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All › Hormones, Hormone Substitutes, and Hormone Antagonists › Hormone Antagonists

Hormone Antagonists (7)

Articles on Hormone Antagonists

  1. Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis...
    Barbara B Renga, Andrea A Mencarelli, ... Stefano S Fiorucci

    PLoS One 7(1):e30443 (2012) PMID 22291955

    We have characterized the activity of this theonellasterol on FXR-regulated genes and biological functions. Interrogation of HepG2 cells, a human hepatocyte cell line, by microarray analysis and transactivation assay shows that theonellasterol is a selective FXR antagonist, devoid of...
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  2. Glucocorticoid causes iron accumulation in liver by up-regulating expression of iron regulatory protein 1 gene through GR and STAT5.
    Fang F He, Long L Ma, ... Min M Li

    Cell Biochem Biophys 61(1):65-71 (2011) PMID 21359952

    These results strongly implicate glucocorticoid receptor and STAT5 in stress-induced up-regulation of IRP-1, which subsequently enhances transferrin receptor-1 expression and down-regulates ferritin, causing iron accumulation in the liver....
  3. Short-term effects of tolvaptan on renal function and volume in patients with autosomal dominant polycystic kidney disease.
    Maria V Irazabal, Vicente E Torres, ... Frank S Czerwiec

    Kidney Int 80(3):295-301 (2011) PMID 21544064

    We sought to clarify the potential renal mechanisms to see whether the antagonist effects were dependent on underlying renal function in 20 patients with autosomal dominant polycystic kidney disease (ADPKD) before and after 1 week of daily split-dose treatment. Tolvaptan induced aquaresis (excretion...
  4. A case of progesterone-induced anaphylaxis, cyclic urticaria/angioedema, and autoimmune dermatitis.
    I Leonard IL Bernstein, David I DI Bernstein, ... Jonathan A JA Bernstein

    J Womens Health (Larchmt) 20(4):643-8 (2011) PMID 21417747

    We report a detailed immunological evaluation of such a woman responsive to a gonadotropin hormone-releasing agonist (GHRA). Skin testing, enzyme-linked immunosorbent assays (ELISAs), leukocyte histamine release (LHR), and inhibition assays were performed to demonstrate progesterone...
  5. Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb ...
    Lynnette K Nieman, Wendy Blocker, ... Alicia Armstrong

    Fertil Steril 95(2):767-72.e1-2 (2011) PMID 21055739

    To evaluate the efficacy and tolerability of the P receptor modulator CDB-2914 (Ulipristal, CDB). Randomized, placebo-controlled double-blind clinical trial. Clinical research center. Premenopausal women with symptomatic uterine fibroid...
  6. Progesterone rapidly attenuates ATP-evoked transient currents in cultured rat dorsal root ganglion neurons.
    Juan Fan, Yi Lu, ... Bei Ma

    Pharmacology 87(1-2):36-44 (2011) PMID 21178388

    We investigated the effects of progesterone on P2X3-receptor-mediated responses of rat dorsal root ganglion neurons by using whole-cell patch clamp techniques. Progesterone (10 pmol/l to 1 μmol/l) inhibited ATP (100 μmol/l)-induced transient currents and the transient component of...
  7. [Hypo- and hypernatremia].
    C C Palm, A A Wagner, and P P Gross

    Dtsch Med Wochenschr 136(1-2):29-33 (2011) PMID 21181613

    Hyponatremia is an electrolyte disorder that is defined by a serum sodium concentration of less than 135 mmol/L. Hyponatremia occurs at a high incidence. It is commonly associated with mild to moderate mental impairment. Hypoosmolar hyponatremia occurs in the setting of plasma volume deficiency ("hy...
  8. Anti-inflammatory action of cholecystokinin and melatonin in the rat parotid gland.
    H Cevik-Aras and J Ekström

    Oral Dis 16(7):661-7 (2010) PMID 20846152

    To define the influence of cholecystokinin and melatonin on the inflammatory response of the lipopolysaccharide-exposed rat parotid gland. Bacterial lipopolysaccharide was infused retrogradely into the parotid duct. The degree of inflammation three hours postadministration was estimated from the act...
  9. Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake.
    Pawel K Olszewski, Anica Klockars, ... Allen S Levine

    Endocrinology 151(10):4736-44 (2010) PMID 20685878

    We examined the involvement of OT in the regulation of sucrose vs. fat intake in C57BL/6 mice that served as a background KO strain. We exposed mice to a meal of sucrose or Intralipid and determined that the percentage of c-Fos-immunoreactive paraventricular hypothalamic OT neurons was elevated at t...