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Abstract
We evaluated the cross-reactivity of recombinant 56-kD proteins from Karp, Kato, Gilliam, TA763, and three chimeric 56-kD proteins. Not all r56s are equally reactive with strain-specific serum samples. These data provide a first glance of how reactive these r56s are toward the antiserum of different...
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PMID: 21633035
PDF is available here.
PDF is available here.
Abstract
We evaluated 12 DNA extraction methods and developed a highly sensitive protocol for mycobacterial DNA extraction directly from sputa using surface-coated magnetic particles. We have also developed a novel multiplex real-time PCR for simultaneous identification of M. tuberculosis complex and the Bei...
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PMID: 21593264
PDF is available here.
PDF is available here.
Abstract
The present research focused on the development of an immunoassay and an immunochemical sol-gel-based immunoaffinity purification (IAP) method for purification and detection of the non-steroid anti-inflammatory drug (NSAID) indomethacin (IMT). A polyclonal antibody (Ab) for IMT was g...
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PMID: 21537913
PDF is available here.
PDF is available here.
Tropical biomedicine (28)1 2011
Abstract
A flow through assay (FTA) was developed on cellulose acetate membrane for the serodiagnosis of porcine cysticercosis using cyst fluid (CFA) and whole cyst antigens (WCA) of Taenia solium metacestode. The assay consisted of antigen of T. solium metacestode coated onto membrane, mounted on a flow-thro...
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PMID: 21602782
PDF is available here.
PDF is available here.
Abstract
Although pecans are associated with IgE-mediated food allergies, the allergens responsible remain to be identified and characterized. The 2S albumin gene was amplified from the pecan cDNA library. Dot-blots were used to screen the recombinant protein with pecan allergic patients' serum. The affinity...
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PMID: 21395309
PDF is available here.
PDF is available here.
Molecular Therapy (19)3 2011
Abstract
We demonstrate that potent mucosal and systemic immune responses, both cellular and humoral, are induced by intranasal immunization using formulated DNA. We show that formulation with the DNA carrier polyethylenimine (PEI) improved by a 1,000-fold the efficiency of gene transfer in the respiratory t...
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PMID: 20959813
PDF is available here.
PDF is available here.
Abstract
Inactivated influenza virus vaccine prepared from a non-pathogenic influenza virus strain A/duck/Hokkaido/Vac-1/2004 (H5N1) from the virus library conferred protective immunity to chickens against the challenge of antigenically drifted highly pathogenic avian influenza virus (HPAIV),...
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PMID: 21476487
PDF is available here.
PDF is available here.
Abstract
We applied here a Bayesian selectivity model to predict hundreds of human PDZ domain interactions, using target sequences of 22,997 non-redundant proteins. Subsequent analysis of these binding scores shows that PDZs can be divided into two genome-wide clusters that coincide well with the division be...
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PMID: 21283644
PDF is available here.
PDF is available here.
Abstract
The newly developed H3-RT-LAMP assay is simple, sensitive, rapid and can identify H3 subtype AIVs visually. Consequently, it will be a very useful screening assay for the surveillance of H3 subtype AIVs in underequipped laboratories as well as in field conditions....
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PMID: 21729297
PDF is available here.
PDF is available here.
Abstract
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (Fusion protein), Rabies virus...
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PMID: 21483777
PDF is available here.
PDF is available here.
Acta clinica Belgica (66)1 2011
Abstract
We subsequently screened our database on patients with positive VIDAS Lyme screening and negative confirmatory testing by Western blot, and found another 5 cases in which Lyme screening was false positive due to cross-reactivity with Treponema pallidum antibodies. Our data show that in patients with...
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PMID: 21485767
PDF is available here.
PDF is available here.
Abstract
The detection of bacterial signaling molecules in liquid or gaseous environments has been occurring in nature for billions of years. More recently, man-made materials and systems has also allowed for the detection of small molecules in liquid or gaseous environments. This chapter will outline some e...
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PMID: 21031306
PDF is available here.
PDF is available here.
Abstract
Abstract
We compared the antibodies against serotypes 19F and 19A induced naturally and after vaccination with different pneumococcal conjugate vaccines. We found that conjugation of the 19F polysaccharide using reductive amination (as in 7vCRM) resulted in the formation of at least one additional epitope th...
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PMID: 21123523
PDF is available here.
PDF is available here.
Abstract
Abstract
To consider how the different distribution of house dust mites and their species in different geographical locations affects the allergens in the environment and their use.
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PMID: 21337903
PDF is available here.
PDF is available here.
Abstract
We have studied lupus AAbs that bind dsDNA and cross-react with the NR2A and NR2B subunits of the NMDA receptor (NMDAR). In adult mouse models, when the blood-brain barrier is compromised, these NMDAR-reactive AAbs access the brain and elicit neuronal death with ensuing cognitive dysfunction and emo...
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PMID: 20921396
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)41 2010
Abstract
Cancer Research (70)20 2010
Abstract
We show that ADAM9-S promotes breast cancer cell migration in a manner requiring its metalloproteinase activity, whereas ADAM9-L suppresses cell migration independent of its metalloproteinase activity. Suppression of migration by ADAM9-L requires a functional disintegrin domain and integrin binding....
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PMID: 20736367
PDF is available here.
PDF is available here.
Abstract
We have developed a single 17-residue peptide immunogen that generates antibodies that target the receptor-binding domain of the type IV pilus of more than one strain of P. aeruginosa. Using the receptor-binding domain sequence, of native strain PAO as a template, we have systematically changed up...
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PMID: 20807222
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
We sought to assess the allergenic potential of red gram by identifying and characterizing the responsible proteins. Immunoblotting was performed to detect IgE binding proteins. Identities of these proteins were confirmed by mass spectrometry. To evaluate allergenic potential, BALB/c mice were sensi...
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PMID: 20600518
PDF is available here.
PDF is available here.
Abstract
In a previous work, the immunolocation of the chickpea XTH1 (xyloglucan endotransglucosylase/hydrolase 1) protein in the cell walls of epicotyls, radicles, and stems was studied, and a role for this protein in the elongation of vascular cells was suggested. In the present work, the presence and the...
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PMID: 20643805
PDF is available here.
PDF is available here.
Abstract
Component resolved diagnostics introduces new possibilities regarding diagnosis of allergic diseases and individualized, allergen-specific treatment. Furthermore, refinement of IgE-based testing may help elucidate the correlation or lack of correlation between allergenic sensitization and allergic d...
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PMID: 20628838
PDF is available here.
PDF is available here.
Abstract
We sought to identify potential CD4+ T cell epitopes and predict the level of cross-reactivity of responding T cells. By performing large-scale major histocompatibility complex II analyses on Hemagglutinin (HA) proteins, we investigated the degree of T-cell cross-reactivity between seasonal influenz...
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PMID: 20716156
PDF is available here.
PDF is available here.
FEBS Journal (277)18 2010
Abstract
It has long been an important task to prepare a catalytic antibody capable of digesting a targeting crucial protein that controls specific life functions. Tumor necrosis factor-α (TNF-α) is a cytokine and an important molecule concerned with autoimmune diseases such as rheumatoid a...
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PMID: 20718866
PDF is available here.
PDF is available here.
Abstract
Abstract
We identified a continuous epitope (55)WIRNNF(60) that was recognized by MAb N2C3. Subsequent studies found that this MAb could recognize several different strains of Noroviruses, not just GII/4. In the present study, we used homology modeling to confirm that the epitope of N2C3 was exposed on the s...
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PMID: 20417671
PDF is available here.
PDF is available here.
Abstract
We have generated a panel of novel monoclonal antibodies (MAbs) against VLY. For the generation of MAbs, we have used recombinant VLY expressed in Escherichia coli. The functional activity of recombinant VLY was confirmed by an in vitro hemolytic assay using human erythrocytes. The MAbs raised again...
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PMID: 20298711
PDF is available here.
PDF is available here.
Analytical Biochemistry (405)1 2010
Abstract
I molecule, and (iv) use of a fragment of the target molecule. A total of 10 haptens were used to generate immunogens, coating antigens, and polyclonal antibodies. One of the heterologous ELISAs developed exhibited an IC(50) of 1.6 ng/ml, a limit of detection (LOD) of 0.03 ng/ml, and a dynamic range...
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PMID: 20522332
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
From 1963 to 1986, human enterovirus 71 (HEV71) infections in the Netherlands were successively caused by viruses of subgenogroups B0, B1 and B2. A genogroup shift occurred in 1987, after which viruses of subgenogroups C1 and C2 were detected exclusively. This is in line with HEV71 typing in Austral...
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PMID: 20375223
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
The spread of the recently emerged, highly pathogenic H5N1 avian influenza virus has raised concern. Preclinical studies suggest that passive immunotherapy could be a new form of treatment for H5N1 virus infection. Here, a neutralizing monoclonal antibody (MAb) against the hemagglutinin (HA) of the...
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PMID: 20519402
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that the sequence of vaccination affects the expansion of cross-reactive CD8(+) T cells after heterologous chimeric flavivirus challenge....
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PMID: 20536361
PDF is available here.
PDF is available here.
Abstract
We used knowledge of HIV-1 envelope (Env) structure to develop antigenically resurfaced glycoproteins specific for the structurally conserved site of CD4 receptor binding. These probes were used to identify sera with NAbs to the CD4-binding site (CD4bs) and to isolate individual B cells from such an...
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PMID: 20616233
PDF is available here.
PDF is available here.
Abstract
Abstract
I interferons, IFN-tau has demonstrated promising antiviral activity against human viral infections in vitro. Additionally, it displays high species cross-reactivity despite its absence in humans. To date, IFN-tau has shown efficacy in reducing replication of human immunodeficiency virus, feline imm...
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PMID: 20626290
PDF is available here.
PDF is available here.
Abstract
Schistosoma mansoni ATP diphosphohydrolase isoforms and potato apyrase share conserved epitopes. By enzyme-linked immunosorbent assays, elevated levels of IgM, IgG2a and IgG1 antibody reactivity against potato apyrase were observed in S. mansoni-infected BALB/c mice during the acute phase of infecti...
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PMID: 20721478
PDF is available here.
PDF is available here.
Abstract
We showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses f...
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PMID: 20721477
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
We demonstrate that the bulk memory cytotoxic T lymphocytes (CTLs) established by seasonal influenza viruses from healthy individuals who have not been exposed to pdmH1N1 can directly lyse pdmH1N1-infected target cells and produce gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alp...
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PMID: 20410263
PDF is available here.
PDF is available here.
Veterinary Record (166)26 2010
Abstract
An indirect ELISA based on a soluble extract of Besnoitia besnoiti tachyzoites was developed and standardised. A set of positive and negative reference bovine sera were characterised using an immunofluorescence antibody test and Western blot. A cut-off with a relative index per cent of 8.1 was deter...
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PMID: 20581359
PDF is available here.
PDF is available here.
Abstract
We describe that the failure of commercially available H5 poultry vaccines in Egypt may be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppresse...
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PMID: 20534457
PDF is available here.
PDF is available here.
Veterinary Record (166)24 2010
Abstract
Abstract
Tumour necrosis factor alpha (TNF-alpha) is an innate pro-inflammatory cytokine involved in protection against intracellular pathogens. Existing methods for measuring TNF-alpha production and function in ruminants are limited to ELISA and many rely on polyclonal antisera. With a view to developing i...
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PMID: 20207016
PDF is available here.
PDF is available here.
Abstract
Most, but not all, patients with EE are highly atopic individuals with frequent allergic sensitivities. Thus, serum IgE measurement of low-titer IgE antibody may be useful in identifying relevant food sensitivities and in distinguishing subgroups of patients with EE, making a more directed approach...
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PMID: 20568382
PDF is available here.
PDF is available here.
Analytical Biochemistry (401)1 2010
Abstract
We present a new application of the noncompetitive phage anti-immunocomplex assay (PHAIA) by converting an existing competitive assay to a versatile noncompetitive sandwich-type format using immunocomplex binding phage-borne peptides to detect the brominated flame retardant, brominated diphenyl ethe...
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PMID: 20152791
PDF is available here.
PDF is available here.
Abstract
In the past decade, enterovirus 71 (EV71) and chikungunya (CHIK) virus have re-emerged periodically causing serious public health problems in Malaysia, since their first emergence in 1997 and 1998 respectively. This study demonstrates that CHIK virus causes similar patterns of cytopathic effect in c...
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PMID: 20614726
PDF is available here.
PDF is available here.
Abstract
Thus, p-ANCAs in autoimmune liver diseases are directed against human TBB-5 cross-reacting with the bacterial protein FtsZ, probably reflecting an abnormal immune response to intestinal microorganisms in susceptible, possibly genetically predisposed individuals....
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PMID: 19951907
PDF is available here.
PDF is available here.
Abstract
Fast migrating cerebrosides (FMC) are derivatives of galactosylceramide (GalCer). The structures of the most hydrophobic FMC-5, FMC-6, and FMC-7 were determined by electrospray ionization linear ion-trap mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy complementing previous N...
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PMID: 20154333
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 6 2010
Abstract
Advax is a polysaccharide-based adjuvant that potently stimulates vaccine immunogenicity without the increased reactogenicity seen with other adjuvants. This study investigated the immunogenicity of a novel Advax-adjuvanted Vero cell culture candidate vaccine against Japanese encephalitis virus (JEV...
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PMID: 20130134
PDF is available here.
PDF is available here.
Journal of Infectious Diseases (201)11 2010
Abstract
Humoral responses against the adjuvanted 3.75-microg hemagglutinin antigen vaccines from both manufacturing sites fulfilled European and US licensure criteria for immunogenicity for influenza vaccines....
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PMID: 20423222
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Two genotypes of porcine circovirus (PCV) have been described, the non-pathogenic PCV1 and the pathogenic PCV2 in pigs. PCV-ORF1 encodes Rep and Rep' proteins which have identical N-terminal sequence (RepN) within each PCV strain, but RepN has only 88% similarity between PCV1 and PCV2. Purified RepN...
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PMID: 20152863
PDF is available here.
PDF is available here.
Abstract
Two or more positive reactions were seen in 411 patients (33.3%). Sensitizations to eight pairs of allergens were found to have significant correlation (P
PDF is available here.
PDF is available here.
Clinica Chimica Acta (411)9-10 2010
Abstract
The antibody used for this ELISA had the same cross-reactivity with MT in humans and experimental animals. NH2 terminal peptide of MT with acetylated methionine was proved to be the epitope of this antibody. The reactivity of this ELISA system with liver, kidney and brain in MT1/2 knock-out mice was...
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PMID: 20184868
PDF is available here.
PDF is available here.
Abstract
The absence of preexisting immunity against porcine adenovirus (Ad) serotype 3 (PAd3) and bovine Ad serotype 3 (BAd3) in humans makes them attractive alternatives to human Ad serotype 5 (HAd5) vectors. To determine whether there is significant cross-reactivity among HAd5, BAd3 and PAd3 at the level o...
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PMID: 20164856
PDF is available here.
PDF is available here.
Abstract
We expressed three different MCV VP1 in insect cells using recombinant baculoviruses. Viruslike particles (VLPs) were obtained with only one of the three VP1 genes. High-titer antibodies against VP1 VLPs were detected in mice immunized with MCV VLPs, and limited cross-reactivity was observed with BK...
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PMID: 20181914
PDF is available here.
PDF is available here.
Der Hautarzt (61)5 2010
Abstract
We present the case of a 30-year-old LTP-sensitized Spanish woman with a history of severe anaphylactic reaction to grapes, apple and cauliflower in which the detection of specific IgE against the recombinant protein Pru p 3 led to the diagnosis....
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PMID: 20390241
PDF is available here.
PDF is available here.
Medical Science Monitor (16)5 2010
Abstract
Although the three EIA tests for anti-B19 IgM detection showed good parameters for the differential diagnosis of measles/rubella, tests with a high specificity should be used....
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PMID: 20424545
PDF is available here.
PDF is available here.
Abstract
Lupus nephritis (LN) remains the most common severe manifestation of systemic lupus erythematosus (SLE) characterized by the presence of autoantibodies (Abs) that are believed to play a central role in the pathogenesis of LN. Among more than 100 Abs reported in SLE, only a few display a direct glomer...
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PMID: 20414746
PDF is available here.
PDF is available here.