Abstract
We have previously created a novel interaction database for oncology prescriptions (OncoRx). In this project, we leverage on 3G networks to further develop this database into an iPhone-specific application for the mobile internet (OncoRx-MI)....
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PMID: 21848450
PDF is available here.
Abstract
We investigated the role of (18)F-FDG PET in patients with degenerative stenosis of the cervical spinal cord in relation to postsurgical outcome....
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PMID: 21852356
PDF is available here.
Abstract
We report the development of a computer system for long-term large-scale recording and storage of multichannel physiologic signals that was built using commercial solutions (software and hardware) and existing hospital IT infrastructure. Both numeric (1Hz) and waveform (62.5-500Hz) data were capture...
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PMID: 21093093
PDF is available here.
Abstract
This study investigated whether peer-nominated prosocial and antisocial children have different perceptions of the motives underlying peers' prosocial actions. Eighty-seven children, aged 10-12 years old, completed peer-nomination measures of social behaviour. On the basis of numbers of social nomina...
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PMID: 21848737
PDF is available here.
Abstract
We present a simple, time- and cost-efficient approach to tackle the proteome of prokaryotic organisms. To obtain large data sets of complex biological experiments high-throughput and time- and cost-efficient methods still have to be developed and refined. In this study, we combined well-approved te...
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PMID: 21751368
PDF is available here.
Abstract
We present a data mining approach that enables the identification of alternative analog series with different core structures, corresponding substitution patterns, and comparable potency progression. Scaffolds can be exchanged between these series and new analogs suggested that incorporate preferred...
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PMID: 21774471
PDF is available here.
Abstract
We present an extension of the activity cliff concept by introducing "activity ridges" that are formed by overlapping "combinatorial" activity cliffs between participating compounds, giving rise to ridge-like structures in activity landscapes. Activity ridges are rich in SAR information. In a system...
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PMID: 21761918
PDF is available here.
Abstract
We sought to develop an appropriate method to examine large sets of GPCR ligand information for both screening collection enhancement and hit expansion. To this end, we have implemented a modified version of BDACCS that removes highly correlated descriptors (rBDACCS). To test the hypothesis that a s...
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PMID: 21761904
PDF is available here.
Abstract
Potential Performance Theory (PPT) is a general theory for parsing observed performance into the underlying strategy and the consistency with which it is used. Although empirical research has supported that PPT is useful, it is desirable to have more information about the bias and standard errors of...
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PMID: 21842621
PDF is available here.
Abstract
We evaluated four docking tools-MOE2009, Glide 5.5, QXP-Flo+0802, and Autodock 4.0-for their ability to simulate complexes between these enzymes and RNA oligomers. To validate our results, we analyzed the docking results with respect to the known key interactions between the protein and the nucleoti...
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PMID: 21120556
PDF is available here.
Abstract
The aim of this study was to compare the ability of final-year Turkish dental students and dentists to assess the level of gingival health status by using the Development of Ability to Assess Gingival Status (DAAGS) computer program. Forty-eight students in their final year of dental education and 24...
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PMID: 21828307
PDF is available here.
Abstract
One of the central challenges to metabolomics is metabolite identification. Regardless of whether one uses so-called 'targeted' or 'untargeted' metabolomics, eventually all paths lead to the requirement of identifying (and quantifying) certain key metabolites. Indeed, without metabol...
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PMID: 21827274
PDF is available here.
Abstract
Some questions remain regarding the anthropometric differences between the feet of young men and women, but the gap is much greater when dealing with older adults. No studies were found concerning these differences in an exclusively older adult population, which makes it difficult to manufacture shoe...
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PMID: 21828380
PDF is available here.
Abstract
We propose to use a robot-tweezer manipulation system to solve the problem of automatic transportation of biological cells, where optical tweezers function as special robot end effectors. Dynamics equation of the cell in optical tweezers is analyzed. A closed-loop controller is designed for transpor...
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PMID: 21764021
PDF is available here.
Abstract
Orientation of the native acetabular plane as defined by the transverse acetabular ligament (TAL) and the posterior labrum was measured intra-operatively using computer-assisted navigation in 39 hips. In order to assess the influence of alignment on impingement, the range of movement...
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PMID: 21768623
PDF is available here.
Abstract
Inaccuracies in the estimation of material properties and errors in the assignment of these properties into finite element models limit the reliability, accuracy, and precision of quantitative computed tomography (QCT)-based finite element analyses of the vertebra. In this work, a new mesh-independen...
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PMID: 21823740
PDF is available here.
Abstract
We analyzed the response of a stenotic trachea after a stent implantation. An endotracheal stent is the common treatment for tracheal diseases such as stenosis, chronic cough, or dispnoea episodes. Medical treatment and surgical techniques are still challenging due to the difficulties in overcoming...
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PMID: 21823742
PDF is available here.
Abstract
Abstract Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous disorder that shows a characteristic dichotomy of familial forms typically displaying Mendelian inheritance patterns, and sporadic ALS showing no or less obvious familial aggregation. While the former is caus...
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PMID: 21702733
PDF is available here.
Abstract
The Feik School of Pharmacy collaborated with a commercial software development company to create a Web-based e-portfolio system to document student achievement of curricular outcomes and performance in pharmacy practice experiences. The multi-functional system also could be used for experiential sit...
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PMID: 21829263
PDF is available here.
Abstract
Objective. To evaluate the effectiveness and impact of a customized Web-based software program implemented in 2006 for school-wide documentation of clinical interventions by pharmacy practice faculty members, pharmacy residents, and student pharmacists.Methods. The implementation process, directed by...
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PMID: 21829264
PDF is available here.
Abstract
We describe how to analyze genome-wide replication timing (RT) in mammalian cells. Asynchronously cycling cells are pulse labeled with the nucleotide analog 5-bromo-2-deoxyuridine (BrdU) and sorted into S-phase fractions on the basis of DNA content using flow cytometry. BrdU-labeled DNA from each fr...
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PMID: 21637205
PDF is available here.
Abstract
The Neurochip-2 is a second generation, battery-powered device for neural recording and stimulating that is small enough to be carried in a chamber on a monkeys head. It has three recording channels, with user-adjustable gains, filters, and sampling rates, that can be optimized for r...
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PMID: 21632309
PDF is available here.
Abstract
We illustrate this analytical approach for two types of DSS, an infection risk index for hop powdery mildew and a simulation model for grass stem rust. Further exploration of analysis methods is needed to address problems associated with assessing uncertainty in multi-decision DSSs....
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PMID: 21091182
PDF is available here.
Abstract
Cherubism is a rare non-neoplastic, fibro-osseous hereditary disorder characterized by bilateral expansion of the maxilla and mandible producing a characteristic facial appearance. It can affect the facial and dental growth of the individual and often results in gross aesthetic and functional deficie...
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PMID: 21780729
PDF is available here.
Abstract
These results reconfirmed that the horizontally transferred genes are exogenous. The analysis of gene function suggested that horizontally transferred genes acquired from an ancestral host insect can increase the efficiency of baculoviruses transmission....
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PMID: 21684870
PDF is available here.
Abstract
We present a subquadratic running time algorithm capable of computing an alignment that optimizes one of the most widely used measures of protein structure similarity, defined as the number of pairs of residues in two proteins that can be superimposed under a predefined distance cutoff. The algorith...
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PMID: 21714130
PDF is available here.
Abstract
We developed a directed weighted graph, the topology graph, to represent the secondary structure assignment problem. We prove that the problem of finding the valid topology with the minimum cost is NP hard. We developed an O(N(2)2(N)) dynamic programming algorithm to identify the topology with the m...
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PMID: 21714133
PDF is available here.
Abstract
Low or negative pressure transients in water distribution systems, caused by unexpected events (e.g. power outages) or routine operation/maintenance activities, are usually brief and thus are rarely monitored or alarmed. Previous studies have shown connections between negative pressure events in wate...
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PMID: 21942194
PDF is available here.
Abstract
This study aimed to introduce a technique using computer-assisted image analysis for measuring body segmental angles during a static strength element on parallel bars. Criterion validity and intra-rater reliability of measurements were evaluated using digital photography, skin markers and a gravity-r...
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PMID: 21834397
PDF is available here.
Abstract
The aim of this study was to evaluate the benefits and limitations of using three dimensional (3D) musculoskeletal modelling (LifeModeler) in assessing the safety and efficacy of exercising on a seated biceps curl resistance training machine. Three anthropometric cases were studied, representing a 5t...
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PMID: 21834398
PDF is available here.
Abstract
In the cell, protein folding into stable globular conformations is in competition with aggregation into non-functional and usually toxic structures, since the biophysical properties that promote folding also tend to favor intermolecular contacts, leading to the formation of β-sheet-...
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PMID: 21538897
PDF is available here.
Abstract
This is the first description of the use of video recorded data in an asynchronous telemedicine application. Primary care providers and consulting psychiatrists have found it easy to work with and a valuable resource to increase the availability of psychiatric consultation in remote rural locations....
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PMID: 21457014
PDF is available here.
Abstract
We sought the correlation between duration of myocardial ischemia and severe left ventricular (LV) diastolic dysfunction (restrictive filling pattern [RFP]) in patients with acute ST-elevation myocardial infarction (STEMI). Duration of ischemia determines infarct size and survival after STEMI. Howev...
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PMID: 21600536
PDF is available here.
Marc M Weber,
Hanno H Teeling,
Sixing S Huang,
Jost J Waldmann,
Mariette M Kassabgy,
Bernhard M BM Fuchs,
Anna A Klindworth,
Christine C Klockow,
Antje A Wichels,
Gunnar G Gerdts,
Rudolf R Amann and
Frank Oliver FO Glöckner
Abstract
We provide a novel implementation, demonstrate its potential and practicability, and provide a web-based service for public usage. Evaluation with published data sets mimicking varyingly complex habitats resulted into classification specificities and sensitivities of close to 100% to above 90% from...
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PMID: 21160538
PDF is available here.
Abstract
We present an automated tool, SimGlycan, for this purpose, which accepts raw/standard MS data files as input and characterizes the associated glycan structure with high accuracy using database searching and scoring techniques. Not only does it predict the glycan structure using an MS/MS database sea...
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PMID: 19882135
PDF is available here.
Abstract
We use Bioconductor analysis packages on a heart development dataset to demonstrate the workflow of microarray data analysis from annotation, normalization, expression index calculation, and diagnostic plots to pathway analysis, leading to a meaningful visualization and interpretation of the data....
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PMID: 19763933
PDF is available here.
Abstract
Candidate gene association study is the most common method for associating human genetic variations with the phenotypes they produce, due to the relative simplicity of acquiring patient samples and genotype data. The study design begins with identifying appropriate DNA samples and an appropriate phe...
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PMID: 19763931
PDF is available here.
Abstract
We initiate this process, a prerequisite for such a study, by narrowing the focus from an entire genome to that of a single biological system. To this end, we examine the 'Hemostaseome,' and more specifically focus on DNA sequence changes pertaining to those human genes known to impact upon hemostas...
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PMID: 21537949
PDF is available here.
Abstract
We have developed a Mobile Instrument for Motion Instruction and Correction (MIMIC) that enables an expert (i.e., physical therapist) to map his/her movements to a trainee (i.e., patient) in a hands-free fashion. MIMIC comprises an Expert Module (EM) and a Trainee Module (TM). Both the EM and TM are...
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PMID: 21511568
PDF is available here.
Abstract
I error probability and the power of the independent samples t test, performed directly on the ranks of scores in combined samples in place of the original scores, are known to be the same as those of the non-parametric Wilcoxon-Mann-Whitney (WMW) test. In the present study, simulations revealed tha...
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PMID: 21492130
PDF is available here.
Abstract
I error rate control and have greater statistical power than those obtained by the conventional F test in various conditions. Therefore, the proposed test statistics are recommended in terms of robustness and easy implementation....
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PMID: 21492132
PDF is available here.
Abstract
The use of covariates is commonly believed to reduce the unexplained error variance and the standard error for the comparison of treatment means, but the reduction in the standard error is neither guaranteed nor uniform over different sample sizes. The covariate mean differences between the treatment...
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PMID: 21492135
PDF is available here.
Abstract
Parameters of the two-parameter logistic model are generally estimated via the expectation-maximization (EM) algorithm by the maximum-likelihood (ML) method. In so doing, it is beneficial to estimate the common prior distribution of the latent ability from data. Full non-parametric ML (FNPML) estimat...
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PMID: 21492136
PDF is available here.
Abstract
In this paper, the extended Rasch model for dichotomously scored items is derived from the general multivariate Bernoulli distribution. The necessary and sufficient conditions for the multivariate Bernoulli distribution to be equal to the extended Rasch model provide a new loglinear representation of...
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PMID: 21492137
PDF is available here.
Abstract
The aim of this study was to assess the influence of inclination of the object on the reliability and reproducibility of linear measurements of anatomic structures of the mandible on images obtained using cone-beam CT (CBCT).
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PMID: 21493881
PDF is available here.
Abstract
I present an open source, web-based program that plots any kind of frequency or count data as pie charts in Google Maps (Google Inc., Mountain View, CA). Pie polygons are then exportable to Google Earth (Google Inc.), a free Geographic Information Systems platform. Import of genetic data into Google...
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PMID: 21481214
PDF is available here.
Abstract
In order to unravel the mechanisms underlying the "sudden" onset of spontaneous absences in genetically prone subjects, we investigated the immediate precursors of spike-wave discharges (SWDs) produced in cortico-thalamo-cortical neuronal networks.
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PMID: 21093357
PDF is available here.
Abstract
An illusion is explored in which a spoken phrase is perceptually transformed to sound like song rather than speech, simply by repeating it several times over. In experiment I, subjects listened to ten presentations of the phrase and judged how it sounded on a five-point scale with endpoints marked "e...
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PMID: 21476679
PDF is available here.
Abstract
In order to unravel the mechanisms underlying the "sudden" onset of spontaneous absences in genetically prone subjects, we investigated the immediate precursors of spike-wave discharges (SWDs) produced in cortico-thalamo-cortical neuronal networks.
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PMID: 21093357
PDF is available here.
Abstract
We investigated the accumulation of the corresponding transcripts to those of two other stilbene biosynthesis related genes phenylalanine ammonia lyase (PAL) and stilbene synthase (STS) in response to pathogen infection. Using three computer-based statistical methods and C (t) values or LRE method g...
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PMID: 21340517
PDF is available here.
Abstract
The aim of the study was to assess the extent of the potential nerve damage following prolonged contact with a piezoelectric device.
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PMID: 21585155
PDF is available here.