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Heterocyclic Oxides (3):
Recent article
Heterocyclic Oxides
Abstract
A series of novel 1,3-disubstituted thieno[3,2-c] [1,2,6]thiadiazin-4(3H)-one 2,2-dioxides (TTDDs), designed as non-nucleoside reverse transcriptase inhibitors (NNRTIs), was synthesized, structurally confirmed by spectral analysis and evaluated for their anti-HIV-1 activities by inhibition of HIV-1(...
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PMID: 17964796
PDF is available here.
PDF is available here.
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Journal of Organic Chemistry (71)17 2006
Abstract
The introduction of a 3-alkyl substituent is a key step in the synthesis of 1,2,4-benzotriazine 1,4-dioxide hypoxia-selective anticancer agents, such as SN29751. The Stille reaction of 3-chloro-1,2,4-benzotriazine 1-oxides (BTOs) 5 was inhibited by the presence of electron donating substituents on t...
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PMID: 16901140
PDF is available here.
PDF is available here.
Abstract
We have obtained new non-nucleoside anti-HCMV derivatives. The activity against HCMV is shown at concentrations that were 10-fold lower than the concentration that was toxic for the host cells, which confirm that these derivatives show a specific antiviral effect against HCMV. SAR conclusions derive...
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PMID: 12735985
PDF is available here.
PDF is available here.
Abstract
We report the first examples of hydrogen-bond-promoted acceleration of hetero-Diels-Alder reactions and the use of such catalysis for the hetero-Diels-Alder reactions of simple, unactivated ketones. Several spiro-fused dihydropyans were synthesized in good yields using this procedure. This activatio...
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PMID: 12175197
PDF is available here.
PDF is available here.
Abstract
The structural and energetic features of the attractive intramolecular through-space S-X interaction [X being oxygen (O) or sulfur (S)] of thioester containing 3-isothiazolidinone 1-oxide heterocycles are described. Density functional theoretical and semiempirical calculations are used to explain th...
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PMID: 11123958
PDF is available here.
PDF is available here.
Abstract
A fast HPLC method for the determination of the oxygen heterocyclic compounds of citrus essential oils was developed. Five different oils were analyzed under identical conditions, by reversed-phase HPLC with photodiode array detector, for a direct comparison of the composition of their oxygen hetero...
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PMID: 10552795
PDF is available here.
PDF is available here.
Ceskoslovenska farmacie (27)4 1978
Abstract
Folia Microbiologica (23)6 1978
Abstract
Atherosclerosis (27)3 1977
Abstract
Cycloalliin is a natural constituent of onion, sulphur-containing but odourless. It was synthesised for this randomised double-blind study; its effect on fibribolytic activity and platelet aggregability was tested in venous blood from 18 male volunteers. It increased the former to a highly significa...
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PMID: 332196
PDF is available here.
PDF is available here.
Ceskoslovenska farmacie (24)2 1975
Abstract