Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Disulfides (1):
Recent article
Disulfides
Xenobiotica (41)5 2011
Abstract
Conjugates of antibodies with cytotoxic agents offer a targeted therapeutic strategy against cancer cells expressing target antigens. Several antibodies against various cancer cell-surface antigens have been conjugated with different cytotoxic agents that inhibit essential cellular targets such as m...
|
PMID: 19252846
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
(1) immediate decondensation if chromatin fibers concomitantly are induced to repel (e.g., through phosphorylation in the ooplasm) and (2) thiols freed from Zn(2+) are available to form disulfide bridges creating a superstabilized chromatin. Spermatozoa in the zinc rich prostatic fluid (in first eja...
|
PMID: 21204594
PDF is available here.
PDF is available here.
Abstract
Our results demonstrate that ajoene has an effect of activating AMPK through LKB1 and inhibit S6K1 activity, contributing to the prevention of SREBP-1c-mediated hepatic lipogenesis via the inhibition of LXRα activity....
|
PMID: 20560786
PDF is available here.
PDF is available here.
Biochemical Journal (433)2 2010
Abstract
We have crystallized the human GLRX5 bound to two [2Fe-2S] clusters and four GSH molecules. The crystal structure revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved β1-α2 loop, Phe⁶⁹ and the GSH molecules. Each [2...
|
PMID: 21029046
PDF is available here.
PDF is available here.
Abstract
An efficient pyrene-assisted method has been developed for the photolysis of disulfide bonds, with 77% of disulfides cleaved after only 20 min of irradiation (0.3W) at 350 nm. By employing a DNA framework, it was possible to observe both a distance-dependent cleavage pathway and a ra...
|
PMID: 21080636
PDF is available here.
PDF is available here.
Abstract
Disulfide bond engineering is an important approach to improve the metabolic half-life of cysteine-containing peptides. Eleven analogues of oxytocin were synthesized including disulfide bond replacements by thioether, selenylsulfide, diselenide, and ditelluride bridges, and their stabilities in huma...
|
PMID: 21117646
PDF is available here.
PDF is available here.
Abstract
Upon X-ray irradiation of hypoxic aqueous solution, modified oligodeoxynucleotides (ODNs) bearing a pair of disulfides at both ends of the strand that forms a stem-and-loop structure with a neighboring arrangement of α,ω-bis-disulfides underwent efficient cyclization via an intramolecular exchange...
|
PMID: 20820660
PDF is available here.
PDF is available here.
Abstract
Negative ion electrospray mass spectra of the peptides produced by tryptic and chymotrypsin digests of bovine insulin, and from the tryptic digest of lysozyme identify at least 80% of the sequences of these proteins. In particular, negative ion mass spectrometry identifies and positions disulfide mo...
|
PMID: 20835491
PDF is available here.
PDF is available here.
Abstract
We discuss metal-protein interactions in the Ag-lysozyme complex by spectroscopic measurements. The analysis of the variation in relative intensities of SERS bands reveals the orientation and the change in conformation of the protein molecules on the Ag surface with time. The interaction kinetics of...
|
PMID: 20685371
PDF is available here.
PDF is available here.
Biophysical Journal (99)4 2010
Abstract
We have carried out molecular dynamics simulations of the SNARE complex in the oxidized and reduced states. Indeed, marked conformational differences and a reduction of helical content in SNAP-25B upon oxidation are seen. Further differences are found for hydrophobic interactions at three locations,...
|
PMID: 20713006
PDF is available here.
PDF is available here.
Abstract
The thermal sensitivity and pH-sensitive spectral properties of firefly luciferase have hampered its application in a variety of fields. It is proposed that the stability of a protein can be increased by introduction of disulfide bridge that decreases the configurational entropy of unfolding. A disu...
|
PMID: 20593108
PDF is available here.
PDF is available here.
Abstract
In the present work, methanethiol and dimethyldisulfide were investigated as sulfur source for methionine synthesis in Corynebacterium glutamicum. In silico pathway analysis has predicted a high methionine yield for these reduced compounds provided that they can be utilized. Wild type cells were abl...
|
PMID: 20798582
PDF is available here.
PDF is available here.
Molecular Membrane Biology (27)4-6 2010
Abstract
We have used a site-directed cross-linking approach to show that, in both bacterial and yeast V-type ATPases, the N-terminal alpha-helical segments of the G and E subunits are closely aligned over a distance of up to 40 A. Furthermore, cross-linking coupled to mass spectrometry shows that the C-term...
|
PMID: 20446876
PDF is available here.
PDF is available here.
Abstract
Catechol-2, 3-dioxygenase (C23O) from Pseudomonas sp. CGMCC2953 identified in our laboratory, which is one of the key enzymes responsible for phenanthrene biodegradation, was expected to get better characteristics tolerant to environment for its further application. With the aim of improving the enz...
|
PMID: 19688300
PDF is available here.
PDF is available here.
Journal of Biochemistry (148)2 2010
Abstract
We also demonstrated that the C145S mutation didn't affect the autologous hexamerization of this protein, and the mutant had increased bioactivities including phosphate transferase and DNase. These findings support the hypothesis that the formation of DBs in NDPK-A is involved in the regulation of t...
|
PMID: 20403806
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We showed that the inhibitory efficacy of the ribbon isomer of AuIB is limited to approximately 50%. The maximal inhibition was stoichiometry-dependent because altering alpha3:beta4 RNA injection ratios either increased AuIB(ribbon) efficacy (10alpha:1beta) or completely abolished blockade (1alpha:1...
|
PMID: 20466726
PDF is available here.
PDF is available here.
Advanced Materials (FRG) (22)25 2010
Abstract
Advanced Materials (FRG) (22)25 2010
Abstract
Advanced Materials (FRG) (22)25 2010
Abstract
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.
Journal of Nutrition (140)7 2010
Abstract
We investigated whether ajoene, a chemically stable garlic by-product, has the ability to activate Nrf2 and induce GCL, and, if so, what is the role of activating Nrf2 in cytoprotection against oxidative stress. Immunoblottings and reporter gene assays were performed in HepG2 cells. Ajoene treatment...
|
PMID: 20463144
PDF is available here.
PDF is available here.