The hygiene hypothesis was proposed more than two decades ago, but its mechanism remains unclear. This review focuses on recent advances in the field, especially on the role played by dendritic cells (DCs) and their modulating effects on various infections and allergic diseases, incl... | PMID: 21200379

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PMID: 20842801

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Over the past few decades, our expanding knowledge of the mammalian immune system - how it is developed, activated, and regulated - has fostered hope that it may be harnessed in the future to successfully treat human cancer. The immune system activated by cancer vaccines may have the unique ability... | PMID: 20217561

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Our combination models to study the balance between thyroid autoimmunity and tumor immunity upon regulatory T-cell perturbation are briefly described.... | PMID: 20146718

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I review the advantages, disadvantages, and perspective of employing the RNAi procedure in the brain. Given that the disadvantages of RNAi can be overcome, the clinical application of RNAi technologies may be useful in realizing the elimination of pathogenic genes not only in the brain, but also in... | PMID: 20217560

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PMID: 19811431

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PMID: 19811430

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This paper presents a novel evolutionary algorithm inspired by protein/substrate binding exploited in enzyme genetic programming (EGP) and artificial immune networks. The immune network-inspired evolutionary algorithm has been developed in direct response to an application in clinical neurology, the... | PMID: 18619513

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