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Articles on Harringtonines
Omacetaxine mepesuccinate for the treatment of leukemia.
Omacetaxine mepesuccinate, formerly known as homoharringtonine, is a first-in-class cephalotaxine that has experienced phases of increasing and waning interest since its first use in traditional Chinese medicine. With activity being reported in patients with chronic myeloid leukemia (CML) resistant...
Successful treatment of childhood Philadelphia chromosome-positive acute myeloid leukemia.
A facile total synthesis of hainanensine via an unusual rearrangement--annulation cascade.
A facile total synthesis of hainanensine (1), a structurally unique Cephalotaxus alkaloid, via an effective acid-mediated rearrangement/Friedel-Crafts annulation cascade (7a/7b --> 8a/8b), is described.
Homoharringtonine in combination with cytarabine and aclarubicin as induction therapy improves remission and survival of patients with highe...
The effect of homoharringtonine in patients with chronic myeloid leukemia who have failed or responded suboptimally to imatinib therapy.
Asymmetric Total Synthesis and Revised Structure of Cephalezomine H
A revised structure of cephalezomine H, Cephalotaxus alkaloids, is presented. The originally assigned and revised structures of cephalezomine H were synthesized from the key intermediate for the synthesis of (-)-cephalotaxine.
Prolonged chronic phase in chronic myelogenous leukemia after homoharringtonine therapy.
Low dose HHT alone showed considerable short term and long term efficacy in the treatment of late stage CML. It may also be a good choice for patients who have failed imatinib, IFN-alpha treatment or haematopoietic stem cell transplantation or cannot afford these treatments....
A phase II study of continuous infusion homoharringtonine and cytarabine in newly diagnosed patients with chronic myeloid leukemia: CALGB st...
Although HHT/cytarabine was generally well tolerated, the cytogenetic response rate did not exceed the level previously seen in patients with interferon-refractory CML and was not nearly as high as associated with imatinib in newly diagnosed patients....
[In vitro effect of bortezomib alone or in combination with harringtonine or arsenic trioxide on proliferation and apoptosis of multidrug re...
Bortezomib can inhibit proliferation and induce apoptosis of HL-60/ADM cells and fresh refractory/relapse acute leukemia cells, especially combined with HT or As2O3....
A second generation formal synthesis of (-)-cephalotaxine.
A second generation formal synthesis of the alkaloid (-)-cephalotaxine has been achieved using an alkylidene carbene 1,5-CH insertion reaction to establish a key quaternary stereocenter. The carbene precursor was readily derived from L-proline, and the 1,5-CH insertion reaction was performed under O...