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Inheritance Patterns (8)
Articles on Inheritance Patterns
Understanding transgenerational epigenetic inheritance via the gametes in mammals.
We consider the evidence for transgenerational epigenetic inheritance via the gametes, including cases of environmentally induced epigenetic changes. The molecular basis of this inheritance remains unclear, but recent evidence points towards diffusible factors, in particular RNA, rather than DNA met...
Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable ma...
We designed a microRNA-based shRNA (miR-shRNA) simultaneously targeting four members of mouse CYP3A subfamily (CYP3A11, CYP3A16, CYP3A41 and CYP3A44), and transgenic mice expressing the designed miR-shRNA were generated by lentiviral transgenesis. Results showed that the CYP3A expression level in tr...
Scientists are to investigate "three parent IVF" for preventing mitochondrial diseases.
Maternal inheritance of plastids and mitochondria in Cycas L. (Cycadaceae).
We show that the chloroplasts and mitochondria in the progeny of interspecific crosses between Cycas taitungensis and Cycas ferruginea were exclusively inherited from the female parent. Epifluorescence microscopic analyses of the pollen cells from Cycas elongata indicated that there was a significan...
Patterns and mechanisms of ancestral histone protein inheritance in budding yeast.
We use a recently developed method for swapping epitope tags to measure the disposition of ancestral histone H3 across the yeast genome over six generations. We find that ancestral H3 is preferentially retained at the 5' ends of most genes, with strongest retention at long, poorly transcribed genes....
Integrating personality disorder with basic personality science.
Schizophrenia: Zooming in on a gene.
Sex differences in sand lizard telomere inheritance: paternal epigenetic effects increases telomere heritability and offspring survival.
We show that telomere length is heritable in free-ranging sand lizards, Lacerta agilis. More importantly, heritability estimates analysed within, and contrasted between, the sexes are markedly different; son-sire heritability is much higher relative to daughter-dam heritability. We assess the effect...
The genetic basis of tooth agenesis: basic concepts and genes involved.
Tooth agenesis is the most prevalent craniofacial congenital malformation in humans. While tooth agenesis may be associated with several syndromes, non-syndromic hypodontia refers to the congenital absence of a few teeth in the absence of any other deformity. Recent advances in molec...
Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code.
Inheritance of DNA methylation patterns is a key mechanism involved in epigenetic cell memory transmission from mother cell to daughter cell. This occurs due to cooperation between the DNA methyltransferase DNMT1 and the ubiquitin ligase UHRF1 (ubiquitin-like, containing plant homeo...