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Gene Frequency (2)
Articles on Gene Frequency
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Neuropeptide Y promoter polymorphism modifies effects of a weight-loss diet on 2-year changes of blood pressure: the preventing overweight u...
Hypertension 60(5):1169-75 (2012) PMID 22966009
We evaluated the potential effect of a functional variant rs16147 located in the NPY gene promoter region on the association between 2-year diet intervention and change in multiple BP measures in the randomized Preventing Overweight Using Novel Dietary Strategies Trial. The NPY rs16147 was genotyped... -
Genome-wide detection of natural selection in African Americans pre- and post-admixture.
Genes Dev 22(3):519-27 (2012) PMID 22128132
We examined 491,526 autosomal single nucleotide polymorphisms (SNPs) genotyped in 5210 individuals and conducted a genome-wide search for selection signals in 1890 AfA. Several genomic regions showing an excess of African or European ancestry, which were considered the footprints of selection since... -
Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5.
Vaccine 30(9):1583-93 (2012) PMID 22230587
We performed evolutionary and population genetic analysis of sera5. The level of inter-species divergence (kS=0.076) between P. falciparum and Plasmodium reichenowi, a closely related chimpanzee malaria parasite is comparable to that of housekeeping protein genes. A signature of purifying selection... -
Survivin gene polymorphism association with papillary thyroid carcinoma.
Pathol Res Pract 208(2):100-3 (2012) PMID 22293278
We evaluated the correlation of this polymorphism with the risk of papillary thyroid carcinoma (PTC) in an Irananian population. The cases consisted of patients with PTC (n=123) and normal controls, composed of non-related healthy people (n=131). The frequency of GC or CC genotype in patients with P... -
A systematic survey of loss-of-function variants in human protein-coding genes.
Science 335(6070):823-8 (2012) PMID 22344438 PMCID PMC3299548
We apply stringent filters to 2951 putative LoF variants obtained from 185 human genomes to determine their true prevalence and properties. We estimate that human genomes typically contain ~100 genuine LoF variants with ~20 genes completely inactivated. We identify rare and likely deleterious LoF al... -
Genetic relationships between Japanese native and commercial breeds using 70 chicken autosomal SNP genotypes by the DigiTag2 assay.
Anim Genet 43(1):98-103 (2012) PMID 22221031
We genotyped 70 chicken autosomal SNPs using DigiTag2 assay to understand the genetic structure of the Japanese native chicken breeds Satsumadori and Ingie, and the relationship of these breeds with other established breeds, Rhode Island Red (RIR), commercial broiler and layer. Five breeds, each con... -
Genetic predictors of cue- and stress-induced cigarette craving: an exploratory study.
Exp Clin Psychopharmacol 20(1):40-6 (2012) PMID 21910549
Study results provide no support for the hypothesis that cue- and stress-induced craving have the same genetic predictors.... -
Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease.
DNA Cell Biol 31(2):211-8 (2012) PMID 21848428
We investigated the effects of genetic polymorphisms of the CYP1A1*2C, GSTT1, and GSTM1 enzymes on CAD risk in a Turkish population. Genotypes were determined for 132 CAD patients and 151 healthy controls by the polymerase chain reaction/restriction fragment length polymorphism method. There were no... -
Serotonin receptor 2A -1438G/A promoter polymorphism in relation to obesity and response to sibutramine.
Genet Test Mol Biomarkers 16(2):109-12 (2012) PMID 21977970
We examined the potential impact of this polymorphism on obesity and related metabolic traits in a cohort of 234 overweight/obese and 103 lean Greek subjects. Additionally, we examined whether the 5HT2AR 1438A/G polymorphism influences weight reduction and change in body composition among 106 out of... -
Extended haplotype studies in South African and Dutch variegate porphyria families carrying the recurrent p.R59W mutation confirm a common a...
Br J Dermatol 166(2):261-5 (2012) PMID 21910705
Our data deliver further confirmation that the South African and Dutch VP families carrying mutation p.R59W shared a common ancestor. © 2011 The Authors. BJD © 2011 British Association of Dermatologists....
