Abstract
We studied alterations of the inflammatory response in relation to neurohormonal patterns after neurosurgery for seizure.
Nine patients were studied before, during and immediately after operation, and then on days 1, 2 and 4 post-operatively. Monocyte HLA-DR (mHLA-DR) expression and plasma interleuk...
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PMID: 20613687
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Abstract
We review the importance of pretransplantation host conditioning and posttransplantation strategies that have been shown to contribute to the therapeutic efficacy of infused T lymphocytes....
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PMID: 20201627
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Abstract
Streptococcus suis is an important pathogen in swine, and it also represents an emerging zoonotic agent. Zebrafish as a model for the evaluation of virulence of S. suis has been demonstrated before. Here, an Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafi...
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PMID: 20206250
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Abstract
The level of IFN production from splenocytes stimulated with rFPV(LP)-delta73LRH5A and rFPV(LP)-delta214LRH5A was significantly higher than that with rFPV(LP)-12LSH5A in vitro, whereas the ratio of CD4+/CD8+ T lymphocyte in rFPV(LP)-delta73LRH5A and rFPV(LP)-delta214LRH5A groups was significantly lo...
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PMID: 20560355
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Abstract
OBJECTIVE: To prepare an O/W ginseng saponins-based nanoemulsion and investigate its amplified immune response. METHOD: The formulation of ginseng saponins-based nanoemulsion was optimized via the range of nanoemulsion zone in phase diagrams and the solubility of ginseng saponins. Its physicochemica...
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PMID: 20450041
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Abstract
We show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-beta (IFN-beta). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS t...
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PMID: 19701189
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Abstract
We analyzed its effect in Arabidopsis (Arabidopsis thaliana) plants following leaf infiltration. CB activates the salicylic acid (SA)-mediated signaling pathway, while the CB ferric complex is ineffective, suggesting that the elicitor activity of this siderophore is due to its iron-binding property....
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PMID: 19448037
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Shehnaz K Hussain,
Li-Na Mu,
Lin Cai,
Shen-Chih Chang,
Sungshim Lani Park,
Sam S Oh,
Yiren Wang,
Binh Y Goldstein,
Bao-Guo Ding,
Qingwu Jiang,
Jianyu Rao,
Nai-Chieh Y You,
Shun-Zhang Yu,
Jeanette C Papp,
Jin-Kou Zhao,
Hua Wang and
Zuo-Feng Zhang
Abstract
We conducted a population-based case-control study including 196 incident stomach cancer cases and 397 matched controls to test the hypothesis that adverse single nucleotide polymorphism (SNP) genotypes and haplotypes within genes of the DNA repair and immune regulatory pathways are associated with...
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PMID: 19661089
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Abstract
The fusion U-M and M protein expressions were verified in transfected BHK-21 cells by indirect fluorescence assay. Furthermore, both pVAX1-M and pVAX1-U-M induced specific humoral and cellar immune responses against PRRSV in the recombinant plasmid injected mice. However, pVAX1-U-M was able to induc...
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PMID: 19673417
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Abstract
We aim to summarize current hypotheses concerning the complex cellular and molecular interactions involved in the immunopathology of MS. Although CD4+ T lymphocytes have long been implicated in the immunopathology of MS, the role of other T-cell subtypes has been recognized. CD4+ and CD8+ cells have...
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PMID: 19483479
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Abstract
Lower survival among men following CAP was not explained by differences in chronic diseases, health behaviors, and quality of care. Patterns of inflammatory, coagulation, and fibrinolysis biomarkers among men may explain reduced short-term and long-term survival....
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PMID: 19325487
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Abstract
The results showed that pigs in the groups given higher immunizing dose were developed higher levels HI antibody. All of vaccinated intramuscularly, intragastric administration and intranasal inoculation could produce HI antibody, but the titer of vaccinated intramuscularly was higher significantly...
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PMID: 19637575
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Abstract
The patients with AS had severe active AS with Bath AS Disease Activity Index 5.5 (+/-1.6) and C-reactive protein (mg/l) 13.8 (+/-12.2) (mean+/-standard deviation). IL-10 concentrations in ex vivo assay supernatants were lower in the AS group compared with controls (p=0.047). There were no statistic...
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PMID: 19228651
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Abstract
Prolactin inducible protein (PIP) is a 17- kDa single polypeptide chain, known by various names due to its versatile nature and function in human reproductive and immunological systems. It is expressed in several exocrine tissues such as the lacrimal, salivary, and sweat glands. Its expression is up...
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PMID: 18854942
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Abstract
We cloned and sequenced all three classical opioid receptors (MOR, DOR and KOR) in common carp, and studied changes in their expression during stress and immune responses. Messenger RNA of opioid receptors was constitutively expressed in brain areas, specially in the preoptic nucleus NPO (homologous...
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PMID: 18977430
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Abstract
Efficient T-cell adaptive immune response require a faultless coordination between migration of naive T-cells into secondary lymphoid organs and critical biological outcomes driven by antigen such as cell division and cell differentiation into effector and memory cells. Recent works have shown that...
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PMID: 20429412
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Abstract
We examine the functional requirements of two-photon imaging instruments necessary for such immune studies. These requirements include frame rate, spatial resolution and the number of emission channels. We use this discussion as a starting point to compare commercial systems and to introduce a custo...
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PMID: 19521679
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Abstract
In the overview it is shown that immune response to ionizing radiation exposure is determined not only by dose and dose rate, as was believed earlier, but also by a complex of factors (individual's age at exposure, genetic status, etc.). The emphasis in the overview is made on analyses of factors of...
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PMID: 19947514
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Abstract
This article demonstrates how the oral biofilm functions and the effects this biofilm has on the host immune system. Various components of the oral biofilm affect the immune system through a variety of ways with a resulting systemic inflammatory response. Treatment of the biofilm is an integral aspe...
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PMID: 19263762
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Vilma Urbonaviciute,
Barbara G Fürnrohr,
Silke Meister,
Luis Munoz,
Petra Heyder,
Francesco De Marchis,
Marco E Bianchi,
Carsten Kirschning,
Hermann Wagner,
Angelo A Manfredi,
Joachim R Kalden,
Georg Schett,
Patrizia Rovere-Querini,
Martin Herrmann and
Reinhard E Voll
Abstract
We demonstrate that HMGB1 remains bound to nucleosomes released from late apoptotic cells in vitro. HMGB1-nucleosome complexes were also detected in plasma from SLE patients. HMGB1-containing nucleosomes from apoptotic cells induced secretion of interleukin (IL) 1beta, IL-6, IL-10, and tumor necrosi...
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PMID: 19064698
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Denis Gaucher,
René Therrien,
Nadia Kettaf,
Bastian R Angermann,
Geneviève Boucher,
Abdelali Filali-Mouhim,
Janice M Moser,
Riyaz S Mehta,
Donald R Drake,
Erika Castro,
Rama Akondy,
Aline Rinfret,
Bader Yassine-Diab,
Elias A Said,
Younes Chouikh,
Mark J Cameron,
Robert Clum,
David Kelvin,
Roland Somogyi,
Larry D Greller,
Robert S Balderas,
Peter Wilkinson,
Giuseppe Pantaleo,
Jim Tartaglia,
Elias K Haddad and
Rafick-Pierre Sékaly
Abstract
We have used functional genomics and polychromatic flow cytometry to define the signature of the immune response to the yellow fever (YF) vaccine 17D (YF17D) in a cohort of 40 volunteers followed for up to 1 yr after vaccination. We show that immunization with YF17D leads to an integrated immune res...
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PMID: 19047440
PDF is available here.
Abstract
We used a mouse model of Parkinson disease in which human alpha-SYN is overexpressed by a recombinant adeno-associated virus vector, serotype 2 (AAV2-SYN); this overexpression leads to slow degeneration of dopaminergic neurons. Microglial activation and components of the adaptive immune response wer...
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PMID: 19018246
PDF is available here.
Abstract
This study shows that tolerogenic presentation of cFVIII to the immune system can significantly reduce immunogenicity of the protein....
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PMID: 18826393
PDF is available here.
Abstract
We present the cumulative evidence implicating GRP in bronchopulmonary dysplasia (BPD), the chronic lung disease of premature infants who survive acute respiratory distress syndrome. The availability of well-characterized animal models of BPD was a critical tool for demonstrating that GRP plays a di...
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PMID: 19076373
PDF is available here.
Abstract
Patients with different forms of multiple sclerosis were treated with a vaccine consisting of myelin-reactive T cells. It was found that after this treatment, lymphocytes from patients acquired the capacity to generate antiidiotypic proliferative response directed towards myelin-reactive T cells. Th...
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PMID: 19145371
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Fabien Reyal,
Martin H van Vliet,
Nicola J Armstrong,
Hugo M Horlings,
Karin E de Visser,
Marlen Kok,
Andrew E Teschendorff,
Stella Mook,
Laura van 't Veer,
Carlos Caldas,
Remy J Salmon,
Marc J van de Vijver and
Lodewyk F A Wessels
Abstract
The study revealed that the nine signatures perform similarly but exhibit a large degree of discordance in prognostic group assignment. Functional analyses indicate that proliferation is a common cellular process, but that other functional categories are also enriched and show independent prognostic...
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PMID: 19014521
PDF is available here.