Abstract
We believe reflects the intratumoral heterogeneity, should be taken into account when applying DNA ploidy to endometrial carcinoma specimens....
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PMID: 20881853
PDF is available here.
Abstract
This article reviews recent trends in nongyn cytology with an emphasis on error reduction, second opinion, and critical diagnosis. Compared with the surgical pathology literature, there is only a limited number of reports addressing these topics in nongyn cytology. Discussion of the error literature...
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PMID: 20966649
PDF is available here.
Abstract
Detecting and classifying error in a surgical pathology (SP) practice is an important part of a comprehensive quality assurance program. There are a number of mechanisms to detect error, including secondary review, examination of amended reports, correlation studies (cytology-histology and frozen-fi...
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PMID: 20733354
PDF is available here.
Abstract
Cytogenetic analysis demonstrated abnormal karyotypes in nearly half of this series of mesenchymal neoplasms, the majority of which consisted of recognized aberrations reported in the literature....
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PMID: 19776087
PDF is available here.
Abstract
This study demonstrates that about 30% of cancer reports do not have all the scientifically validated elements required by the ACS CoC. Pathology departments in which checklists are not routinely used have a substantially lower rate of reports that include all the required elements....
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PMID: 20586623
PDF is available here.
Abstract
We describe our methods for reducing error as much as possible during the pre-analytical and analytical phases. This was achieved by revising procedures, and by using computer technology and automation. Most mistakes are the result of human error in the identification and matching of patient and sam...
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PMID: 21171512
PDF is available here.
Abstract
We are also faced with a global rethinking of lung cancer care, especially once novel therapy strategies have been made available on the basis of the diverse characteristics of tumors. Although morphology still remains a not easily replaceable tool for lung cancer classification, we are now challeng...
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PMID: 20460313
PDF is available here.
Abstract
This article summarizes annual workloads for staff positions and work flow productivity (WFP) values from 247 human pathology, 31 veterinary, and 35 forensic histology laboratories (histolabs). There are single summaries for veterinary and forensic histolabs, but the data from human pathology are di...
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PMID: 20471564
PDF is available here.
Abstract
During the study period, 34 cases of soft tissue lesions were received for review and second opinion. The mean age of the patients was 39 22 years and immunohistochemistry was performed in 21 (62%) of 34 cases. Concurrence between the review and initial diagnosis was seen in 18 (53%) cases (category...
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PMID: 20699503
PDF is available here.
Abstract
In the four years, 759 frozen sections have been done, 25 of which showed discordant results. The most common site of frozen section and discrepancy was in central nervous system tumors. The reason for inaccuracy in frozen section diagnosis in 52% of cases was proved to be interpretative, 44% sampli...
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PMID: 20699493
PDF is available here.
Abstract
We present our experience and the difficulties faced by a gynecologic pathologist (first author) and try to provide some clues for their solution.
Sample size was 153 consecutive laparoscopic specimens, which varied from in toto uterus with cervix, fibroid or ovarian cyst to morcellated specimens. 1...
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PMID: 21045383
PDF is available here.
Abstract
We recommend a single radiographic view along with proper documentation in the postoperative report to confirm the removal of internal fixation hardware in lieu of pathologic evaluation....
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PMID: 20345357
PDF is available here.
Abstract
To address terminology and other issues related to thyroid fine-needle aspiration (FNA), the National Cancer Institute (NCI) hosted the NCI Thyroid FNA State of the Science Conference. The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atl...
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PMID: 19846805
PDF is available here.
Abstract
Revisions were made to the TNM classification in areas with the strongest basis in evidence and practical effect. Lymph node staging data were expanded markedly to reflect its significant prognostic value. T3 and T4 were redefined and stage groupings were added that applied current understanding in...
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PMID: 19653721
PDF is available here.
Abstract
The practice of surgical oncology requires a multidisciplinary approach involving the pathologist, surgeon, clinicians and other workers. The task of a pathologist is to provide adequate, and accurate diagnosis sufficient for the clinician to take decision for patient management. In the tropics, the...
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PMID: 20229744
PDF is available here.
Abstract
Significant progress has been made in the standardization of bladder neoplasm classification and reporting. Accurate staging using the American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) TNM system is essential for patient management, and has been reinforced by clinical...
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PMID: 19494855
PDF is available here.
Abstract
Western-style medicine was introduced to Malaya by the Portuguese, Dutch and British between the 1500s and 1800s. Although the earliest pathology laboratories were developed within hospitals towards the end of the 19th Century, histopathology emerged much later than the biochemistry and bacteriology...
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PMID: 19694308
PDF is available here.
Abstract
Twenty-three cases of surgically resected pulmonary infarcts sent in consultation were reviewed to evaluate their morphology and to assess reasons for consultation. The morphology of these infarcts demonstrated that only a minority had the classical triangular shape at low magnification (26%) wherea...
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PMID: 19287460
PDF is available here.
Abstract
We focused our lens internally on our own laboratory processes, with measurement tools designed to identify potential misidentification defects and their root causes. Based on this knowledge, aligned with our lean work culture in the Henry Ford Production System, we redesigned our surgical pathology...
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PMID: 19289582
PDF is available here.
Abstract
Pathologists play a key role in the evaluation of pathologic response, which is extremely important as a prognostic factor for individual patients, as a short-term endpoint for clinical trials, and as an adjunct for research studies. Therefore, surgical pathologists must be familiar with the gross e...
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PMID: 19391665
PDF is available here.
Abstract
Metastasis to regional lymph nodes detected in cancer surgery specimens is a significant prognosticator and is also critical for subsequent planning of therapeutic options. Consequently, the status of regional lymph nodes has become a mandatory element of the synotic reporting on cancer resection sp...
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PMID: 19051293
PDF is available here.
Abstract
We should not forget those pioneers who, with their medical actions and inspiration, changed the course of their era and left their mark on medical history. One of those is the Greek surgeon Emmanuil Kondoleon (1879-1940). His brilliant scientific personality, numerous teaching activities, and his n...
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PMID: 19499767
PDF is available here.
Abstract
The essential difference between frozen sections and formalin-fixed sections is the greater use of an automated laboratory system to process the smaller size and greater number of blocks produced using the latter process. An effective Mohs service based on formalin-fixed sections requires a minimum...
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PMID: 19210500
PDF is available here.
Anthony J AJ Gill,
Amber L AL Johns,
Robert R Eckstein,
Jaswinder S JS Samra,
Antony A Kaufman,
David K DK Chang,
Neil D ND Merrett,
Peter H PH Cosman,
Ross C RC Smith,
Andrew V AV Biankin,
James G JG Kench and
Abstract
AJCC stage could not be inferred from 44% of free text reports, whereas stage was reported in all 68 synoptic reports. In the free text reports 28 different names were used to designate margins. All margins were reported in only 12 (11%) of the free text reports compared with 64 (94%) of the synopti...
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PMID: 19320058
PDF is available here.
Abstract
Immunohistochemical (IHC) staining of formalin-fixed and paraffin-embedded tissues (FFPE) is widely used in diagnostic surgical pathology. All anatomical and surgical pathologists use IHC to confirm cancer cell type and possible origin of metastatic cancer of unknown primary site. Wh...
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PMID: 20126585
PDF is available here.
Abstract
Precise micro-surgical removal of tumour with minimal damage to the surrounding normal tissue requires a series of excisions, each guided by an examination of frozen histology of the previous. An example is Mohs surgery for the removal of basal cell carcinomas (BCCs) in skin. The preparation of froze...
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PMID: 19196421
PDF is available here.
Abstract
To investigate the factors related to delay in pathology reporting and to improve the quality of pathology service.
A total of 24 months pathology reports (total number = 21,038) issued by Department of Pathology, Dongyang People's Hospital (randomly selected during the period from 1999 to 2006) wer...
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PMID: 19489225
PDF is available here.
Abstract
We performed a nonconcurrent cohort study at a large institution that practices subspecialty surgical pathology sign-out to compare the effectiveness and usefulness of error detection using a targeted 5% random review process and a focused review process. Pathologists reviewed 7,444 cases using a ta...
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PMID: 19019767
PDF is available here.
Stephen M Hewitt,
Fraser A Lewis,
Yanxiang Cao,
Richard C Conrad,
Maureen Cronin,
Kathleen D Danenberg,
Thomas J Goralski,
John P Langmore,
Rajiv G Raja,
P Mickey Williams,
John F Palma and
Janet A Warrington
Abstract
Development of RNA-based assays from formalin-fixed, paraffin-embedded tissue is feasible. Greater attention to tissue handling and processing is essential to improve the quality of biospecimens for the development of robust RNA-based assays. Standardization of procedures and vigorous testing of alt...
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PMID: 19061293
PDF is available here.
Abstract
The accurate diagnosis of inflammatory conditions in dermatopathology requires integrating the histopathologic findings with the clinical features. This second part of a 2-part review of inflammatory cutaneous conditions presents a pattern-based approach to the diagnosis of dermatologic disorders an...
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PMID: 18948765
PDF is available here.
Abstract
We assessed interobserver and intraobserver agreement among 6 thyroid experts by using 15 cases in which original pathologists suspected FVPC. There was unanimous expert agreement in diagnosing FVPC in only 2 cases (13%) and majority agreement in 6 cases (40%). Unanimous agreement on benign and mali...
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PMID: 18854266
PDF is available here.
Abstract
Critical values (CVs) are well established in clinical pathology, and an analogous concept has recently been suggested in anatomic pathology, with the terminology of critical values, or, alternatively, critical diagnoses (CDs). To better identify anatomic pathology CVs, a survey was sent to 225 memb...
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PMID: 18854265
PDF is available here.
Abstract
Overall satisfaction scores for surgical pathology reports as well as satisfaction with report TAT, completeness, and style were high. Report TAT received the lowest scores of all parameters....
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PMID: 18976005
PDF is available here.
Abstract
At Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana, a breakdown of technical equipment and lack of pathologists resulted in closure of the surgical pathology laboratory in 2004. At an international meeting in January 2005, 1 USA and 1 Norwegian pathologist were asked if their departments coul...
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PMID: 18837026
PDF is available here.
Abstract
We aimed to ensure that pathology is properly represented by developing a core pathology curriculum created in consultation with local pathologists. Appropriate information technology to track the delivery of this material within the integrated curriculum structure was developed using a learning con...
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PMID: 18791733
PDF is available here.
Abstract
Clinicians sought a second opinion mainly to verify histological diagnoses and report important pathological details for staging and confirmation of hormonal receptor and c-erbB-2 status prior to therapy. Borderline breast lesions are worrisome for both clinicians and pathologists in view of implica...
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PMID: 18752122
PDF is available here.
Mathieu Latour,
Mahul B Amin,
Athanase Billis,
Lars Egevad,
David J Grignon,
Peter A Humphrey,
Victor E Reuter,
Wael A Sakr,
John R Srigley,
Thomas M Wheeler,
Ximing J Yang and
Jonathan I Epstein
Abstract
The distinction between cribriform Gleason pattern 3 and 4 prostate cancer is controversial. Out of 3590 prostate cancers sent to one of the authors over 7 months, 30 needle biopsy cases were selected that possibly represented cribriform Gleason pattern 3 cancer. Thirty-six digital images were taken...
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PMID: 18724248
PDF is available here.
Andrew J Evans,
Pauline C Henry,
Theodorus H Van der Kwast,
Douglas C Tkachuk,
Kemp Watson,
Gina A Lockwood,
Neil E Fleshner,
Carol Cheung,
Eric C Belanger,
Mahul B Amin,
Liliane Boccon-Gibod,
David G Bostwick,
Lars Egevad,
Jonathan I Epstein,
David J Grignon,
Edward C Jones,
Rodolfo Montironi,
Madeleine Moussa,
Joan M Sweet,
Kiril Trpkov,
Thomas M Wheeler and
John R Srigley
Abstract
We report the first study to address interobserver variability in a group of expert pathologists concerning extraprostatic soft tissue (EPE) and SM interpretation for radical prostatectomy specimens. A panel of 3 urologic pathologists selected 6 groups of 10 slides designated as being positive, nega...
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PMID: 18708939
PDF is available here.
Abstract
These recommendations afford a framework for the creation of an SPR containing all of the components that are required or optimal for patient care....
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PMID: 18834219
PDF is available here.
Abstract
The rapid turnaround capability of the new tissue-processing system has allowed the pathology laboratory to render the final report in the majority of specimens on the day they are received. The feasibility of preserving macromolecules in the same clinical samples used for diagnosis is a timely adva...
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PMID: 18722935
PDF is available here.
Abstract
Surveillance of quality of surgical pathology reports, with feedback, is significantly associated with an improvement in the quality of reports....
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PMID: 18788854
PDF is available here.