Philipp A Lang,
Mike Recher,
Nadine Honke,
Stefanie Scheu,
Stephanie Borkens,
Nicole Gailus,
Caroline Krings,
Andreas Meryk,
Andreas Kulawik,
Luisa Cervantes-Barragan,
Nico Van Rooijen,
Ulrich Kalinke,
Burkhard Ludewig,
Hans Hengartner,
Nicola Harris,
Dieter Häussinger,
Pamela S Ohashi,
Rolf M Zinkernagel and
Karl S Lang
Abstract
We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrated that Kupffer cells are essential for the efficient capture of infectious virus and for preventing viral replication. The latter process invol...
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PMID: 20578253
PDF is available here.
Abstract
This study demonstrated that long-term (18-month) zinc supplementation at nutritional levels delayed immunological failure and decreased diarrhea over time. This evidence supports the use of zinc supplementation as an adjunct therapy for HIV-infected adult cohorts with poor viral control. Trial regi...
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PMID: 20455705
PDF is available here.
Abstract
Mean postoperative follow-up was similar for both cases (18.6 +/- 6.6 months) and controls (18.4 +/- 8.7 months). Preoperative CT and endoscopy scores (i.e., disease severity) were similar in both cases and controls. Postoperative endoscopy scores were significantly improved for both cases (p < 0.00...
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PMID: 20537292
PDF is available here.
Yufang Shi,
Gangzheng Hu,
Juanjuan Su,
Wenzhao Li,
Qing Chen,
Peishun Shou,
Chunliang Xu,
Xiaodong Chen,
Yin Huang,
Zhexin Zhu,
Xin Huang,
Xiaoyan Han,
Ningxia Xie and
Guangwen Ren
Abstract
We showed that there is a species variation in the mechanisms of MSC-mediated immunosuppression: immunosuppression by cytokine-primed mouse MSCs is mediated by nitric oxide (NO), whereas immunosuppression by cytokine-primed human MSCs is executed through indoleamine 2, 3-dioxygenase (IDO). Additiona...
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PMID: 20368733
PDF is available here.
Abstract
We describe the recent progress made in exploring the biological function of ISG15 and its reversible modification of target proteins and thus in their implication in immune diseases.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20153823
PDF is available here.
Abstract
The 2010 American Academy of Allergy, Asthma and Immunology (AAAAI) meeting, held in New Orleans, included topics covering new therapeutic developments in the fields of allergy, asthma and immunological diseases. This conference report highlights selected presentations on potential treatments for fo...
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PMID: 20432184
PDF is available here.
Abstract
The median follow-up of the patients was 6.2 years, and median overall survival was 5.3 years. Twenty-four patients (5.3%) developed MDS with median time of onset of 4.2 years (range, 8 months to 7.5 years). An additional 5 patients developed clonal karyotypic abnormalities in the bone marrow withou...
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PMID: 20371446
PDF is available here.
Abstract
The precise mechanisms whereby gastro-oesophageal reflux disease causes reflux oesophagitis and Barrett's oesophagus are not clear, even though these diseases have been known to be linked for many years. Recent studies indicate a role for the reflux-induced inflammatory response of oesophageal squam...
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PMID: 20298181
PDF is available here.
Abstract
We have already shown that Thymosin alpha1 (Talpha1), a naturally occurring thymic peptide first described and characterized by Allan Goldstein in 1972, by modulating signals delivered through innate immune receptors on dendritic cells, affects adaptive immune responses via modulation of Th cell eff...
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PMID: 20536444
PDF is available here.
Abstract
We present an overview of Z-DNA and known ZBPs as drug targets, and summarize recent progress in the structure-based identification of ZBP inhibitors....
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PMID: 20210758
PDF is available here.
Abstract
We would like to call attention to a different application of a special group of adult stem cells, the stromal cells in the bone marrow (also called mesenchymal stem cells or MSCs). These cells have been discovered to modulate immune function. They can easily be expanded in culture and surprisingly,...
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PMID: 19656313
PDF is available here.
Abstract
We would like to call attention to a different application of a special group of adult stem cells, the stromal cells in the bone marrow (also called mesenchymal stem cells or MSCs). These cells have been discovered to modulate immune function. They can easily be expanded in culture and surprisingly,...
|
PMID: 19656313
PDF is available here.
Abstract
We would like to call attention to a different application of a special group of adult stem cells, the stromal cells in the bone marrow (also called mesenchymal stem cells or MSCs). These cells have been discovered to modulate immune function. They can easily be expanded in culture and surprisingly,...
|
PMID: 19656313
PDF is available here.
Abstract
We would like to call attention to a different application of a special group of adult stem cells, the stromal cells in the bone marrow (also called mesenchymal stem cells or MSCs). These cells have been discovered to modulate immune function. They can easily be expanded in culture and surprisingly,...
|
PMID: 19656313
PDF is available here.
Philipp A Lang,
Mike Recher,
Nadine Honke,
Stefanie Scheu,
Stephanie Borkens,
Nicole Gailus,
Caroline Krings,
Andreas Meryk,
Andreas Kulawik,
Luisa Cervantes-Barragan,
Nico Van Rooijen,
Ulrich Kalinke,
Burkhard Ludewig,
Hans Hengartner,
Nicola Harris,
Dieter Häussinger,
Pamela S Ohashi,
Rolf M Zinkernagel and
Karl S Lang
Abstract
We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrated that Kupffer cells are essential for the efficient capture of infectious virus and for preventing viral replication. The latter process invol...
|
PMID: 20578253
PDF is available here.
Abstract
We identified a mixture of probiotics that up-regulates CD4(+)Foxp3(+) regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced gener...
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PMID: 20080669
PDF is available here.
Abstract
We will discuss current platforms that report on E3 ligase activity and can detect E3 inhibitors, and underline the advantages and disadvantages of each approach....
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PMID: 20074047
PDF is available here.
Abstract
The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carr...
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PMID: 20044880
PDF is available here.
Abstract
We critically analyze recent literature on the efficacy and safety of biologics in the management of rheumatoid arthritis, psoriasis, psoriatic arthritis and immune thrombocytopenia. Our analysis of benefits, resistance to the therapy, risk of infections, tumors and other serious complications relat...
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PMID: 20393640
PDF is available here.
Abstract
Modem immunopathogenetic concepts of tuberculosis infection are summarized. Th1-mediated immune response is shown to play a leading role in the formation of antituberculosis immunity. Cytokine balance (especially that of interferon-y) has marked influence on the outcome of infection....
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PMID: 21395021
PDF is available here.
Abstract
We have proposed several models to study this fact. The established models of premature aging have been mice and humans with poor response to stress and anxiety versus subjects of the same chronological age without that characteristic, isolation, males versus females, menopausal models (in rodents a...
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PMID: 20134206
PDF is available here.