Abstract
Clinical handover is an essential process occurring at many levels of inpatient care. Multiple studies within a hospital setting have identified that a breakdown in the handover process can lead to poor patient outcomes and serious adverse events. The use of electronic handover tools is an interventi...
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PMID: 21871202
PDF is available here.
Abstract
We report the development of a new algorithm, PocketAlign for obtaining structural super-positions of binding sites. The software is available as a web-service at http://proline.physics.iisc.ernet.in/pocketalign/. The algorithm encodes shape descriptors in the form of geometric perspectives, supplem...
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PMID: 21662242
PDF is available here.
Abstract
We reviewed 114 consecutive patients with CRT implanted from 2005 through 2009 who received usual care after implantation or underwent protocol-driven CRT care after implantation. Preimplantation characteristics in patients receiving usual versus protocol-driven care were similar in left ventricular...
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PMID: 21550578
PDF is available here.
Abstract
The research demonstrates the applicability of archetype patterns to ontology development in HIS. While numerous ontologies exist in biomedicine, there are few well-developed ontologies for general healthcare. Properly modeled, archetype patterns have potential to reconcile the differences in high-l...
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PMID: 21336420
PDF is available here.
Abstract
We introduce the Network-Free Stochastic Simulator (NFsim), a general-purpose modeling platform that overcomes the combinatorial nature of molecular interactions. Unlike standard simulators that represent molecular species as variables in equations, NFsim uses a biologically intuitive representation...
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PMID: 21186362
PDF is available here.
Abstract
Hospital education departments can better align with the strategic direction of the organization, effectively prioritize work processes, and focus on what matters most to the organization when the organization adopts an assessment process known as the Baldrige Health Care Criteria fo...
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PMID: 21229932
PDF is available here.
Abstract
Computer applications based on Virtual Reality (VR) has been outstanding in training and teaching in the medical filed due to their ability to simulate realistic in which users can practice skills and decision making in different situations. But was realized in these frameworks a hard interaction of...
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PMID: 21335824
PDF is available here.
Abstract
Graphics technology has extended medical imaging tools to the hands of surgeons and doctors, beyond the radiology suite. However, a common issue in most medical imaging software is the added complexity for non-radiologists. This paper presents the development of a unique software toolset that is high...
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PMID: 21335815
PDF is available here.
Abstract
We present an approach to create archetypes using an iterative development process. It includes automated generation of electronic case report forms from archetypes. We evaluated our approach by developing 128 archetypes which represent 446 clinical information items from the diabetes domain....
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PMID: 21685584
PDF is available here.
Abstract
We can provide an interface to manipulate realistic, 3D models of common anatomical ailments, chosen from a database frequently updated at the request of the medical community. Physicians will be able to show patients exactly what their condition looks like internally, and explain in better detail h...
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PMID: 21335769
PDF is available here.
Abstract
We introduce a novel language that facilitates the development of surgical simulations and also supports semantic embedding in the surgical simulation development without extra programming effort....
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PMID: 21335790
PDF is available here.
Abstract
We design a Technological Enhanced Learning (TEL) system. This project belongs to a multidisciplinary field including computer, orthopedic surgery, medical imaging, didactic and cognitive sciences. The article presents the design principles of TEL with a particular interest in the development of a s...
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PMID: 21335812
PDF is available here.
Abstract
This paper reports results of an assessment of e-learning materials with the INTERFACE software evaluation methodology. On the one hand, this method of analysis allows us to identify ergonomics problems; on the other, to decide to what extent those problems and their severity concern all users in gen...
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PMID: 21679663
PDF is available here.
Daniel Höfer,
Arezu Aliabadi,
Christian Ebner,
Christoph Hörmann,
Stephane Mahr,
Regina Mascherbauer,
Gerhard Pölzl,
Albert Reiter,
Andrä Wasler,
Thomas Weber,
Michael Zink,
Andreas Zuckermann,
Herwig Antretter and
Arbeitskreis "Herztransplantation" der Österreichischen Gesellschaft für Kardiologie
Abstract
Regarding limited availability of organ donors for heart transplantation, it is necessary to discuss optimal donor evaluation and donor management. In this manuscript general donor-related parameters as well as heart-specific parameters are discussed regarding international literature. In addition,...
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PMID: 20628904
PDF is available here.
Abstract
Guided by how weather data from the National Oceanic and Atmospheric Administration fuels all kinds of weather reports, maps and forecasts, HHS officials saw parallels on how to distribute health data so software developers could create tools to be used by patients and providers. "We thought that wa...
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PMID: 20575484
PDF is available here.
Abstract
Distributed networks are capable of addressing nearly all anticipated uses of routinely collected electronic healthcare data. Distributed networks would obviate the need for centralized databases, thus avoiding numerous obstacles....
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PMID: 20473204
PDF is available here.
Abstract
Posttraumatic instability of the elbow in children can be a very challenging problem to diagnose and treat. Posterolateral rotatory instability (PLRI) has been well described with regard to diagnosis and treatment in adults but best clinical practices are less clear for pediatric cases. Children wit...
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PMID: 20526166
PDF is available here.
Abstract
We present a comparison between the transcriptional regulatory network of a well-studied bacterium (Escherichia coli) and the call graph of a canonical OS (Linux) in terms of topology and evolution. We show that both networks have a fundamentally hierarchical layout, but there is a key difference: T...
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PMID: 20439753
PDF is available here.
Abstract
A non-invasive piezo-film-based measurement method for haemodynamic assessment is proposed. The design of a system, able to reconstruct the blood pressure waveform online by dealing with problems arising from the piezo-film capacitive nature in the targeted frequency range (from quasi-dc up to 12 Hz...
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PMID: 20395651
PDF is available here.
Abstract
We investigated whether intracranial pressure (ICP) pulse morphological metrics could be used to realize continuous detection of low cerebral blood flow. Sixty-three acutely brain injured patients with ICP monitoring, daily (133)Xenon cerebral blood flow (CBF) and daily transcranial Doppler (TCD) as...
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PMID: 20348611
PDF is available here.
Abstract
Exchanging and sharing scientific results are essential for researchers in the field of computational modelling. BioModels.net defines agreed-upon standards for model curation. A fundamental one, MIRIAM (Minimum Information Requested in the Annotation of Models), standardises the ann...
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PMID: 19939940
PDF is available here.
Abstract
We have developed the BASIS system for the simulation and storage of stochastic SBML models together with associated simulation results. This system is exposed as a set of web services to allow users to incorporate its simulation tools into their workflows. Parameter inference for stochastic models...
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PMID: 20056731
PDF is available here.
Abstract
We provide a brief description of the tool DiVinE adapted for automatized analysis of biological systems dynamics. The tool employs high-performance computing techniques to enable analysis of large models....
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PMID: 20478855
PDF is available here.
Abstract
We introduce a pure web-based, interactive, extendable, 2D and 3D medical image processing and visualization application that requires no client installation. Our software uses a four-layered design consisting of an algorithm layer, web-user-interface layer, server communication layer, and wrapper l...
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PMID: 20022133
PDF is available here.
Abstract
A virtual-reality simulator was developed for the training of Otolaryngology (Ear-Nose-Throat) surgical residents to perform myringotomy, a relatively common surgical procedure in which an incision is made in the eardrum mainly to treat middle-ear infections. The simulator presents the trainee with...
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PMID: 19854532
PDF is available here.
Abstract
Applied research in both biomedical discovery and translational medicine today often requires the rapid development of fully featured applications containing both advanced and specific functionalities, for real use in practice. In this context, new tools are demanded that allow for efficient generat...
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PMID: 20047774
PDF is available here.
Abstract
A continuous wave near infrared instrument has been developed to monitor in vivo changes in the hemoglobin concentration of the trabecular compartment of human bone. The transmitter uses only two laser diodes of wavelengths 685 and 830 nm, and the receiver uses a single silicon photodiode operating...
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PMID: 20441329
PDF is available here.
Abstract
We introduce a novel concept of Enzyme Cut Order - a biological property-based characteristic of DNA sequences which can be defined and analyzed computationally without any alignment algorithm. In this alignment-free approach, a similarity matrix is developed based on the pairwise Longest Common Sub...
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PMID: 20401943
PDF is available here.
Abstract
The newly developed evaluation tool for the risk level of abnormal glucose metabolism morbidity in middle-aged and elder populations is both simple and practical. With an excellent practicability; it may be used to screen abnormal glucose metabolism in middle-aged and elder populations....
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PMID: 20450625
PDF is available here.
Abstract
We have designed an algorithm and software tool that eliminates the systematic errors from the peptide ion masses in MS/MS data. We demonstrate that the elimination of the systematic mass measurement errors allows for the use of tighter criteria on the deviation of measured mass from theoretical mon...
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PMID: 20019053
PDF is available here.
Abstract
Chinese dietary exposure evaluation software was developed successfully. On the rationality, the results from probabilistic model were lower than that from the point estimation (e.g., cucumber: the result of point estimation of acephate was 4.78 microg x kg(-1) x d(-1), while the results of probabil...
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PMID: 20450740
PDF is available here.
Abstract
Deciding whether to use intravenous fibrinolytic therapy for acute cerebral ischemia within 3 hours of onset is challenging for patients, family members, and health care providers. Visual displays can permit individuals to rapidly understand response patterns to therapy. This study sought to evaluat...
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PMID: 20056928
PDF is available here.
Abstract
We have already proposed the inverse function delayed (ID) model as a novel neuron model. The ID model has a negative resistance similar to Bonhoeffer-van der Pol (BVP) model and the network has an energy function similar to Hopfield model. The neural network having an energy can converge on a solut...
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PMID: 20007029
PDF is available here.
Abstract
Dry-lab experimentation is being increasingly used to complement wet-lab experimentation. However, conducting dry-lab experiments is a challenging endeavor that requires the combination of diverse techniques. JAMES II, a plug-in-based open source modeling and simulation framework, fa...
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PMID: 20118105
PDF is available here.
Abstract
This work identifies highly probable co-regulating miRNAs, which are refined from the prediction by computational tools using (1) signal-to-noise ratio to get high accurate regulating miRNAs for every gene, and (2) Gene Ontology to obtain functional related co-regulating miRNA groups. Our result has...
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PMID: 20183876
PDF is available here.
Abstract
Neurosurgery in functionally relevant brain structures carries a high risk for surgery induced post-operative neurological deficits. Functional magnetic resonance imaging (fMRI) is one of the most commonly used functional neuroimaging techniques for pre-surgical brain mapping. Preoperative fMRI is o...
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PMID: 20687368
PDF is available here.
Abstract
High-throughput data production has revolutionized molecular biology. However, massive increases in data generation capacity require analysis approaches that are more sophisticated, and often very computationally intensive. Thus, making sense of high-throughput data requires informatics support. Gal...
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PMID: 20069535
PDF is available here.
Abstract
Ageing commonly disrupts the balance control and compensatory postural responses that contribute to maintaining balance and preventing falls during perturbation of posture. This can lead to increased risk of falling in old adults (65 years old and over). Therefore, improving compensatory postural re...
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PMID: 20630113
PDF is available here.
Abstract
This paper presents the new DNAStat version 2.1 for processing genetic profile databases and biostatistical calculations. The popularization of DNA studies employed in the judicial system has led to the necessity of developing appropriate computer programs. Such programs must, above all, address two...
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PMID: 21516944
PDF is available here.
Abstract
We introduce an approach that combines standard 1D motif detection methods with structural alphabets to discover locally conserved protein motifs. These 1D structural motifs can characterize protein groups at different levels, e.g., families, super families, and folds in SCOP, as group features....
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PMID: 20865493
PDF is available here.
Abstract
We also discuss many factors that will greatly influence the performance after porting the Amber scoring to GPU, including thread management, data transfer, and divergence hidden. Our experiments show that the GPU-accelerated Amber scoring achieves a 6.5× speedup with respect to the original versio...
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PMID: 20865535
PDF is available here.
Abstract
Next Generation Sequencing technologies are limited by the lack of standard bioinformatics infrastructures that can reduce data storage, increase data processing performance, and integrate diverse information. HDF technologies address these requirements and have a long history of use in data-intensi...
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PMID: 20865556
PDF is available here.
Abstract
A methodology for elucidation of structural, functional, and mechanistic knowledge on promiscuous proteins is proposed that constitutes a workflow of integrated bioinformatics analysis. Sequence alignments with closely related homologues can reveal conserved regions which are functionally important....
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PMID: 20865513
PDF is available here.
Abstract
Nine production rules were established and standardized by Drools and Arden Syntax. The developed software autonomously controls training sessions on a bicycle ergometer on the basis of vital signs data. Thus it offers a new way for the rehabilitation of COPD patients. CONCLUSION: Evaluation with ni...
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PMID: 20011809
PDF is available here.
Abstract
The features and accessible artifacts that can be composed with OmniSCOPE have provided therapists with the possibility to enhance their therapy procedures and to reach a wider audience of patients even while out of the office. Additionally, the data gathering options that can be included within the...
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PMID: 20011806
PDF is available here.
Abstract
In 2007, the Department of Health and Human Services commissioned the Nationwide Health Information Network (NHIN) Trial Implementations project to demonstrate the secure exchange of data among health information exchange organizations around the country. The project's Core Services Content Work Gro...
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PMID: 20064795
PDF is available here.
Abstract
Signout and progress notes proved to be particularly redundant, with an average of 78% and 54% information duplicated from previous documents respectively. There was also significant information duplication between document types (eg, from an admission note to a progress note). CONCLUSION: The study...
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PMID: 20064801
PDF is available here.
Abstract
We describe a new natural language processing system (MedEx), which extracts medication information from clinical notes. MedEx was initially developed using discharge summaries. An evaluation using a data set of 50 discharge summaries showed it performed well on identifying not only drug names (F-me...
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PMID: 20064797
PDF is available here.
Abstract
The proposed propulsion training protocol may lead to favorable changes in manual wheelchair propulsion technique. These changes could limit or prevent upper limb injuries among manual wheelchair users. In addition, many of the motor learning theory-based techniques examined in this study could be a...
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PMID: 20397442
PDF is available here.
Abstract
In today's environment, providers are extremely time-constrained. Assembling relevant contextual data to make decisions on laboratory results can take a significant amount of time from the day. The Regenstrief Institute has created a system which leverages data within Indiana Health Information Exch...
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PMID: 20064809
PDF is available here.
Abstract
High quality research is essential to the provision of excellent health care in both primary and hospital settings. Midwives, health visitors, other community practitioners and allied health professionals should be encouraged to initiate and participate in research. No one should und...
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PMID: 21319671
PDF is available here.
Abstract
We also provide an overview of the basic considerations of setting up and running a biological radar study.
Program radR provides a convenient, open source platform for the acquisition and analysis of radar data of biological targets....
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PMID: 20977735
PDF is available here.