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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Azoles (8):
Recent article
Azoles
Abstract
The human pathogen Mycobacterium tuberculosis (Mtb) encodes 20 cytochrome P450 (P450) enzymes. Gene essentiality for viability or host infection was demonstrated for Mtb P450s CYP128, CYP121 and CYP125. Structure/function studies on Mtb P450s revealed key roles contributing to bacter...
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PMID: 21426022
PDF is available here.
PDF is available here.
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Abstract
A recent pharmacoepidemiological study has found a more than five-fold incidence ratio in the adjusted rate of sudden death from cardiac diseases among those patients who were given simultaneously inhibitors of cytochrome P450 (CYP) enzymes and their substrates. Although new triazole antifungals are...
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PMID: 20610983
PDF is available here.
PDF is available here.
Abstract
The relationship between susceptibilities to fluconazole and itraconazole and microsatellite CAI genotypes were examined from a total of 154 Candida albicans isolates (97 isolates causing vulvovaginitis in Chinese women and 6 vaginal isolates and 51 oral cavity isolates from asymptomatic carriers)....
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PMID: 20516286
PDF is available here.
PDF is available here.
Abstract
Azole derivatives were synthesized by iron-catalyzed oxidative reactions of azoles and ethers in good to excellent yields. A wide variety of azoles and ethers were selectively transformed into the corresponding oxidative coupling products under neutral reaction conditions.
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PMID: 20377238
PDF is available here.
PDF is available here.
Abstract
This paper provides a brief review of recent progress in the field of metal coordination polymers assembled from azole-containing carboxylic acids and gives a diagrammatic summary of the diversity of topological structures in the resulting infinite metal-organic coordination networks (MOCNs). Azole-...
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PMID: 20657495
PDF is available here.
PDF is available here.
Abstract
Abstract
In an attempt to find novel azole antifungal agents with improved activity and broader spectrum, computer modeling was used to design a series of new azoles with piperidin-4-one O-substituted oxime side chains. Molecular docking studies revealed that they formed hydrophobic and hydrogen-bonding inte...
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PMID: 20362444
PDF is available here.
PDF is available here.
Abstract
We have investigated an effective novel inhibitor of human influenza A and B viruses, triazavirine [2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7(4I)-one] (TZV). TZV suppressed the replication of influenza virus in cell culture and in chicken chorioallantoic membranes, and it protected...
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PMID: 20194696
PDF is available here.
PDF is available here.
Abstract
A rapid turnaround is a prerequisite of therapeutic drug monitoring (TDM). For antifungals, this need is still unmet, since hardly any method has been established to simultaneously quantitate concentrations of different antifungal classes. A liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
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PMID: 20176892
PDF is available here.
PDF is available here.
Abstract
In the present work, a solid phase extraction (SPE) is hyphenated with an automatic MSFIA system to improve the selenite determination based on the reaction of selenite with aromatic o-diamines (such as 2,3-diaminonaphthalene (DAN)) to form the piazselenol complex. This reaction is greatly influence...
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PMID: 20188964
PDF is available here.
PDF is available here.
Hospital practice (1995) (38)2 2010
Abstract
Invasive fungal disease by Candida spp. is on the rise in the modem era of prolonged patient survival by virtue of improved critical care measures, novel chemotherapy regimens, and increasing immunosuppression following organ transplants. Invasive candidiasis (IC) in the setting of an intensive care...
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PMID: 20469617
PDF is available here.
PDF is available here.
Journal of Trauma (68)4 2010
Abstract
Treatment of skeletal muscle soft tissue trauma with the glutathione peroxidase mimic ebselen is highly effective in restoration of disturbed microcirculation. Moreover, reduced inflammatory cell response helps to prevent leukocyte-dependent secondary tissue injury....
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PMID: 20386280
PDF is available here.
PDF is available here.
Clinics in Dermatology (28)2 2010
Abstract
There presently exists a wide selection of choices in the treatment of superficial mycoses. The main categories of broad-spectrum agents are the allylamines and imidazoles, which have been tried and proven over more than 2 decades of usage with good safety. Nystatin and griseofulvin have even longer...
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PMID: 20347665
PDF is available here.
PDF is available here.
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
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PMID: 20157915
PDF is available here.
PDF is available here.
Abstract
We identified the CaPTC4 gene in Candida albicans and demonstrated that the CaPtc4p protein is a typical PP2C enzyme, which is highly conserved in fungal species. Deletion of CaPTC4 renders Candida cells sensitive to sodium and potassium ions as well as to antifungal azole drugs. In addition, we hav...
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PMID: 20014041
PDF is available here.
PDF is available here.
Abstract
We identified the CaPTC4 gene in Candida albicans and demonstrated that the CaPtc4p protein is a typical PP2C enzyme, which is highly conserved in fungal species. Deletion of CaPTC4 renders Candida cells sensitive to sodium and potassium ions as well as to antifungal azole drugs. In addition, we hav...
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PMID: 20014041
PDF is available here.
PDF is available here.
Abstract
We identified the CaPTC4 gene in Candida albicans and demonstrated that the CaPtc4p protein is a typical PP2C enzyme, which is highly conserved in fungal species. Deletion of CaPTC4 renders Candida cells sensitive to sodium and potassium ions as well as to antifungal azole drugs. In addition, we hav...
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PMID: 20014041
PDF is available here.
PDF is available here.
Abstract
We identified the CaPTC4 gene in Candida albicans and demonstrated that the CaPtc4p protein is a typical PP2C enzyme, which is highly conserved in fungal species. Deletion of CaPTC4 renders Candida cells sensitive to sodium and potassium ions as well as to antifungal azole drugs. In addition, we hav...
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PMID: 20014041
PDF is available here.
PDF is available here.
Abstract
We identified the CaPTC4 gene in Candida albicans and demonstrated that the CaPtc4p protein is a typical PP2C enzyme, which is highly conserved in fungal species. Deletion of CaPTC4 renders Candida cells sensitive to sodium and potassium ions as well as to antifungal azole drugs. In addition, we hav...
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PMID: 20014041
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
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PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
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PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed m...
|
PMID: 20157915
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
|
PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
|
PMID: 19847668
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
We evaluated the in vitro antifungal susceptibility of these environmental Cryptococcus strains to amphotericin B, azoles and caspofungin. C. neoformans var. neoformans (n = 10), C. laurentii (n = 3), Candida spp. (n = 14), Rhodotorula mucilaginosa (n = 6) and Trichosporon sp. (n = 3) were isolated...
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PMID: 19847668
PDF is available here.
PDF is available here.
Abstract
We have reported the molecular cloning and preliminary characterization of the Mycobacterium CDase (MtCDase) (J. Biol. Chem., 274, 36616-36622 (1999)). To determine its function further, MtCDase was expressed in Escherichia coli and purified by Ni-Sepharose and gelfiltration. The purified recombinan...
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PMID: 20139604
PDF is available here.
PDF is available here.
Abstract
We have developed a heterologous membrane protein expression system that can be used to study the structure and function of these proteins in the non-pathogenic, genetically stable, and versatile eukaryotic model organism, Saccharomyces cerevisiae. In this chapter we describe the techniques used to...
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PMID: 20717788
PDF is available here.
PDF is available here.
Abstract
Biofilms have been found to be involved in a wide variety of microbial infections in the body, by one estimate 80% of all infections. Infectious processes in which biofilms have been implicated include common problems such as urinary tract infections, catheter infections, middle-ear infections, sinu...
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PMID: 20552348
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (55)9-10 2010
Abstract
The experimental study of the prophylactic efficacy of Triazaverin against the experimental form of the influenza virus A (H5N1) on albino mice intranasally infected with the influenza virus A/Chicken/Kurgan/Russia/02/05 vs. the reference drugs Tamiflu, Remantadin and Arbidol showed that in doses of...
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PMID: 21400750
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (17)28 2010
Abstract
Abscisic acid (ABA) is a plant hormone involved in stress tolerance, stomatal closure, seed dormancy, and other physiological events. Although ABA is registered as a farm chemical (plant growth regulator), its practical use has been limited, mainly due to its weak effect in field trials, which is co...
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PMID: 20666721
PDF is available here.
PDF is available here.
Abstract
We have developed a protein hyperexpression system to facilitate functional analysis of efflux pumps using a Saccharomyces cerevisiae strain as the host for heterologous expression. The system is well suited for the hyperexpression of individual fungal ABC transporters for structural and functional...
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PMID: 20467195
PDF is available here.
PDF is available here.
Abstract
The Gram-positive bacterium Propionibacterium acnes is the causative agent of acne vulgaris. Antibiotics such as tetracycline and macrolide derivatives are used to treat this skin disease; however, the isolation frequency of antibiotic-resistant P. acnes has been increasing. The anti-P. acnes activi...
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PMID: 20045949
PDF is available here.
PDF is available here.
Abstract
Echinocandins have become the drug of choice in infections caused by Candida glabrata. The objective of this study was to evaluate the in vitro activity of caspofungin alone and in combination against C. glabrata. In vitro assays demonstrated that caspofungin alone showed excellent fungicidal activi...
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PMID: 19841143
PDF is available here.
PDF is available here.
Abstract
We identified thimerosal, thiram, and ebselen as effective inhibitors of Heamophilus influenzae MurA by screening a chemical library that consisted of a wide range of bioactive compounds. When MurA was preincubated with these inhibitors, their 50% inhibitory concentrations (IC50s) were found to rang...
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PMID: 20075623
PDF is available here.
PDF is available here.
Abstract
ABLC is effective and well-tolerated in the treatment of systemic fungal infections and remains a valuable therapeutic option in a variety of immunocompromised patients due to its broad antifungal spectrum and rarity of resistance. LIMITATIONS: Data from randomised controlled trials of lipid-based a...
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PMID: 19849324
PDF is available here.
PDF is available here.
Abstract
The present research investigates the study of a set of 27 (con)azoles and their reproductive toxicity. (Con)azoles are used as fungicides and herbicides in agriculture for treatment of fruits, vegetables, cereals, and seeds, or as human antimycotic therapeutics. According to EEC Directive 91/414, a...
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PMID: 20024805
PDF is available here.
PDF is available here.
médecine/sciences (25)10 2009
Abstract
Thrombolysis remains the main therapeutic strategy used in stroke, but with a limited use to only a part of stroke patients. A neuroprotective approach would be necessary with a double objective : (1) to serve as an add-on treatment with thrombolysis to improve safety and increase therapeutic window...
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PMID: 19849988
PDF is available here.
PDF is available here.
Abstract
Enantioenriched diaryl-, aryl heteroaryl-, and diheteroarylmethanols exhibit important biological and medicinal properties. One-pot catalytic asymmetric syntheses of these compounds beginning from readily available aryl bromides are introduced. Thus, lithium-bromide exchange with commercially availa...
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PMID: 19653691
PDF is available here.
PDF is available here.
Chemmedchem (4)9 2009
Abstract
We illustrate the recent advances in structure-based and in silico strategies aimed at discovering and optimizing Hsp90 inhibitors....
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PMID: 19685544
PDF is available here.
PDF is available here.
Abstract
We review the pharmacological, microbiological and clinical development progress with the so-called 'second generation' triazoles: voriconazole, posaconazole, ravuconazole, isavuconazole and albaconazole. All these drugs exhibit a favourable pharmacokinetic and toxicity profile and possess high acti...
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PMID: 19678798
PDF is available here.
PDF is available here.
Chemical Reviews (109)8 2009
Abstract