Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Phenylbutazone (3):
Recent article
Phenylbutazone
Abstract
To evaluate the adverse effects of flunixin, ketoprofen and phenylbutazone when administered I/V to clinically normal miniature donkeys.
Twenty clinically normal adult (2.0-2.5 years old) male miniature donkeys weighing 113-136 kg and 0.81- 0.86 m tall were randomly assigned to one of four groups, a...
|
PMID: 20927172
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We identified eighteen TB race horses that were given PBZ on race day and sent for intended slaughter by matching their registered name to their race track drug record over a five year period. Sixteen rescued TB race horses were given PBZ on race day. Thus, PBZ residues may be present in some horsem...
|
PMID: 20176071
PDF is available here.
PDF is available here.
Abstract
Abstract
Significant changes in gastrointestinal sounds, fecal output, and plasma cortisol concentrations were evident in each treatment group over time, compared with preoperative values. At any time point, assessed variables and signs of pain did not differ significantly among groups, although the duration...
|
PMID: 19912042
PDF is available here.
PDF is available here.
Abstract
SBZ and PBZ did not show significant differences in alleviating lameness in horses. However, SBZ had better product acceptability when administered orally with some food. POTENTIAL RELEVANCE: SBZ is a good therapeutic alternative to PBZ in horses since there is no significant difference in alleviati...
|
PMID: 19927590
PDF is available here.
PDF is available here.
Abstract
We report a case of necrotising fasciitis caused by an adulterate traditional Asian medication--Jamu Pegal Linu, containing toxic levels of phenylbutazone and dipyrone. The patient presented with severe neutropenia and sepsis. An urgent extensive debridement was carried out (within 6 hours of presen...
|
PMID: 19721158
PDF is available here.
PDF is available here.
Prescrire international (18)100 2009
Abstract
Abstract
The interactions between phenylbutazone, a well-established nonsteroidal anti-inflammatory drug, with different generations of poly(amidoamine) (PAMAM) dendrimers, have been investigated by aqueous solubility, two dimensional nuclear Overhauser effect spectroscopy (2D-NOESY) and isothermal titration...
|
PMID: 18680167
PDF is available here.
PDF is available here.
Abstract
No adverse treatment-related events were detected. Horses that were treated with DLC or phenylbutazone had significant clinical improvement of lameness, unlike the control horses. Treatment with DLC induced significant improvement in staining and total articular glycosaminoglycan content, compared w...
|
PMID: 19231953
PDF is available here.
PDF is available here.
Abstract
We have the advantage of several approved NSAIDs for which there are excellent published studies and US Food and Drug Administration or foreign approval to guide clinical use and safe dosages....
|
PMID: 18954683
PDF is available here.
PDF is available here.
Abstract
Advances in analytical technology now make it feasible to detect and confirm exceptionally low concentrations (pg to fg/mL) of drugs and their metabolites in equine biological fluids. These new capabilities complicate the regulatory interpretation of drug positives and bring into question the fair a...
|
PMID: 19000266
PDF is available here.
PDF is available here.
Abstract
We reported that PB C-glucuronide formation is catalyzed by UGT1A9. Interestingly, despite UGT1A8 sharing high amino acid sequence identity with UGT1A9, UGT1A8 had no PB C-glucuronidating activity. In the present study, we constructed eight UGT1A9/UGT1A8 chimeras and evaluated which region is import...
|
PMID: 18602884
PDF is available here.
PDF is available here.
Abstract
A series of potential biologically active 2-aryloxy methyl oxazolines 3a-n have been synthesized from substituted hydroxybenzenes 1a-n with good chemical yield. The compounds 3a-n were screened for their anti-inflammatory, ulcerogenic, cyclooxygenase activities and also for their acute toxicity. The...
|
PMID: 18662873
PDF is available here.
PDF is available here.
Abstract
A number of indanyl tetrazolederivatives namely 5-(6'-chloroindan-1'-yl)tetrazole (CIT), 5-(6'-bromoindan-1'-yl)tetrazole (BIT), 5-(6'-chloroindan-1'-yl)methyltetrazole (CIMT), 5-(6'-bromoindan-1'-yl)methyl-tetrazole (BIMT) were evaluated for the anti-inflammatory activity in carragennan induced rat...
|
PMID: 18614428
PDF is available here.
PDF is available here.
Abstract
A 15 year old Oldenburger gelding was treated during 3 weeks for laminitis with the anticoagulant phenprocoumone (27 mg orally, once daily) and concurrent administration of phenylbutazone (2-4 g orally, twice daily). After this treatment the animal was presented to the Equine Clinic University of Zu...
|
PMID: 18714939
PDF is available here.
PDF is available here.
Abstract
The pharmacokinetic parameters of phenylbutazone were determined in 18 elephants (Loxodonta africana and Elephas maximus) after single-dose oral administration of 2, 3, and 4 mg/kg phenylbutazone, as well as multiple-dose administrations with a 4-wk washout period between trials. After administratio...
|
PMID: 18634209
PDF is available here.
PDF is available here.
Abstract
We report the case of a 20-year-old woman with adult-onset Still's disease (AOSD), retinal microangiopathy and concurrent macrophage activation syndrome (MAS), in the context of sHLH. Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated...
|
PMID: 18183612
PDF is available here.
PDF is available here.
Abstract
We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications.
|
PMID: 18353110
PDF is available here.
PDF is available here.
Abstract
We report a case of Sweet's syndrome with sialadenitis induced by phenylbutazone. CASE-REPORT: A 54-year-old woman presented lumbar pains treated with phenylbutazone for three days. Six days later, she exhibited inflammation of the submaxillary and parotid salivary glands, followed by an erythematou...
|
PMID: 18420076
PDF is available here.
PDF is available here.
Abstract
Abstract
Drug binding to albumins from different mammalian species was investigated to disclose evidence of species-dependent stereoselectivity in drug-binding processes and affinities. This aspect is important for evaluating the reliability of extrapolating distribution data among species. The circular dich...
|
PMID: 18172833
PDF is available here.
PDF is available here.
Abstract
Abstract
Alleviation of lameness was greater after administration of the combination of NSAIDs than after oral administration of phenylbutazone alone. Improvement in horses after a combination of NSAIDs did not completely mask lameness. Five horses did not improve after either NSAID treatment regimen. All po...
|
PMID: 18241011
PDF is available here.
PDF is available here.
Abstract
The objective was to test the hypothesis that phenylbutazone (PBZ) alleviates lameness in an adjustable heart bar shoe model of equine foot pain. Eight Quarter Horse mares underwent 4-weekly treatments randomly: 0.9% saline placebo (SAL: 1 mL/45 kg body weight i.v.) with no lameness; SAL with lamene...
|
PMID: 18177317
PDF is available here.
PDF is available here.
Abstract
The efficacy of top-dress antiinflammatory drugs ultimately depends on a patient's willingness to consume treated feed. The current study compares the palatability of two phenylbutazone top-dress formulations (Equipalazone Powder, Dechra Pharmaceuticals, and Pro-Dynam, VetXX, Ltd.) a...
|
PMID: 18597250
PDF is available here.
PDF is available here.
Abstract
High-throughput characterization of drug-drug interactions in plasma protein binding was demonstrated by using a surface plasmon resonance (SPR) biosensor. The method used in this study enabled the discrimination between the two modes of binding inhibition, direct competition and negative allosteric...
|
PMID: 18445992
PDF is available here.
PDF is available here.
Abstract
Chiropractic treatment and massage therapy increased spinal MNTs within horses not exhibiting signs of lumbar pain. POTENTIAL RELEVANCE: Pressure algometry provides an objective tool to evaluate the effects of commonly used, but currently unproven treatment modalities on spinal MNTs. Future studies...
|
PMID: 18083655
PDF is available here.
PDF is available here.
Abstract
Proportion of horses clinically improved on day 14 for the firocoxib group (104/123 [84.6%]) was not significantly different from the proportion for the phenylbutazone group (103/119 [86.6%]). Proportion of horses that were improved on day 14 was significantly greater for horses treated with firocox...
|
PMID: 18167116
PDF is available here.
PDF is available here.
Tijdschrift voor diergeneeskunde (132)24 2007
Abstract
Biochemical Pharmacology (74)1 2007
Abstract
We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (E(m)) and altered surface expression of K(+) channels. Epithelial cell migration in response to the wounding of confluent IEC-6...
|
PMID: 17499219
PDF is available here.
PDF is available here.
Journal of Chromatography B (848)2 2007
Abstract
Direct-injection LC-LC hybrid tandem MS methods have been developed for undertaking broad-based screening for acidic drugs in protein-precipitated plasma and neutral doping agents in equine urine. In both analyses, analytes present in the matrix were trapped using a HLB extraction co...
|
PMID: 17101303
PDF is available here.
PDF is available here.
Joint Bone Spine (74)2 2007
Abstract
We report two cases with early and predominant involvement of the upper cervical spine. Synovitis of the atlanto-odontoid joint and fusion of multiple facet joints were noted in one patient. In the other patient, the main finding was atlanto-axial subluxation with erosions of the odontoid process an...
|
PMID: 16987680
PDF is available here.
PDF is available here.
Abstract
No significant differences were found between control and treatment groups or temporally for the biomarkers chondroitin sulfate 846, procollagen type II C-propeptide, collagen type II cleavage, and C-terminal telopeptide of type I collagen in serum or synovial fluid. A significant increase in osteoc...
|
PMID: 17269876
PDF is available here.
PDF is available here.
Abstract
Abstract
Out of 135 horses at the facility, 117 displayed signs of EHV-1 infection. Forty-six horses developed neurologic deficits characterized by symmetrical hind limb ataxia and weakness. Twelve horses that developed neurologic deficits became recumbent and did not survive. The development of severe neuro...
|
PMID: 17338164
PDF is available here.
PDF is available here.
Abstract
We separated a standard mixture of 1 mM ibuprofen, naproxen, and phenylbutazone using a commercially available C18 analytical column. The S/N measurements from the NMR acquisitions indicated that we achieved signal enhancement factors up to 10.4 (+/-1.2)-fold. Furthermore, we observed that preconcen...
|
PMID: 17037915
PDF is available here.
PDF is available here.
Abstract
The sub-effective dose of VN potentiated anti-inflammatory activity of phenlbutazone and ibuprofen significantly in carrageenin induced hind paw oedema and cotton pellet granuloma models. INTERPRETATION & CONCLUSION: The potentiation of anti-inflammatory activities phenlbutazone and ibuprofen by VN...
|
PMID: 17159267
PDF is available here.
PDF is available here.
Abstract
These results demonstrate for the first time that PB C-glucuronidation is catalyzed by only UGT1A9....
|
PMID: 16949544
PDF is available here.
PDF is available here.
Journal of Molecular Biology (361)2 2006
Abstract
We aim to correlate NMR and structural data for FA to provide a more complete description of the binding capacity of HSA. Our recent mutagenesis studies allowed us to identify two high affinity binding sites in domain III of HSA. Here, we use NMR to study the binding of (13)C-carboxyl labeled palmit...
|
PMID: 16844140
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (148)18 2006
Abstract
Abstract
Evaluation of skeletal muscle tolerance during development of new drug formulations for i.m. use is most often based on terminal methods performed in the target species after slaughtering. The objective of this study was to evaluate the effect of muscle damage on the pharmacokinetic parameters of th...
|
PMID: 16612034
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (148)14 2006
Abstract
Abstract
Abstract
Abstract
Abstract
Abstract
The level within the central nervous system where non-steroidal anti-inflammatory drugs (NSAIDs) produce analgesia and the mechanisms by which they mediate this effect are still uncertain. This study assessed the central analgesic effects of ketoprofen, phenylbutazone, salicylic acid and tolfenamic...
|
PMID: 16085153
PDF is available here.
PDF is available here.
Abstract
1 horse was euthanatized with severe hypoproteinemia, hypoalbuminemia, and colitis during the combination treatment. Comparisons revealed no significant difference between control horses and horses treated with PBZ alone. There was a significant difference between control and treated horses when adm...
|
PMID: 16506899
PDF is available here.
PDF is available here.
Abstract
We have determined the Km and Vmax and intrinsic clearance values for specific UGTs viz., UGT 1A1, 1A3 and 1A8. The apparent Km and Vmax values are 23 +/- 7.2 microM, 3.44 +/- 0.17 microg/min/mg protein for UGT1A1, 60 +/- 7.9 microM, 3.67 +/- 0.11 microg/min/mg protein for UGT1A3, 96 +/- 8.0 microM,...
|
PMID: 17315542
PDF is available here.
PDF is available here.
Wiadomosci Lekarskie (59)7-8 2006
Abstract
Ornithine transcarbamylase deficiency is the most common inherited urea cycle disorder. Its clinical manifestations as lethargy, vomites, coma and cerebral edema are the effect of the higher concentration of the ammonia in plasma. Hyperammonemia, caused by mutation in ornithine transcarbamylase gene...
|
PMID: 17209350
PDF is available here.
PDF is available here.
Tijdschrift voor diergeneeskunde (130)20 2005
Abstract
Pharmacological Research (52)4 2005
Abstract
We report on the inhibitory activity of the NSAIDs meloxicam, carprofen, phenylbutazone and flunixin, on blood cyclooxygenases in the horse using in vitro enzyme-linked assays. As expected, comparison of IC50 indicated that meloxicam and carprofen are more selective inhibitors of COX-2 than phenylbu...
|
PMID: 15939622
PDF is available here.
PDF is available here.
Abstract
An eighteen-month old quarter horse gelding was diagnosed with chip fractures from the distal lateral trochlear ridge of the talus. The horse presented with the symptom of persistent synovitis. The diagnosis was based on radiographic evidence. The horse was treated initially with arthroscopic surger...
|
PMID: 16171559
PDF is available here.
PDF is available here.
Abstract
Rapid expansion of supercritical solutions (RESS) technique was applied for the preparation of phenylbutazone fine particles. The operating temperature and pressure affected the yield of the drug fine particles, which was evaluated by dissolving the sprayed product of drug into ethanol. Effect of pr...
|
PMID: 16079541
PDF is available here.
PDF is available here.
Abstract
Mean +/- SE TPSs in horses receiving phenylbutazone or saline solution did not change significantly during the study. After the third treatment, mean +/- SE TPS (2.1 +/- 0.6) in horses receiving electroacupuncture stimulation was significantly lower than baseline (6.0 +/- 0.6) TPS. Mean +/- SE TPSs...
|
PMID: 16047667
PDF is available here.
PDF is available here.
Abstract
14 days after shoeing, mean %BWF in both forelimbs significantly increased from baseline; additional administration of phenylbutazone significantly increased %BWF applied from the more lame forelimb. Compared with shoeing alone, there was no significant change in %BWF after injection of the DIPJ wit...
|
PMID: 16111165
PDF is available here.
PDF is available here.
Abstract
I on HSA, and BCA-induced enhancement in site II binding. The limited drug-drug interaction experiments suggested that BCA influences both site I and site II drug-HSA bindings via different mechanisms; a competitive displacement and a probable allosteric conformational change in HSA, respectively....
|
PMID: 16109627
PDF is available here.
PDF is available here.
Clinical Infectious Diseases (40)12 2005
Abstract
Abstract
A 12-year-old American Saddlebred gelding was referred to a veterinary teaching hospital for evaluation of a chronic lameness problem in the right radiocarpal joint. The horse had been treated for osteoarthritis of the right radiocarpal joint with multiple injections of cortisone during the past 3 y...
|
PMID: 15989187
PDF is available here.
PDF is available here.
Veterinary Record (156)17 2005
Abstract