David D Abramson,
Miguel O MO Bernabeu,
Blair B Bethwaite,
Kevin K Burrage,
Alberto A Corrias,
Colin C Enticott,
Slavisa S Garic,
David D Gavaghan,
Tom T Peachey,
J J Pitt-Francis,
E E Pueyo,
Blanca B Rodriguez,
Anna A Sher and
Jefferson J Tan
Abstract
We discuss the use of a parametric modelling toolkit, called Nimrod, that makes it possible both to explore model behaviour as parameters are changed and also to tune parameters by optimizing model output. Importantly, Nimrod leverages computers on the Grid, accelerating experiments by using availab...
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PMID: 20643684
PDF is available here.
Abstract
The experience sampling method (ESM) represents a valuable way of assessing clinical phenomena in real world settings and across time. Despite its theoretical advantages, using this methodology in psychiatric populations is challenging. This paper acts as a guide to researchers wishing to employ this...
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PMID: 20712828
PDF is available here.
Abstract
Cloud computing provides information processing power and business services, delivering these services over the Internet from centrally hosted locations. Major technology corporations aim to supply these services to every sector of the economy. Deploying business processes 'in the cloud' requires sp...
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PMID: 20443161
PDF is available here.
Abstract
The bidomain equations are frequently used to model the propagation of cardiac action potentials across cardiac tissue. At the whole organ level, the size of the computational mesh required makes their solution a significant computational challenge. As the accuracy of the numerical solution cannot b...
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PMID: 19457741
PDF is available here.
Abstract
Ubiquitous (pervasive) computing is a term for a synergetic use of sensing, communication and computing. Pervasive use of computing has seen a rapid increase in the current decade. This development has propagated in applied sport science and everyday life. The work presents a survey of recent develo...
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PMID: 19764000
PDF is available here.
Abstract
A number of current trends that are being adopted to reshape the field of high-performance computing exist, including multi-core systems, accelerators, and software frameworks for large-scale intrinsically parallel applications. These trends intersect with recent developments in computational chemis...
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PMID: 19396740
PDF is available here.
Abstract
The shift in the drug discovery paradigm that has resulted in increased dependence on large volumes of information for decision making has created new challenges and opportunities in chemoinformatics research. The large volumes of data that are now available present an opportunity for the developmen...
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PMID: 19396738
PDF is available here.
Abstract
We use stickers to construct a solution space of DNA for the maximal clique problem (MCP). Simultaneously, we also apply the DNA operation in the sticker-based model to develop a DNA algorithm. The results of the proposed algorithm show that the MCP is resolved with biological operations in the stic...
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PMID: 18992786
PDF is available here.
Abstract
The experimental outcome shows the efficiency and advantages of the new approach as the probabilistic SSM performs better in modeling shape details and differences....
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PMID: 19562228
PDF is available here.
Abstract
The field of high-performance computing (HPC) has provided a wide array of strategies for supplying additional computing power to the goal of reducing the total "clock time" required to complete various computational processes. These strategies range from the development of higher-performance hardwa...
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PMID: 19623493
PDF is available here.
Abstract
We address the study of the interaction of a flavonoid-derivative licochalcone A (LA) with human serum albumin (HSA). The application of circular dichroism, UV-Vis absorption, fluorescence and laser flash photolysis combined with molecular mechanics, molecular dynamics and quantum mechanical calcula...
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PMID: 18989470
PDF is available here.
Abstract
We do not know whether this option provides better results than using the master bank with greater restriction in the maximum exposure rates (Sympson & Hetter, 1985). In order to investigate this issue, we worked with several simulated banks of 2100 items, comparing them, for RMSE and overlap rate,...
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PMID: 18988447
PDF is available here.
Abstract
In current cognitive psychology, naming latencies are commonly measured by electronic voice keys that detect when sound exceeds a certain amplitude threshold. However, recent research (e.g., K. Rastle & M. H. Davis, 2002) has shown that these devices are particularly inaccurate in precisely detectin...
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PMID: 18823214
PDF is available here.
Abstract
The scattering of guided waves by complex shaped defects in three-dimensional (3D) waveguides is considered. For such problems, analytical solutions do not exist, and modal decomposition techniques based on the establishment of the displacement and stress fields in the vicinity of the scatterer are...
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PMID: 18472122
PDF is available here.
Abstract
We present a novel method, MUSIDH, an acronym for multiple use of simulated demographic histories, to reduce computation time. Demographic history refers to the processes of birth, death and all other demographic events that should be unrelated to the natural course of an infection, thus non-fatal i...
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PMID: 18534713
PDF is available here.
Abstract
We offer our view of past developments and future prospects in this area. The astonishing progress in computer hardware over the past decade has fueled a significant increase in computational power available for the solution of macromolecular structures. At the same time the relatively slow growth a...
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PMID: 18406627
PDF is available here.
Abstract
We present an implementation of the demons algorithm using the NVIDIA 8800 GTX GPU and the new CUDA programming language. The GPU performance will be compared with single threading and multithreading CPU implementations on an Intel dual core 2.4 GHz CPU using the C programming language. CUDA provide...
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PMID: 18777915
PDF is available here.
Abstract
These results were obtained by using logistic regression approaches, as well as statistical methods that address potential residual confounding and covariate endogeneity. Furthermore, STI-positive participants were more likely than STI-negative participants to underreport risk behavior in the face-t...
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PMID: 18525081
PDF is available here.
Abstract
We propose two methods. One is based on a geometric idea, where-akin to support vector classification-the margin between the failed observation and the observations currently at risk is maximised. The other approach is based on obtaining a sparse model by adding observations one after another akin t...
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PMID: 18515276
PDF is available here.
Abstract
From the set of perspectives taken, the study illustrates that mobile computing technologies offer new and innovative approaches to improve intersectional acute stroke care. It also teaches the participants that interdisciplinary research can significantly deepen the understanding of such technologi...
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PMID: 18542893
PDF is available here.
Xiuxia Du,
Stephen J Callister,
Nathan P Manes,
Joshua N Adkins,
Roxana A Alexandridis,
Xiaohua Zeng,
Jung Hyeob Roh,
William E Smith,
Timothy J Donohue,
Samuel Kaplan,
Richard D Smith and
Mary S Lipton
Abstract
Biological systems are in a continual state of flux, which necessitates an understanding of the dynamic nature of protein abundances. The study of protein abundance dynamics has become feasible with recent improvements in mass spectrometry-based quantitative proteomics. However, a nu...
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PMID: 18442284
PDF is available here.
Abstract
We have designed sets of active molecules of increasing fingerprint bit density relative to average database compounds and potential hits and carried out systematic similarity search trials. We find that the more complex reference molecules are, the lower the search performance becomes. However, a m...
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PMID: 18466274
PDF is available here.
Abstract
We aim at the development of computational approaches for the study of structure-selectivity relationships and prediction of target-selective ligands. In previous studies, we have introduced the concept of selectivity searching. Here we study compound selectivity on the basis of 18 selectivity sets...
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PMID: 18482335
PDF is available here.
Abstract
Participants in the vibrotactile group took 4.08 min (95% CI = 1.22) to deliver definitive treatment compared with 7.21 min (95% CI = 2.07) for the control group (P < 0.05). Despite the reduced time to treatment, no improvement in SA was measured. CONCLUSION: Our study provides evidence that vibrota...
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PMID: 18349190
PDF is available here.
Abstract
A text analysis of 47 suicide notes identified no reliable or psychologically meaningful differences by sex, age, or method used for suicide.
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PMID: 18567226
PDF is available here.
Abstract
A new procedure to compute weighted kappa with multiple raters is described. A resampling procedure to compute approximate probability values for weighted kappa with multiple raters is presented. Applications of weighted kappa are illustrated with an example analysis of classifications by three inde...
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PMID: 18567232
PDF is available here.
Abstract
The development of the medical knowledge has became a multidisciplinary process that can be called life sciences. The new biotechnologies are changing the insight of pathology and medical therapy itself. So, the rule of the physician is changing together with the overwhelming centrality of the patie...
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PMID: 18488523
PDF is available here.
Abstract
We propose two recently developed classification algorithms for the analysis of mass-spectrometric data-the supervised neural gas and the fuzzy-labeled self-organizing map. The algorithms are inherently regularizing, which is recommended, for these spectral data because of its high dimensionality an...
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PMID: 18334515
PDF is available here.
Abstract
We present a practical method for incorporating multiple-race respondents into analyses that use public-use microdata. Our method is a modification of the regression method developed by the National Center for Health Statistics (NCHS), which uses multiple-race respondents' specific combination of ra...
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PMID: 18390296
PDF is available here.
Abstract
The focus of this article is to provide the oral and maxillofacial surgeon with an overview of some of the recent information and computer technologies available in the marketplace as they relate to diagnostic imaging, implantology, orthognathic surgery, and craniofacial surgery. In so doing, the au...
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PMID: 18194740
PDF is available here.
Abstract
This article reviews recent disclosures of bio-inspired, bio-mimicked and bionanotechnologies. Among the patents discussed is a nanoscale porous structure for use in nanocomposites and nanoscale processing. Patents disclosing methods for printing biological materials using nanolithography techniques...
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PMID: 19076043
PDF is available here.
Abstract
After a brief outline of the available hypotheses on the mechanism of biological evolution, attention is called on the global nature of the variations leading to the generation of new species. Integrated changes may hardly be attributed to beneficial random mutations of single traits even if assiste...
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PMID: 18600634
PDF is available here.
Abstract
Computational resources and computationally expensive processes are two topics that are not growing at the same ratio. The availability of large amounts of computing resources in Grid infrastructures does not mean that efficiency is not an important issue. It is necessary to analyze the whole proces...
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PMID: 18560112
PDF is available here.
Abstract
Structural and functional magnetic resonance imaging (MRI) are increasingly common research methods among investigators interested in typically and atypically developing populations. However, the effective use of these tools requires an understanding of the basis of the magnetic resonance signal, as...
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PMID: 18838030
PDF is available here.
Abstract
We also demonstrate how new and existing tools can be deployed as Web services so that they can be easily integrated into novel computational pipelines using the scientific workflow paradigm....
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PMID: 18712319
PDF is available here.
Abstract
We propose a framework to compute large scale cardiac models. Decomposition of anatomical data in segments to be distributed on a parallel computer is carried out by optimal recursive bisection (ORB). The algorithm takes into account a computational load parameter which has to be adjusted according...
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PMID: 19162721
PDF is available here.
Abstract
SMART fabrics and interactive textiles (SFIT) are conceived as innovative textile structure integrating sensing, actuation, electronic, and power and/or communication functions. Due to their multifunctional interactivity, enabled by wearable devices that are flexible and conformable to the human bod...
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PMID: 19163496
PDF is available here.
Abstract
We have designed and built a prototype framework that allows the addition of parallelised functions to R to enable the easy exploitation of HPC systems. The Simple Parallel R INTerface (SPRINT) is a wrapper around such parallelised functions. Their use requires very little modification to existing s...
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PMID: 19114001
PDF is available here.
Abstract
The WGCNA R software package is a comprehensive collection of R functions for performing various aspects of weighted correlation network analysis. The package includes functions for network construction, module detection, gene selection, calculations of topological properties, data simulation, visua...
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PMID: 19114008
PDF is available here.
Abstract
The performance of the proposed algorithm is validated via comparison to popular progressive multiple alignment approaches, ClustalW and T-Coffee, and to the more recently developed algorithms MAFFT, MUSCLE, Kalign, and PSAlign using the BAliBASE 3.0 database of amino acid alignment files and a set...
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PMID: 18616828
PDF is available here.
Abstract
In this paper the graphical-oriented workflow design system called Quascade and its efficient usage for comparative phyloinformatics are presented. In particular, we focus on how this task can be effectively performed in a distributed computing environment. As a proof of concept, the designed workfl...
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PMID: 18315855
PDF is available here.
Abstract
We give an update on current results on the global organization of neural systems. For neural systems, we outline how the spatial and topological architecture of neuronal and cortical networks facilitates robustness against failures, fast processing and balanced network activation. Finally, we discu...
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PMID: 17855223
PDF is available here.
Abstract
We develop a gaussian process model for clustering. The variances of predictive values in gaussian processes learned from a training data are shown to comprise an estimate of the support of a probability density function. The constructed variance function is then applied to construct a set of contou...
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PMID: 17883350
PDF is available here.
Abstract
We then assume a situation where virtual vectors, called interpolating vectors, are densely placed along line segments connecting all pairs of reference vectors of the same label. From these interpolating vectors, we choose the one that has the largest similarity to the test vector. Its label shows...
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PMID: 17714913
PDF is available here.
Abstract
We refer to the resulting architecture as GFAM. We demonstrate through extensive experimentation that GFAM exhibits good generalization and is of small size (creates few ART categories), while consuming reasonable computational effort. In a number of classification problems, GFAM produces the optima...
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PMID: 17851035
PDF is available here.
Abstract
Blood temperature-varying has been widely applied in clinical practice such as extracorporeal circulation for whole-body perfusion hyperthermia (WBPH), body rewarming and blood temperature-varying in organ transplantation. This paper reports a novel DCS (Computer distributed control)-based blood tem...
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PMID: 18027677
PDF is available here.
Abstract
We develop and experimentally validate an electrical modeling approach for DIB networks by applying it to describe the current flow through a simple network containing protein pores and blocking molecules. We demonstrate the use of SPICE (Simulation Program with Integrated Circuit Emphasis) for simu...
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PMID: 17764183
PDF is available here.
Abstract
We present an algorithm that provides a significant reduction in computational cost. Because most of the fast reactants and their quickly decomposing reaction products are localized near emission sources, we use a series of reduced chemical models of decreasing complexity with increasing distance fr...
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PMID: 17715302
PDF is available here.
Abstract
We extend an existing analytical expression for the leave-one-out cross-validation error [Cawley, G. C., & Talbot, N. L. C. (2003b). Efficient leave-one-out cross-validation of kernel Fisher discriminant classifiers. Pattern Recognition, 36(11), 2585-2592] such that the leave-one-out error can be re...
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PMID: 17600674
PDF is available here.
Abstract
We discuss several aspects related to load balancing of database search jobs in a distributed computing environment, such as Linux cluster. Load balancing is a technique for making the most of multiple computational resources, which is particularly relevant in environments in which the usage of such...
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PMID: 17663575
PDF is available here.