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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Genetic Variation (5):
Recent article
Genetic Variation
Abstract
We investigated the association of 51 single-nucelotide polymorphisms (SNPs) in anti-inflammatory cytokines (IL-10, TGFB1, IL-6, IL-4, and IL-13) and receptors (IL-10RA, IL-10RB, TGFBR1, TGFBR2, IL-6R, IL-4R, IL-5RA, IL-5RB, and IL-13RA1) with susceptibility to leprosy in a case-control study from N...
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PMID: 21917900
PDF is available here.
PDF is available here.
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Abstract
We first conducted 4 association studies (2639 individuals) that showed a protective effect of the -308A allele (odds ratio [OR] = 0.77; P = .005). Next, results of a meta-analysis reinforced this association after inclusion of our new data (OR = 0.74; P = .04). Furthermore, a subgroup analysis incl...
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PMID: 21917899
PDF is available here.
PDF is available here.
Abstract
The dipteran Chironomus riparius is found across the entire Palearctic region; its larvae are among the most abundant macroinvertebrates inhabiting inland waterbodies. Chironomid larvae have been extensively used in ecotoxicological and cytogenetic research, but relatively little is...
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PMID: 21901555
PDF is available here.
PDF is available here.
American Naturalist (178)S1 2011
Abstract
We walk through a set of interrelated spatial scenarios that illustrate interesting complexities of this interplay. To motivate our individual-based model results, we consider a hypothetical zooplankter in a landscape of discrete water bodies coupled by dispersal. We examine how patterns of dispersa...
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PMID: 21956092
PDF is available here.
PDF is available here.
Abstract
We review differential gene regulation focusing on evolutionary-developmental (evodevo) biology, global comparison of genomic sequences, whole-genome gene expression, and transcription factor (TF) binding profiles. We also explore the relationship between divergence rate of regulatory sequences, cod...
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PMID: 21721942
PDF is available here.
PDF is available here.
Abstract
We briefly review the types of transposable elements present in the human genome and their mechanisms of mobility. We next highlight how advances in DNA sequencing and genomic technologies have enabled the discovery of novel retrotransposons in individual genomes. Finally, we discuss how L1-mediated...
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PMID: 21801021
PDF is available here.
PDF is available here.
Abstract
We discovered that WT PRL-3 does not dephosphorylate the tested phosphopeptides in vitro. However, as shown by two complementary biochemical assays, PRL-3 is active toward the phosphoinositide PI(4,5)P(2). Our experimental results substantiated by molecular docking studies suggest that PRL-3 is a ph...
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PMID: 21806020
PDF is available here.
PDF is available here.
Abstract
Cell lines overexpressing the individual UGTs 1A4 and 2B10 exhibited glucuronidation activity against olanzapine. The UGT1A4 variant exhibited a 3.7-fold (P<0.0001) higher Vmax/KM for the formation of the olanzapine-10-N-glucuronide isomer 1, and a 4.3-fold (P<0.0001) higher Vmax/KM for the formatio...
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PMID: 21750471
PDF is available here.
PDF is available here.
Abstract
The aim of the present study was to investigate the distribution of the Beijing strains of Mycobacterium tuberculosis (MTB) in Taipei and other Asian cities. A total of 323 MTB isolates were analyzed by spacer oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive unit (MIRU...
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PMID: 21851415
PDF is available here.
PDF is available here.
Avian Diseases (55)3 2011
Abstract
Samples collected in 2008 and 2009, from 49 turkey flocks of 6 to 43 days in age and presenting clinical signs of enteric disease and high mortality, were tested by polymerase chain reaction and reverse transcription-polymerase chain reaction for the presence of viruses currently ass...
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PMID: 22017049
PDF is available here.
PDF is available here.
Abstract
We report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences...
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PMID: 21886157
PDF is available here.
PDF is available here.
Abstract
We identified a third candidate early domestication gene and conducted haplotype analyses of all three genes to address a recent, controversial hypothesis about the origin of cultivated sunflower. Although the scientific consensus had long been that sunflower was domesticated once in eastern North A...
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PMID: 21844335
PDF is available here.
PDF is available here.
Abstract
We examine the epidemiology of EV71, with three waves of increased EV71 activity since the 1970s and discuss the genotypic changes in phylogeny between the outbreaks or epidemics. Genetic changes including mutations and recombinations as well as the diversity of antigenic properties among EV71 strai...
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PMID: 21715436
PDF is available here.
PDF is available here.
Zoological Science (28)8 2011
Abstract
We analyzed mussels from marine lakes located on different islands and conducted morphological, phylogenetic and population genetic characterization to clarify their evolutionary history. The mussels were morphologically classified into three differentiated morphs: NS, ON, and MC. Their common chara...
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PMID: 21800997
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)8 2011
Abstract
We focus on the miRNA-related genetic variations and cancer susceptibility and progression....
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PMID: 21831803
PDF is available here.
PDF is available here.
Abstract
We utilized the WTCCC data set evaluating 1748 CD and 2938 controls. The identification of candidate genes/loci was performed by a two-step procedure: first of all chromosomal regions enriched of weak association signals were localized; subsequently, weak signals clustered in gene regions were ident...
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PMID: 21411385
PDF is available here.
PDF is available here.
Abstract
We utilized the WTCCC data set evaluating 1748 CD and 2938 controls. The identification of candidate genes/loci was performed by a two-step procedure: first of all chromosomal regions enriched of weak association signals were localized; subsequently, weak signals clustered in gene regions were ident...
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PMID: 21411385
PDF is available here.
PDF is available here.
Abstract
Adenoviruses are medium-sized double stranded DNA viruses that infect vertebrates. Human adenoviruses cause an array of diseases. Currently there are 56 human adenovirus types recognized and characterized within seven species (A-G). Of those types, a majority belongs to species D. In...
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PMID: 21570490
PDF is available here.
PDF is available here.
Abstract
The results of intraspecies heterogeneity analysis of 4 bifidobacterial species, B. longum, B. animalis subsp. lactics, B. bifidum and B. dentium colonizing intestines of people of different age groups are presented in the paper. A high level of intraspecies variability has been revealed for all spec...
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PMID: 21809682
PDF is available here.
PDF is available here.
Abstract
Our study implicates disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process leading to PD....
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PMID: 21763482
PDF is available here.
PDF is available here.
Abstract
We investigated an Austrian family with 16 affected individuals by exome sequencing. We found a missense mutation, c.1858G>A (p.Asp620Asn), in the VPS35 gene in all seven affected family members who are alive. By screening additional PD cases, we saw the same variant cosegregating with the disease i...
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PMID: 21763483
PDF is available here.
PDF is available here.
Abstract
We identify a family in which all known RP/LCA-related genes are unlikely to be associated with their disorder. A combination of homozygosity mapping and exome sequencing identifies a homozygous nonsense mutation, c.496C>T (p.Arg166X), in a gene, KCNJ13, encoding a potassium channel subunit Kir7.1....
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PMID: 21763485
PDF is available here.
PDF is available here.
Abstract
Multi-sample pooling and Illumina Genome Analyzer (GA) sequencing allows high throughput sequencing of multiple samples to determine population sequence variation. A preliminary experiment, using the RET proto-oncogene as a model, predicted ≤30 samples could be pooled to reliably d...
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PMID: 21738440
PDF is available here.
PDF is available here.
Abstract
We studied four lines of Drosophila melanogaster that have a standardized nuclear DNA but variable mtDNA. We completed the sequencing of the mitochondrial genomes (excluding the A+T rich region) and compiled the differences. We then assayed male influence on oviposition, starvation resistance, lipid...
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PMID: 21757031
PDF is available here.
PDF is available here.
Abstract
We perform a genome-wide survey to understand the population history of the Siddis. Using hundreds of thousands of autosomal markers, we show that they have inherited ancestry from Africans, Indians, and possibly Europeans (Portuguese). Additionally, analyses of the uniparental (Y-chromosomal and mi...
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PMID: 21741027
PDF is available here.
PDF is available here.
Fungal Biology (115)7 2011
Abstract
We have undertaken an expressed sequence tag (EST) study, and report on the first dataset of 486 ESTs, assembled into 217 unigenes. Of these, 144 had significant sequence similarity with known genes, including 47 with ribosomal protein homology. Potential virulence factors included genes involved in...
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PMID: 21724174
PDF is available here.
PDF is available here.
PLoS Genetics (7)7 2011
Abstract
We hypothesized that some of this unexplained heritability might be due to common and rare variants that reside in GWAS identified loci but lack appropriate proxies in modern genotyping arrays. To assess this hypothesis, we re-examined 7 genes (APOE, APOC1, APOC2, SORT1, LDLR, APOB, and PCSK9) in 5...
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PMID: 21829380
PDF is available here.
PDF is available here.
Abstract
We are able to support the conservation of native forest resources of medicinal use by means of vegetative propagation techniques....
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PMID: 21834239
PDF is available here.
PDF is available here.
Abstract
Seed ethanolic extracts of 21 Brazilian plants were evaluated for ovicidal, larvicidal, and pupicidal activities against insecticide-susceptible (SS) and field-collected (FC) strains of Aedes aegypti (L.) (Diptera: Culicidae), as well as for their effects on nontarget organisms. Myracrodruon urundeuv...
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PMID: 21845944
PDF is available here.
PDF is available here.
Abstract
Personalized medicine uses traditional, as well as emerging concepts of the genetic and environmental basis of disease to individualize prevention, diagnosis and treatment. Personalized genomics plays a vital, but not exclusive role in this evolving model of personalized medicine. The distinctions be...
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PMID: 21706342
PDF is available here.
PDF is available here.
Abstract
We know little about the phylogeny and diversity of Tuber species in Japan. We have collected 186 new Tuber ascoma samples in Japan over a 10-year period. The identities and phylogenies of the samples were analyzed by using sequences of four nuclear loci, i.e., internal transcribed spacer (ITS) and...
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PMID: 21307163
PDF is available here.
PDF is available here.
Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution.
Abstract
A directed evolution approach has been used for the generation of variants of galactose oxidase (GOase) that can selectively oxidize glycans on glycoproteins. The aldehyde function introduced on the glycans d-mannose (Man) and d-N-acetyl glucosamine (GlcNAc) by the enzyme variants could then be used...
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PMID: 21526835
PDF is available here.
PDF is available here.
Abstract
Cancer arises as a consequence of mutations in genomes of cancer cells, which over time allow them to proliferate and spread to distant sites. Large-scale sequencing of cancer genomes is revealing an increasing number of potential driver mutations that may allow specific targeting of cancer genes, pr...
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PMID: 21643984
PDF is available here.
PDF is available here.
Abstract
We characterized the F strain of herpes simplex virus-1 passaged in the presence of a natural carrageenan isolated from the red seaweed Gigartina skottbergii in view of the virulence for mice of isolated viral clones.
Viral clones (syn14-1 and syn17-2) showed a syncytial phenotype an...
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PMID: 22256337
PDF is available here.
PDF is available here.
Abstract
We bring this 'bottom-up' approach alongside the current NGS-driven genetic study of genetic variations and disease aetiology. We describe experimental and computational techniques for assessing genetic variants and their deleterious effects on protein structure and function....
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PMID: 21350909
PDF is available here.
PDF is available here.
Plant Biology (62)1 2011
Abstract
The epigenomic regulation of chromatin structure and genome stability is essential for the interpretation of genetic information and ultimately the determination of phenotype. High-resolution maps of plant epigenomes have been obtained through a combination of chromatin technologies...
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PMID: 21438682
PDF is available here.
PDF is available here.
Proteomics (11)12 2011
Abstract
Designing an experiment for quantitative proteomic analysis is not a trivial task. One of the key factors influencing the success of such studies is the number of biological replicates included in the analysis. This, along with the measured variation will determine the statistical po...
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PMID: 21591257
PDF is available here.
PDF is available here.
Abstract
We will address how protein homeostasis (proteostasis) is achieved at the level of the cell and organism, and how the threshold of the stress response is set to detect and combat protein misfolding. For metazoans, the requirement for coordinated function and growth imposes additional constraints on...
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PMID: 21536706
PDF is available here.
PDF is available here.
Abstract
Five short-diapause laboratory lines of western corn rootworm, Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae), were selected for resistance to MON863, a variety of corn genetically modified with the Bacillus thuringiensis Berliner (Bt) transgene that expresses the Cry3Bb1 delta-en...
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PMID: 21735927
PDF is available here.
PDF is available here.
Abstract
Hull split date, shell seal, and navel orangeworm, Amyelois transitella (Walker) (Lepidoptera: Pyralidae), infestation data for 19 varieties of almonds, Prunus dulcis (Mill.) D.A. Webb, were analyzed to determine the relationship of shell seal and hull split date on A. transitella infestation. Data f...
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PMID: 21735917
PDF is available here.
PDF is available here.
Abstract
We used wheat lacking H genes to compare the survival and growth of a nonadapted strain to two H-adapted strains. The two adapted strains differed in that one had been selected for adaptation to H9, whereas the other strain had been selected for adaptation to H13. Tests showed that two H-adapted str...
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PMID: 21735929
PDF is available here.
PDF is available here.
Abstract
Galactose binding protein (PpGalec) plays an important role in the specificity of Phlebotomus papatasi sandfly for Leishmania major. The molecular diversity of this ligand is currently unknown but might have some influence on the ability of PpGalec to efficiently recognize L. major in natural sandfly...
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PMID: 21715727
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)21 2011
Abstract
Abstract
From 2009 to 2010, 3129 sandflies were caught in CDC light traps placed in various habitats in Ghomrassen, Tataouine governorate, southeast Tunisia, a mixed focus of human cutaneous leishmaniasis caused by Leishmania tropica and Leishmania major. Species diversity was quantified in anthropogenic, sem...
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PMID: 21605538
PDF is available here.
PDF is available here.
Abstract
We sequenced about 200 kb of the male-specific region of the human Y chromosome (MSY) from each of seven Y chromosomes belonging to clades A1, A2, A3, and BT. We detected 146 biallelic variant sites through this analysis. We used these variants to construct a patrilineal tree, without taking into ac...
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PMID: 21601174
PDF is available here.
PDF is available here.
Abstract
In past years, substantial insight regarding the pathogenesis of diffuse large B-cell lymphoma has been obtained. Particularly, based on gene expression profile analysis, this disease can be classified into distinct phenotypic subgroups and specific transcriptional programs have been identified. New...
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PMID: 21842702
PDF is available here.
PDF is available here.
Abstract
We initiate this process, a prerequisite for such a study, by narrowing the focus from an entire genome to that of a single biological system. To this end, we examine the 'Hemostaseome,' and more specifically focus on DNA sequence changes pertaining to those human genes known to impact upon hemostas...
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PMID: 21537949
PDF is available here.
PDF is available here.
Genetika (Moskva) (47)5 2011
Abstract
We suggest that C. x ventricosum plants in southern Primorye were formed by hybridization between C. macranthon and C. calceolus x C. shanxiense hybrids. Thus, they differ from plants inhabiting the Urals and West Siberia, which originated by hybridization between C. macranthon and C. calceolus. The...
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PMID: 21786667
PDF is available here.
PDF is available here.
Genetika (Moskva) (47)5 2011
Abstract
Using five SSR markers, polymorphism ofmicrosatellite loci was examined in 46 cultivars and five species of pear (Pyrus ussuriensis, P. bretscgneideri, P. pyraster, and P. elaegnifolia). Most of the accessions examined demonstrated the presence of unique allele sets. The degree of relationship betwee...
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PMID: 21786670
PDF is available here.
PDF is available here.
Genetika (Moskva) (47)5 2011
Abstract
Genetic differentiation and gene geographic variation of house mouse from the territory of Russia and neighboring countries was examined based on the allozyme analysis of samples from natural, semisynanthropic, and obligate synanthropic populations. The results of analysis of genetic differentiation,...
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PMID: 21786673
PDF is available here.
PDF is available here.
Abstract
Estrogen receptor (ER) remains one of the most important biomarkers for breast cancer subtyping and prognosis, and comparative genome hybridization has greatly contributed to the understanding of global genetic imbalance. The authors used single-nucleotide polymorphism (SNP) arrays to compare overall...
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PMID: 21523713
PDF is available here.
PDF is available here.
Abstract
A total of 222 urinary Escherichia coli isolates from 20 tertiary hospitals in 15 different provinces and 4 municipalities in mainland China were characterized by antimicrobial susceptibility, phylogrouping, and the presence of plasmid-mediated quinolone resistance genes. A subset of 138 suspected ex...
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PMID: 21525216
PDF is available here.
PDF is available here.
Trends in Genetics (27)5 2011
Abstract
We review how the asymmetry in histone variants and post-translational modifications between paternal and maternal genomes and their respective pericentric heterochromatin domains evolve during early cleavage stages in mouse. We draw a parallel between these data and the burst of pericentric satelli...
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PMID: 21497937
PDF is available here.
PDF is available here.
Abstract
All the 20 studied molecular markers were found to be polymorphic in both the tribal population groups and showed similarities with respect to allele frequencies, with a low coefficient of gene differentiation (G(ST)) value. Moreover, sharing and distribution patterns of haplotypes of the β-globin...
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PMID: 21486165
PDF is available here.
PDF is available here.
Abstract
We describe the genomic comparison of 18 strains of L. sakei originating mainly from processed meat against the 23K strain by comparative genome hybridization. Pulsed field gel electrophoresis was used to estimate the genome sizes of the strains, which varied from 1.880 to 2.175 Mb, and the 23K gen...
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PMID: 21369871
PDF is available here.
PDF is available here.
Abstract
We identified a second independent FL-associated locus on 6p21.32, rs2647012 (OR(combined) = 0.64, P(combined) = 2×10(-21)) located 962 bp away from rs10484561 (r(2)<0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012:OR(ad...
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PMID: 21533074
PDF is available here.
PDF is available here.
Zoological Research (32)2 2011
Abstract
We determined 592 bp D-loop sequences of 87 cape hares from Xinjiang Province. Forty-four haplotypes were defined based on 148 polymorphic sites. Both the haplotype diversity (0.977+/-0.005) and nucleotide diversity (0.064+/-0.031) are high. FST P values are significantly high and no haplotype was s...
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PMID: 21509964
PDF is available here.
PDF is available here.
Tropical biomedicine (28)1 2011
Abstract
We provided an update on the prevalence of Legionella in mist fans (N=28), household water heaters with storage tanks (N=19) and instantaneous heaters (N=30); and extended the survey to spa pools (N=29) and aerosol-generating fixtures in nursing homes (N=116). The prevalence of Legionella were 21.1%...
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PMID: 21602781
PDF is available here.
PDF is available here.
Ageing Research Reviews (10)2 2011
Abstract
There is substantial evidence that mitochondria are involved in the aging process. Mitochondrial function requires the coordinated expression of hundreds of nuclear genes and a few dozen mitochondrial genes, many of which have been associated with either extended or shortened life sp...
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PMID: 20601194
PDF is available here.
PDF is available here.
Abstract
We identify five ways in which substantial advances could be made in the next few years: (i) improving the accessibility and efficiency of biodiversity monitoring data, (ii) quantifying the main determinants of the sensitivity of species to climate change, (iii) incorporating community dynamics into...
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PMID: 21474198
PDF is available here.
PDF is available here.