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Inheritance Patterns (8)
Articles on Inheritance Patterns
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Understanding transgenerational epigenetic inheritance via the gametes in mammals.
Nat Rev Genet 13(3):153-62 (2012) PMID 22290458
We consider the evidence for transgenerational epigenetic inheritance via the gametes, including cases of environmentally induced epigenetic changes. The molecular basis of this inheritance remains unclear, but recent evidence points towards diffusible factors, in particular RNA, rather than DNA met... -
Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable ma...
PLoS One 7(1):e30560 (2012) PMID 22291988
We designed a microRNA-based shRNA (miR-shRNA) simultaneously targeting four members of mouse CYP3A subfamily (CYP3A11, CYP3A16, CYP3A41 and CYP3A44), and transgenic mice expressing the designed miR-shRNA were generated by lentiviral transgenesis. Results showed that the CYP3A expression level in tr... -
Scientists are to investigate "three parent IVF" for preventing mitochondrial diseases.
BMJ (2012) PMID 22267657
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Maternal inheritance of plastids and mitochondria in Cycas L. (Cycadaceae).
Mol Genet Genomics 286(5-6):411-6 (2011) PMID 22071672
We show that the chloroplasts and mitochondria in the progeny of interspecific crosses between Cycas taitungensis and Cycas ferruginea were exclusively inherited from the female parent. Epifluorescence microscopic analyses of the pollen cells from Cycas elongata indicated that there was a significan... -
Patterns and mechanisms of ancestral histone protein inheritance in budding yeast.
PLoS Biol 9(6):e1001075 (2011) PMID 21666805
We use a recently developed method for swapping epitope tags to measure the disposition of ancestral histone H3 across the yeast genome over six generations. We find that ancestral H3 is preferentially retained at the 5' ends of most genes, with strongest retention at long, poorly transcribed genes.... -
Integrating personality disorder with basic personality science.
Acta Psychiatr Scand 123(5):325-6 (2011) PMID 21488844
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Schizophrenia: Zooming in on a gene.
Audio, Transactions of the IRE Profess... 471(7339):455-6 (2011) PMID 21430769
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Sex differences in sand lizard telomere inheritance: paternal epigenetic effects increases telomere heritability and offspring survival.
PLoS One 6(4):e17473 (2011) PMID 21526170 PMCID PMC3081292
We show that telomere length is heritable in free-ranging sand lizards, Lacerta agilis. More importantly, heritability estimates analysed within, and contrasted between, the sexes are markedly different; son-sire heritability is much higher relative to daughter-dam heritability. We assess the effect... -
The genetic basis of tooth agenesis: basic concepts and genes involved.
J Indian Soc Pedod Prev Dent 29(2):84-9 (2011) PMID 21911943
Tooth agenesis is the most prevalent craniofacial congenital malformation in humans. While tooth agenesis may be associated with several syndromes, non-syndromic hypodontia refers to the congenital absence of a few teeth in the absence of any other deformity. Recent advances in molec... -
Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code.
Audio, Transactions of the IRE Professional... 4(157):pe3 (2011) PMID 21266713
Inheritance of DNA methylation patterns is a key mechanism involved in epigenetic cell memory transmission from mother cell to daughter cell. This occurs due to cooperation between the DNA methyltransferase DNMT1 and the ubiquitin ligase UHRF1 (ubiquitin-like, containing plant homeo...
