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Heterocyclic Compounds, 1-Ring (25):
Recent article
Heterocyclic Compounds, 1-Ring
Analyst (Cambridge UK) (135)11 2010
Abstract
We have prepared and explored a novel nano-interface based probe for the rapid identification and highly sensitive detection of cancer cells by means of an electrochemical study. The new probe tetrathiafulvalene (TTF) carboxylate salt (TTF-(COONBu(4))(2), ditetrabutylammonium salt for propylenedithi...
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PMID: 20838668
PDF is available here.
PDF is available here.
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Analyst (Cambridge UK) (135)8 2010
Abstract
The two members of peroxide-based explosives, triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD), can be manufactured from readily accessible reagents, and are difficult to detect by conventional analytical methods. TATP and HMTD were securely synthesized, taken up with aceto...
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PMID: 20532268
PDF is available here.
PDF is available here.
Nanotechnology (21)29 2010
Abstract
The characterization of biodistribution is a central requirement in the development of biomedical applications based on the use of nanoparticles, in particular for controlled drug delivery. The blood circulation time, organ biodistribution and rate of excretion must be well characterized in the proc...
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PMID: 20601764
PDF is available here.
PDF is available here.
Abstract
We investigated imaging of insulinomas with DOTA-conjugated exendin-3 labelled with (68)Ga.
Targeting of insulinomas with [Lys(40)(DOTA)]exendin-3 labelled with either (111)In or (68)Ga was investigated in vitro using insulinoma tumour cells (INS-1). [Lys(40)((111)In-DTPA)]Exendin-3...
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PMID: 20111963
PDF is available here.
PDF is available here.
Abstract
We evaluated locally injected (213)Bi-DOTA-substance P in patients with critically located gliomas as the primary therapeutic modality.
In a pilot study, we included five patients with critically located gliomas (WHO grades II-IV). After diagnosis by biopsy, (213)Bi-DOTA-substance P...
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PMID: 20157707
PDF is available here.
PDF is available here.
Abstract
Radiolabeled IgG and Fab showed specific binding to ERC-expressing mesothelioma cells with high affinity. Both radiolabeled IgG and Fab internalized into cells after binding to ERC on the cell surface. In-labeled IgG accumulated in ERC-expressing tumors and resulted in a moderate tumor-to-blood rati...
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PMID: 20072072
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)4 2010
In vivo evaluation of (64)Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent.
Abstract
A novel nanoparticle-based dual-modality positron emission tomograph/magnetic resonance imaging (PET/MRI) contrast agent was developed. The probe consisted of a superparamagnetic iron oxide (SPIO) core coated with PEGylated phospholipids. The chelator 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraac...
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PMID: 20353170
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)4 2010
Abstract
We have previously imaged mutant KRAS2 mRNA activation in pancreatic cancer xenografts by positron emission tomography (PET) based on a single radiometal, (64)Cu, chelated to a 1,4,7,10-tetra(carboxymethylaza)cyclododecane (DOTA) chelator, connected via a flexible, hydrophilic spacer, aminoethoxyeth...
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PMID: 20232877
PDF is available here.
PDF is available here.
Abstract
(18)F-Fluorodeoxyglucose ((18)F-FDG) is the most common molecular imaging agent in oncology, with a high sensitivity and specificity for detecting several cancers. Antibodies could enhance specificity; therefore, procedures were developed for radiolabeling a small ( approximately 1451 Da) hapten pep...
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PMID: 20354120
PDF is available here.
PDF is available here.
Biomaterials (31)11 2010
Abstract
We utilized dopamine to modify the surface of IONPs, yielding nanoconjugates that can be easily encapsulated into human serum albumin (HSA) matrices (clinically utilized drug carriers). This nanosystem is well-suited for dual encapsulation of IONPs and drug molecules, because the encapsulation is ac...
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PMID: 20092887
PDF is available here.
PDF is available here.
Abstract
We performed targeted radioimmunotherapy with a SWCNT-([(225)Ac]DOTA) (E4G10) construct directed at the tumor vasculature in a murine xenograft model of human colon adenocarcinoma (LS174T). The specific construct reduced tumor volume and improved median survival relative to controls. We also perform...
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PMID: 21042424
PDF is available here.
PDF is available here.
Abstract
The novel carbon based acid has been synthesized via one-step hydrothermal carbonization of furaldehyde and hydroxyethylsulfonic acid. A highly efficient procedure for the synthesis of fructone has been developed using the novel carbon based acid. The results showed that the catalyst possessed high...
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PMID: 20714302
PDF is available here.
PDF is available here.
Abstract
SUMMARY INTRODUCTION: Expression of vascular adhesion protein-1 (VAP-1) is induced at the sites of inflammation where extravasation of leukocytes from blood to the peripheral tissue occurs. VAP-1 is a potential target for anti-inflammatory therapy and for in vivo imaging of inflammat...
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PMID: 19840033
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)19 2009
Abstract
Expression of MMP9 protein and mRNA, water content, Evans blue content, TNF-alpha, IL-1, and IL-6 increased in rat brain tissue after CPR, indicating disruption of the blood-brain barrier and excess inflammatory reaction. MMP9 expression was reduced with SB-3CT, resulting in reduced brain injury....
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PMID: 20079138
PDF is available here.
PDF is available here.
Journal of Physiology and Pharmacology (60 Suppl 4) 2009
Abstract
Angiogenesis in the rodent model of combined myocardial hypertrophy and infarction was successfully assessed with alphavbeta3-targeted agent in relation to tissue hypoxia measured with 99mTc -labeled nitroimidazole retained in hypoxic myocardium. Regional retention of RP748 correlated well with BRU-...
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PMID: 20083860
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (113)33 2009
Abstract
Our results show that the -CN or -N3 group plays a very important role in increasing the HOF values of the 1,2,4,5-tetrazine derivatives. An analysis of the bond dissociation energies for the weakest bonds indicates that substitutions of the -N3, -NH2, -CN, -OH, or -Cl group are favorable for enhanc...
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PMID: 19642635
PDF is available here.
PDF is available here.
Abstract
We have determined the systemic biodistribution of the hormone leptin by PET imaging. PET imaging using (18)F- and (68)Ga-labeled leptin revealed that, in mouse, the hormone was rapidly taken up by megalin (gp330/LRP2), a multiligand endocytic receptor localized in renal tubules. In addition, in rhe...
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PMID: 19656493
PDF is available here.
PDF is available here.
Oncology Reports (22)1 2009
Abstract
Our findings demonstrate the effectiveness and feasibility of preparing an effective mAb-based dual functional imaging agent for PET and NIRF targeting the CD20 expression in lymphoma....
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PMID: 19513512
PDF is available here.
PDF is available here.
Abstract
We were able to deduce that two free carboxylate groups of the radiogallium-DOTA complex may be utilized for coupling to functional moieties that recognize molecular targets for in vivo imaging without reducing the radiogallium-complex stability. Thus, we designed 2,2'-[4,10-bis(2-{[2-(2-methyl-5-ni...
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PMID: 19481944
PDF is available here.
PDF is available here.
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue (21)6 2009
Abstract
In the sham-operated group, the water content, Evans blue content, MMP-9 protein, and MMP-9 mRNA did not change significantly, and there was no obvious change in microstructure of brain tissue. The expression of MMP-9 protein and MMP-9 mRNA in the resuscitation control group were obviously up-regula...
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PMID: 19570337
PDF is available here.
PDF is available here.
Abstract
The unimolecular chemiluminescent decomposition of unsubstituted dioxetanone was studied at the complete active space self-consistent field level of theory combined with the multistate second-order multiconfigurational perturbation theory energy correction. The calculations revealed interesting feat...
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PMID: 19358608
PDF is available here.
PDF is available here.
Abstract
The results showed that the new complex could be considered for further evaluation in animals and possibly in humans as a new radiopharmaceutical for use in radioimmunotherapy against breast cancer....
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PMID: 19423003
PDF is available here.
PDF is available here.
Abstract
We have developed a 96-well microtiter-plate assay to measure directly the concentration of DOTA and other chelators in antibody-chelator conjugate solutions. Coupled with a commercial assay for measuring protein concentration, the dual microtiter-plate method can rapidly determine chelator/antibody...
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PMID: 19423007
PDF is available here.
PDF is available here.
Electrophoresis (30)6 2009
Abstract
We report on the application of sweeping-MEKC, for the first time, using the Environmental Protection Agency Method 8330 stock standard (a mixture of 14 explosives). The use of a traditional MEKC mode provided the LODs (at S/N=3) ranging from 1.5 to 2.9 microg/mL for the 14 explosives standards, whi...
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PMID: 19229840
PDF is available here.
PDF is available here.
Abstract
We present a study of the kinetics of acid-catalyzed dissociation, thermodynamic stability, serum stability, and biodistribution of a series of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-tetraamide complexes that have been substituted with peripheral hydroxyl groups. The data in...
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PMID: 19083028
PDF is available here.
PDF is available here.
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
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PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
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PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
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PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.
Organic Letters (11)3 2009
Abstract
A new class of C(2) symmetric bisoxazaborolidinone compounds is described which exhibits bidentate binding to carbonyl substrates. Using the Diels-Alder reaction as a model system, the catalytic activity of these bis-Lewis acids is probed. Reaction rates and selectivities are observe...
|
PMID: 19175350
PDF is available here.
PDF is available here.