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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Estrogen Antagonists (1):
Recent article
Estrogen Antagonists
Abstract
We evaluate the effects of BP-4 in eleuthero-embryos and in the liver, testis and brain of adult male fish on the transcriptional level by focusing on target genes involved in hormonal pathways to provide a more complete toxicological profile of this important UV-absorber. Eleuthero-embryos and male...
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PMID: 20937294
PDF is available here.
PDF is available here.
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Abstract
We aimed to develop a protocol for tamoxifen-induced gene inactivation with minimal effects on gene transcription and in vivo cardiac function, allowing studies of acute loss of the targeted gene. In mRNA microarrays, 35% of the 34,760 examined genes were significantly regulated in MCM(+/0) compared...
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PMID: 20802136
PDF is available here.
PDF is available here.
European Journal of Pharmacology (645)1-3 2010
Abstract
The purpose of this study was to investigate the effects and mechanisms of 17beta-estradiol pharmacological postconditioning on gastric epithelial cells hypoxia/reoxygenation injury by using an in vitro model of human gastric epithelial cells. The model of hypoxia/reoxygenation was established with...
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PMID: 20654613
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)41 2010
Abstract
Abstract
This research was conducted to evaluate the effect of naringenin (NAG) on fate and dispositions of deoxynivalenol (DON) in piglets following intravenous (i.v.) administration. Three piglets (Group 1) were pretreated orally with NAG at a dosage of 25 mg/kg bw, once a day for 3 consecutive days, follo...
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PMID: 20467205
PDF is available here.
PDF is available here.
Abstract
I trial of steroid sulfatase inhibitors are encouraging. The activity of the human epidermal growth factor receptor (HER) pathway correlates negatively with that of the ER. HER2 is overexpressed in 22% of all breast cancers. In the decade since HER2 began being targeted, the monoclonal antibody tras...
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PMID: 20644568
PDF is available here.
PDF is available here.
Abstract
We evaluated the effect of estrogen antagonist, raloxifene (Ral), on the prevention and treatment of BPH by investigating its effect on the proliferation of two different prostate cell lines: a stromal cell line, WPMY-1, and a benign prostatic hyperplasia epithelial cell line, BPH-1. We additionally...
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PMID: 20473319
PDF is available here.
PDF is available here.
The Nurse Practitioner (35)9 2010
Abstract
Abstract
We have previously demonstrated that prolonged treatments with raloxifene (RAL) in vitro will result in phase II RAL resistance and RAL-induced tumor growth. Clinical interest prompted us to re-examine RAL resistance in vivo, particularly the effects of long-term treatments (a decade or more) on the...
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PMID: 20596666
PDF is available here.
PDF is available here.
Brain research (1345) 2010
Abstract
We found that OA induced in vitro tau hyperphosphorylation, which was prevented by E2 in a dose-dependent manner. This effect of E2 was partially blocked by an estrogen receptor (ER) antagonist, ICI 182,780. In addition to tau hyperphosphorylation, inhibition of serine/threonine phosphorylation indu...
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PMID: 20457142
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (28)21 2010
Abstract
Journal of Clinical Oncology (28)21 2010
Abstract
We hypothesized that anastrozole may be more effective in women with a high body mass index (BMI). PATIENTS AND METHODS: The Arimidex, Tamoxifen Alone or in Combination (ATAC) study was a double-blind randomized clinical trial in which postmenopausal women with early-stage breast cancer were randoml...
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PMID: 20547990
PDF is available here.
PDF is available here.
Abstract
Hereditary angioedema (HAE) is a rare and potentially fatal disease that is important to recognize early. It is usually associated with low levels or impaired function of C1 inhibitor, which is involved in several inflammatory pathways. The treatment of HAE is very different from other causes of ang...
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PMID: 20531165
PDF is available here.
PDF is available here.
Abstract
We evaluated the effects of pseudoprotodiocsin (PPD), a steroid saponin from Dioscorea nipponica Makino (a type of Dioscorea), on adipogenesis and the mechanisms underlying this effect. Treatment with PPD at the onset of adipogenic differentiation resulted in significantly decreased adipogenesis in...
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PMID: 20427709
PDF is available here.
PDF is available here.
Abstract
Studies of gene regulated by estrogen in breast cancer 1 (GREB1) have focused on mRNA levels with limited evidence about GREB1 protein expression in normal and breast cancer cells. A monoclonal antibody that recognizes GREB1 protein in breast tissues could be applied to correlate pro...
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PMID: 19842031
PDF is available here.
PDF is available here.
Abstract
We hypothesize that the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in the use of calcitriol for the prevention and/or treatment of BCa.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20156557
PDF is available here.
PDF is available here.
Abstract
We investigated how activation of this pathway by E2, the estrogenic environmental contaminants o,p'-DDT, beta-HCH and p,p'-DDE, and epidermal growth factor (EGF) influences the expression of ER target genes, such as TFF1, ER, PR, BRCA1 and CCND1, and the proliferation of breast cancer cells. Despit...
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PMID: 20206645
PDF is available here.
PDF is available here.
Abstract
Tamoxifen was found to be used off-label in only 5.8% of the patients who received the drug in 2008 in this HMO, and only 18 patients (2.1%) received tamoxifen for a diagnosis that did not have some supporting evidence of efficacy. Since off-label prescribing of tamoxifen was found to be relatively...
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PMID: 20518588
PDF is available here.
PDF is available here.
American Journal of Roentgenology (194)6 Suppl 2010
Abstract
Anticancer Research (30)6 2010
Abstract
Neither OHT nor fulvestrant inhibited cell growth, nor did they induce apoptosis. Gefitinib, everolimus and perifosine inhibited proliferation in all cell lines. Only perifosine induced apoptosis. In PTEN-positive HEC1A cells, combined treatment of gefitinib plus OHT showed increased antiproliferati...
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PMID: 20651347
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of raloxifene analogue (LY117018) on cell proliferation and collagen metabolism using cultured rat Achilles tendon fibroblasts. 17beta-Estradiol (E(2); 10(-11)-10(-9) M) and LY117018 (10(-9)-10(-7) M) had no significant effects on tendon fibroblast proliferation, based on...
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PMID: 20073985
PDF is available here.
PDF is available here.
Abstract
We suggest that the occurrence or aggravation of epilepsy, despite estrogen deficiency in the menopausal or post-menopausal period, is related to excessive accumulation of FSH and LH....
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PMID: 20063987
PDF is available here.
PDF is available here.
Abstract
The influence of an estrogen-deficient state was evaluated in this study and also its treatments with estrogen (E(2)) or with raloxifene (RLX) on the expression of osteocalcin during the periods of the chronology of the alveolar bone healing process (7, 14, 21, 28 and 42 post-extraction days) by mea...
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PMID: 20036346
PDF is available here.
PDF is available here.
Annals of Internal Medicine (152)7 2010
Abstract
Abstract
IMPORTANCE OF THE FIELD: The role of estrogen deprivation for the treatment of breast cancer has been understood since the 1800s. Pharmacologic advances in the field in the past decades, including tamoxifen and the aromatase inhibitors, have contributed significantly to the reduced mortality of estr...
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PMID: 20151846
PDF is available here.
PDF is available here.
Abstract
We previously reported that fulvestrant-induced ERalpha degradation depends on the interaction of ERalpha with cytokeratins 8 and 18 (CK8/CK18). Here we further investigate the role of these two cytokeratins in the antagonistic activity of the SERD. Using ER-responsive reporter assays, we demonstrat...
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PMID: 20061804
PDF is available here.
PDF is available here.
Abstract
We will analyze the hormonal causes, clinical relevance, and biologically relevant estrogen-modulated animal models potential for BOO study. In light of the data presented in this review, it becomes apparent that direct inhibition of estrogen action may provide important pharmaceutical treatment of...
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PMID: 19900549
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (315)1-2 2010
Abstract
We previously showed that unliganded ERbeta inhibits ERalpha-mediated proliferation of MCF-7 cells. We investigated if tamoxifen might have a potential negative effect on some breast cancer cells by blocking the effects of unliganded ERbeta on gene regulation. Gene expression profiles demonstrated t...
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PMID: 19744542
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)2 2010
Abstract
The naringinase-treated methanol extract of Sophora japonica L. (Fabaceae) seeds showed potent estrogen agonist activity. Through bioassay-guided isolation of the main active constituents from the naringinase-treated methanol extract of S. japonica, the aglycones genistein and kaempferol were found...
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PMID: 20645836
PDF is available here.
PDF is available here.
Cancer Causes & Control (21)2 2010
Abstract
We used multivariable linear regression to assess the associations of active smoking and secondhand smoke (SHS) exposure with mammographic density in 799 pre- and early perimenopausal women in the Study of Women's Health Across the Nation (SWAN).
We observed that current active smoki...
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PMID: 19915951
PDF is available here.
PDF is available here.
Acta Chirurgica Belgica (110)3 2010
Abstract
If a patient presents with incision pain and a palpable mass after gynaecologic surgery, an incisional endometrioma should be considered. Surgical excision and hormone therapy are effective treatment approaches in these patients....
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PMID: 20690511
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)2 2010
Abstract
We observed modest inverse associations of dietary fat with estrone (P < 0.01), estradiol (P < 0.05), testosterone (P < 0.01), free testosterone (P < 0.01), and DHEA (P < 0.01) for higher vs. lower fat intake; but there was no evidence for a trend. Associations were consistent across measures (perce...
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PMID: 20099190
PDF is available here.
PDF is available here.
Abstract
We performed a kinome-wide RNA interference (RNAi) screen in Drosophila melanogaster S2 cells. RNAi targeting components of the p38 stress-activated kinase cascade prevented the cell size increase elicited by depletion of the TOR negative regulator TSC2. In mammalian and Drosophila tissue culture, a...
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PMID: 19917724
PDF is available here.
PDF is available here.
Abstract
We characterized several ERalpha-repressed targets and examined in detail the mechanism for estrogen repression of Reprimo (RPRM), a cell cycle inhibitor. Estrogen repression of RPRM is rapid and robust and requires a tripartite interaction between ERalpha, histone deacetylase 7 (HDAC7), and FoxA1....
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PMID: 19917725
PDF is available here.
PDF is available here.
Abstract
We and others have reported that mouse embryonic testes contain a subpopulation of somatic cells expressing estrogen receptor alpha (ERalpha). In order to provide evidence for a possible direct estrogen effect on mammalian testes from the early stage of their differentiation, here we devised a metho...
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PMID: 20209442
PDF is available here.
PDF is available here.
Endocrine Journal (57)6 2010
Abstract
We developed a cell-based transcription assay system in which 293T cells were transfected with the luciferase reporter plasmid with estrogen responsive element and either human ER alpha or ER beta expression plasmid. CC at lower doses (10(-10) M and 10(-12) M), but not higher doses (10(-6) M and 10(...
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PMID: 20379036
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (17)10 2010
Abstract
Fulvestrant is a novel endocrine therapy for breast cancer, with a unique structure and mode of action. It binds competitively to the oestrogen receptor (ER), with high affinity, and downregulates ER by functional blockade and increased turnover. Fulvestrant has reached the clinic via extensive pre-...
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PMID: 20156170
PDF is available here.
PDF is available here.
Abstract
Abstract
The cytochome P450 enzyme system is responsible for the metabolism of xenobiotics, including > 75% of commonly prescribed medications. Many of the cytochrome enzymes exhibit polymorphic genotypes, partly accounting for the variations observed in individual drug responses. Recent advances in the unde...
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PMID: 20072940
PDF is available here.
PDF is available here.
Abstract
Aromatase inhibitors are compounds that block aromatase which converts androgens to estrogens. These compounds have been investigated for many years in a variety of conditions in which estrogen blockade is desired. During the past decade, a third generation of aromatase inhibitors has been developed...
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PMID: 20088436
PDF is available here.
PDF is available here.
Abstract
The FSH, luteinizing hormone and testosterone levels were significantly increased after the use of oral TC 20 mg daily. The sperm counts of the patients in the lower initial FSH group had a significantly higher increase in sperm count and concentration compared to the relatively higher FSH group. CO...
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PMID: 19381855
PDF is available here.
PDF is available here.
Abstract
We estimated the cell cycle time TC and the proportion of NG2 cells that is actively cycling (the growth fraction) at approximately postnatal day 6 (P6), P60, P240 and P540. In the corpus callosum, TC increased from <2 days at P6 to approximately 9 days at P60 to approximately 70 days at P240 and P5...
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PMID: 20346197
PDF is available here.
PDF is available here.
Postgraduate Medicine (121)6 2009
Abstract
We review available therapies and clinical characteristics that will both help clinicians diagnose HAE and distinguish among emergencies and nonemergency cases....
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PMID: 19940422
PDF is available here.
PDF is available here.
Abstract
We show that menin expressed in breast cancer cell line MCF-7 is colocalized with ERalpha and functions as a direct coactivator of ER-mediated transcription in breast cancer cells. In MCF-7 cells, coexpression of menin and estrogen-response element-luciferase induced the activity of the latter in a...
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PMID: 19847644
PDF is available here.
PDF is available here.
Cell Metabolism (10)4 2009
Abstract
We generated conditional knockout mice with a deletion of the Lkb1 gene in the beta cell compartment of pancreatic islets; these mice display improved glucose tolerance and protection against diet-induced hyperglycemia. Lkb1(-/-) beta cells are hypertrophic because of elevated mTOR activity; they al...
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PMID: 19808021
PDF is available here.
PDF is available here.
Abstract
Such results emphasize the need of determining T3 levels, before the introduction of antiestrogenic forms of treatment in breast cancer patients....
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PMID: 19942988
PDF is available here.
PDF is available here.
Prescrire international (18)103 2009
Abstract
Three cases of confusion between brand names have been reported in detail. Previscan (the anticoagulant fluindione) was taken instead of Permixon (saw palmetto extract for prostatic hyperplasia, "serenoa repens") or Preservision (a nutritional supplement for the prevention of age-related eye disease...
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PMID: 19882793
PDF is available here.
PDF is available here.
Abstract
These findings showed that in tamoxifen-treated groups, the cell number of pyramidal neurons of CA1 and subiculum significantly decreased comparing to control groups in E22, P1 and P7 but not in third weeks. The mitochondria of the above mentioned groups also showed a dilated feature with less crist...
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PMID: 19946350
PDF is available here.
PDF is available here.
Medicina Clínica (133)10 2009
Abstract
These data demonstrate that Flv is an effective and safe therapy for heavily pre-treated postmenopausal women with advanced breast cancer....
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PMID: 19339025
PDF is available here.
PDF is available here.
Abstract
Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Increasingly, endometriosis is also becoming recognized as a condition in which ectopic endometrial cells exhibit abnormal proliferative and apoptotic regulation in re...
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PMID: 19609865
PDF is available here.
PDF is available here.
Biology of Reproduction (81)2 2009
Abstract
We have previously shown that 17beta-estradiol (E(2)) increases vascular endothelial growth factor A (Vegfa) gene expression in the rat uterus, resulting in increased microvascular permeability, and that this involves the simultaneous recruitment of hypoxia-inducible factor 1 (HIF1) and estrogen rec...
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PMID: 19420388
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (16)24 2009
Abstract
We discuss here. We review the growing body of evidence which demonstrates immunomodulatory effects of tamoxifen, including in vitro and in vivo studies as well as observations made in breast cancer patients treated with tamoxifen. Taken together these studies suggest that tamoxifen is capable of in...
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PMID: 19689284
PDF is available here.
PDF is available here.
Abstract
BPA at very low concentrations (10(-9) to 10(-12) M) similar to those found in human fluids stimulated JKT-1 cell proliferation in vitro. BPA activated both cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways and triggered a rapid (15 min) phosphorylation of the transcription fa...
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PMID: 19654912
PDF is available here.
PDF is available here.
Abstract
Clinical Trials (6)3 2009
Abstract
Aromatase inhibitors provide superior disease control when compared with tamoxifen as adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer.
To present the design, history, and analytic challenges of the Breast International Group (BI...
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PMID: 19528136
PDF is available here.
PDF is available here.
Oncology Reports (21)6 2009
Abstract
Our results support the proposal of cP as a new, potentially effective therapeutic agent for the management of mammary cancer....
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PMID: 19424616
PDF is available here.
PDF is available here.
Anticancer Research (29)6 2009
Abstract
Transition from normal breast to grade 1 tumors was characterized by down-regulation of ERbeta (relative quantification [RQ]=0.83, p=0.019), while transition from grade 1 to grade 3 tumors was associated with the decrease of ERalpha expression (RQ=1.14 vs. RQ=0.65, p<0.001). In stimulation assays, t...
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PMID: 19528477
PDF is available here.
PDF is available here.
Journal of Neuroscience (29)18 2009
Abstract
We show that estradiol regulates auditory processing of acoustic signals in the vertebrate brain, more specifically in the caudomedial nidopallium (NCM), the songbird analog of the mammalian auditory association cortex. Multielectrode recordings coupled with local pharmacological manipulations in aw...
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PMID: 19420261
PDF is available here.
PDF is available here.
Abstract
TAS-108 is a novel steroidal anti-oestrogen, expected to be useful for the treatment of breast cancer. The present study was conducted to investigate the safety, tolerability and pharmacokinetics of TAS-108 following the administration at a single oral dose of 40 mg to up to 120 mg in 12 post-menopa...
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PMID: 19175362
PDF is available here.
PDF is available here.
Abstract
A descriptive analysis of available data on reported cases of uterine carcinosarcomas associated with tamoxifen therapy is undertaken. The role of aromatase inhibitors as alternative to tamoxifen therapy in the adjuvant setting of breast cancer is discussed. The eventual implications of the presumed...
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PMID: 19394886
PDF is available here.
PDF is available here.