Abstract
We report here the first comprehensive HCV customized biomedical text-mining based online web resource, dragon exploratory system on hepatitis C virus (DESHCV), a biomedical text-mining and relationship exploring knowledge base was developed by exploring literature on HCV. The pre-compiled dictionar...
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PMID: 21194573
PDF is available here.
Abstract
We present a large database of over 50,000 user-labeled videos collected from YouTube. We develop a compact representation called "tiny videos" that achieves high video compression rates while retaining the overall visual appearance of the video as it varies over time. We show that frame sampling us...
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PMID: 21252400
PDF is available here.
Abstract
This paper presents a semantic rule-based system for the composition of successful algorithmic pathways capable of solving medical computational problems (MCPs). A subset of medical algorithms referring to MCP solving concerns well-known medical problems and their computational algor...
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PMID: 21335316
PDF is available here.
Abstract
We face VO management services as part of the PMI supporting access control to healthcare resources inside the HSOA. In order to achieve a completely open and interoperable PMI, we review and apply standards of security and architectural design. Moreover, semantic technologies are introduced in deci...
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PMID: 21216720
PDF is available here.
Abstract
We will review the current status of the TP53 mutation database, its application to various fields of research, and how data quality and curation can be improved. We will also discuss how the genetic data will be stored and handled in the future and the consequences for database management....
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PMID: 21704230
PDF is available here.
Abstract
P-glycoprotein (P-gp) is one of the best characterized transporters responsible for the multidrug resistance (MDR) phenotype exhibited by cancer cells. Therefore, there is widespread interest in elucidating whether existing drugs are candidate P-gp substrates or inhibitors. With this...
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PMID: 21235729
PDF is available here.
Abstract
We give an overview of current technologies to study signal transduction. We argue that along with the opportunities the new technologies open, their heterogeneous nature poses critical challenges for data handling that are further increased when data are to be integrated in mathematical models. Eff...
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PMID: 21325202
PDF is available here.
Abstract
We propose a multi-centre, multinational approach to accelerate the data mining of large samples and facilitate data-led clinical translation of neuroimaging results in stroke. Such data-driven approaches are likely to have an early impact on clinically relevant brain recovery while we simultaneousl...
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PMID: 21175009
PDF is available here.
Abstract
Challenges exist in comparing foodborne disease outbreaks (FBDOs) across states due to important differences in reporting practices and investigations. Variables such as FBDO size, population size, number of tourists, and suspected etiology are important to consider when interpreting FBDO data. Anal...
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PMID: 20873527
PDF is available here.
Abstract
PubMed and Ichushi are the most common bibliographic databases used by clinicians and medical researchers in Japan. Searching for articles has been greatly facilitated by the development of the internet and electronic media. The use of reference management software and importing data from bibliograp...
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PMID: 20533740
PDF is available here.
Abstract
We address this issue by developing a framework for storing metadata in NIfTI for DWI (MiND). We utilize the standard NIfTI format extension mechanism to store essential DWI metadata in an extended header for multiple commonly-encountered DWI data structures. We demonstrate the utility of this appro...
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PMID: 20206274
PDF is available here.
Abstract
Many different public and private organizations from across the globe are collaborating on neglected diseases drug-discovery and development projects with the aim of identifying a cure for tropical infectious diseases. These neglected diseases collaborations require a global, secure, multi-organizat...
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PMID: 20443162
PDF is available here.
Abstract
Rational drug design relies on the 3D structures of biological macromolecules, with a particular emphasis on proteins. The structural genomics-based high-throughput structure determination platforms established by the Protein Structure Initiative (PSI) of the National Institute of General Medical Sc...
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PMID: 20443167
PDF is available here.
Abstract
Researchers investigating many areas of disease recognize the value of integrating large-scale genomic experiments across species and experimental methods. Analysis methods have been developed to make use of the breadth and depth of data from new technologies. Current paradigms of data storage, shar...
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PMID: 20443164
PDF is available here.
Abstract
Exchanging and sharing scientific results are essential for researchers in the field of computational modelling. BioModels.net defines agreed-upon standards for model curation. A fundamental one, MIRIAM (Minimum Information Requested in the Annotation of Models), standardises the ann...
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PMID: 19939940
PDF is available here.
Abstract
The Jackson Laboratory Colony Management System (JCMS) is a software application for managing data and information related to research mouse colonies, associated biospecimens, and experimental protocols. JCMS runs directly on computers that run one of the PC Windows operating systems, but can be acc...
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PMID: 20140675
PDF is available here.
Abstract
We propose the implementation of a distributed system based on a Wireless Sensor Network for the control of a chemical analysis system for fresh water. This implementation is presented by describing the nodes that form the distributed system, the communication system by wireless networks, control st...
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PMID: 20152412
PDF is available here.
Abstract
For all patients, mean A-CCI and R-CCI were 5.3 +/- 2.1 (range 2 - 11) and 5.4 +/- 2.1 (range 2 - 11), respectively. High correlation was found between A-CCI and R-CCI scores (r = 0.88, p < 0.01). The sensitivity of A-CCI was high (0.57 - 1.00) for nine comorbidities, but sensitivities for chronic p...
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PMID: 20178719
PDF is available here.
Abstract
This study aims to document a range of risk of psychiatric and physical comorbidities among PD patients using a nationwide population-based dataset in Taiwan.
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PMID: 20156213
PDF is available here.
Abstract
We designed an open-source system to meet these requirements. Based on the Apache-PHP-MySQL platform on a Linux server, the system allows multiple users to access the database from any location on the internet using a web browser, and requires no specialized computer skills. Multi-level security sys...
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PMID: 20192052
PDF is available here.
Abstract
Next Generation Sequencing technologies are limited by the lack of standard bioinformatics infrastructures that can reduce data storage, increase data processing performance, and integrate diverse information. HDF technologies address these requirements and have a long history of use in data-intensi...
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PMID: 20865556
PDF is available here.
Abstract
We offer a quality assurance and assessment framework for biological dataset management from both the producers' and users' perspective. In order to assist the producers in high-quality end-results, we consider the integration of a process-oriented data/metadata model enriched with quality declarati...
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PMID: 20865490
PDF is available here.
Abstract
Genome research is becoming increasingly dependent on access to multiple, distributed data sources, and bioinformatic tools. The importance of integration across distributed databases and Web services will continue to grow as the number of requisite resources expands. Use of bioinformatic workflows...
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PMID: 20865520
PDF is available here.
Ilya I Kupershmidt,
Qiaojuan Jane QJ Su,
Anoop A Grewal,
Suman S Sundaresh,
Inbal I Halperin,
James J Flynn,
Mamatha M Shekar,
Helen H Wang,
Jenny J Park,
Wenwu W Cui,
Gregory D GD Wall,
Robert R Wisotzkey,
Satnam S Alag,
Saeid S Akhtari and
Mostafa M Ronaghi
Abstract
Our work presents a practical strategy for organizing, mining, and correlating global collections of large-scale genomic data to explore normal and disease biology. Using a hypothesis-free approach, we demonstrate how a data-driven analysis across very large collections of genomic data can reveal no...
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PMID: 20927376
PDF is available here.
Abstract
Rochester General Hospital developed an exceedingly well received homegrown database, CMReview, for its CMs. The right team comprised of a data analyst, IT programmers, technology-appreciative CMs, and administrative support has created an asset to the functioning of the care management department....
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PMID: 20234294
PDF is available here.
Abstract
We present CardioVINEdb, a data warehouse approach developed to interact with and explore life science data. The data warehouse architecture provides a platform independent web interface that can be used with any common web browser. A monitor component controls and updates the data from the differen...
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PMID: 20585146
PDF is available here.
Abstract
We present EHRflex, a generic system based on archetypes. It empowers the clinician and allows him to manage his own EHR system in a simple and generic way, assuring that the user works with underlying standardized data structures. These can be exchanged with other people and systems when needed. EH...
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PMID: 20543331
PDF is available here.
Abstract
Knowledge can range from complex, accumulated expertise (tacit knowledge) to structured explicit content like service procedures. For most of us, knowledge management should only be one of many collaborative means to an end, not the end in itself (unless you are the corporate knowledge management di...
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PMID: 20715351
PDF is available here.
Abstract
Adverse events associated with medical device use can be better understood when they are reported using a consistent and well-defined code set. This FDA initiative was an attempt to improve the structure and add control mechanisms to an existing code set, improve analysis tools that will better iden...
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PMID: 20715359
PDF is available here.
Abstract
Since its establishment in 2008, the National Kidney Registry has facilitated 213 kidney transplants between unrelated living donors and recipients at 28 transplant centers. Rapid innovations in matching strategies, advanced computer technologies, good communication and an evolving u...
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PMID: 21696051
PDF is available here.
Abstract
Excel platform was used for transition of results of multiple aligned nucleotide sequences obtained using the BLAST network service to the form appropriate for visual analysis and editing. Two macros operators for MS Excel 2007 were constructed. The array of aligned sequences transformed into Excel...
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PMID: 20882774
PDF is available here.
Abstract
Informatics for Integrating Biology and the Bedside (i2b2) is one of seven projects sponsored by the NIH Roadmap National Centers for Biomedical Computing (http://www.ncbcs.org). Its mission is to provide clinical investigators with the tools necessary to integrate medical record and clinical resear...
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PMID: 20190053
PDF is available here.
Abstract
The development of an integrated and standardized system of data collection (VICAD) helps to support clinical decision making processes and report findings in a more timely manner. It is available free for use and modification under the GNU General Public License. The open source nature of VICAD cou...
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PMID: 20051748
PDF is available here.
Abstract
We used open source software to build a data management system and an internet application with a Flex client on a Java application server with a MySQL database backend. The application is hosted on Amazon Elastic Compute Cloud. This solution named Phynx supports data management, Web-based display o...
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PMID: 19777533
PDF is available here.
Abstract
We introduce several novel visualization and interaction paradigms for visual analysis of published protein-protein interaction networks, canonical signaling pathway models, and quantitative proteomic data. We evaluate them anecdotally with domain scientists to demonstrate their ability to accelerat...
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PMID: 20467059
PDF is available here.
Abstract
We have established "IMMUNOCAT", an interactive data management system for the epitope discovery research projects conducted by our group. The system provides functions to store, query, and analyze clinical and experimental data, enabling efficient, systematic, and integrative data management. We de...
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PMID: 20490281
PDF is available here.
Abstract
RefMed is the first multi-level relevance feedback system for PubMed, which achieves a high accuracy with less feedback. It effectively learns an accurate relevance function from the user's feedback and efficiently processes the function to return relevant articles in real time....
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PMID: 20406504
PDF is available here.
Abstract
Molecular interactions are crucial components of the cellular process. In order to understand this complex machinery, one needs to gather published data from various sources. Many projects have initiated the collection of interaction data for this purpose since 2002. However, the lack of standardisa...
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PMID: 20013380
PDF is available here.
Abstract
We have investigated the misannotation levels for molecular function in four public protein sequence databases (UniProtKB/Swiss-Prot, GenBank NR, UniProtKB/TrEMBL, and KEGG) for a model set of 37 enzyme families for which extensive experimental information is available. The manually curated database...
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PMID: 20011109
PDF is available here.
Abstract
Despite the great effort to design efficient systems allowing the electronic indexation of information concerning genes, proteins, structures, and interactions published daily in scientific journals, some problems are still observed in specific tasks such as functional annotation. The annotation of...
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PMID: 20050264
PDF is available here.
Abstract
We have developed and tested a concept of extracting semi-structured EMRs (Journal III, Profdoc) data from 776 diabetes patients in a general practice clinic over a 5 year period. We used standard database management techniques commonly applied in clinical research in the pharmaceutical industry to...
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PMID: 20007655
PDF is available here.
Abstract
For over a decade, the United States Food and Drug Administration (US FDA) has been engaged in the applied research, development, and evaluation of computational toxicology methods used to support the safety evaluation of a diverse set of regulated products. The basis for evaluating computational to...
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PMID: 20017581
PDF is available here.
Abstract
Our findings indicate that the control of hypertension and dyslipidemia among adult diabetics in the beginning of the decade was poor. On the contrary, utilization of antihypertensive agents (especially angiotensin receptor blockers) and lipid-lowering drugs has increased remarkably by the end of 20...
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PMID: 19834341
PDF is available here.
Abstract
We use a computational model known as Latent Semantic Analysis (LSA) on a diagnostic corpus with the aim of retrieving definitions (in the form of lists of semantic neighbors) of common structures it contains (e.g. "storm phobia", "dog phobia") or less common structures that might be formed by logic...
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PMID: 19899645
PDF is available here.
Abstract
Efficient execution of data-intensive workflows has been playing an important role in bioinformatics as the amount of data has been rapidly increasing. The execution of such workflows must take into account the volume and pattern of communication. When orchestrating data-centric workflows, a central...
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PMID: 20180269
PDF is available here.
Abstract
We outline the challenges and opportunities associated with the implementation of electronic medical records (EMR) in complex environments such as intensive care units (ICU). We share our initial experience in the design, maintenance and application of a customized critical care, Microsoft SQL based...
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PMID: 19912124
PDF is available here.
Abstract
OpenCDLig (freely available at https://kdd.di.unito.it/casmedchem ) implements a repository of complexes formed by cyclodextrins (CDs) and ligands (L) with related experimental data and make it available by an easy to use web interface. At the present time, the application supports two kinds of data...
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PMID: 19533371
PDF is available here.
Abstract
Since the creation of SAGEC 67, more than 300 physicians have found the use of its baseline helpful, especially to avoid problems linked to the fact that emergency departments are overloaded most of the time. CONCLUSION: SAGEC 67 is a website, which helps the physician in case of mass casualty disas...
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PMID: 19318965
PDF is available here.
Abstract
We have designed a communication architecture for use in image-guided catheter ablation therapy. Communication between the system components is through a database which contains an event queue and auxiliary data tables. The communication scheme is unique in that each system component is responsible...
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PMID: 19285747
PDF is available here.
Abstract
We have developed the SNP Integration Tool (SNPit) system to address this need. Built upon a federated data integration system, SNPit provides current information on a comprehensive list of SNP data sources. Additional logical inference analysis was included through an inference engine plug in. The...
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PMID: 19327864
PDF is available here.
Yuko Makita,
Norio Kobayashi,
Yoshiki Mochizuki,
Yuko Yoshida,
Satomi Asano,
Naohiko Heida,
Mrinalini Deshpande,
Rinki Bhatia,
Akihiro Matsushima,
Manabu Ishii,
Shuji Kawaguchi,
Kei Iida,
Kosuke Hanada,
Takashi Kuromori,
Motoaki Seki,
Kazuo Shinozaki and
Tetsuro Toyoda
Abstract
We have developed an integrated database system powered by an intelligent data-retrieval engine termed PosMed-plus (Positional Medline for plant upgrading science), allowing us to prioritize highly promising candidate genes in a given chromosomal interval(s) of Arabidopsis thaliana and rice, Oryza s...
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PMID: 19528193
PDF is available here.
Abstract
The study population included 507,966 patients, who received a total of 5.5 million inhaled SABA, 4.0 million inhaled corticosteroids (ICS) and 1.3 million LABA prescriptions. In patients who recently started asthma medication, there were substantial changes in the hazard rates of MI over time: haza...
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PMID: 19491706
PDF is available here.