Abstract
Search methods described attempt to overcome the bias inherent in the publication and distribution of clinical evidence. Bibliographic databases and search strategies are discussed with special emphasis on searching for observational studies and harms data. Other techniques described include the use...
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PMID: 21684115
PDF is available here.
Abstract
To examine whether statins can reduce the risk of atrial fibrillation.
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PMID: 21411487
PDF is available here.
Abstract
To determine the comparative effects of the thiazolidinediones (rosiglitazone and pioglitazone) on myocardial infarction, congestive heart failure, and mortality in patients with type 2 diabetes.
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PMID: 21415101
PDF is available here.
Abstract
Mechanistic reasoning suggests that since antireflux surgery treats the gastroesophageal reflux that is the major known risk factor for Barrett's esophagus, it should have a beneficial effect on the biology of Barrett's disease. Due to a lack of adequate data, whether this is the case remains uncerta...
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PMID: 21389920
PDF is available here.
Abstract
We compared the rate of reporting of positive outcomes in clinical trials to describe potential bias.
In total, 307 Chinese papers, 117 Indian papers, and 304 Western papers were included. Reports of Indian trials were slightly better than Chinese papers on the trial reporting quality indicators and...
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PMID: 20554429
PDF is available here.
Abstract
Tumor necrosis factor-α (TNF-α) plays a very important role in the development and progress of cancer. Some TNF-α polymorphisms have been confirmed to increase cancer risks; however, the association between TNF-α-238 polymorphism and cancers remains controversial and ambiguous. The aim of this st...
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PMID: 21818296
PDF is available here.
Abstract
We performed a meta-analysis on a large population to address this inconsistency.
A meta-analysis was performed to examine the association between TNF-
promoter polymorphisms (-1031T/C, -863C/A, -857C/T, -308G/A and-238G/A) and chronic hepatitis B infection. Odds ratio (OR) an...
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PMID: 21572952
PDF is available here.
Abstract
Forty bias terms were used in the title or abstract of more than 100 articles each. Pseudo-inclusion clustering identified 252 clusters of terms. The clusters were organized into macroscopic maps that cover a continuum of research fields. The resulting maps highlight which types of biases tend to co...
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PMID: 20400265
PDF is available here.
Abstract
Systematic reviews and meta-analyses are being submitted to, and being published by biomedical journals with increasing frequency. In order to maintain the utility of such publications and avoid misguidance it is important that these studies are conducted to a high standard. This article aims to pro...
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PMID: 20732826
PDF is available here.
Abstract
We identified 6,218 potential articles yielding 10 relevant methodological evaluations. One evaluation found that adverse effects were reported more often in unpublished trials. For anecdotal case reports, two evaluations found a higher frequency of unpublished cases, whereas one study identified a...
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PMID: 20457510
PDF is available here.
Abstract
Published data on the association between TGFBR1*6A/9A polymorphism and cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 32 studies including 13,662 cases and 14,147 controls were involved in this meta-analysis. Overall,...
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PMID: 19882361
PDF is available here.
Abstract
The published data on the predictive and prognostic value of KRAS mutations in metastatic colorectal cancer (mCRC) treated with cetuximab seemed inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Systematic computerised searches of the PubMed, EMBas...
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PMID: 20580219
PDF is available here.
Abstract
We tested two phenotypes: response rate and remission rate. OR was used as a measure of the effect of the association in a fixed/random effect model. Meta-analysis was performed for genotypes Met/Met versus Val/Val, Val/Met versus Val/Val, Met/Met versus Val/Met, Val/Met+Met/Met versus Val/Val, Met/...
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PMID: 20167454
PDF is available here.
Abstract
The observed heterogeneity precludes a summary effect estimate. We also cannot conclude that reminder-only intervention strategies are more effective than alternate strategies. Additional studies are needed to identify methods or strategies that could increase repeat mammography....
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PMID: 20587790
PDF is available here.
Abstract
The high quality literatures on acupuncture RCTs that has been published in China and the United States in recent years are retrieved. The analysis of random methods, research design and application status and social conditions is carried out. The statistical analysis of China population and the Uni...
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PMID: 20862947
PDF is available here.
Abstract
The bibliographic search yielded 12 studies that met the inclusion criteria, which were supplemented with the data from a large Dutch cohort (n=426). The OR based on the 12 studies including 1721 patients was 1.24 (95% CI 0.98 to 1.56) and the SMD based on 11 studies including 2579 patients was -0.1...
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PMID: 19966089
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We consider the problem of evaluating a statistical hypothesis when some model characteristics are nonidentifiable from observed data. Such a scenario is common in meta-analysis for assessing publication bias and in longitudinal studies for evaluating a covariate effect when dropouts are likely to b...
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PMID: 19645705
PDF is available here.
Abstract
We define and discuss several aspects of publication bias: why it occurs; its importance to dental practitioners, dental educators, and dental students; its potential to affect treatment decisions; and how it can be detected. In addition, we briefly discuss attempts to reduce publication bias. Ideal...
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PMID: 20516298
PDF is available here.
Abstract
Study results are often presented as abstracts at scientific conferences before publication as full articles in peer-reviewed journals. Given the current emphasis on evidence-based decision-making, it is vital that the peer-reviewed literature represents as broad and un-biased a selection of studies...
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PMID: 20338648
PDF is available here.
Abstract
These results suggest that overall IL-8 -251 A/T gene polymorphism is not associated with the risk of GC and the association may be varied according to histological type, tumor location, H. pylori infection and ethnicity/country. More well-designed studies based on larger population are needed to co...
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PMID: 20363644
PDF is available here.
Abstract
Plasma concentrations of a variety of drugs are known to be increased by concomitant administration of grapefruit juice (GFJ) when the drugs are administered orally. Dihydropyridine Ca channel blockers, that form one of the major categories of antihypertensive, have been studied for interactions for...
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PMID: 20503932
PDF is available here.
Abstract
We performed this meta-analysis to update the clinical evidences on the relation between clopidogrel non-responsiveness and clinical outcomes in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention. An electronic literature search through MEDLINE, EMBASE, Web...
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PMID: 20135063
PDF is available here.
Abstract
We performed a systematic review and meta-analysis of the available studies to assess the association between protein Z and vascular thrombotic diseases. We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, The Cochrane Library, bibliographies of retr...
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PMID: 20076855
PDF is available here.
Abstract
The issue of violent video game influences on youth violence and aggression remains intensely debated in the scholarly literature and among the general public. Several recent meta-analyses, examining outcome measures most closely related to serious aggressive acts, found little evidence for a relati...
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PMID: 20192554
PDF is available here.
Abstract
RFA seems to be a superior ablative therapy than PEI for HCC, particularly for tumours >2 cm. PAI did not differ significantly from PEI for all the outcomes evaluated. RFA and PAI have similar survival rates. For tumours 2 cm outcome benefits comparing RFA and PEI are similar. PAI needs re-evaluatio...
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PMID: 20149473
PDF is available here.
Abstract
There were positive associations between the use of solid fuels and COPD (OR=2.80, 95% CI 1.85 to 4.0) and chronic bronchitis (OR=2.32, 95% CI 1.92 to 2.80). Pooled estimates for different types of fuel show that exposure to wood smoke while performing domestic work presents a greater risk of develo...
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PMID: 20335290
PDF is available here.
Abstract
Characteristics of participants, studies, and the environments in which they are conducted may affect the accuracy of ambient PM2.5 as a proxy for personal exposure....
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PMID: 20087191
PDF is available here.
Abstract
Cancer stories (N = 5,327) in the top 50 U.S. newspapers were analyzed by a team of four coders and the results were compared with the earliest analyses of this type (from 1977 and 1980). Using cancer incidence rates as a comparison, three cancers were found to be consistently underreported (male re...
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PMID: 20390983
PDF is available here.
Abstract
The treatment changed for the benefit of Quetiapine and Haloperidol. The use of both Risperidone and Olanzapine decreased markedly. CONCLUSION: The antipsychotic treatment changed due to critical publication. But, the evidence for the risk profile is still a matter of debate....
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PMID: 19724997
PDF is available here.
Abstract
We would like to discuss the importance and implication of publication bias in this meta-analysis....
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PMID: 20135731
PDF is available here.
Abstract
Although the efficacy of psychological treatment for panic disorder (PD) with or without agoraphobia has been the subject of a great deal of research, the specific contribution of techniques such as exposure, cognitive therapy, relaxation training and breathing retraining has not yet been clearly es...
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PMID: 19775792
PDF is available here.
Abstract
Dissemination of research findings is likely to be a biased process, although the actual impact of such bias depends on specific circumstances. The prospective registration of clinical trials and the endorsement of reporting guidelines may reduce research dissemination bias in clinical research. In...
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PMID: 20181324
PDF is available here.
Abstract
Ten publications fulfilling the inclusion criteria were found. Premedication with clonidine, in comparison with midazolam, exhibited a superior effect on sedation at induction (OR=0.49 [0.27, 0.89]), decreased the incidence of emergence agitation (OR=0.25 [0.11, 0.58]) and produced a more effective...
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PMID: 20085541
PDF is available here.
Abstract
Despite the growing strength of the field of suicidology, various commentators have recently noted that insufficient effort is being put into intervention research, and that this is limiting our knowledge of which suicide prevention strategies might be the most effective.
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PMID: 21134848
PDF is available here.
Abstract
Both panegyric and criticism of evidence-based dentistry tend to be clumsy because the concept is poorly defined. This analysis identifies several contributions to the profession that have been made under the EBD banner. Although the concept of clinicians integrating clinical epidemi...
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PMID: 21485345
PDF is available here.
Abstract
We performed a meta-analysis on all available studies, which included 5,368 and 6,683 XPD Lys(751)Gln cases and controls and 3,220 and 4,391 Asp(312)Asn cases and controls, respectively. Overall, Significant risk effects of Lys(751)Gln genotype was found under recessive model contrast [Gln/Gln vs. (...
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PMID: 19669592
PDF is available here.
Abstract
We performed a meta-analysis from all eligible case-control studies to address the association of IGFBP3 A-202C and Gly32Ala polymorphisms to cancer. 20 articles including 41 studies for A-202C variant including 28,322 cancer patients and 36,772 healthy controls and six articles for Gly32Ala variant...
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PMID: 19449212
PDF is available here.
Abstract
Associations between polymorphisms of the osteoprotegerin gene (OPG) and bone mineral density (BMD) have been studied by several research groups, but results are mixed. Accordingly, the authors performed a meta-analysis on studies of associations between OPG polymorphisms and BMD. Appropriate studie...
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PMID: 19642016
PDF is available here.