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Graft vs Host Disease (0):
Recent article
Graft vs Host Disease
Abstract
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Abstract
Bulletin du cancer (98)8 2011
Abstract
Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice of hematologic malignancies. Acute graft versus host disease (GvHD) is common after HSCT and directly related to graft versus leukemia effect. Little progress has been done in the treatment of acute...
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PMID: 21835730
PDF is available here.
PDF is available here.
Abstract
Chronic graft-versus-host disease (GVHD) is an immune-mediated disorder that adversely affects quality of life and clinical outcomes in patients following hematopoietic stem cell transplantation. Conventional treatment of GVHD includes prolonged and high-dose corticosteroids; however...
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PMID: 21810577
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)7 2011
Abstract
We performed myeloablative bone marrow transplantation from an unrelated donor during the patient's first complete remission. After engraftment, he developed acute graft-versus-host disease involving the gastrointestinal tract on day 32. Steroids and mycophenolate mofetil were initiated from day 39....
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PMID: 21821990
PDF is available here.
PDF is available here.
Abstract
We show that Rapamycin (Rapa) enhances TGFß-dependent Foxp3 expression and induces a potent suppressor function in naive (CD4+ 25-45RA+) T cells. Rapa/TGFß iTregs are anergic, express CD25 at levels higher than expanded nTregs and few cells secrete IL-2, IFNγ or IL-17 even after PMA and Ionomycin...
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PMID: 21564534
PDF is available here.
PDF is available here.
Abstract
We conducted a retrospective study between January 1, 1990, and December 31, 2008, of 338 upper GI endoscopies (gastroscopies) performed on patients who underwent allogeneic stem cell transplantation with clinical suspicion of GVHD (198 patients). Acute and chronic GVHD were confirmed from histologi...
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PMID: 21093601
PDF is available here.
PDF is available here.
Abstract
I disparate bm1 × B6 F1 mice. Allospecific killing of anti-H-2(bm1) splenic and hepatocyte targets was assessed by 4-h (51)Cr release and 16-h DNA lysis assays, respectively, utilizing spleen cells (SpC) and IHL isolated (1) from sublethally irradiated bm1 × B6 F1 who had received B6 splee...
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PMID: 21091241
PDF is available here.
PDF is available here.
Abstract
Transferring parental splenocytes into unirradiated F1 mice induces a chronic graft-versus-host disease (GVHD), characterized by the production of Th2 cytokines and immunocomplex-mediated glomerulonephritis resembling systemic lupus erythematosus (SLE). The effects of H1521, a new de...
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PMID: 21195814
PDF is available here.
PDF is available here.
Abstract
This study aimed to describe the Rarebit (RB) visual field and optic nerve size/morphology in patients treated with allogeneic stem-cell transplantation (SCT) in childhood, and to determine the impact of ocular status and conditioning regimens such as total body irradiation (TBI), ch...
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PMID: 20064124
PDF is available here.
PDF is available here.
Abstract
We evaluated the feasibility of combining RIC regimens with low-dose TBI in de novo MDS. The RIC regimen combined with low-dose TBI in this study consisted of fludarabine (150 mg/m(2)), intravenous busulfan (6.4 mg/kg), and TBI (400 cGy). Antithymocyte globulin was used to overcome HLA mismatching....
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PMID: 21411986
PDF is available here.
PDF is available here.
Abstract
We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by overall survival (OS) and disease-free survival (DFS). Acute and late toxicity were secondary endpoints. Meta-an...
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PMID: 21460603
PDF is available here.
PDF is available here.
Clinical Transplantation (25)2 2011
Abstract
We electronically searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and relevant articles (1987.01-2009.12). Comparative studies were carried out on clinical therapeutic effect of RIC and MAC on the survival outcomes and the transplantation-related complications...
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PMID: 21092011
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)1 2011
Abstract
To assess the relationship between early lymphocyte recovery and outcomes after allogeneic hematopoietic stem cell transplantation (SCT) for acute leukemia in remission, 79 adult patients (AML: 48, ALL: 31) who received transplantation between January 2000 and November 2009 were retrospectively analy...
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PMID: 21378474
PDF is available here.
PDF is available here.
Abstract
Extracorporeal photochemotherapy (ECP) is widely used to treat cutaneous T-cell lymphoma, graft-versus-host disease, and allografted organ rejection. Its clinical and experimental efficacy in cancer immunotherapy and autoreactive disorders suggests a novel mechanism. This study reveals that ECP indu...
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PMID: 20720185
PDF is available here.
PDF is available here.
Abstract
Recurrence is a major cause of treatment failure after allogeneic transplantation for acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), and treatment options are very limited. Azacitidine is a DNA methyltransferase inhibitor with activity in myeloid disease. The au...
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PMID: 20672358
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
We observed increased ATP concentrations in the peritoneal fluid after total body irradiation, and during the development of GVHD in mice and in humans. Stimulation of antigen-presenting cells (APCs) with ATP led to increased expression of CD80 and CD86 in vitro and in vivo and actuated a cascade of...
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PMID: 21102458
PDF is available here.
PDF is available here.
Abstract
To evaluate the efficacy of topical cyclosporine-A 0.05% (CsA) in the treatment of dry eye syndrome in ocular graft-versus-host disease after bone marrow transplantation (BMT) of hematopoietic stem cells.
One-hundred five patients were enrolled in a retrospective, comparative, interventional case se...
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PMID: 20847658
PDF is available here.
PDF is available here.
Abstract
To update our knowledge on hematopoietic stem cell transplantation (SCT) and graft-versus-host disease (GVHD) and summarize the current treatment options for ocular GVHD.
Allogeneic (allo)-SCT represents a treatment option for a number of hematological malignancies and bone marrow disorders; the ind...
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PMID: 20729735
PDF is available here.
PDF is available here.
Abstract
We retrospectively analyzed 27 patients treated during 5 years with ECP for steroid-refractory acute and chronic GVHD. We performed an "off-line" approach using a continuous flow cell separator (Cobe Spectra) and a Ultraviolet A irradiator (UVAMATIC). Among acute GVHD patients, 11 of 21 obtained a c...
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PMID: 20962677
PDF is available here.
PDF is available here.
Abstract
We evaluated the protective effect of CP-690550, a newly developed Janus kinase inhibitor, in an acute GVHD model.
CP-690550 was chemically synthesized. Acute GVHD was induced through the transfer of parent B6 (H-2) bone marrow and CD4 T cells into lethally irradiated (B6×bm12)F1 (H...
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PMID: 20697326
PDF is available here.
PDF is available here.
Abstract
We show that mice that received allogeneic splenocytes deficient in DNAX accessory molecule-1 (DNAM-1) had significantly milder GVHD and lower mortality than those that received allogeneic WT splenocytes. Donor CD8(+) T cells deficient in DNAM-1 showed significantly less proliferation and infiltrati...
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PMID: 20937876
PDF is available here.
PDF is available here.
Abstract
We tested the feasibility of alemtuzumab dose deescalation in the context of fludarabine-melphalan conditioning and human leukocyte antigen (HLA)-identical sibling transplantation. Alemtuzumab was given 1-2 days before graft infusion, and dose reduced from 60 mg to 20 mg in 4 sequential cohorts (tot...
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PMID: 20587785
PDF is available here.
PDF is available here.
Abstract
Minnesota medicine (93)10 2010
Abstract
Hematopoietic stem-cell transplantation is a potentially curative therapy for many high-risk hematologic malignancies and other life-threatening disorders. Advances in transplantation over the last four decades have resulted in an increasing number of long-term survivors who may be at risk for devel...
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PMID: 21140762
PDF is available here.
PDF is available here.
Journal of Immunology (185)7 2010
Abstract
We investigated the role of host APCs in the suppression of GVHD by donor Tregs. We found that alloantigen expression by the host APCs is necessary and sufficient for induction of GVHD protection by donor Tregs. This requirement was independent of their effect on the maintenance of Treg numbers and...
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PMID: 20810991
PDF is available here.
PDF is available here.
Abstract
We used a highly sensitive patient-specific nested quantitative PCR to look for evidence of genomic BCR-ABL1 DNA in patients who sustained CMR after stopping imatinib therapy. Seven of eight patients who sustained CMR off therapy had BCR-ABL1 DNA detected at least once after stopping imatinib, but n...
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PMID: 20811403
PDF is available here.
PDF is available here.
Leukemia Research (34)9 2010
Abstract
We examined the levels of CD4(+)CD25(+) Tregs by assessment of CD4(+)CD25(high) and CD4(+)CD25(+)CD127(low) in peripheral blood, and the levels of serum TGF-beta and TNF-alpha in 56 patients at early immune reconstitution following aHSCT. Our data showed a significant reduction in the frequency of T...
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PMID: 20409584
PDF is available here.
PDF is available here.
Archives de Pédiatrie (17)9 2010
Abstract
We discuss the potential clinical applications of ECP in children and emphasize the need for a rigorous and specifically pediatric clinical evaluation of ECP.
Copyright © 2010 Elsevier Masson SAS. All rights reserved....
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PMID: 20709512
PDF is available here.
PDF is available here.
Abstract
We describe a multicenter experience of 11 pediatric patients diagnosed with acute or chronic GVHD (aGVHD, cGVHD) treated for compassionate use with GMP-grade unrelated HLA-disparate donors' bone marrow-derived MSCs, expanded in platelet-lysate (PL)-containing medium. Eleven patients (aged 4-15 year...
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PMID: 20350611
PDF is available here.
PDF is available here.
Abstract
We studied the correlation between the presence of Th17 cells with histologic and clinical parameters. We first analyzed a cohort of 40 patients with GVHD of the gastrointestinal tract. Tumor necrosis factor (TNF), TNF receptors, and Fas expression, and apoptotic cells, CD4(+)IL-17(+) cells (Th17),...
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PMID: 20484086
PDF is available here.
PDF is available here.
Abstract
These results emphasise the critical role of gut microbiota, innate immunity and TLR9 in iGvHD and highlight anti-TLR9 strategies as novel therapeutic options....
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PMID: 20639251
PDF is available here.
PDF is available here.
Abstract
Allogeneic stem cell transplantation (allo-HSCT) is largely employed for treating patients affected by many hematological disorders, but despite the considerable improvement in the treatment of its complications, graft-versus-host disease and infections remain important causes of mor...
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PMID: 21083033
PDF is available here.
PDF is available here.
Clinical Immunology (136)2 2010
Abstract
We found no impact of the polymorphism on the incidence of graft-versus-host disease (GvHD), or on disease-free and overall survival in these SCT recipients. However, patients from patient-donor pairs bearing the wild-type allele who where colonized with Candida had a significant increased incidence...
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PMID: 20452827
PDF is available here.
PDF is available here.
Experimental Dermatology (19)8 2010
Abstract
We chose different skin diseases (cutaneous leishmaniasis, contact hypersensitivity, UV radiation-induced suppression, and graft-versus-host disease) to describe the biological interactions between different DC subtypes and T cells that lead to the development of efficient or unwanted immune respons...
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PMID: 20590820
PDF is available here.
PDF is available here.
Abstract
We report here the 10-year follow-up of 86 patients who underwent allogeneic stem cell transplantation (ASCT) for myelodysplastic syndrome (MDS). All patients received the busulfan, cytosine arabinoside, and cyclophosphamide (BAC) preparative regimen which consisted of busulfan 16 mg/kg, cytosine ar...
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PMID: 20578198
PDF is available here.
PDF is available here.
Abstract
We review the limits of currently available transplant therapies and the innovative strategies being developed to overcome resistance to therapy or to fill therapeutic modalities not currently available. These novel strategies include nonimmunologic therapies, such as targeted preparative regimens a...
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PMID: 20580849
PDF is available here.
PDF is available here.
Transplantation (90)1 2010
Abstract
We hypothesized that methotrexate (MTX) could be used in a similar fashion. In patients with genetic diseases, the use of MTX rather than an alkylating agent such as cyclophosphamide would be preferable due to its reduced risk of promoting secondary malignancies.
Using our standard c...
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PMID: 20626083
PDF is available here.
PDF is available here.
Abstract
In allogeneic hematopoietic stem cell transplantation, donor-derived T cells are key players for early immune reconstitution and efficient engraftment, as well as the graft-versus-leukemia and graft-versus-infection effects. However, a severe and quite common life-threatening complication is the dev...
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PMID: 20636006
PDF is available here.
PDF is available here.
Abstract
We summarize the mechanisms of NKT cell- and Treg-mediated protection against GVHD in mice while maintaining graft anti-tumor activity. In addition, we also examine the interactions between NKT cells and Treg in the context of BMT, and integrate the data from murine experimental models with the obse...
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PMID: 20583031
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
We observed that females receiving unfractionated DBA splenocytes (CD8 intact --> F1) exhibited greater clinical and histological severities of renal disease at 13 weeks compared to males. Surprisingly, sex-based differences in renal disease severity were lost in CD8 depleted --> F1 mice due to an i...
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PMID: 20451460
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
Our present studies show that B cells require "nurturing" by CD4 T cells through much of their ontogeny in order to respond to allo-signaling and become autoreactive. The nurturing process does not require antigen-specific cognate interactions between CD4 T cells and B cells. It is mediated by IL-4,...
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PMID: 20381429
PDF is available here.
PDF is available here.
Abstract
Pharmacological study is predictably effective in establishing an optimal monitoring strategy for the usage of cyclosporine A (CsA) to prevent graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation recipients. Pharmacokinetic profiling of 33 recipients administered Cs...
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PMID: 20533008
PDF is available here.
PDF is available here.
Abstract
We have reported two cases of the patients with acute steroid-refractory GVHD who underwent allogeneic HSCT. These patients received infusions of third-party clonal mesenchymal stem cells (cMSCs), which were isolated by a subfractionation culturing method (SCM) developed recently by our group, and s...
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PMID: 20514533
PDF is available here.
PDF is available here.
Abstract
These results suggest that graft-versus-T-cell lymphoma activity is responsible for long-term disease control....
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PMID: 20507311
PDF is available here.
PDF is available here.
Abstract
We retrospectively analyzed 226 adult AML CR1 patients undergoing myeloablative unrelated donor (URD) (10/10 match, n=62; 9/10, n=29) or MRD (n=135) HCT from 1996 to 2007. The 5-year estimates of overall survival, relapse and nonrelapse mortality (NRM) were 57.9, 29.7 and 16.0%, respectively. Failur...
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PMID: 20485378
PDF is available here.
PDF is available here.
Intensive Care Medicine (36)7 2010
Abstract
Abstract
Over time, ocular GvHD developed in 54% of patients and consisted mainly of dry eyes and conjunctivitis, which increased in severity during follow-up; blepharitis and uveitis were less often encountered. Acute systemic GvHD, especially the involvement of mouth and skin, was strongly associated with...
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PMID: 20489577
PDF is available here.
PDF is available here.
Abstract
We conclude that PCR-guided modulation of IS may play a role in early intervention for EBV-PTLD and a prospective, randomized study is needed....
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PMID: 20463647
PDF is available here.
PDF is available here.
Journal of Immunology (184)12 2010
Abstract
We have recently observed a new role for NK cells in the control of the proliferation of CD4 T cells under persistent antigenic stimulation. Monoclonal anti-male CD4 T cells transferred into Rag2-/- male recipients did not expand or were rapidly eliminated. Remarkably, T cells transferred into NK ce...
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PMID: 20488796
PDF is available here.
PDF is available here.
Medical Mycology (48)4 2010
Abstract
We report a false-positive case for both galactomannan (GM) antigenemia and Aspergillus PCR due to nutritional supplement intake in a bone marrow transplant recipient with digestive graft-versus-host disease. Our case report also suggests that fungal DNA can pass into the serum from the intestinal t...
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PMID: 20392146
PDF is available here.
PDF is available here.
Abstract
Rinsho Ketsueki (51)6 2010
Abstract
We retrospectively surveyed patients who received a second transplantation for graft failure (GF) after allogeneic hematopoietic stem cell transplantation (SCT) in hospitals participating in the Kanto Study Group for Cell Therapy. A second SCT was performed in 21 of 45 patients with primary GF and i...
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PMID: 20622484
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)6 2010
Abstract
These results strongly suggest that Vbeta2T cells, derived from the first donor, may have been cytotoxic lymphocytes against both leukemic cells and cord blood stem cells....
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PMID: 20622488
PDF is available here.
PDF is available here.
Abstract
We demonstrate that alloreactive CD8(+) T(E) rapidly diminished in vivo when adoptively transferred into irradiated secondary congenic recipient mice. In contrast, although alloreactive CD8(+) T(E) underwent massive apoptosis upon chronic exposure to alloantigens, they proliferated in vivo in second...
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PMID: 20116439
PDF is available here.
PDF is available here.
Abstract
Journal of the Neurological Sciences (292)1-2 2010
Abstract
We report on a female allogeneic bone marrow transplanted patient who developed GBS as a leading manifestation of GvHD subsequent to discontinuation of her immunosuppressive medication with cyclosporine. In contrast to former case reports both IVIg and plasma exchange failed while resumption of immu...
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PMID: 20163810
PDF is available here.
PDF is available here.
Abstract
Mesenchymal stem cells (MSC) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple mesenchymal tissues. MSC are able to reconstitute the functional human hematopoietic microenvironment and promote engraftment of hematopoietic stem cells. MSC constitutively exp...
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PMID: 20490429
PDF is available here.
PDF is available here.
Abstract
In vitro and in vivo preclinical studies and phase I/II clinical trials have demonstrated that the retroviral-mediated transfer of the suicide gene HSV-thymidine kinase into donor T-cells prior to infusion (ie, a 2-week ex vivo process including activation, retroviral transduction and selection of t...
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PMID: 20419602
PDF is available here.
PDF is available here.
Oncology Nursing Forum (37)3 2010
Abstract