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Prenazone (0):
Recent article
Prenazone
Abstract
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Xenobiotica (27)5 1997
Abstract
1. The construction of three-dimensional models of CYP2B isozymes from rat (CYP2B1), rabbit (CYP2B4) and man (CYP2B6), based on a multiple sequence alignment with CYP102, a unique eukaryotic-like bacterial P450 (in terms of possessing an NADPH-dependent FAD- and FMN-containing oxidoreductase redox p...
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PMID: 9179987
PDF is available here.
PDF is available here.
Abstract
Abstract
Significantly higher (p < 0.0001) frequencies of the B22 and Cw1 antigens were found in the 36 patients with FDE. CONCLUSION: Our data are the first to suggest a genetic predisposition to FDE....
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PMID: 8277031
PDF is available here.
PDF is available here.
Xenobiotica (23)11 1993
Abstract
These results show no impairment of the elimination of feprazone in RA or RI patients; Vd and Cl are greater than in healthy young volunteers or elderly subjects, the AUC values are lower, but t1/2 values are similar in all groups. 4. It is suggested that the greater Cl and Vd, and lower AUC, in RA...
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PMID: 8310707
PDF is available here.
PDF is available here.
Contact Dermatitis (28)2 1993
Abstract
Dermatology (186)3 1993
Abstract
We analyzed the cutaneous reactions to systemic analgesic-antipyretics and non-steroidal anti-inflammatory drugs reported to the spontaneous reporting system of the Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED). The system has been active since 1988, with periodic intensive surveillan...
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PMID: 8453140
PDF is available here.
PDF is available here.
Abstract
Fixed drug eruptions following the use of pyrazolone derivatives occurred in 4 members of the same family: a 12-year-old girl, her grandmother, and two of her great aunts. Although the pathophysiologic events leading to this type of reaction are unknown, these cases of familial occurrence suggest th...
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PMID: 1357892
PDF is available here.
PDF is available here.
Abstract
A 31-year-old woman with three pemphigus-prone antigens in her HLA haplotype (B7, DR4, DQw7) developed the disease soon after taking a pyrazolone derivative, viz. feprazone. The pemphigus lesions persisted despite withdrawal of the drug and worsened appreciably when she used ceftriaxone (a new cepha...
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PMID: 1350145
PDF is available here.
PDF is available here.
Xenobiotica (21)9 1991
Abstract
We were unable to detect any changes in feprazone pharmacokinetics which are related to age, or to the concurrent use of chronic medications, such as digoxin, diuretics, or hormones....
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PMID: 1788989
PDF is available here.
PDF is available here.
Abstract
The ability of feprazone to induce the hepatic microsomal mixed-function oxidases was investigated in the rat, with emphasis being placed on the nature of the cytochrome P-450 family induced. Treatment with feprazone enhanced the p-hydroxylation of aniline and the dealkylations of benzphetamine and...
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PMID: 2402005
PDF is available here.
PDF is available here.
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale (10 Suppl 28) 1990
Abstract
Tiaprofenic acid is a new generation anti-inflammatory drug synthesized to be a valid alternative to both cortisone preparations and other NSADs since it is less toxic yet equally effective. Its anti-inflammatory, analgesic, antipyretic activity is due to a particular interference mechanism active i...
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PMID: 2248025
PDF is available here.
PDF is available here.
La Clinica terapeutica (128)2 1989
Abstract
In a controlled clinical study of 40 patients, aged 18 to 65, suffering from acute inflammatory pathology of the upper respiratory tract or from a chronic form flaring into acute crisis, without any general symptoms of infection, were assigned at random to treatment with nimesulide in tablet form (1...
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PMID: 2523772
PDF is available here.
PDF is available here.
Xenobiotica (18)7 1988
Abstract
1. 14C-Feprazone administered as a single oral dose (17 mg/subject) to each of 3 human volunteers on the 6th day of repeated dosage with unlabelled feprazone (200 mg/subject, twice daily) was excreted slowly, with only 19-38% of the dose excreted in the urine in 8 days, with a further 27-49% of the...
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PMID: 3176523
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
The inducing effect of feprazone, a pyrazolone anti-inflammatory agent, on hepatic drug-metabolizing enzymes has been studied in healthy volunteers. The ratio of 6 beta-hydroxycortisol (6 beta-OHF) to 17-hydroxycorticosteroids (17-OHCS) in urine, used as an indicator of oxidative drug-metabolizing e...
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PMID: 3780819
PDF is available here.
PDF is available here.
Minerva Pediatrica (37)20 1985
[Niflumic acid in otorhynolaryngologic inflammation in childhood. Controlled study versus feprazone]
Abstract
Abstract
Scottish Medical Journal (30)3 1985
Abstract
Approximately 30 non-steroidal anti-inflammatory agents are available for the treatment of rheumatoid arthritis. In this study patient acceptability of five such agents (benoxaprofen, fenbufen, feprazone, flurbiprofen, ketoprofen) is compared in groups of 50 patients with rheumatoid arthritis. Less...
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PMID: 4059903
PDF is available here.
PDF is available here.
La Clinica terapeutica (113)4 1985
Abstract
Arzneimittel-Forschung (35)1 1985
Abstract
The influence of aluminium hydroxide (given as a suspension, Aludrox) on the oral bioavailability of feprazone was tested. The degree and speed of absorption of feprazone from capsules (400 mg feprazone as a single dose; 8 volunteers) was investigated by determining plasma levels of feprazone and on...
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PMID: 4039147
PDF is available here.
PDF is available here.
Abstract
La Clinica terapeutica (107)3 1983
Abstract
Pharmatherapeutica (3)6 1983
Abstract
In a double-blind crossover trial, 200 mg feprazone 3-times a day was compared with 200 mg twice a day in the treatment of osteoarthritis. There was no difference in clinical efficacy or in adverse effects between the two dosage schedules. Because of its long elimination half-life (approximately 24...
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PMID: 6353430
PDF is available here.
PDF is available here.
Journal of Chromatography A (232)1 1982
Abstract
Two procedures suitable for pharmacokinetic routine analysis are described for the simultaneous determination of feprazone and one of its metabolites (DA 3505) in plasma samples. After extraction from acidified plasma feprazone and DA 3505 are determined by measuring UV absorbance after thin-layer c...
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PMID: 7142323
PDF is available here.
PDF is available here.
Abstract
Abstract
We have studied the potential hemolytic activity of feprazone, a nonsteroidal antiinflammatory compound in vitro and in vivo. Agents that may be hemolytic for glucose-6-phosphate dehydrogenase-deficient erythrocytes will stimulate the hexose monophosphate shunt in normal erythrocytes. Eleven normal...
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PMID: 7130431
PDF is available here.
PDF is available here.
British Medical Journal (1981 - 1988) (284)6308 1982
Abstract
Arzneimittel-Forschung (32)4 1982
Abstract
By means of the exploration of patients suffering from an active, unequivocal rheumatoid arthritis it was possible to show the unequivocal, and antiinflammatory effect of 4-phenyl-1,2-diphenyl-3,5-pyrazolidinedione (feprazone, Zepelin). Moreover, it was documented that thermography is a very suitabl...
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PMID: 7201815
PDF is available here.
PDF is available here.
Wiener Medizinische Wochenschrift (131)23-24 1981
Abstract
The so-called non-steroid antirheumatics have considerable significance in medical armamentarium for controlling polyetiological complexes of diseases. The numerous new developments are designed to reduce the side effects, some of which seem inevitable with increased efficacy. In this two-part study...
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PMID: 7039147
PDF is available here.
PDF is available here.
Abstract
Two cases of feprazone-induced hepatic injury are reported. Both patients developed jaundice within one month of commencing therapy. Histological investigation showed a granulomatous reaction in one case and hepatitic changes in the other. The changes were similar to those seen as a complication of...
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PMID: 6452677
PDF is available here.
PDF is available here.
Human toxicology (1)1 1981
Abstract
Safety and efficacy of feprazone for long-term treatment of rheumatoid arthritis and osteoarthritis.
Abstract
Long-term safety and efficacy of feprazone (4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione), an antirheumatic drug that is well tolerated in the gastrointestinal tract, were assessed in a noncontrolled multicenter trial. Administered at a daily dosage of 600 mg for a mean duration of 114.1 days, fepraz...
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PMID: 7471130
PDF is available here.
PDF is available here.
Abstract
In two monitored-release studies of feprazone (Methrazone), one in hospital and the other in general practice and involving a total of about 4,000 patients, there were 343 patients with a variety of sero-negative rheumatological conditions or soft tissue lesions. The diagnoses included spondylosis,...
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PMID: 6973494
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (31)3 1981
Abstract
Abstract
A double-blind trial was carried out in 24 patients with acute gout to compare the efficacy and tolerance of feprazone, a non-steroidal anti-inflammatory drug, with that of phenylbutazone. Patients received 800 mg of either drug daily for 2 days and then 600 mg daily for up to 8 days. The results of...
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PMID: 6988172
PDF is available here.
PDF is available here.
Abstract
Methrazone, a non-steroidal anti-inflammatory drug, was used on a monitored release study in general practice to treat 2,693 patients with rheumatoid or osteoarthritis. In a dose of 200 mg three times daily, it appeared to produce clear benefit in between 50% and 60% of patients. Adverse reactions s...
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PMID: 6447635
PDF is available here.
PDF is available here.
Abstract
Abstract
A high-pressure liquid chromatographic method was developed for the quantitative determination of feprazone, a nonsteroidal anti-inflammatory agent, in different pharmaceutical formulations. The results agree with those obtained with GLC and UV spectrophotometric assays.
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PMID: 458589
PDF is available here.
PDF is available here.
Ryumachi. [Rheumatism] (19)2 1979
Abstract
Abstract
Two male volunteers received 400 mg of nonlabeled feprazone, 1,2-diphenyl-3,5-dioxo-4-(3'-methyl-but-2'-enyl)pyrazolidine. Metabolites were extracted and isolated by chromatography on silica gel. Isolated metabolites were unchanged drug, E-1,2-diphenyl-3,5-dioxo-4-(3'-hydroxymethyl-but-2'-enyl)pyraz...
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PMID: 40778
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (29)5 1979
Abstract
4-Prenyl-1,2-diphenyl-3,5-pyrazolidinedione (prenazone) in the medium of sulphuric acid concentrated (92-98%) undergoes an intramolecular rearrangement to 6',6'-dimethyl-4',5'-dihydropyrane-[2',3'-d]-1,2-diphenyl-3-pyrazolinone. The main decomposition product of prenazone, formed due to the hydrolyt...
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PMID: 582968
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (29)4 1979
Abstract
From an aqueous solution of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione sodium salt (Prenazone) subjected to accelerated ageing at 80 degrees C in anaerobic and in aerobic conditions the following decomposition products were isolated: N,N'-diphenylhydrazide-5-methyl-4-hexenoic acid,N,N'-diphenylhydr...
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PMID: 582752
PDF is available here.
PDF is available here.
Minerva Pediatrica (30)15 1978
Abstract
Abstract
Abstract
Panminerva Medica (20)2 1978
Abstract
Archiv der Pharmazie (Weinheim) (310)10 1977
Abstract
Abstract
Feprazone, a non-steroidal anti-inflammatory drug, was compared with indomethacin in a double-blind cross-over trial in 24 patients with ankylosing spondylitis, over eight weeks. Both regimes caused significant reduction in pain. There were fewer side-effects and more patient preferences with fepraz...
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PMID: 333540
PDF is available here.
PDF is available here.
Die Medizinische Welt (28)21 1977
Abstract
Minerva Pediatrica (29)5 1977
Abstract
Abstract
A double-blind crossover study was carried out in 21 patients with osteoarthrosis of the hip to compare the efficacy and tolerance of feprazone (600 mg/day) and ibuprofen (1200 mg/day), each drug being given for 4 weeks. No statistically significant changes were noted in any of the objective paramet...
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PMID: 338255
PDF is available here.
PDF is available here.
La Clinica terapeutica (77)4 1976
Abstract
Abstract
Feprazone, 200 mg t.d.s., was compared with indomethacin, 25 mg t.d.s. rising to 50 mg t.d.s., in an eight-week double-blind cross-over study in twenty-three patients with active rheumatoid arthritis. Both therapies proved equally efficacious and acceptable. Measurement of the plasma levels of the t...
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PMID: 132695
PDF is available here.
PDF is available here.
Abstract
Feprazone, a new anti-inflammatory drug, is a useful antirheumatic preparation which causes little gastrointestinal upset. This short cross-over study shows no significant gastrointestinal blood loss with either feprazone or phenylbutazone by the red-cell chromium-51 labelling method.
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PMID: 132693
PDF is available here.
PDF is available here.
Minerva ginecologica (28)5 1976
Abstract
Abstract
Minerva medica (67)14 1976
Abstract
Topical anti-inflammatory management of superficial and deep phlebopathy with feprazone and benzidamine was compared in a double-blind test. Both drugs were active and well tolerated. Significantly less time was needed to obtain a cure with feprazone.
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PMID: 772478
PDF is available here.
PDF is available here.