Yukinari Masuda,
Akira Shimizu,
Mitue Kataoka,
Takashi Arai,
Arimi Ishikawa,
Xuanyi Du,
Sabine Kyoko Saito,
Kaoru Aki,
Shinya Nagasaka,
Akiko Mii,
Emiko Fujita and
Yuh Fukuda
Abstract
We examined the effect of inhibition of glomerular capillary repair after capillary injury in GN. Experimental Thy-1 GN was induced in rats that were divided into two groups: rats that received anti-VEGF neutralizing antibody (50 μg per 100 g body weight per day) and those treated with the vehi...
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PMID: 20644521
PDF is available here.
Abstract
We present a 16-year-old girl who presented with polyarthritis in association with Raynaud's phenomenon, malar rash, oral ulcers, photosensitivity and alopecia of 6 months duration. On evaluation, it emerged that she had a mixed connective tissue disorder with a mesangio-proliferative glomerulonephr...
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PMID: 21189705
PDF is available here.
Abstract
A 67-year-old, hepatitis C virus (HCV)-positive woman was admitted to our hospital because of proteinuria and leg edema. Laboratory examination showed decreased serum albumin and complement activity and positive cryoglobulin. The HCV RNA genotype was 1b with high viral load. Kidney biopsy showed mem...
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PMID: 20467773
PDF is available here.
Abstract
A 77-year-old diabetic man newly contracted pulmonary mucormycosis. A rapidly progressing clinical course including severe worsening of pneumonia and renal failure culminated in death. This patient presented with hypocomplementemia and dermal vasculitis. Autopsied organs were examined by histologica...
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PMID: 20461433
PDF is available here.
Abstract
We diagnosed the patient with monoclonal immunoglobulin deposition disease (MIDD) associated with monoclonal IgA (mIgA). After the initiation of a monthly treatment with melphalan and predonisolone (MP therapy), the patient's serum IgA levels declined, and clinical remission was ultimately achieved....
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PMID: 20454825
PDF is available here.
Abstract
This report of a partial remission of IgA nephropathy by treatment of pleural tuberculosis supports the hypothesis that there may be a causal relationship between mycobacterial infections and IgA nephropathy.
Georg Thieme Verlag KG Stuttgart New York....
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PMID: 20533156
PDF is available here.
Abstract
At the initiation, the 24-h urine protein excretion was 4.1 +/- 1.4 g, serum creatinine (Scr) 131.0 +/- 44.9 mmol/l, and estimated glomerular filtration rate (eGFR) 63.3 +/- 26.8 ml/min/1.73 m(2). After prednisone therapy for at least 2 months, the 24-h urine protein excretion and eGFR did not chang...
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PMID: 20420795
PDF is available here.
Abstract
We herein report a case of AIH who presented with massive proteinuria, haematuria, pleural fluid and arthritis simulating SLE....
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PMID: 19444448
PDF is available here.
Gwenola Maigne,
Sophie Ferlicot,
Frederic Galacteros,
Xavier Belenfant,
Tim Ulinski,
Patrick Niaudet,
Pierre Ronco,
Bertrand Godeau,
Antoine Durrbach,
Sabrinel Sahali,
Philippe Lang,
Olivier Lambotte and
Vincent Audard
Abstract
We reviewed 18 renal biopsies from patients with SCD and glomerular involvement and studied the expression of hypoxic markers in the biopsy specimens. Four histopathologic variants were distinguished: focal segmental glomerulosclerosis (FSGS) (39%), membranoproliferative glomerulonephritis (28%), th...
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PMID: 20075701
PDF is available here.
Abstract
The article presents a review of the literature on the modern mechanisms of proliferation of mesangial cells, which underlie the development of proliferative forms of glomerulonephritis: the role of cytokines, growth factors, PIP-complex and vasoconstrictive factors.
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PMID: 21137204
PDF is available here.
Abstract
We can confirm the presence of ghrelin in tubular epithelial cells in normal and diseased human kidneys. Lack or low level of this protein in proliferative glomerulopathies may be, in part, responsible for interstitial accumulation of monocytes/macrophages in these cases....
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PMID: 21113212
PDF is available here.
Abstract
To evaluate the long- term outcome of a group of systemic lupus erythematosus (SLE) patients with diffuse proliferative glomerulonephritis (DPGN) treated with pulse steroids and a short course of pulse cyclophosphamide (Cyc) in order to find out baseline predictor variables of disease outcome at the...
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PMID: 21052569
PDF is available here.
Abstract
Glucocorticoid induced alternative macrophage activation failed to ameliorate rat mesangial proliferative glomerulonephritis, whereas MZR suppression of this disease model was attributed, in part, to inhibition of M1-like pro-inflammatory macrophage activation.
2010 S. Karger AG, Basel....
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PMID: 20110667
PDF is available here.
Abstract
The nephropathy of monoclonal gammopathies is principally caused by light chain deposits of fragmented immunoglobins. Paraprotein-related renal diseases are associated with such deposits of intact (heavy chain) or fragmentary (light chain) immunoglobins. A condition of pathological light chain depos...
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PMID: 20440451
PDF is available here.
Abstract
Abnormal CTLA-4 expression may participate in the pathogenesis of MsPGN and be one of mechanisms of GC resistance....
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PMID: 20113596
PDF is available here.
Abstract
We studied 80 adult diabetic Iraqi patients who were diagnosed with glomerular disease on native kidney biopsies from January 2000 to April 2008. Membranoproliferative GN was seen in 32 patients (40%), focal and segmental glomerulosclerosis in 16 patients (20%), membranous nephropathy in 20 patients...
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PMID: 19736492
PDF is available here.
Abstract
We studied the pattern of histopathology in children with SRNS who presented to the King Abdul Aziz University Hospital (KAUH), Jeddah, Saudi Arabia. The records of all children with primary SRNS, who were seen between 2002 and 2007 were reviewed. Only patients who had undergone a renal biopsy were...
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PMID: 19736491
PDF is available here.
Abstract
To analysis the clinical and pathological characteristics of children with dense deposit disease (DDD).
12 Children diagnosed as DDD by electron microscope were enrolled in this study. The clinical and pathological data were analyzed.
Of the 12 cases, 7 were males and 5 females, mean age 9.1 +/- 3.9...
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PMID: 19951492
PDF is available here.
Abstract
We speculate engagement of FcgammaRs on cells such as monocytes/macrophages may be important for the clearance of deposited immune complexes and extracellular matrix proteins....
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PMID: 19528347
PDF is available here.
Abstract
We aimed to study the frequency and type of renal involvement in a group of patients with BD in Azerbaijan province that is one of the prevalent areas of BD in Iran. All cases of BD were prospectively followed between June 2004 and January 2007, and evaluated for renal dys-function (serum creatinine...
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PMID: 19587503
PDF is available here.
Abstract
These results suggest that a shift toward the Th1 pathway of Th cell activation occurs in MsPGN patients, and that sinomenine has the potential to counter this shift in the Th1/Th2 balance and thereby produce therapeutic effects....
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PMID: 19336263
PDF is available here.
Abstract
These results suggest that a shift toward the Th1 pathway of Th cell activation occurs in MsPGN patients, and that sinomenine has the potential to counter this shift in the Th1/Th2 balance and thereby produce therapeutic effects....
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PMID: 19336263
PDF is available here.
Abstract
Our study suggests a predominance of IgG3-kappa glomerular deposits of nondeleted whole immunoglobulin molecules in PGNMID associated with membranoproliferative features. The clinical outcome in patients with this entity appears to be poor....
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PMID: 19640387
PDF is available here.
Abstract
Tacrolimus rapidly and effectively induced remission of SRNS in Chinese adults with disease refractory to treatment with intravenous cyclophosphamide. Treatment may be less effective in patients with FSGS....
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PMID: 19406543
PDF is available here.
Abstract
We report a patient who had simultaneous onset of membranoproliferative glomerulonephritis and thrombotic thrombocytopenic purpura. She did not improve after 48 plasmapheresis sessions. A 6-week course of weekly intravenous doses of rituximab was then given. This achieved complete remission of her n...
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PMID: 19494376
PDF is available here.
Abstract
We herein report the case of a 12-year-old boy with dense deposit disease (DDD) evoked by streptococcal infection. He had been diagnosed to have asymptomatic hematuria syndrome at the age of 6 during school screening. At 12 years of age, he was found to have macrohematuria and overt proteinuria with...
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PMID: 19473640
PDF is available here.
Abstract
We present a 38-year-old female patient on peritoneal dialysis for 3 years due to mesangioproliferative glomerulonephritis since early adolescence and chronic failure of the right kidney transplants. In early 2006 she was treated with high-dose cortisone due to cryptogenic, organized pneumonia. Duri...
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PMID: 19473621
PDF is available here.
Abstract
We examined the expression of the RLX receptor and effects of RLX administration in antithymocyte serum (ATS) nephritis. The nephritic glomeruli showed an increased immunostaining for LGR7 compared to normal glomeruli. The administration of RLX for 7 days to rats with ATS nephritis did not cause an...
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PMID: 19416208
PDF is available here.
Abstract
Our results suggest that renal injury in PGD is associated with ER stress and ER stress may be involved in the rapid progression of PGN to renal failure....
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PMID: 19107326
PDF is available here.
Abstract
We describe a case of acute renal failure with crescentic glomerulonephritis, due to pneumococcal infective endocarditis on an endoprosthetic pulmonary valve. The patient's renal insufficiency subsequently improved following eradication of the microbe with antibiotics alone. Moreover, this is the fi...
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PMID: 19281744
PDF is available here.
Abstract
We report a 70-year-old man who presented with cervical lymphadenopathy, hypercalcemia, and acute renal failure. Lymph node biopsy revealed caseating granulomas. Renal biopsy showed immune complex-mediated diffuse proliferative glomerulonephritis with crescentic formation. Ultrastructural features o...
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PMID: 19281742
PDF is available here.
Abstract
We will review our current knowledge of pathogenesis of MPGN and will present a novel classification system of the disease based on pathogenesis rather than on morphology. A better understanding of the pathogenesis of MPGN is crucial for the development of novel, specific treatment strategies....
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PMID: 19190809
PDF is available here.
Abstract
In this paper, epidemiology, pathogenesis and typical morphological aspects of all three types of membranoproliferative glomerulonephritis (MPGN), of the haemolytic uraemic syndrome (HUS) as well as of thrombotic thrombopenic purpura (TTP) will be reviewed on the light microscopical, immunohistologi...
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PMID: 19190808
PDF is available here.
Abstract
We examined the alteration of angiotensin II receptors' expression and the action of ARB on acute glomerular injuries in GN. Thy-1 GN was induced in rats that were divided into three groups (n=7, in each group); high dose (3 mg/kg/day) or low dose (0.3 mg/kg/day) olmesartan (Thy-1 GN+HD- or LD-ARB g...
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PMID: 19139720
PDF is available here.
Abstract
The nephrotic syndrome of our patient occurred 20 months after the onset of Kimura disease. Renal biopsy revealed minimal-change lesions. The patient was responsive to the steroid, but proteinuria recurred. In most of the 19 other cases, the onset of nephrotic syndrome occurred after subcutaneous ma...
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PMID: 19052471
PDF is available here.
Abstract
We describe a case of pulmonary-renal syndrome on autoimmune basis, with alveolar hemorrhage and worsening renal failure. The patient was positive for anti-MPO and anti-SCL/70. Immunosuppressive therapy was effective to treat the pulmonary condition, but chronic renal failure emerged. The clinical c...
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PMID: 19725477
PDF is available here.
Abstract
IgG treatment is an effective treatment approach in rats with progressive glomerulonephritis. Our data also indicate that studies using specific antibodies need to be controlled for nonspecific IgG effects.
Copyright (c) 2009 S. Karger AG, Basel....
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PMID: 19506398
PDF is available here.
Abstract
We present a 42-year-old Japanese woman with a giant tumor on the right inguinal region. The tumor was diagnosed as Kimura's disease, because of massive infiltration of lymphoid follicle-forming lymphocytes and eosinophils with elevated serum immunoglobulin E and blood eosinophilia. She also had nep...
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PMID: 19620037
PDF is available here.