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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Blood (3):
Recent article
Blood
Abstract
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Abstract
Clinical practice guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L in patients with acute myocardial infarction (AMI). These guidelines are based on small studies that associated low potassium levels with ventricular arrhythmias in the pre-β-blocker...
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PMID: 22235086
PDF is available here.
PDF is available here.
Abstract
Abstract
Links are well established between both family history of diabetes and reduced birthweight and increased risk of diabetes in adulthood.
1) To investigate the influence of parental history of type 2 diabetes (T2DM) on offspring birthweight and adult offspring glucose t...
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PMID: 21916855
PDF is available here.
PDF is available here.
Clinical Science (122)2 2012
Abstract
We aim to provide an overview of the vast literature on angiogenesis and anti-angiogenesis factors in pre-eclampsia that have been published over the last decade. We introduce work from basic research groups who have focused on the pathophysiological basis of the disease. Furthermore, we review stud...
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PMID: 21929511
PDF is available here.
PDF is available here.
Abstract
Experimental Parasitology (129)3 2011
Abstract
Our data show that at the site of infection in the footpad and in the draining popliteal lymph node, numbers of regulatory T cells remain unchanged between WT and IL-6-deficient mice. However, the spleens of IL-6(-/-) mice contained fewer regulatory T cells after infection with L. major. The develop...
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PMID: 21819984
PDF is available here.
PDF is available here.
Abstract
The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury.
To determine if dietary su...
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PMID: 21976613
PDF is available here.
PDF is available here.
Abstract
Type 2 diabetes mellitus (T2DM) and its attendant complications, such as diabetic nephropathy (DN), impose a significant societal and economic burden. The investigation of discovering potential biomarkers for T2DM and DN will facilitate the prediction and prevention of diabetes. Phos...
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PMID: 21872008
PDF is available here.
PDF is available here.
Abstract
We observed a false-positive case in which plakoglobin signal was reduced in a patient initially believed to have ARVC but who actually had cardiac sarcoidosis. Sarcoidosis can masquerade clinically as ARVC but has not been previously associated with altered desmosomal proteins.
We o...
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PMID: 21859801
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)14 2011
Abstract
We concluded a randomized trial involving 1088 patients with multiple sclerosis, 18 to 55 years of age, with a score of 0 to 5.5 on the Expanded Disability Status Scale and at least one relapse in the previous year or at least two relapses in the previous 2 years. Patients were randomly assigned (in...
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PMID: 21991951
PDF is available here.
PDF is available here.
Abstract
We studied Tregs in the pancreas and peripheral blood.
We recruited 44 patients with IgG4-related AIP. For comparison, we recruited 37 patients with other pancreatic diseases and 27 healthy subjects as controls. We studied infiltrating cells in the pancreas by immunohistochemistry an...
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PMID: 21926547
PDF is available here.
PDF is available here.
Journal of Surgical Research (170)2 2011
Abstract
We induced POLF by combining extended left hepatectomy and ischemia of the small liver remnant of 150 min duration. Subsequently, the remnant liver parenchyma was reperfused and the animals were closely monitored for 24 h.
Twelve Landrace pigs (weight 25-30 kg) were randomly assigned...
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PMID: 21816413
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
We analyzed the changes in FEV(1) after administration of a bronchodilator over a 3-year period in 2163 patients. A random-coefficient model was used to evaluate possible predictors of both FEV(1) levels and their changes over time.
The mean (±SE) rate of change in FEV(1) was a decl...
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PMID: 21991892
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
A total of 432 patients underwent randomization to receive one of four doses of BIBF 1120 (50 mg once a day, 50 mg twice a day, 100 mg twice a day, or 150 mg twice a day) or placebo. In the group receiving 150 mg of BIBF 1120 twice a day, FVC declined by 0.06 liters per year, as compared with 0.19 l...
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PMID: 21992121
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We hypothesized that ESRD patients with relative thrombocytosis (platelet count >300 × 10(3)/μL) have a higher mortality rate and that this association may be related to malnutrition-inflammation cachexia syndrome (MICS).
We examined the associations of 3-mo-averaged platelet count...
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PMID: 21813809
PDF is available here.
PDF is available here.
Abstract
We examined the association between ambulatory activity and biological markers of health in smokers.
Baseline data from 985 subjects enrolled in a pharmacologic smoking cessation trial were examined. Body size, blood pressure, total cholesterol (TC), low density lipoprotein cholester...
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PMID: 21885891
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)11 2011
Abstract
We included all patients with systemic autoimmune diseases in whom the indication for treatment with TPE was a flare of the disease between 1999 and 2010. The indications for treatment, complications and outcomes were obtained from review of medical records.
A total of 31 patients (1...
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PMID: 21569864
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)11 2011
Abstract
Refractory vasculitis occurs in 4-5% of patients with anti-neutrophil cytoplasmic antibody associated vasculitis (AAV). Differences between therapies used for refractory disease are mostly reflected in the percentages of complete and partial remissions, but also in the number of seri...
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PMID: 21600312
PDF is available here.
PDF is available here.
Abstract
Results of our study indicate significant increase of TAS level in plasma of MS patients of WBCT treatment. This indicate that WBCT might be a therapy which suppress oxidative stress in MS patients....
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PMID: 21991843
PDF is available here.
PDF is available here.
Abstract
Primary hyperparathyroidism is systemic, polymorphic disease. Authors present a case of woman suffered from primary hyperparathyroidism misdiagnosed as disseminated neoplastic disease. There was shown a clinical picture complex, difficulties in diagnostic process, treatment and facto...
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PMID: 21991847
PDF is available here.
PDF is available here.
Abstract
Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology, which is characterized by a variable clinical presentation and course. The diagnosis of this disease is usually supported by the three elements: compatible clinical and radiologic findings, tissue biopsy speci...
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PMID: 21991850
PDF is available here.
PDF is available here.
Abstract
We report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences...
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PMID: 21886157
PDF is available here.
PDF is available here.
Abstract
We show that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice. Accordingly, exposing a young mouse to an old systemic environment or to plasma from old mice decreased synaptic plasticity, and impaired contextual fear con...
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PMID: 21886162
PDF is available here.
PDF is available here.
Abstract
To develop a preclinical large animal model of autoimmune diabetes to facilitate the translational research of autoimmune diabetes in human.
Nine young rhesus monkeys received multiple-low-dose (MLD) intravenous injections of streptozotocin for five consecutive days,...
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PMID: 21821007
PDF is available here.
PDF is available here.
Abstract
We here studied the effects of ghrelin on unloading-induced muscle atrophy using a mouse model of hindlimb suspension (HS). Ghrelin administration during 2-week HS alleviated reductions of muscle mass in the fast-twitch fiber-rich plantaris muscle and the slow-twitch fiber-rich soleus muscle of the...
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PMID: 21820418
PDF is available here.
PDF is available here.
Abstract
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. A low dose (approxima...
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PMID: 21830940
PDF is available here.
PDF is available here.
Abstract
Abstract
We estimated the effective propagation number, which reflects the relative importance of contrasting within-host control mechanisms through time and is sensitive to the inoculating parasite dose. Our analysis showed that the capacity of innate responses to restrict initial parasite growth saturates...
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PMID: 21852493
PDF is available here.
PDF is available here.
Circulation (124)8 2011
Abstract
We first show that negatively charged dextran sulfate cellulose columns adsorb sFlt-1 in vitro. In 5 women with very preterm preeclampsia and elevated circulating sFlt-1 levels, we next demonstrate that a single dextran sulfate cellulose apheresis treatment reduces circulating sFlt-1 levels in a dos...
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PMID: 21810665
PDF is available here.
PDF is available here.
Journal of Chromatography B (879)24 2011
Abstract
We investigated and compared the profiles of metabolites in nude mice with alcohol-induced liver injury or bearing a HCC xenograft (HCCX). Alcohol-induced liver injury was achieved by daily administration of grain liquor, and HCC xenografts were generated by subcutaneous inoculation of HepG2 cells i...
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PMID: 21763219
PDF is available here.
PDF is available here.
Abstract
Noninvasive prenatal determination of fetal sex using cell-free fetal DNA provides an alternative to invasive techniques for some heritable disorders. In some countries this testing has transitioned to clinical care, despite the absence of a formal assessment of performance....
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PMID: 21828326
PDF is available here.
PDF is available here.
Abstract
Federal Register (76)153 2011
Abstract
The Food and Drug Administration (FDA) is amending the special controls for the herpes simplex virus (HSV) serological assay device type, which is classified as class II (special controls). These device types are devices that consist of antigens and antisera used in various serologic...
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PMID: 21826824
PDF is available here.
PDF is available here.
EuroIntervention (7)4 2011
Abstract
We identified a set of whole blood transcripts induced at the site of coronary occlusion in the acute phase of myocardial infarction. Resolved genes indicate a predominant role for chemokines, cell-extracellular matrix, and lipoprotein alterations in the pathophysiology of acute myocardial infarctio...
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PMID: 21764664
PDF is available here.
PDF is available here.
EuroIntervention (7)4 2011
Abstract
We identified a set of whole blood transcripts induced at the site of coronary occlusion in the acute phase of myocardial infarction. Resolved genes indicate a predominant role for chemokines, cell-extracellular matrix, and lipoprotein alterations in the pathophysiology of acute myocardial infarctio...
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PMID: 21764664
PDF is available here.
PDF is available here.
Abstract
We aimed at investigating (i) whether a daily dose of 300 mg resveratrol/kg body weight in healthy male Wistar rats for a period of 8 wk affects the selected parameters of glucose and lipid metabolism and (ii) whether the resulting plasma concentrations of resveratrol metabolites were effective...
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PMID: 21732533
PDF is available here.
PDF is available here.
Abstract
We demonstrated that cholera induces an early proinflammatory cellular immune response that results in priming of Th1- and Th17-type cytokine responses to ex vivo antigenic stimulation and an increase in the ratio of Th1 to Th2 CD4(+) T-cell responses. Comparable priming of Th1 and Th17 responses, w...
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PMID: 21697339
PDF is available here.
PDF is available here.
Abstract
Neurocritical care bioinformatics is a new field that focuses on the acquisition, storage and analysis of physiological and other data relevant to the bedside care of patients with acute neurological conditions such as traumatic brain injury or stroke. The main focus of neurocritical...
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PMID: 21750522
PDF is available here.
PDF is available here.
Abstract
We obtained and analysed samples of blood serum from 23 patients with MF, and 29 psoriasis patients and 22 healthy donors as controls. Protein profiling was carried out using SELDI TOF MS SELDI-TOF and also profiling of 27 cytokines with multiplex immunoassay technology was implemented....
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PMID: 21751413
PDF is available here.
PDF is available here.
Abstract
Hepatitis C virus (HCV), a major cause of liver disease throughout the world, is difficult to treat with interferon (IFN) (and various formulations and combinations thereof) being the only approved molecule available. It has been investigated recently that proinflammatory chemokine i...
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PMID: 21554996
PDF is available here.
PDF is available here.
Abstract
This study aimed to examine the participation of Australian Chinese in cardiovascular risk factor and cancer screening.
A telephone survey of a random sample of Chinese in New South Wales, Australia, was conducted. The presence of, and participation in screening for,...
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PMID: 21819359
PDF is available here.
PDF is available here.
Abstract
We performed a randomized trial comparing these two ATG formulations in conventional regimens. Patients were treated at a single facility. The primary outcome was hematologic response at 6 months, as determined by blood counts. The study was designed to enroll 60 patients each for the rabbit-ATG and...
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PMID: 21812672
PDF is available here.
PDF is available here.
Abstract
Structurally-functional myocardium parameters and their interconnection with erythropoietin and tumour necrosis factor-alpha levels in blood plasma of patients with heart failure were analysed. Prevalence of erythropoietin over tumour necrosis factor-alpha in blood had positive effec...
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PMID: 21961313
PDF is available here.
PDF is available here.
Abstract
Peroxynitrite (ONOO-) besides its toxic possesses regulatory action that includes the modulation of oxygen binding properties of blood. The aim of this work was to estimate ONOO- effect on the haemoglobin oxygen affinity (HOA) in vitro in presence of different partial pressure of car...
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PMID: 21961310
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons...
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PMID: 21813697
PDF is available here.
PDF is available here.
Abstract
Compared to other chronic inflammatory diseases, gout appears to based on a rather "simple" pathophysiology and therefore the amount of teaching time in medical school and during internship is rather limited. On the other hand, several problems in short- and long-term management stil...
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PMID: 21833886
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated that serum vascular endothelial growth factor (VEGF) is elevated in cystic fibrosis (CF) patients and declines with therapy for pulmonary exacerbation. We hypothesized that VEGF is elevated early in the course of CF and is associated with markers of tissue hypoxia. A prosp...
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PMID: 21365780
PDF is available here.
PDF is available here.
Abstract
We evaluated time-courses of glucose, insulin, C-peptide, and the incretin glucagon like peptide-1 (GLP-1) following an oral glucose load. Insulin-sensitivity was measured by a hyperinsulinemic-isoglycemic-clamp-test; glucose-turnover was determined using D-[6,6-(2)H(2)] glucose. Examinations were p...
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PMID: 21494227
PDF is available here.
PDF is available here.
Abstract
We characterized levels of acute-phase reactants (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cell (WBC) count), adhesion molecules (E-selectin, vascular cell adhesion molecule-1), and coagulation products (fibrinogen, plasminogen activator inhibito...
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PMID: 21233809
PDF is available here.
PDF is available here.
Abstract
Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia and vascular complications, leading to significant morbidity and mortality. All forms of diabetes are ultimately related to insufficient functional pancreatic β-cell mass to maintain euglycemia....
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PMID: 21644916
PDF is available here.
PDF is available here.
Abstract
Our results underscore the value of genotyping in the clinical trial setting to avoid misinterpretations that could lead to terminating development of a promising new agent....
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PMID: 21412181
PDF is available here.
PDF is available here.
Abstract
We examined the dynamics of TNF capture within porous, polymeric sorbent beads used in a cytokine adsorption device. We sought to quantify how perturbation of TNF oligomeric structure accelerates TNF removal within the device. TNF was incubated with 10% DMSO for 24 h, which promoted complete monomer...
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PMID: 21504054
PDF is available here.
PDF is available here.
Abstract
We examined the dynamics of TNF capture within porous, polymeric sorbent beads used in a cytokine adsorption device. We sought to quantify how perturbation of TNF oligomeric structure accelerates TNF removal within the device. TNF was incubated with 10% DMSO for 24 h, which promoted complete monomer...
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PMID: 21504054
PDF is available here.
PDF is available here.