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All › Cells › Antigen-Presenting Cells › Dendritic Cells

Dendritic Cells (1)

    Articles on Dendritic Cells

    1. Tyrosine phosphorylation of WASP promotes calpain-mediated podosome disassembly.
      Lee Macpherson, James Monypenny, ... Yolanda Calle

      Haematologica 97(5):687-91 (2012) PMID 22133775

      We now report that in myeloid cells, tyrosine phosphorylation of the Wiskott Aldrich Syndrome Protein-tyrosine291 (Human)/tyrosine293 (mouse) not only enhances Wiskott Aldrich Syndrome Protein-mediated actin polymerization but also promotes its calpain-dependent degradation during podosome disassemb...
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    2. Early exposure of interferon-γ inhibits signal transducer and activator of transcription-6 signalling and nuclear factor κB activation in a ...
      D D Rojas-Canales, R R Krishnan, ... P T PT Coates

      Clin Exp Immunol 167(3):447-58 (2012) PMID 22288588

      We examined the reported paradoxical proinflammatory effects of IFN-γ and confirmed in this system that late IFN-γ exposure does not inhibit DC maturation marker expression. Early IFN-γ exposure is critical in promoting the generation of regulatory DC. Early IFN-γ modulated DC generated in 48 h...
    3. Activation of invariant Natural Killer T lymphocytes in response to the α-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nan...
      Elodie E Macho Fernandez, Jiang J Chang, ... François F Trottein

      Int J Pharm 423(1):45-54 (2012) PMID 21575695

      We intended to characterize and compare the effect of KRN encapsulated in poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs, 90nm) and microparticles instead of macroparticles (MPs, 715nm) on the iNKT cell response. Our data show that whatever the size of the particles, vectorized KRN in...
    4. Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients.
      Ray R Wilkinson, Katherine K Woods, ... Kristen J KJ Radford

      Cancer Immunol Immunother 61(2):169-79 (2012) PMID 21874303

      We identified a naturally processed, HLA-A*0201-restricted peptide epitope within the signal sequence region of KLK4 that induced CTL responses in vitro in most healthy donors and prostate cancer patients tested. These CTL lysed HLA-A*0201+ KLK4 + cell lines and KLK4 mRNA-transfected monocyte-derive...
    5. Clinicopathological features and prognostic significance of CXCL12 in blastic plasmacytoid dendritic cell neoplasm.
      Keiko K Hashikawa, Daisuke D Niino, ... Koichi K Ohshima

      J Am Acad Dermatol 66(2):278-91 (2012) PMID 21835496

      We reviewed the clinical features and stained markers of various hematopoietic lineages, chemokines, and their receptors. Bone-marrow infiltration was detected in 13 of the 19 cases examined and leukemic changes in 18. Complete remission was achieved in 14 cases, but more than half o...
    6. Indeterminate cell tumor of the spleen.
      Mingyi M Chen, Renuka R Agrawal, ... Lawrence M LM Weiss

      Hum Pathol 43(2):307-11 (2012) PMID 21820146

      We report a case of indeterminate cell tumor arising from the spleen, a previously unreported site for indeterminate cell tumor. Histologically, the tumor showed nests, nodules, and sheets of large polygonal cells with mostly oval nuclei; open chromatin; variable nucleoli; and abundant, eosinophilic...
    7. Measurement of mucosal biomarkers in a phase 1 trial of intravaginal 3% StarPharma LTD 7013 gel (VivaGel) to assess expanded safety.
      Anna-Barbara AB Moscicki, Rupert R Kaul, ... Craig R CR Cohen

      J Acquir Immune Defic Syndr 59(2):134-40 (2012) PMID 22067666

      The aim of this study was to examine the effect of the 3% StarPharma LTD 7013 gel (VivaGel) on mucosal immune markers hypothesized to be associated with HIV-1 acquisition. Phase 1, placebo-controlled, randomized, double-blind clinical trial was performed in 54 young w...
    8. IFN-γ and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leuke...
      Ying Y Lu, Cynthia R CR Giver, ... Edmund K EK Waller

      119(4):1075-85 (2012) PMID 22130799

      We have reported previously that donor bone marrow precursors of plasmacytoid dendritic cells (pre-pDCs) can activate donor T cells toward T-helper 1 immune polarization in murine allogeneic HSCT. To optimize the GVL activity of these activated donor T cells and limit their graft versus host activit...
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    9. Transcriptional programming of the dendritic cell network.
      Gabrielle T GT Belz and Stephen L SL Nutt

      Nat Rev Immunol 12(2):101-13 (2012) PMID 22273772

      We discuss new evidence regarding the coordination of the specification and commitment of precursor cells to different DC subsets and highlight the ensemble of transcription factors that control these processes....
    10. HIV-1 induces NALP3-inflammasome expression and interleukin-1β secretion in dendritic cells from healthy individuals but not from HIV-positi...
      Alessandra A Pontillo, Lais T LT Silva, ... Alberto J S AJ Duarte

      AIDS 26(1):11-8 (2012) PMID 21971358

      We hypothesized the involvement of inflammasome in the early defense against HIV-1 and in the full maturation of dendritic cells: for this, we evaluated the response of dendritic cells pulsed with HIV-1 in terms of inflammasome activation in healthy donors. Moreover, inflammasome response to HIV was...