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All › Heterocyclic Compounds › Heterocyclic Compounds, 2-Ring › Benzazepines › 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (0)

      Articles on 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine

      1. SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism.
        Hong-Yuan HY Chu, Qianqian Q Wu, ... Xuechu X Zhen

        J Neurosci Res 89(8):1259-66 (2011) PMID 21538463

        These results demonstrate that SKF83959 suppressed the excitatory synaptic transmission in hippocampal CA1 area, which was independent of D(1) -like receptor. The mechanism underlying the effect could be mainly inhibition of Na(+) channel in the afferent fibers. The suppression of excitatory synapti...
      2. [Interaction of N-methyl-D-aspartate and Dopamine D1 receptors in modulation of passive avoidance extinction at mice with depressive-like st...
        N I NI Dubrovina and D V DV Zinov'eva

        Ross Fiziol Zh Im I M Sechenova 97(7):700-7 (2011) PMID 21961294

        We observed acceleration of the extinction start and development of complete extinction of the memory trace about pain impact as compared with single injections of D-cycloserine and SKF 38393....
      3. Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual ...
        Vaneeta V Verma, Ahmed A Hasbi, ... Susan R SR George

        J Biol Chem 285(45):35092-103 (2010) PMID 20807772 PMCID PMC2966123

        We identified that activation of the G(q)-linked dopamine D1-D2 receptor hetero-oligomer generates a PLC-dependent intracellular calcium signal. Confocal FRET between endogenous dopamine D1 and D2 receptors in striatal neurons confirmed a physical interaction between them. Pretreatment with SKF 8395...
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      4. Opioid regulation of Pavlovian overshadowing in fear conditioning.
        Moriel M Zelikowsky and Michael S MS Fanselow

        Behav Neurosci 124(4):510-9 (2010) PMID 20695650

        We tested the effects of an opioid antagonist and dopamine agonist on the ability of a salient white noise to overshadow a less salient light. Rats were conditioned to fear a light or a noise-light compound using a mild footshock. Compound-conditioned rats trained under the saline vehicle revealed s...
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      5. Involvement of different types of dopamine receptors in the formation of latent inhibition of a conditioned passive avoidance reaction in ra...
        L V Loskutova, N V Kostyunina, and N I Dubrovina

        Neurosci Behav Physiol 40(5):483-7 (2010) PMID 20490693

        These results suggest that while D(1) receptors have no influence as an independent substrate on the formation of latent inhibition, activation of these receptors is required for the complete manifestation of D(2)-mediated modulation of this process....
      6. Infusions of anti-sense oligonucleotides for DARPP-32 to the ventral tegmental area reduce effects of progesterone- and a dopamine type 1-li...
        Cheryl A CA Frye and Alicia A AA Walf

        Behav Brain Res 206(2):286-92 (2010) PMID 19782104 PMCID PMC2791500

        We hypothesized that, in the VTA, dopamine type 1-like receptor (D1)-mediated increases in progesterone (P4)-facilitated lordosis involve DARPP-32. To investigate this, ovariectomized hamsters and rats, primed with estradiol (E2; 10 microg), received infusions to the VTA of saline vehicle or sense o...
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      7. Effects of activation and blockade of dopamine receptors on the extinction of a passive avoidance reaction in mice with a depressive-like st...
        N I Dubrovina and D V Zinov'eva

        Neurosci Behav Physiol 40(1):55-9 (2010) PMID 20012492

        Learning and extinction of a conditioned passive avoidance reaction resulting from neuropharmacological actions on dopamine D(1) and D(2) receptors were demonstrated to be specific in intact mice and in mice with a depressive-like state. Learning was degraded only after administratio...
      8. Dopamine D1-like receptor activation induces brain-derived neurotrophic factor protein expression.
        Stacey N Williams and Ashiwel S Undieh

        Neuroreport 20(6):606-10 (2009) PMID 19295451

        Recent studies showed that dopamine or D1 receptor-selective agonists increased brain-derived neurotrophic factor (BDNF) mRNA and protein expression in neuronal cultures, and this action was blocked by SCH23390. Moreover, SKF38393 activated Trk receptors and downstream signaling in striatal neurons....
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      9. [Involvement of dopamine receptors of different types in formation of latent inhibition of passive avoidance reaction in Wistar rats].
        L V LV Loskutova, N V NV Kostiunina, and N I NI Dubrovina

        Zh Vyssh Nerv Deiat Im I P Pavlova 59(2):185-91 (2009) PMID 19445386

        The effect of the intraperitoneal injection of dopaminergic agents on normal and weak latent inhibition of step-through passive avoidance task was studied in rats. Normal latent inhibition was caused by 20-fold preexposure (four times daily) of environmental conditional stimulus before training. For...
      10. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area.
        Cheng Xiao, Xuesi Max Shao, ... Jiang-Hong Ye

        Neuropsychopharmacology 34(2):307-18 (2009) PMID 18596684

        We report here that in midbrain slices from rats, clinically relevant concentrations of ethanol (10-80 mM) increase the amplitude of evoked EPSCs and reduce their paired-pulse ratio in dopamine neurons in the VTA. The EPSCs were mediated by glutamate alpha-amino-3-hydroxy-5-methylisoxazole-4-propion...
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