Abstract
We examined genetic structure in a large racially and ethnically diverse sample consisting of five ethnic groups of the Multiethnic Cohort study (African Americans, Japanese Americans, Latinos, European Americans and Native Hawaiians) using 2,509 SNPs distributed across the genome. Principal compone...
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PMID: 20499252
PDF is available here.
Abstract
We investigated the population structure of this native anchialine shrimp to test the hypothesis that genetic population structure differs between the two shrimp species and that M. lohena is genetically unstructured across its range. A survey of 605 bp of the mitochondrial cytochrome c oxidase subu...
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PMID: 20411714
PDF is available here.
Abstract
We investigated the genetic structure of Sciadopitys verticillata, an endemic conifer in Japan, using 11 microsatellite markers. Average expected heterozygosity varied from 0.282 to 0.450, with between 2 and 17 alleles per locus, and allelic richness varied from 2.14 to 2.94 within a population. Wil...
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PMID: 20142455
PDF is available here.
Abstract
We investigated the genetic structure of Sciadopitys verticillata, an endemic conifer in Japan, using 11 microsatellite markers. Average expected heterozygosity varied from 0.282 to 0.450, with between 2 and 17 alleles per locus, and allelic richness varied from 2.14 to 2.94 within a population. Wil...
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PMID: 20142455
PDF is available here.
Abstract
We investigated the genetic structure of Sciadopitys verticillata, an endemic conifer in Japan, using 11 microsatellite markers. Average expected heterozygosity varied from 0.282 to 0.450, with between 2 and 17 alleles per locus, and allelic richness varied from 2.14 to 2.94 within a population. Wil...
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PMID: 20142455
PDF is available here.
Abstract
We investigated the genetic structure of Sciadopitys verticillata, an endemic conifer in Japan, using 11 microsatellite markers. Average expected heterozygosity varied from 0.282 to 0.450, with between 2 and 17 alleles per locus, and allelic richness varied from 2.14 to 2.94 within a population. Wil...
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PMID: 20142455
PDF is available here.
Abstract
We used RAPD-PCR markers to assess the levels of genetic variability and differentiation among populations of Ae. aegypti (the vector of dengue and yellow fever) in Córdoba, the second largest city in Argentina. We detected similar levels of genetic variability (He between 0.351-0.404) across sam...
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PMID: 19722088
PDF is available here.
Abstract
General and genetic statistical methods are commonly used to deal with microsatellite data (highly variable neutral genetic markers). In this paper, the self-organizing map (SOM) that belongs to the unsupervised artificial neural networks (ANNs) was applied to analyse the structure o...
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PMID: 19393128
PDF is available here.
Abstract
Within the past year, schizophrenia genetics has focused on a more detailed investigation of previously implicated candidate genes. In addition, investigation of copy number variations has led to the identification of rare structural DNA variants that might play a major role in some cases of schizop...
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PMID: 19553868
PDF is available here.
Abstract
We often encounter nonrandom patterns of genetic affinity over relatively small spatial scales, labelled fine-scale genetic structure. Both the extent and decay rate of that pattern can be expected to depend on numerous interesting demographic, ecological, historical, and mating system factors, and...
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PMID: 18677808
PDF is available here.
Abstract
We examined the connectivity between populations of the common scleratinian coral Stylophora pistillata at the northern tip of the Gulf of Aqaba (Red Sea), using the rDNA ITS (internal transcribed spacer) as a molecular marker. Sequence comparisons among recruits indicated very similar, equally-dive...
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PMID: 18155069
PDF is available here.
Abstract
We discuss the necessity of enhancing the statistical approaches to face the challenges posed by the ever-increasing amounts of molecular data generated by scientists over a wide range of research areas and introduce an array of new statistical tools implemented in the most recent version of BAPS. W...
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PMID: 19087322
PDF is available here.
Abstract
We found that the highland Daghestani populations had contrasting histories for the mitochondrial DNA and Y-chromosome data sets. Y-chromosomal haplogroup diversity was reduced among highland Daghestani populations when compared to other populations and to highland Daghestani mitochondrial DNA haplo...
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PMID: 18637195
PDF is available here.
Abstract
These results suggest a clinal distribution of genetic variability, as observed for variation in plumage color of the two A. aestiva subspecies. Bottleneck analysis did not show a recent reduction in population size. Thus, for the management and conservation of the species, the populations from Arge...
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PMID: 18949701
PDF is available here.
Abstract
I show that node centrality and graph breadth are significantly correlated to population genetic parameters Phi(ST) and M; (rho=-0.95;rho=-0.98, respectively), which are commonly used in quantifying among population genetic structure and isolation by distance. Next, the topological consequences of m...
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PMID: 16919694
PDF is available here.
Abstract
We describe the cloning, exon-intron structure, phylogeny, and estimated expression of four novel genes from Ciona intestinalis. We also describe the gene structure and phylogeny of homologous genes in Ciona savignyi. Comparing these genes with other members of the CYP clan 3, show that the Ciona se...
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PMID: 16777437
PDF is available here.
Abstract
A Cu,Zn superoxide dismutase (SOD1) gene was cloned from the bumblebee, Bombus ignitus. The SOD1 gene of B. ignitus spans 1,317 bp and consists of three introns and four exons encoding 151 amino acid residues. The B. ignitus SOD1 (BiSOD1) possesses the typical metal-binding ligands of six histidines...
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PMID: 16730205
PDF is available here.
Abstract
We addressed this question by analyzing the spatial and temporal distribution of introns in actins of foraminifera, a group of testate protists whose exceptionally rich fossil record permits the calibration of molecular phylogenies to date intron origins. We identified 24 introns dispersed along the...
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PMID: 16755352
PDF is available here.
Abstract
We report here that the frequency of phase 0 increases and phase 1 declines from the 5' region to the 3' end of genes. This trend is particularly noticeable in genomes of Homo sapiens and Arabidopsis thaliana, in which gains of novel introns in the 3' portion of genes were probably a dominant proces...
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PMID: 16736103
PDF is available here.
Abstract
I types corresponded to three groups identified by phylogenetic trees of archaeal DnaK proteins including the same archaeal subdivisions. These archaeal DnaK groups were not significantly interrelated, clustering instead with DnaKs from three bacterial lineages, Methanosarcinales with Firmicutes, Th...
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PMID: 16788741
PDF is available here.
Abstract
Twenty microsatellite markers selected from the chicken GENBANK were analyzed for polymorphism in two new Silkies laying breeds. Allele frequencies were tested by the auto scan on ABI 3100-Avant Genetic Analyzer. The results suggested that the optimization test of multiplex PCR was successful and 18...
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PMID: 16520307
PDF is available here.
Abstract
The statistical tools incorporated in the system are allowing to obtain global views of important sequence features. It is expected that the results obtained will permit identification of general rules that govern codon context and codon usage in any genome. Additionally, identification of genes con...
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PMID: 16538282
PDF is available here.
Abstract
A rich repertoire of proteins involved in phosphate metabolism, phototrophic growth and extracellular protective polymers, including the largest archaeal protein (9159 amino acids), a homolog to eukaryotic mucins, are amongst the most outstanding features. A relatively low GC content (47.9%), 15-20%...
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PMID: 16820047
PDF is available here.
Abstract
A single orthologue of FAK and the related PYK2 was found in non-vertebrate species. Gene duplication probably occurred in deuterostomes after the echinoderma embranchment, leading to the evolution of PYK2 with distinct properties. The amino acid sequence of FAK and PYK2 is conserved in their functi...
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PMID: 16889663
PDF is available here.
Abstract
We examine differences in protein and coding sequence conservation between dominant and recessive human disease genes. Our analysis shows that disease genes affected by dominant mutations are more conserved than those affected by recessive mutations. This could be a consequence of the fact that rece...
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PMID: 16817963
PDF is available here.
Abstract
Two UCP2 genes were identified in the rainbow trout genome, UCP2A and UCP2B. These genes are 93% similar in their predicted amino acid sequences and display the same genomic structure as other vertebrates (8 exons and 7 introns) spanning 4.2 kb and 3.2 kb, respectively. UCP2A and UCP2B were widely e...
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PMID: 16899121
PDF is available here.
Abstract
Using the cDNA of rye cytoplasmic ribosomal protein ScRPS7 as a query probe, a highly homologous rice genomic contig was obtained from Huada rice genome database. The full-length cDNA sequence of rice cytoplasmic ribosomal protein S7 was assembled by informatics based on the contig. Furthermore, wit...
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PMID: 15639984
PDF is available here.
Toshio Higuchi,
Takuya Orita,
Setsuko Nakanishi,
Ken Katsuya,
Hirotaka Watanabe,
Yoshiki Yamasaki,
Iwao Waga,
Toyomichi Nanayama,
Yoshihisa Yamamoto,
William Munger,
Hong-Wei Sun,
Ronald J Falk,
J Charles Jennette,
David A Alcorta,
Huiping Li,
Tadashi Yamamoto,
Yutaka Saito and
Motonao Nakamura
Abstract
We identify a cDNA encoding a novel mucin protein, shown previously to be up-regulated in IgAN patients, from a human kidney cDNA library. This protein contains a mucin tandem repeat of 19 amino acids consisting of many threonine, serine, and proline residues and likely to be extensively O-glycosyla...
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PMID: 14565953
PDF is available here.
Abstract
We propose that comprehensive analysis of the functions of these genes in Arabidopsis will firmly establish serine, cysteine and aspartic proteases as regulators and effectors of a wide range of plant processes....
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PMID: 14697270
PDF is available here.
Abstract
We present the complete coding sequence for a novel gene, cordon-bleu (cobl), expressed specifically in the node and its derivatives until organogenesis stages. The deduced sequence does not resemble any gene of known function. However, cobl is widely conserved: apparent orthologs and paralogs are f...
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PMID: 14512015
PDF is available here.
Abstract
OBJECTIVE: To determine the genome structure of human telomeric repeat binding factor 1 (TERF1) and its pseudogenes. METHODS: Sequences were obtained from GenBank and analyzed using the BLAST program and other relevant biology program (Sequencher, DNA Strider and Autoassembler, etc) to determine the...
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PMID: 14610740
PDF is available here.
Abstract
These results would indicate that the population structure of P. avellanae is clonal either in northern Greece or in central Italy. The recent outbreaks of the bacterium in new areas of hazelnut cultivation would explain the current clonal structure that is persisting over decades....
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PMID: 14523121
PDF is available here.
Abstract
We show here that ceh-36 and ceh-37, the remaining two Otx-like genes in the C. elegans genome, specify the identities of AWC, ASE, and AWB chemosensory neurons, defining a role for this gene family in sensory neuron specification. All C. elegans Otx genes and rat Otx1 can substitute for ceh-37 and...
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PMID: 14536063
PDF is available here.
Abstract
Scorpion venoms contain different types of low molecular mass toxic peptides acting on ion channels. Many cDNAs and genomic genes encoding these toxins have been isolated and sequenced while the mechanisms of expression and regulation of scorpion toxins is not well studied yet. BmTXK beta, one of th...
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PMID: 14579537
PDF is available here.
Abstract
I = 0.132; H = 0.087) was higher than that of Chuanminshen violaceum (A = 1.217; P = 21.7; I = 0.103; H = 0.067). CONCLUSION: The genetic variation of Changium smyrnioides is high and the majority of genetic variation occur among populations. Substantial genetic divergence is shown by cluster analys...
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PMID: 15139099
PDF is available here.
Abstract
The DNA of 251 Magnaporthe grisea isolates from Shiping County, which originated from monoculture and mixture fields, was extracted and amplified by rep-PCR which primer was from palindromes Pot2 of Magnaporthe grisea. The result showed that all isolates were amplified 9-17 DNA bands, the size was a...
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PMID: 12924129
PDF is available here.
Abstract
Genetic structure and diversity of mummichog (Fundulus heteroclitus) populations were investigated using mitochondrial DNA (mtDNA) sequences. Forty-six haplotypes were identified among 208 mummichog from the Elizabeth and York Rivers in Virginia, USA. No evidence of decreased gene or nucleotide dive...
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PMID: 12627657
PDF is available here.
Abstract
We propose hierarchical modeling of LD (HLD) for fine-scale mapping. This approach incorporates information on haplotype block structure and chromosomal spatial relations to refine the pattern of LD, increasing the ability to localize disease genes. Here, we present a framework for HLD, a simulation...
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PMID: 12525994
PDF is available here.
Abstract
We cloned the pufferfish ( Takifugu rubripes) Mx gene and sequenced 80 kb from the Mx locus. The Fugu Mx gene spans 3.4 kb from the transcription start site to the polyadenylation signal, and is made up of 12 exons and 11 introns. The protein sequence encoded by the Fugu Mx gene is 77%, 48%, and 51%...
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PMID: 12557057
PDF is available here.
Abstract
The frequencies of 19 classical genetic markers for a total of 54 alleles were studied in a sample of 1,164 individuals born and residing in five different regions of Corsica. The results, which are also discussed in the context of the Mediterranean populations, show the existence within Corsica of...
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PMID: 12621603
PDF is available here.
Abstract
We have elucidated the size, structure, and functional components of c-Myc-induced extrachromosomal elements (EEs). Scanning electron microscopy revealed that EEs isolated from MycER-activated Pre-B+ cells are an average of 10 times larger than EEs isolated from non-MycER-activated control Pre-B- ce...
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PMID: 12659683
PDF is available here.
R A RA Welch,
V V Burland,
G G Plunkett,
P P Redford,
P P Roesch,
D D Rasko,
E L EL Buckles,
S-R SR Liou,
A A Boutin,
J J Hackett,
D D Stroud,
G F GF Mayhew,
D J DJ Rose,
S S Zhou,
D C DC Schwartz,
N T NT Perna,
H L T HL Mobley,
M S MS Donnenberg and
F R FR Blattner
Abstract
We present the complete genome sequence of uropathogenic Escherichia coli, strain CFT073. A three-way genome comparison of the CFT073, enterohemorrhagic E. coli EDL933, and laboratory strain MG1655 reveals that, amazingly, only 39.2% of their combined (nonredundant) set of proteins actually are comm...
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PMID: 12471157
PDF is available here.
Abstract
Population genetic characteristics of mummichog, Fundulus heteroclitus, from the heavily industrialized Elizabeth River and nearby York River (Virginia USA) were assessed relative to sediment PAH concentrations. Allozyme genotype frequencies for all loci were consistent with random mating expectatio...
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PMID: 12359390
PDF is available here.
Abstract
These results support our view that the acquisition of large DNA regions, such as PAIs, by horizontal gene transfer is an important factor for the evolution of bacterial pathogens....
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PMID: 12379716
PDF is available here.
Abstract
The human ov-serpin monocyte neutrophil elastase inhibitor (MNEI) is encoded by a single gene SERPINB1. It is a highly efficient inhibitor of neutrophil granule proteases. Four murine genes with high sequence identity with MNEI were identified and fully sequenced, and these were named EIA, EIB, EIC,...
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PMID: 12189154
PDF is available here.
Abstract
We previously reported the identification of 48 cadmium-inducible mRNAs in the nematode Caenorhabditis elegans. Here we describe a new cadmium-responsive gene, designated cdr-1, whose rate and level of inducible expression parallel those of the C. elegans metallothioneins. The CDR-1 mRNA contains an...
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PMID: 12189149
PDF is available here.
Harry Dolstra,
Björn de Rijke,
Hanny Fredrix,
Antonio Balas,
Frans Maas,
Frank Scherpen,
Maria J Aviles,
Jose L Vicario,
Nico J Beekman,
Ferry Ossendorp,
Theo M de Witte and
Elly van de Wiel-van Kemenade
Abstract
We previously defined the molecular nature of the B cell lineage-specific mHag HB-1. The CTL epitope was identified as the decamer peptide EEKRGSLHVW presented in the context of HLA-B44. The HB-1 antigen is encoded by a locus of yet unknown function on chromosome 5q32. A single nucleotide polymorphi...
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PMID: 12355426
PDF is available here.
Abstract
We now report the characterization of the complete mouse gene. The structural organization of the mouse gene is identical to the human profilaggrin gene and consists of three exons with a 4 kb intron within the 5' noncoding region and a 1.7 kb intron separating the sequences encoding the calcium-bin...
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PMID: 12406337
PDF is available here.
Abstract
We show that the gene of the cytoplasmic tyrosine kinase SYK spans a region of 90kb with 13 coding exons, an alternative exon 14 and at least two 5' untranslated regions exons 1a and 1b. 5' RACE (Rapid amplification of cDNA ends) of human Syk cDNAs demonstrated a complex promoter usage and splicing...
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PMID: 12400606
PDF is available here.
Abstract
Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron...
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PMID: 12069995
PDF is available here.