trace the evolution of domain promiscuity in eukaryotic genomes. We find an increase in average promiscuity along many branches of the eukaryotic tree. Moreover, domain promiscuity can proceed at almost a steady rate over long evolutionary...
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PMID: 21127809
PDF is available here.
PDF is available here.
Abstract
Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA seque...
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PMID: 21266344
PDF is available here.
PDF is available here.
Abstract
Abstract
We documented effects in adult lobsters at the metabolic and gene expression levels. In this study we have documented morphologic corollaries to our prior observations. We examined the light and electron microscopic changes in the hepatopancreas of adult lobsters following in vivo acute exposure to...
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PMID: 20825991
PDF is available here.
PDF is available here.
EMBO Reports (11)11 2010
Abstract
We report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fe...
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PMID: 20930845
PDF is available here.
PDF is available here.
Abstract
All complex life is composed of eukaryotic (nucleated) cells. The eukaryotic cell arose from prokaryotes just once in four billion years, and otherwise prokaryotes show no tendency to evolve greater complexity. Why not? Prokaryotic genome size is constrained by bioenergetics. The endosymbiosis that...
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PMID: 20962839
PDF is available here.
PDF is available here.
Abstract
We exploited cross-species comparison to predict miRNAs and identified 266 genes encoding 274 mature miRNAs in Oryctolagus cuniculus. Comparative analyses among mammalian genomes demonstrated that most of the identified miRNAs and their clusters are ancient in origin and conserved among mammals but...
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PMID: 20213505
PDF is available here.
PDF is available here.
Abstract
In this paper, the complete mitochondrial genome of Acraea issoria (Lepidoptera: Nymphalidae: Heliconiinae: Acraeini) is reported; a circular molecule of 15,245 bp in size. For A. issoria, genes are arranged in the same order and orientation as the complete sequenced mitochondrial genomes of the oth...
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PMID: 20091125
PDF is available here.
PDF is available here.
Abstract
Our experiment suggested that the swine MAPKAPK3 gene might play an important role in the growth and development differences between mini-type Diannan small-ear pigs and large-type Diannan small-ear pigs....
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PMID: 19921547
PDF is available here.
PDF is available here.
Abstract
We constructed small RNA cDNA libraries from skeletal muscle and adipose tissue and identified 89 distinct miRNAs that are conserved in pig, of which 15 were new. Expression analysis of all newly identified and selected known porcine miRNAs revealed that some miRNAs were enriched in a tissue-specifi...
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PMID: 20180025
PDF is available here.
PDF is available here.
New Phytologist (188)1 2010
Abstract
• Ectocarpus siliculosus has been proposed as a genetic and genomic model for the brown algae and the 214 Mbp genome of this organism has been sequenced. The aim of this project was to obtain a chromosome-scale view of the genome by constructing a genetic map using microsatellite markers that w...
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PMID: 20456050
PDF is available here.
PDF is available here.
Abstract
We are thus able to present the first complete gene map of sea bass. It will facilitate linkage studies and the identification of candidate genes and Quantitative Trait Loci (QTL). The RH map further positions sea bass as a genetic and evolutionary model of Perciformes and supports their ongoing aqu...
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PMID: 20659549
PDF is available here.
PDF is available here.
Abstract
Abstract
Nature Biotechnology (28)10 2010
Abstract
What are the key considerations to take into account when large-scale epigenomics projects are being implemented?
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PMID: 20944594
PDF is available here.
PDF is available here.
PLoS Genetics (6)10 2010
Abstract
We used Dicer1-null ES cells, which lack all endogenous mature miRNAs, and introduced just miR-294 into these ES cells. We then employed two approaches to discover miR-294 targets in mouse ES cells: transcriptome profiling using microarrays and a biochemical approach to isolate mRNA targets associat...
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PMID: 20975942
PDF is available here.
PDF is available here.
Molecular BioSystems (6)10 2010
Abstract
Systematic analysis of literature- and experimentally-derived datasets using text mining with ontological enrichment and network modeling revealed global trends in the microRNA (miRNA) interactome. A total of 756 unique miRNAs were resolved from PubMed abstracts and 1165 direct relat...
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PMID: 20539892
PDF is available here.
PDF is available here.
Discovery medicine (10)53 2010
Abstract
Repetitive DNA sequences constitute a large fraction of the genomes of humans and other animal species. Tandem repeats are a major class of repetitive DNA and the extent of their polymorphic distributions and functions within the human genome are only beginning to be explored. Tandem repeat polymorp...
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PMID: 21034672
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
Based on the gene and pathway centric concept of cancer, current approaches to cancer drug treatment have been focused on key molecular targets specific and essential for cancer progression and drug resistance. This approach appears promising in many experimental models but unfortunately has not wor...
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PMID: 20840073
PDF is available here.
PDF is available here.
Abstract
We describe the overall structure of NYCOMPS and provide details on the high-throughput pipeline....
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PMID: 20690043
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
Genetika (Moskva) (46)9 2010
Abstract
Genetika (Moskva) (46)9 2010
Abstract
The review summarizes modern views on to the structure and differentiation of the nuclear apparatus in ciliates. The genetic system of ciliates (type Ciliophora) includes two types of nuclei: germinal micronucleus (MIC) and somatic macronucleus (MAC). The MAC development is associated with the rearr...
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PMID: 21061616
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
Recently accumulated data provide insight into some generally accepted models of mitochondrial genome. Here brief review of the new data is presented.
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PMID: 21061626
PDF is available here.
PDF is available here.