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Hematopoietic System (1):
Recent article
Hematopoietic System
Abstract
Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia and vascular complications, leading to significant morbidity and mortality. All forms of diabetes are ultimately related to insufficient functional pancreatic β-cell mass to maintain euglycemia....
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PMID: 21644916
PDF is available here.
PDF is available here.
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Abstract
We determined that epithelial cells (ECs) also contributes to this balance. Mechanistically, EC-mediated protection occurred through a Toll-like receptor 3/Toll/IL-1 receptor domain-containing adaptor-inducing interferon (TLR3/TRIF)-dependent pathway converging on indoleamine 2,3-dioxygenase (IDO) v...
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PMID: 20835271
PDF is available here.
PDF is available here.
Abstract
We used a combination of comparative genomics, locus-wide chromatin immunoprecipitation assays, functional validation in cell lines, and extensive transgenic mouse assays to identify and characterize the complete ensemble of Gfi1 regulatory elements. This concerted effort identified five distinct re...
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PMID: 20516218
PDF is available here.
PDF is available here.
Abstract
The aryl hydrocarbon receptor (AhR) is a basic helix-loop-helix protein that belongs to the superfamily of environment-sensing PAS (Per-ARNT-Sim) proteins. A large number of ligands have been described to bind AhR and promote its nuclear translocation. In the nucleus, the AhR and its dimerization pa...
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PMID: 20171126
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (18)1 2010
Abstract
Leptin, the product of obese gene, is a secreting protein that exerts multiple biological functions by binding to its receptor. Leptin regulates nutrient intake and metabolism, and is secreted from adipocytes, which occupy most of the bone marrow cavity and constitute the microenvironment. Leptin not...
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PMID: 20137154
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (18)1 2010
Abstract
The aim of this study was to investigate the role of mesenchymal stem cells in the hematopoietic reconstitution of patients who had received haploidentical allogeneic hematopoietic stem cell transplantation (hi-allo-HSCT). 15 patients who underwent treatment with both MSCs and HSCs, were selected as...
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PMID: 20137138
PDF is available here.
PDF is available here.
Nature Immunology (10)9 2009
Abstract
We examined the global function of the SAP family using mice lacking SAP, EAT-2 and ERT. These adaptors acted together in a mechanism that was essential for the elimination of hematopoietic but not nonhematopoietic cells by NK cells. This function was mediated by many receptors of the SLAM family on...
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PMID: 19648922
PDF is available here.
PDF is available here.
Abstract
We have developed methods for visualizing zebrafish adipocytes in vivo by labeling neutral lipid droplets with Nile Red. Our results establish that neutral lipid droplets first accumulate in visceral adipocytes during larval stages and increase in number and distribution as zebrafish grow. We show t...
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PMID: 19366995
PDF is available here.
PDF is available here.
Abstract
Several important studies have been published recently addressing the embryonic development of hematopoietic stem cells. These studies have helped clarify several controversial topics in developmental hematopoiesis, including the concepts of the hemangioblast and hemogenic endothelium. In particular...
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PMID: 19491671
PDF is available here.
PDF is available here.
Abstract
Implantable three-dimensional (3D) constructs to engineer tissue have great therapeutic potential in regenerative medicine and immunotherapy. However, autonomous recruitment of cells into the engineered scaffold in vivo is hampered by lack of attracting scaffolds. As a first step to...
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PMID: 19108679
PDF is available here.
PDF is available here.
Abstract
Implantable three-dimensional (3D) constructs to engineer tissue have great therapeutic potential in regenerative medicine and immunotherapy. However, autonomous recruitment of cells into the engineered scaffold in vivo is hampered by lack of attracting scaffolds. As a first step to engineering immu...
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PMID: 19108679
PDF is available here.
PDF is available here.
Abstract
We find that miR-24 is upregulated during postmitotic differentiation of hematopoietic cell lines and regulates the histone variant H2AX, a protein that has a key role in the double-stranded break response. We show that the H2AX 3' untranslated region contains conserved miR-24 binding sites that are...
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PMID: 19377482
PDF is available here.
PDF is available here.
Abstract
We attained HESC subpopulations expressing two significantly different levels of Osx, following lentiviral gene transfer. Both subpopulations exhibited spontaneous differentiation and reduced expression of markers characteristic of the pluripotent phenotype, such as SSEA3, Tra1-60, and Nanog, In ord...
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PMID: 18932205
PDF is available here.
PDF is available here.
Stem Cells (27)3 2009
Abstract
We employed an OP9 differentiation system to characterize the hematopoietic and endothelial differentiation potential of seven human iPSC lines obtained from human fetal, neonatal, and adult fibroblasts through reprogramming with POU5F1, SOX2, NANOG, and LIN28 and compared it with the differentiatio...
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PMID: 19259936
PDF is available here.
PDF is available here.
Abstract
I review the activity of TAL-1, a basic-helix-loop-helix transcription factor, which plays a key role in the formation and functioning of both blood and endothelial systems, with a particular emphasis on recent data that associate TAL-1 with angiogenesis....
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PMID: 19527627
PDF is available here.
PDF is available here.
Abstract
We tested whether moderate expression of TRF2 in the hematopoietic system leads to cancer development in the mouse. TRF2 and a GFP-TRF2 fusion protein were introduced into hematopoietic precursors, and tested for function. TRF2 overexpressing cells were integrated into the hematopoietic system of C5...
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PMID: 20046894
PDF is available here.
PDF is available here.
Nature Genetics (41)1 2009
Abstract
We identify biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. We then demonstrate that restoration of AK2 expression in the bone marrow cells of individuals with reticula...
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PMID: 19043416
PDF is available here.
PDF is available here.
Abstract
We show that targeted deletion of the mouse Pot1b gene results in increased apoptosis in highly proliferative tissues. In the setting of telomerase haploinsufficiency, loss of Pot1b results in depletion of germ cells and complete bone marrow failure due to increased apoptosis, culminating in prematu...
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PMID: 18936156
PDF is available here.
PDF is available here.
Abstract
The purpose of this work was the study in experiments on mice of influence of mexidol on current and outcome of an acute radiation sickness. At an irradiation in a dose 6.0 Gy was studied a condition of hemopoietic system, and at an irradiation in a dose 7.7 Gy a survival rate of animals. In all exp...
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PMID: 19368329
PDF is available here.
PDF is available here.
Abstract
The overview presents an outline of the radiobiological mechanisms governing the origin of tissue reactions manifested by a number of systems influencing the course and the outcomes of chronic exposure of man. The issues under consideration include the key mechanisms of tissue reactions and adaptati...
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PMID: 19368316
PDF is available here.
PDF is available here.
Abstract
We sequenced 3616 bp in HAS1 exons and introns involved in aberrant splicing, from 17 patients. We identified a total of 197 HAS1 genetic variations (GVs), a range of 3 to 24 GVs/patient, including 87 somatic GVs acquired in splicing regions of HAS1. Nearly all newly identified inherited and somatic...
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PMID: 18815290
PDF is available here.
PDF is available here.
Abstract
We report that W(sh) animals exhibit splenomegaly with expanded myeloid and megakaryocyte populations. Hematopoietic abnormalities extend to the bone marrow and are reflected by neutrophilia and thrombocytosis. In contrast, mast cell-deficient WBB6F1-Kit(W)/Kit(W-v) (W/W(v)) mice display mild neutro...
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PMID: 18988802
PDF is available here.
PDF is available here.
Abstract
We were interested in determining which infiltrating hematopoietic cells produce IFN-gamma within the 4T1 tumor microenvironment. 4T1 tumors were infiltrated with progressively increasing numbers of F4/80(+)/CD11c(+) myeloid cells, many of which were also Gr-1(+), and Gr-1(+)/CD11b(+) granulocytes....
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PMID: 18929358
PDF is available here.
PDF is available here.
Abstract
We have previously shown that an upstream enhancer, Eng -8, together with the promoter region, mediates robust endothelial expression yet is inactive in blood. To identify hematopoietic regulatory elements, we used array-based methods to determine chromatin accessibility across the entire locus. Sub...
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PMID: 18805961
PDF is available here.
PDF is available here.
Abstract
We used in vitro and mouse transplantation assays to study hematopoiesis in trisomy 21 fetal livers with normal GATA1 alleles. Remarkably, trisomy 21 progenitors exhibited enhanced production of erythroid and megakaryocytic cells that proliferated excessively. Our findings indicate that trisomy 21 i...
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PMID: 18812473
PDF is available here.
PDF is available here.
Abstract
We positionally cloned a nonsense mutation in the Hem1 gene. Hem1 deficiency results in defective F-actin polymerization and actin capping in lymphocytes and neutrophils caused by loss of the Rac-controlled actin-regulatory WAVE protein complex. T cell development is disrupted in Hem1-deficient mice...
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PMID: 19015308
PDF is available here.
PDF is available here.
Toxicology (253)1-3 2008
Abstract
We hypothesized the protoxicants would attain greater systemic exposure and therefore deliver higher doses of acrolein to the internal organs. By extension, the higher systemic exposure to acrolein we hypothesized should lead to more internal organ toxicity in the allyl acetate and allyl alcohol tre...
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PMID: 18817840
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)46 2008
Abstract
The role of intracellular Ca2+ (Ca2+i) on hematopoiesis was investigated in long term bone marrow cultures using cytokines and agonists of P2 receptors. Cytokines interleukin 3 and granulocyte/macrophage colony stimulator factor promoted a modest increase in Ca2+i concentration ([Ca2+]i) with activa...
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PMID: 18775989
PDF is available here.
PDF is available here.
Abstract
Primary myelofibrosis (PMF) is the rarest and the most severe Philadelphia-negative chronic myeloproliferative syndrome. By associating a clonal proliferation and a mobilization of hematopoietic stem cells from bone marrow to spleen with profound alterations of the stroma, PMF is a remarkable model...
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PMID: 18669872
PDF is available here.
PDF is available here.
Hemocyte-lineage marker proteins in a crustacean, the freshwater crayfish, Pacifastacus leniusculus.
Abstract
We also provide evidence that SGC and GC most likely differentiate to maturation as separate lineages. We found that after laminarin or lipopolysaccharide (LPS) injection into crayfish, the transcript levels of PCNA and SOD increased in the Hpt cells, whereas the KPI transcript never was present in...
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PMID: 18814328
PDF is available here.
PDF is available here.
Annals of Hematology (87)10 2008
Abstract
These results indicate that the CD56 molecule is expressed on both HSCs and BM stromal cells (containing MSCs) in monkeys, and therefore it can be speculated that CD56 also contributes to the human hematopoietic system....
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PMID: 18575864
PDF is available here.
PDF is available here.
Abstract
We investigated the hematopoietic response of rats pretreated with CV and exposed to the impact of acute escapable, inescapable or psychogenical stress on responsiveness to an in vivo challenge with Listeria monocytogenes. No consistent changes were observed after exposure to escapable footshock. Co...
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PMID: 18420376
PDF is available here.
PDF is available here.
Abstract
In this article, whole mount in situ hybridization is used to examine early blood vessel and blood cell development in the embryos of the brown trout Salmo trutta lacustris. cDNAs encoding for the angiogenic markers fli1 and flk1, and for the hematopoietic markers gata1 and gata2, were identified fr...
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PMID: 18512703
PDF is available here.
PDF is available here.
Abstract
We show that PI3K activity specifically overrides delayed mechanisms effecting permanent G(1) and G(2) phase arrests, but does not affect transient checkpoints arresting cells up to 10 hours after gamma-irradiation. Assessing the status of cell cycle regulators in hematopoietic cells arrested after...
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PMID: 18769155
PDF is available here.
PDF is available here.
Transgenic tools for analysis of the haematopoietic system: knock-in CD45 reporter and deletor mice.
Abstract
We have produced and characterised reporter knock-in CD45-YFP and CD45-Cre mice that drive expression of yellow fluorescent protein (YFP) and Cre-recombinase, respectively under control of the haematopoietic CD45 locus. CD45-YFP expression was characterised in various haematopoietic cells population...
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PMID: 18602924
PDF is available here.
PDF is available here.
Abstract
We show that central tolerance of MHC class I-restricted T cells specific for classic myelin basic protein (MBP), a component of the myelin sheath, is mediated by both bone marrow (BM)-derived and nonBM-derived cells. Unexpectedly, BM-derived cells induce tolerance directly by using classic MBP that...
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PMID: 18772374
PDF is available here.
PDF is available here.
Abstract
We show that a MDS can be transplanted to WT recipients. Recipients of the MDS bone marrow displayed all of the critical features of MDS, including peripheral blood cytopenias, dysplasia, and transformation to AML. Even when transplanted with a 10-fold excess of WT cells, the NHD13 cells outcompeted...
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PMID: 18768819
PDF is available here.
PDF is available here.
Abstract
We can isolate some of them using sorting methods with specific antibodies. The molecular characterization of these stem populations will be critical to developing an effective therapy for these tumours with very dismal prognosis. To achieve this aim, the development of a mouse model which recapitul...
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PMID: 18782002
PDF is available here.
PDF is available here.
Circulation Research (103)4 2008
Abstract
We developed a transgenic model of Cre recombinase-mediated activation of a constitutively active mouse Notch1 allele (N1ICD(+)) and studied transgene activation in Tie2-expressing lineages. The in vivo phenotype was compared to effects of Notch1 activation on endothelial tubulogenesis, paracrine re...
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PMID: 18617694
PDF is available here.
PDF is available here.
Development (135)14 2008
Abstract
We deleted c-myc in selected cell lineages. Embryos lacking c-myc in endothelial and hematopoietic lineages phenocopied those lacking c-myc in the entire embryo proper. At embryonic day (E) 10.5, both mutant embryos were grossly normal, had initiated primitive hematopoiesis, and both survived until...
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PMID: 18550710
PDF is available here.
PDF is available here.
Immunological Reviews (224) 2008
Abstract
We provide an overview of current knowledge of membrane proximal events in signaling by inhibitory/regulatory receptors focusing on structural and functional characteristics of receptors and their effectors Src homology 2 (SH2) domain-containing tyrosine phosphatase 1 and SH2 domain-containing inosi...
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PMID: 18759919
PDF is available here.
PDF is available here.
Journal of Experimental Biology (211)Pt 16 2008
Induced cell proliferation in putative haematopoietic tissues of the sea star, Asterias rubens (L.).
Abstract
The coelomic fluid of the echinoderm Asterias rubens possesses large populations of circulating coelomocytes. This study aimed to expand the knowledge about the haematopoietic sources of these cells. Injection of the immune-stimulating molecules lipopolysaccharide (LPS) and concanavalin A (ConA) res...
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PMID: 18689408
PDF is available here.
PDF is available here.
Abstract
We present how a new flow technology, the ImageStream (Amnis Corporation, Seattle, WA), blends morphology and flow cytometry and can be used to analyze cell populations in ways not possible by standard histology or flow cytometry alone. The ImageStream captures brightfield, darkfield and multiple fl...
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PMID: 18539294
PDF is available here.
PDF is available here.
Cancer Research (68)14 2008
Abstract
These results suggested that mM-CSF should be a positive regulator in the development of hematopoietic malignancies by abnormally activating infiltrating macrophages, which in turn promote the malignant development. Thus, mM-CSF may be a critical linker between macrophages and malignant cells in the...
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PMID: 18632616
PDF is available here.
PDF is available here.
Abstract
We generated mice with interferon-inducible deletion of Cul4A. Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic fail...
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PMID: 18339895
PDF is available here.
PDF is available here.
Abstract
We demonstrate that IL-3 expands a subset of CD45+ circulating angiogenic cells clonally derived from the hemopoietic progenitors. Moreover, CD45+ cells exposed to IL-3 acquire arterial specification and contribute to the formation of vessels in vivo. Depletion of signal transducer and activator of...
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PMID: 18460645
PDF is available here.
PDF is available here.
Abstract
We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes....
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PMID: 18599440
PDF is available here.
PDF is available here.
Experimental Physiology (93)7 2008
Abstract
We studied the effects of temporary myocardial ischaemia and reperfusion in blood cell-restricted beta1 integrin knockout mice (beta1(-/-)). The left descending coronary artery in conditional beta1(-/-) integrin (beta1(-/-)), beta1 integrin +/+ (beta1(+/+)) and beta1 integrin -/- bone marrow chimeri...
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PMID: 18296493
PDF is available here.
PDF is available here.
Industrial Health (46)3 2008
Abstract
The aim of the study is to evaluate if occupational exposure to urban stressors could cause alterations in red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), mean cell volume (MCV), mean cell hemoglobin (MCH), mean corpuscular hemoglobin concentrations (MCHC) in traffic police compared to a...
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PMID: 18544891
PDF is available here.
PDF is available here.
Cell Research (18)6 2008
Abstract
We identified a zebrafish homolog of Gfi1 (named gfi1.1) and analyzed its function during embryonic development. Expression of both an endogenous gfi1.1 gene and a GFP reporter gene inserted near its genomic locus was detected in hematopoietic cells of zebrafish embryos. Morpholino (MO) knockdown of...
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PMID: 18504458
PDF is available here.
PDF is available here.
Abstract
This review is focused on methods that are used to derive hematopoietic cells from embryonic stem cells (ESCs). One of the strategies that have been recently used to achieve this goal is an approach of mimicking the hematopoietic niche in vitro by using hematopoiesis-supportive feeder cells, cocktai...
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PMID: 18593612
PDF is available here.
PDF is available here.
Molecular Immunology (45)11 2008
Abstract
We show that soluble MD-2 (sMD-2) circulates in plasma of healthy individuals as a polymeric protein. The total amount of sMD-2 in septic plasma was strongly elevated and contained both sMD-2 polymers and monomers, the latter representing the putative biologically active form of MD-2. Moreover, duri...
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PMID: 18384879
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated that when isolated epidermal stem cells were placed into an embryonic environment, their potential was extended beyond the keratinocyte lineage. Here, we present evidence that cells isolated using a modification of our published method for epidermal stem cells can be speci...
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PMID: 18094731
PDF is available here.
PDF is available here.
Journal of Immunology (180)11 2008
Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin.
Abstract
We measured both innate and adaptive immune responses of flagellin-treated MyD88 radiation bone marrow chimeras. We observed that radiosensitive and radioresistant cells played distinct roles in the innate response to flagellin, with the radiosensitive cells producing the majority of the TNF-alpha,...
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PMID: 18490717
PDF is available here.
PDF is available here.
Stem Cells (26)5 2008
Abstract
We have examined the regenerating microenvironment and find that following injury it has an enhanced ability to support HSCs. During this regenerative phase, both hematopoietic and stromal cell elements within the bone marrow microenvironment show increased expression of Wnt10b, which can function t...
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PMID: 18308947
PDF is available here.
PDF is available here.
Stem Cells (26)5 2008
Abstract
We examined whether CPM is expressed by hematopoietic and stromal cells and could degrade stromal cell-derived factor (SDF)-1alpha, a potent chemoattractant for hematopoietic stem/progenitor cells (HSPC). We found that (a) CPM transcript is expressed by bone marrow (BM) and mobilized peripheral bloo...
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PMID: 18292211
PDF is available here.
PDF is available here.
Developmental Cell (14)5 2008
Abstract
We assess the concordance of histone H3 lysine 4 dimethylation (H3K4me2) and trimethylation (H3K4me3) on a genome-wide scale in erythroid development by analyzing pluripotent, multipotent, and unipotent cell types. Although H3K4me2 and H3K4me3 are concordant at most genes, multipotential hematopoiet...
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PMID: 18477461
PDF is available here.
PDF is available here.
Leukemia Research (32)5 2008
Abstract
We assessed the role of Prv-1 in thrombopoietin (Tpo)/Mpl signaling with the goal of identifying molecular mechanisms which augment Tpo-induced proliferation. By engineering the cytokine-dependent hematopoietic cell line BaF3 to express both Prv-1 and wild-type or mutant forms of Mpl, we were able t...
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PMID: 17980909
PDF is available here.
PDF is available here.
Abstract
HIV-associated hematological abnormalities involve all lineages of blood cells, thus implying that the virus impairs the function of early HSCs. However, the underlying mechanisms of this defect are unknown, particularly since HSCs are largely resistant to HIV-1 infection. In this issue of the JCI,...
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PMID: 18431512
PDF is available here.
PDF is available here.
Abstract
We report that CXCL12 produced by bone marrow (BM) stromal cells is not only the major chemoattractant for HSCs but also a regulatory factor that controls the quiescence of primitive hematopoietic cells. Addition of CXCL12 into the culture inhibits entry of primitive hematopoietic cells into the cel...
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PMID: 18378795
PDF is available here.
PDF is available here.