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All › Hormones, Hormone Substitutes, and Hormone Antagonists

Hormones, Hormone Substitutes, and Hormone Antagonists (2)

Articles on Hormones, Hormone Substitutes, and Hormone Antagonists

  1. Assessment of hydroxylated metabolites of polychlorinated biphenyls as potential xenoestrogens: a QSAR comparative analysis(∗)
    P Ruiz, E Myshkin, ... R J Brennan

    SAR QSAR Environ Res (2013) PMID 23557136

    We performed QSAR analyses using available estrogenic activity (human estrogen receptor ER alpha) data for 71 OH-PCBs. The modelling was performed using multiple molecular descriptors including electronic, molecular, constitutional, topological, and geometrical endpoints. Multiple linear regressions...
  2. The ETS Domain Transcription Factor Elk1 Directs a Critical Component of Growth Signaling by the Androgen Receptor in Prostate Cancer Cells.
    Mugdha Patki, Venkatesh Chari, ... Manohar Ratnam

    J Biol Chem (2013) PMID 23426362

    The androgen receptor (AR) is essential for diverse aspects of prostate development and function. Molecular mechanisms by which prostate cancer (PC) cells redirect AR signaling to genes that primarily support growth are unclear. A systematic search for critical AR tethering proteins...
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  3. Ovarian hormones and the heterogeneous receptor mechanisms mediating the discriminative stimulus effects of ethanol in female rats.
    Christa M CM Helms, Aubrey D AD McCracken, ... Travis M TM Moschak

    Behav Pharmacol 24(2):95-104 (2013) PMID 23399883

    Past studies have suggested that progesterone-derived ovarian hormones contribute to the discriminative stimulus effects of ethanol, particularly via progesterone metabolites that act at γ-aminobutyric acid type A (GABAA) receptors. It is unknown whether loss of ovarian hormones in...
  4. Identification of Key Residues Involved in Adrenomedullin Binding to the AM1 Receptor.
    H A Watkins, M Au, ... D L Hay

    Br J Pharmacol (2013) PMID 23351143

    Chemical shift perturbation experiments located the main binding epitope for AM22-52 at the AM1 receptor to the C-terminal 8 amino acids. Isothermal titration calorimetry of AM22-52 alanine substituted peptides indicated that Y52, G51 and I47 are essential for AM1 receptor binding and that K46 and P...
  5. Antagonistic Peptide Technology for Functional Dissection of CLV3/ESR Genes in Arabidopsis.
    Xiu-Fen XF Song, Peng P Guo, ... Chun-Ming CM Liu

    Annu Rev Plant Physiol 161(3):1076-85 (2013) PMID 23321419

    We used the well-characterized stem cell-restricting CLV3 to develop an antagonistic peptide technology by transformations of wildtype Arabidopsis with constructs carrying the full-length CLV3 with every residues in the peptide-coding region replaced, one at a time, by Ala. Analyses of transgenic pl...
  6. Analogs of sulfakinin-related peptides demonstrate reduction in food intake in the red flour beetle, Tribolium castaneum, while putative ant...
    Na Yu, Veronica Benzi, ... Guy Smagghe

    Peptides (2012) PMID 23246802

    The insect sulfakinins (SKs) constitute a family of neuropeptides that display both structural and functional similarities to the mammalian hormones gastrin and cholecystokinin (CCK). As a multifunctional neuropeptide, SKs are involved in muscle contractions as well as food intake re...
  7. Structure-function relations of strigolactone analogs: activity as plant hormones and plant interactions.
    Maja M Cohen, Cristina C Prandi, ... Yoram Y Kapulnik

    Mol Plant 6(1):141-52 (2013) PMID 23220943

    We found that each of the tested organisms differs in its response to the various examined synthetic SL analogues. Structurefunction relations of the SL analogues suggest substitutions on the A ring as the cause of this variation. Moreover, the description of competitive antagonistic analogues sugge...
  8. Effects of GnRH antagonists vs agonists in domestic carnivores, a review.
    C C Gobello

    Reprod Domest Anim (2012) PMID 23279542

    Gonadotrophin-releasing hormone (GnRH) stimulates the pituitary secretion of both luteinizing and follicle-stimulating hormones, and thus controls the hormonal and reproductive functions of the gonads. GnRH analogs, which include agonists and antagonists, have been produced by amino...
  9. Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: Enhanced enzymatic stability and biological properties.
    Despina D Laimou, Theodora T Katsila, ... Theodore T Tselios

    Eur J Med Chem (2012) PMID 23127987

    This article describes the rational design, synthesis and pharmacological properties of amide-linked cyclic analogues of Luteinizing Hormone-Releasing Hormone (LHRH) with substitutions at positions 1 (Pro), 6 (d-Leu/d-Trp), 9 (Aze) and 10 (BABA/Acp). These LHRH analogues fulfil the c...
  10. Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes.
    Vanessa V Delfosse, Marina M Grimaldi, ... Patrick P Balaguer

    Proc Natl Acad Sci U S A 109(37):14930-5 (2012) PMID 22927406 PMCID PMC3443136

    We report that the mechanisms by which BPA and two congeners, bisphenol AF and bisphenol C (BPC), bind to and activate estrogen receptors (ER) α and β differ from that used by 17β-estradiol. We show that bisphenols act as partial agonists of ERs by activating the N-terminal activation function 1...