Pubget: learning materials for Mutation

Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results. To determine the relationships between BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS), progression-free... | PMID: 21990299

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JAMA (306)14 2011

Defining variations in survival of BRCA1 and BRCA2 mutation carriers.

Victor R Grann and Ramon E Parsons

Abstract

PMID: 21990304

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Audio, Transactions of the IRE Professional Group on (85)19 2011

Mechanisms governing the selection of translation initiation sites on foot-and-mouth disease virus RNA.

Tuija A A TA Pöyry and Richard J RJ Jackson

Abstract

Translation initiation dependent on the foot-and-mouth disease virus (FMDV) internal ribosome entry site (IRES) occurs at two sites (Lab and Lb), 84 nucleotides (nt) apart. In vitro translation of an mRNA comprising the IRES and Lab-Lb intervening segment fused to a chloramphenicol acetyltransferase... | PMID: 21813609

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Audio, Transactions of the IRE Professional Group on (418)2 2011

TAK1 regulates NF-KappaB and AP-1 activation in airway epithelial cells following RSV infection.

Nilay N Dey, Tianshuang T Liu, Roberto P RP Garofalo and Antonella A Casola

Abstract

We have investigated the signaling pathway leading to activation of these two transcription factors in response to RSV infection. Our results show that IKKβ plays a key role in viral-induced NF-κB activation, while JNK regulates AP-1-dependent gene transcription, as demonstrated by using kinase in... | PMID: 21835421

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Audio, Transactions of the IRE Professional Group on (514)1-2 2011

Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury. LID - 10.1016/j.abb.2011.07.014 [doi]

Waisin W Lee, Mingjing M Xu, Yue Y Li, Yong Y Gu, Jianping J Chen, Derek D Wong, Peter C W PC Fung and Jiangang J Shen

Abstract

We investigated productions of superoxide anions (O(2)(-)) and nitric oxide (NO), and apoptotic cell death in wild type Chinese hamster ovary (CHO) cells and cholesterol accumulated CHO cells genetically and chemically. Oxidative stress was induced by menadione challenge. The results revealed that a... | PMID: 21843500

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Audio, Transactions of the IRE Professional Group on (136)4 2011

The application of molecular diagnostic studies interrogating EGFR and KRAS mutations to stained cytologic smears of lung carcinoma.

Bryan L BL Betz, Michael H MH Roh, Helmut C HC Weigelin, Jeremiah B JB Placido, Lindsay A LA Schmidt, Sara S Farmen, Doug A DA Arenberg, Gregory P GP Kalemkerian and Stewart M SM Knoepp

Abstract

We investigated the usefulness of cytologic direct smears as an alternative specimen source for mutation testing. Tumor cell-enriched areas from freshly prepared and archived rapid Romanowsky-stained direct smears in 33 cases of lung carcinoma were microdissected for DNA isolation and evaluated for... | PMID: 21917678

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Audio, Transactions of the IRE Professional Group on (31)20 2011

Dynamics of the putative RNA helicase Spb4 during ribosome assembly in Saccharomyces cerevisiae.

Juan José JJ García-Gómez, Simon S Lebaron, Carine C Froment, Bernard B Monsarrat, Yves Y Henry and Jesús J de la Cruz

Abstract

We have studied the composition of complexes that copurify with Spb4 tagged by tandem affinity purification (TAP-tagged Spb4). These complexes contain mainly the 27SB pre-rRNAs and about 50 ribosome biogenesis proteins, primarily components of early pre-60S ribosomal particles. To a lesser extent, s... | PMID: 21825077

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Audio, Transactions of the IRE Professional Group on (79)10 2011

The LuxS-dependent quorum-sensing system regulates early biofilm formation by Streptococcus pneumoniae strain D39.

Jorge E JE Vidal, Herbert P HP Ludewick, Rebekah M RM Kunkel, Dorothea D Zähner and Keith P KP Klugman

Abstract

We show that this QS system plays a major role in the control of S. pneumoniae biofilm formation. Our results demonstrate that the luxS gene is contained by invasive isolates and normal-flora strains in a region that contains genes involved in division and cell wall biosynthesis. The luxS gene was m... | PMID: 21825061

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Nature Structural & Molecular Biology (18)10 2011

Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Francisca E Reyes-Turcu, Ke Zhang, Martin Zofall, Eesin Chen and Shiv I S Grewal

Abstract

We show that cells lacking Mlo3, a protein involved in mRNP biogenesis and RNA quality control, assemble functional heterochromatin in RNAi-deficient cells. Heterochromatin restoration is linked to RNA surveillance because loss of Mlo3-associated TRAMP also rescues heterochromatin defects of RNAi mu... | PMID: 21892171

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Nature Structural & Molecular Biology (18)10 2011

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Marcel Hohl, Youngho Kwon, Sandra Muñoz Galván, Xiaoyu Xue, Cristina Tous, Andrés Aguilera, Patrick Sung and John H J Petrini

Abstract

We constructed rad50 alleles encoding truncations of the coiled-coil domain to determine which Mre11 complex functions required the full length of the coils. These mutations abolished telomere maintenance and meiotic double-strand break (DSB) formation, and severely impaired homologous recombination... | PMID: 21892167

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