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Oxyphenbutazone (0):
Recent article
Oxyphenbutazone
Abstract
In the process of drug development, preclinical testing using experimental animals is an important aspect, for verification of the efficacy and safety of a drug. Serum albumin is a major binding protein for endogenous and exogenous ligands and regulates their distribution in various...
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PMID: 17979211
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PDF is available here.
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Abstract
Our data suggest that 4OH-OPB may be useful as an immunosuppressive drug for patients with inflammatory diseases....
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PMID: 15941686
PDF is available here.
PDF is available here.
Biochemistry (Washington) (43)46 2004
Abstract
Phospholipase A(2) (PLA(2); EC 3.1.1.4) is a key enzyme involved in the production of proinflammatory mediators known as eicosanoids. The binding of the substrate to PLA(2) occurs through a well-formed hydrophobic channel. To determine the viability of PLA(2) as a target molecule for...
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PMID: 15544328
PDF is available here.
PDF is available here.
Abstract
The antirheumatic effect of pirfenidone was compared with a positive control drug, oxyphenbutazone which is used in patients suffering from rheumatoid arthritis, in a double blind clinical trial in humans. The data collected in this pilot project revealed that pirfenidone was more effective (p < 0.0...
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PMID: 17564304
PDF is available here.
PDF is available here.
Abstract
Adulterations with synthetic drugs are common problems with herbal medicine and this can potentially cause serious adverse effects. It is therefore important to determine the presence of synthetic drugs in herbal medicine to ensure patients' safety. The objective of this study was to develop sensiti...
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PMID: 12609680
PDF is available here.
PDF is available here.
Abstract
The interactions between a nonsteroidal anti-inflammatory drugs, oxyphenbutazone (OPB), with two cyclodextrins, beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), have been studied in an aqueous medium and in the solid state. Differential scanning calorimetry, hot stage microscopy, therm...
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PMID: 12039640
PDF is available here.
PDF is available here.
Abstract
Serum concentrations decreased rapidly after IV administration of phenylbutazone, and they reached undetectable concentrations within 4 hours. Values for mean residence time ranged from 0.5 to 3.0 hours (median, 1.1 hour), whereas total body clearance ranged from 4.2 to 7.5 ml/kg/min (mean, 5.8 ml/k...
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PMID: 11341383
PDF is available here.
PDF is available here.
Abstract
Ethyl acetate extracts of equine serum, containing 0-5 microg/ml of hydrocortisone (HYD), dexamethasone (DEX), oxyphenbutazone (OPB), indomethacin (IND), phenylbutazone (PB) and probenecid as internal standard, were evaporated with nitrogen, resuspended in methanol and analyzed by HPLC, using a C-18...
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PMID: 10778922
PDF is available here.
PDF is available here.
Abstract
Suxibuzone (SBZ), a nonsteroidal anti-inflammatory drug, was administered to 6 horses at a dose rate of 7.5 mg/kg bwt by intravenous (i.v.) route. Plasma and synovial fluid concentrations of suxibuzone and its main active metabolites, phenylbutazone (PBZ) and oxyphenbutazone (OPBZ), were measured si...
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PMID: 10505957
PDF is available here.
PDF is available here.
Abstract
Dissolution-dialysis studies of commercial tablets of oxyphenbutazone were carried out to establish the applicability of this technique for the in vitro evaluation of oxyphenbutazone dosage form. While disintegration time and dissolution rate studies did not give a true indication of bioavailability...
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PMID: 10518246
PDF is available here.
PDF is available here.
Mutation Research (420)1-3 1998
Abstract
Phenylbutazone (PB), oxyphenbutazone (OPB), antipyrine (AP) and dipyrone (DP) are four important pyrazolone derivatives mainly used as anti-inflammatory, antipyretic and analgesic drugs. At present these are the most widely used pyrazolone derivatives throughout the world. The widespread use of thes...
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PMID: 9838026
PDF is available here.
PDF is available here.
Abstract
Flunixin meglumine (FM, 1.1 mg/kg) and phenylbutazone (PBZ, 4.4 mg/kg) were administered intravenously (i.v.) as a single dose to eight sheep prepared with subcutaneous (s.c.) tissue-cages in which an acute inflammatory reaction was stimulated with carrageenan. Pharmacokinetics of FM, PBZ and its ac...
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PMID: 9731955
PDF is available here.
PDF is available here.
Abstract
We have combined distance information obtained from the Conformational Analyzer with Molecular Dynamics And Sampling (CAMDAS) calculation and experimental NOE spectroscopy measurements to determine a "binding conformation" for each drug which binds to site I of HSA. For OXY, only one conformer (conf...
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PMID: 9523993
PDF is available here.
PDF is available here.
Abstract
A direct injection HPLC method has been developed for the determination of phenylbutazone and its active metabolite oxyphenylbutazone in serum using a semipermeable surface (SPS) column. The method is easy to perform and requires 20 microliters of a filtered serum sample. The chromatographic time is...
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PMID: 9408846
PDF is available here.
PDF is available here.
Abstract
Cimetidine was administered intravenously and by the intragastric route to six mares at a dose of 4.0 mg/kg of body weight (bw). Specific and sensitive high performance liquid chromatographic methods for the determination of cimetidine in horse plasma and urine and cimetidine sulfoxide in urine are...
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PMID: 9350255
PDF is available here.
PDF is available here.
Abstract
The elimination half-life and total body clearance of phenylbutazone in camels are intermediate between reported values in horses and cattle. Extrapolation of a dosage regimen from either species to camels is, therefore, not appropriate. Elimination of phenylbutazone in camels is mainly via metaboli...
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PMID: 9185972
PDF is available here.
PDF is available here.
Abstract
These results may have implications for our understanding of the mechanisms responsible for the therapeutic effects of interferon-alpha/beta preparations in multiple sclerosis....
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PMID: 9166751
PDF is available here.
PDF is available here.
Abstract
Phenylbutazone was administered intravenously and intramuscularly at a dosage rate of 4.4 mg/kg to a group of 6 female camels in a two-period crossover study. After intravenous (i.v.) administration, disposition was characterised by a two-compartment open model, with a low volume of distribution (0....
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PMID: 9049950
PDF is available here.
PDF is available here.
Veterinary Record (140)2 1997
Abstract
Phenylbutazone was administered intravenously and orally to six goats as a single dose of 4.4 mg/kg and its disposition and bioavailability and the disposition of its active metabolite, oxyphenbutazone, in plasma were investigated. The effect of the administration of the drug of oxyphenbutazone on e...
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PMID: 9123796
PDF is available here.
PDF is available here.
Abstract
Significant differences were found in several pharmacokinetic variables of phenylbutazone and oxyphenbutazone in horses, compared with donkeys. Mean total body clearance of phenylbutazone in horses was fivefold less than that in donkeys (29.3 and 170.3 ml/kg/h, respectively). Mean values for area un...
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PMID: 8989496
PDF is available here.
PDF is available here.
Abstract
I domain was inhibited. Covalent binding was also detected in vivo to human plasma proteins. The half-life of the gemfibrozil-protein adducts was 2.5-3 days. Albumin plays an important role in the disposition of acyl glucuronides by acting as: i) a transporter protein; ii) a potential catalyst for t...
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PMID: 9010630
PDF is available here.
PDF is available here.
Abstract
These results have possible implications regarding the administration of PBZ to the horse close to race-day....
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PMID: 8971677
PDF is available here.
PDF is available here.
Abstract
Recoveries of PBZ, OXY, and probenecid from spiked samples were acceptable (ie, > or = 80%) and within run retention times were reproducible. Chromatograms were free of interfering substances, and linearity of calibration curves was observed throughout operational ranges. Coefficients of variation a...
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PMID: 8915422
PDF is available here.
PDF is available here.
Planta Medica (62)3 1996
Abstract
The topical anti-inflammatory activity of three non-phenolic linear 1,7-diarylheptanoids, previously isolated from a Thai medicinal plant, Curcuma xanthorrhiza (Zingiberaceae) and four new semi-synthetic derivatives of the naturally occurring compounds were assessed in the murine model of ethyl phen...
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PMID: 8693036
PDF is available here.
PDF is available here.
Abstract
Lebanese Medical Journal (44)1 1996
Abstract
A 50-year-old woman sought a rheumatological consultation for anterior chest pain of three weeks duration. The diagnosis of superficial phlebitis of the anterior chest wall (Mondor's disease) was made. This was confirmed thereafter by the pathological report. She was treated with a non-steroidal ant...
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PMID: 8885560
PDF is available here.
PDF is available here.
Abstract
Five days after the induction of acute systemic inflammation in greyhounds by intramuscular and subcutaneous injections of Freund's adjuvant, the hepatic concentrations of cytochromes P-450 and b5, the activities of the hepatic microsomal enzymes aniline p-hydroxylase and aminopyrine n-demethylase a...
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PMID: 8588103
PDF is available here.
PDF is available here.
Abstract
We conclude that it would be impossible to predict the timing of the PBZ administration or the plasma concentration of PBZ from the measurement of the concentration of PBZ in a single sample of urine....
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PMID: 8579562
PDF is available here.
PDF is available here.
Abstract
The separation of phenylbutazone (PB) and its major metabolite oxyphenbutazone (OPB) using supercritical fluid chromatography (SFC) has been investigated. The separations were studied on octadecylsilane, silica and cyano packed columns with 5% methanol in carbon dioxide as mobile phase and detection...
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PMID: 7718635
PDF is available here.
PDF is available here.
Abstract
Single doses (2.2 mg/kg of body weight) of phenylbutazone (PBZ) were administered IV to 6 neonatal horses (5 to 17 hours old at time of dosing). Plasma concentrations of PBZ and its metabolite oxyphenbutazone were monitored serially for 120 hours after drug administration. Pharmacokinetic variables...
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PMID: 8116939
PDF is available here.
PDF is available here.
Abstract
The plasma concentrations of phenylbutazone (PBZ) and its major metabolites, oxyphenbutazone (OPBZ) and gamma-OH-phenylbutazone (OHPBZ) were determined for up to 72 h in six horses, following intravenous (i.v.) and intramuscular (i.m.) administration of 4 g phenylbutazone, 20 ml Phenylarthrite Vento...
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PMID: 8126767
PDF is available here.
PDF is available here.
Abstract
A high performance liquid chromatographic method is described to determine the anti-inflammatory drug suxibuzone (SXB) and its major metabolites phenylbutazone (PBZ) and oxyphenbutazone (OPBZ) in equine plasma and urine. When suxibuzone (6 mg/kg) was administered intravenously (i.v.) or orally (p.o....
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PMID: 8230399
PDF is available here.
PDF is available here.
Abstract
Drug-induced parotitis is a relatively uncommon adverse drug reaction. Most of the data on drug-induced parotitis consist of isolated case reports with few attempts at rechallenge to confirm the aetiology. Phenylbutazone and oxyphenbutazone have a significant number of reports suggesting that these...
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PMID: 7901230
PDF is available here.
PDF is available here.
Journal of Chromatography A (581)1 1992
Abstract
A solid-phase extraction method was validated for the simultaneous high-performance liquid chromatographic determination of indomethacin, suxibuzone, phenylbutazone, oxyphenbutazone and their degradation products. Indomethacin was added as internal standard to plasma samples, which were then acidifi...
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PMID: 1429991
PDF is available here.
PDF is available here.
Abstract
We measured the binding of a drug oxyphenylbutazone to the N-terminal peptic fragment of human serum albumin in 0.1 M Tris buffer, pH 8.0 (Kass = 2.4 10(5) M-1) and in reverse micelles of sodium bis(2-ethylhexyl) sulfosuccinate and buffer in isooctane (Kass. = 2.7 10(5) M-1). In the absence of any m...
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PMID: 1558538
PDF is available here.
PDF is available here.
Abstract
Abstract
The behaviour of human serum albumin in the presence of three chemically distinct ligands: oxyphenylbutazone, dansylsarcosine and hemin, has been compared in buffer and in reverse micelles of isooctane, water, and either sodium bis(2-ethylhexyl)sulfosuccinate or hexadecyl trimethylammonium bromide,...
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PMID: 1712302
PDF is available here.
PDF is available here.
Abstract
The solid-state 13C NMR spectra of mofebutazone, phenylbutazone, and oxyphenbutazone monohydrate and anhydrate are presented. The crystal structures of these pyrazolidinedione derivatives, obtained by single-crystal X-ray analysis, were previously reported, revealing distinct differences in crystal...
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PMID: 1865336
PDF is available here.
PDF is available here.
Clinical Journal of Pain (7 Suppl 1) 1991
Abstract
Our study primarily focused on assessing the effectiveness and tolerability of this drug in 82 patients affected with extraarticular rheumatism localized in various sites. Meclofenamic acid (as a sodium salt) was orally administered in doses of 100 mg twice daily for 2 weeks. The assessment of the d...
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PMID: 1810526
PDF is available here.
PDF is available here.
Contact Dermatitis (24)1 1991
Abstract
Abstract
We found that aspirin, indomethacin and phenylbutazone caused gastric mucosal damage in 90.9%, 100%, respectively while ibuprofen and paracetamol caused gastric mucosal damage in 33.3% and 37.5% respectively. Thus latter two drugs were safer NSAID's. Further more we have demonstrated that endoscopic...
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PMID: 2096127
PDF is available here.
PDF is available here.
Abstract
We have compared the effect of the converting enzyme inhibitors, captopril and enalapril, on two models of gastric ulcers, viz; ethanol and oxyphenbutazone-induced lesions in rats. Both captopril and enalapril did not affect ethanol-induced lesions. While captopril significantly protected against ox...
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PMID: 2286425
PDF is available here.
PDF is available here.
Journal of Chromatography A (528)2 1990
Abstract
A rapid and sensitive method of extraction of human plasma containing acetaminophen, chlorzoxazone, oxyphenbutazone and diazepam along with their active metabolites was developed. The plasma samples were extracted by a solid-phase extraction procedure with theophylline as an internal standard for ac...
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PMID: 2384578
PDF is available here.
PDF is available here.
Agents and Actions (29)3-4 1990
Abstract
The elimination kinetics of inorganic blood sulfate in mice was followed for four hours after a single, oral administration of an antirheumatic drug. Sodium salicylate, aspirin, diflunisal and benorylate, all in a dose of 1.25 mmol/kg, reduced the sulfate level to the less than half that of control....
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PMID: 1971139
PDF is available here.
PDF is available here.
European Journal of Pharmacology (177)1-2 1990
Abstract
We studied the effect of the angiotensin converting enzyme inhibitor, captopril, on two models of gastric ulcers; oxyphenbutazone and ethanol-induced lesions. There was a significant protective effect against oxyphenbutazone-induced ulcers, which was prevented by prior administration of indomethacin...
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PMID: 2187703
PDF is available here.
PDF is available here.
Abstract
We studied prospectively the effects of 2% hydroxypropylmethylcellulose (HPMC), instilled in to the anterior chamber during extracapsular cataract extraction with posterior chamber intraocular lens implantation in 122 patients. Significant pressure rise was noted at 12 and 24 hours post-operatively...
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PMID: 2323463
PDF is available here.
PDF is available here.
Abstract
Two crystal forms of oxyphenbutazone (a monohydrate and an anhydrate) were prepared by recrystallization. The forms were characterized by means of differential scanning calorimetry, thermogravimetry, infrared spectrophotometry, X-ray powder diffraction patterns, thermomicroscopy, scanning electron m...
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PMID: 2585271
PDF is available here.
PDF is available here.
Abstract
Acidic and basic nonsteroidal anti-inflammatory drugs were encapsulated with cellulose derivatives having different functional groups, acidic (carboxymethyl cellulose), basic (chitosan), and neutral (hydroxypropylmethyl cellulose). The properties of the microcapsules were studied and the interaction...
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PMID: 2569510
PDF is available here.
PDF is available here.
Abstract
The bioavailability and gastric ulcerogenic activity of oxyphenbutazone and glafenine (acidic and basic nonsteroidal anti-inflammatory drugs), coated with different cellulose derivatives were assessed in albino rats. The cellulose derivatives chosen have different functional groups, acidic (carboxym...
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PMID: 2569511
PDF is available here.
PDF is available here.
Abstract
Teucrium polium is widely used by the folk-medicine practitioners in Saudi Arabia for the treatment of inflammations, rheumatism, diabetes and ulcers. Scientific reports are lacking to confirm these activities. The present study reports the effect of ethanolic extract of T. polium on carrageenan-ind...
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PMID: 2634627
PDF is available here.
PDF is available here.
Abstract
Two pseudopolymorphic forms of oxyphenbutazone, a benzene solvate (Solvate B) and a cyclohexane solvate (Solvate C), were prepared by recrystallization from benzene and cyclohexane, respectively. The forms were characterized by means of differential scanning calorimetry, thermogravimetry, infrared s...
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PMID: 3244109
PDF is available here.
PDF is available here.
Abstract
Biochemical Journal (250)2 1988
Abstract
The binding of oleic acid to human serum albumin causes progressive changes in (a) the pK of some amino acid residues, as detected by pH-stat titration and (b) the induced molar ellipticities of albumin-bound drugs (diazepam and oxyphenbutazone), as measured by c.d. It is concluded that albumin unde...
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PMID: 2833243
PDF is available here.
PDF is available here.
Abstract
The influence of thrombosis prophylaxis on the occurrence of heterotopic ossification after implantation of total hip endoprostheses was analyzed in a series of randomized studies. When low-dose heparin or dextran 40 was administered, the rate of ossification was comparatively high (30.1% and 65.1%)...
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PMID: 2452239
PDF is available here.
PDF is available here.
Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (85)6 1988
Abstract
Abstract
Abstract
Abstract
The absorption, metabolism and urinary excretion of phenylbutazone were investigated in six adult cattle in a cross-over study involving administration intravenously, intramuscularly and orally at a dose rate of 4.4 mg kg-1. Following intravenous injection plasma disposition was described by a three...
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PMID: 3375589
PDF is available here.
PDF is available here.
Abstract
A simple, specific, and rapid 1H nuclear magnetic resonance spectroscopic method for the assay of phenylbutazone and oxyphenbutazone is described. Spectra are recorded in CDCI3 containing 1,3-dichloro-5-nitrobenzene as an internal standard. The aromatic proton resonances for the standard, at delta 7...
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PMID: 3391955
PDF is available here.
PDF is available here.