Abstract
Traumatic injuries can interrupt muscle contraction by damaging the skeletal muscle and/or the peripheral nerves. The healing process results in scar tissue formation that impedes muscle function. Electrospinning and metal nanoparticles (Nps) can create a scaffold that will trigger m...
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PMID: 21695797
PDF is available here.
Abstract
We are able to conjugate GNP with peptides, drugs, and other molecules to gain astonishing effects. High quality, non-invasive imaging will inevitably lead to astonishing accuracy diagnostic tools with effective use during surgery. The same principles may be used in the future for drug delivery and...
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PMID: 21780364
PDF is available here.
Abstract
I monoclonal antibodies (Mabs) were prepared by hybridoma technique and firstly used to develop a Sudan I immunosensor by immobilizing the Mabs on a gold electrode. o-Mercaptobenzoic acid (MBA) was covalently conjugated on the gold electrode to form a self-assembled monolayer (SAM). The immobilizati...
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PMID: 21315921
PDF is available here.
Abstract
The potential role of arbuscular mycorrhizal fungi (AMF) in the revegetation of an alkaline gold mine tailing was studied in Barberton, South Africa. The tailing, characterized by a slow spontaneous plant succession, is colonized by the shrub Dodonaea viscosa and the grasses, Andropogon eucomus and I...
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PMID: 21598786
PDF is available here.
Abstract
Two novel, bionanocomposite scaffolds were evaluated in a rodent model over the course of three months to determine whether these scaffolds possessed adequate biocompatibility characteristics to warrant further evaluation as possible tissue reconstruction scaffolds. These bionanocomp...
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PMID: 21210516
PDF is available here.
Abstract
A gold/sodium dodecylbenzene sulfonate nanoparticles modified glassy carbon electrode (nano-Au/SDBS/GCE) was electrochemically fabricated with a constant potential at -0.4V. The obtained nano-Au/SDBS/GCE was characterized with scanning electronic microscopy, X-ray photoelectron spectroscopy and elec...
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PMID: 20832258
PDF is available here.
Abstract
We present the concept of metallophilic hydrogels, supramolecular systems in which the gelator species are metal-thiolates that self-assemble through metallophilic attractions. The principle is applied for a small drug, the mucolytic agent N-acetyl-l-cysteine (NAC), which readily forms hydrogels in...
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PMID: 20882249
PDF is available here.
Abstract
Large area chiral supramolecular self-assembly of rubrene has been achieved on Au(111) surface at room temperature. The basic building block of such self-assembled layers consists of two double-layered Y-shape supramolecular structures containing eight twisted rubrene molecules. Chirality is maintai...
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PMID: 20820574
PDF is available here.
Abstract
A study of the charge transfer and self-assembly characteristics of two new rigid-rod molecular wires 1 and 2 assembled on polycrystalline gold electrodes was carried out using electrochemical impedance spectroscopy and cyclic voltammetry. This class of wires have precisely controlled (ca. 1.5-2.5 n...
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PMID: 20890500
PDF is available here.
Abstract
Herein we report that a visual, label-free gold nanoparticle-based assay for rapid and efficient screening of Alzheimer's disease β-amyloid inhibitors.
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PMID: 20931124
PDF is available here.
Abstract
We have used peptide motifs that have been selected to bind to gold, platinum, glass and titanium to modify surfaces with poly(ethylene glycol) anti-fouling polymer and the integrin-binding RGD sequence. The peptides have several advantages over conventional molecular immobilization techniques; they...
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PMID: 20601249
PDF is available here.
Abstract
We have demonstrated that 0.4 and 1 μm beads conjugated with antibodies can be rapidly assembled into the microwells by applying a pulsed electric field across the chamber. By assembling step-wise a mixture of fluorescently labeled antibody-conjugated microbeads, we incorporated both spatial and fl...
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PMID: 20820631
PDF is available here.
Riccardo Rubbiani,
Igor Kitanovic,
Hamed Alborzinia,
Suzan Can,
Ana Kitanovic,
Liliane A Onambele,
Maria Stefanopoulou,
Yvonne Geldmacher,
William S Sheldrick,
Gerhard Wolber,
Aram Prokop,
Stefan Wölfl and
Ingo Ott
Abstract
Gold(I) complexes such as auranofin have been used for decades to treat symptoms of rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer drugs. The enzyme thioredoxin reductase (TrxR) is considered as the most relevant molecular target for these species. The her...
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PMID: 21082862
PDF is available here.
Abstract
We found that the gold-chlorine bond is significantly stronger in the case of the complex containing five-membered metallacyclic rings....
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PMID: 20886134
PDF is available here.
Abstract
Positively-charged gold nanoparticles possess intrinsic peroxidase-like activity, and can catalyze oxidation of the peroxidase substrate 3,3,5,5-tetramethylbenzidine (TMB) by H(2)O(2) to develop a blue color in aqueous solution, thus providing a simple approach to colorimetric detection of H(2)O(2)...
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PMID: 20871928
PDF is available here.
Abstract
This article describes efforts to build a model biological membrane at a surface of a gold electrode. In this architecture, the membrane may be exposed to static electric fields on the order of 10(7) to 10(8) V m(-1). These fields are comparable in magnitude to the static electric field acting on a...
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PMID: 20852809
PDF is available here.
Abstract
The multilayer formation of two different sulfonated polyanilines with cytochrome c is presented and mechanistic aspects of the contributions of the polyelectrolytes' properties to the characteristics of the assemblies are discussed. These two modified polymers, PASA1 and PASA2 are chemically synthe...
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PMID: 20882225
PDF is available here.
Abstract
Tumor vascular disrupting agents (VDAs) represent a promising approach to the treatment of cancer, in view of the tumor vasculature's pivotal role in tumor survival, growth and metastasis. VDAs targeting the tumor's dysmorphic endothelial cells can cause selective and rapid occlusion of the tumor va...
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PMID: 20959684
PDF is available here.
Abstract
We have modified the synthesis procedure to obtain a mesoporous SiO(2) core and a porous Au shell that allows drugs to be loaded within the core porous space. The release of a model drug (ibuprofen) upon NIR activation is demonstrated....
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PMID: 20830418
PDF is available here.
Abstract
We describe the use of simple 1-pot thiol exchange reactions to generate a library of mixed ligand-coated gold nanoparticles that was screened for antibiotic activity. A library of 120 nanoparticle conjugates was assembled and antibiotic activity toward E. coli was determined and found to depend upo...
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PMID: 20835461
PDF is available here.
Abstract
Luminol functionalized gold nanoparticles were used as labels for electrochemiluminescence signal amplification and an ultrasensitive, highly selective, convenient, low cost DNA detection strategy was developed.
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PMID: 20852765
PDF is available here.
Abstract
In this paper an enzyme-carrier-based microfluidic chip coupled with a gold nanoband microelectrode as electrochemical detector for Triglyceride (TG) determination was developed by co-immobilized lipase, Glycerokinase (GK) and glycerol-3-phosphate oxidase (GPOx) on chitosan/Fe(3)O(4) composite nanop...
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PMID: 20877885
PDF is available here.
Abstract
Gold nanoparticles immobilized on gold surfaces (AuNPs/Au) function as an excellent SERS substrate for the detection of bacteria biomarkers. The possibility of the reactivity of bacteria biomarkers on such a nanoparticle-based substrate poses complications for the spectroscopic identification and qu...
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PMID: 20877832
PDF is available here.
Abstract
A method was developed for the synthesis of molecularly imprinted Au nanoparticle (NP) composites on electrodes by electrochemical means. The resulting composites include specific recognition sites for mono- or disaccharides. The method is based on the formation of a boronate complex between the res...
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PMID: 20830445
PDF is available here.
Abstract
We report a molecular recognition between adenosine and its aptamer, which leads to the formation of a four-stranded tetraplex structures (G-quartet) of the aptamer. It is found that the formed G-quartet could induce the side-by-side self-assembly of gold nanorods (AuNRs) owing to the electrostatic...
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PMID: 20830327
PDF is available here.
Abstract
The objective of this study was to establish a new test system for the monitoring of platelet aggregation during extracorporeal circulation (ECC) procedures. Even though extensive progress has been made in improving the haemocompatibility of extracorporeal circulation devices, activation of blood co...
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PMID: 20877907
PDF is available here.
Abstract
We discuss the influence of temperature, the composition of the ionic liquids and the electrode material on the differential capacitance/potential curves. For different systems these curves have various overall shapes, but all include several extremes and a common minimum near the open circuit poten...
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PMID: 20721389
PDF is available here.
Abstract
We have investigated the fundamental amidation reaction by a model system consisting of an electrochemically functionalised Au surface by aminophenyl and 4-nitrobenzoic acid activated by EEDQ. The development of the NO(2) related stretching vibrations with time reveals that the amidation process is...
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PMID: 20737098
PDF is available here.
Abstract
Ag(0) and Au(0) nanoparticles suspended in dilute aqueous solutions containing (CH(3))(2)SO are photochemically unstable. The light source of a diode-array spectrophotometer induces, within less than a minute, particle growth and aggregation. The results indicate that this process is triggered by UV...
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PMID: 20820594
PDF is available here.
Abstract
Monodisperse gold nanocrystals with unique near-infrared optical properties were synthesized by simple mixing of highly shortened and well disperse single-walled carbon nanotubes and chloroauric acid in water at ambient conditions with a step-wise increase of gold ion concentration.
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PMID: 20737105
PDF is available here.
Abstract
A significant increase (ca. 22-fold) in the electricity generation due to a Shewanella oneidensis MR-1 biofilm was observed in the presence of Fe(3)O(4)/Au nanocomposites.
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PMID: 20717577
PDF is available here.
Abstract
Water-soluble luminescent AuNPs of 1.3 ± 0.3 nm in diameter with a large Stokes shift were facilely synthesized by a new molten matrix sputtering (MMS) method.
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PMID: 20740224
PDF is available here.
Abstract
A thermosensitive liposome with embedded AuNPs in a bilayer was prepared using supercritical CO(2). The AuNPs-liposome can absorb a certain wavelength light, convert optical energy into heat, induce phase transition, and release drug. The results show that drug release from the liposome is due to th...
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PMID: 20820547
PDF is available here.
Abstract
We show that a fluidic slit with appropriately tailored topography has a spatially modulated electrostatic potential that can trap and levitate charged objects in solution for up to several hours. We illustrate this principle with gold particles, polymer beads and lipid vesicles with diameters of te...
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PMID: 20930840
PDF is available here.
Abstract
Highly efficient gold nanoparticle uptake was observed. Transfected islets demonstrated normal mitochondrial function, calcium influx, and insulin release when stimulated by glucose. These islets produced a 100% diabetes cure rate after transplantation. Intraperitoneal glucose tolerance test demonst...
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PMID: 20800254
PDF is available here.
Abstract
Inorganic nanomaterials (INMs) and nanoparticles (NPs) are important in our lives because of their use as drugs, imaging agents, and antiseptics. Among the most promising INMs being developed are metal, silica, dendrimers, organic-inorganic hybrids, and bioinorganic hybrids. Gold NPs...
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PMID: 20417314
PDF is available here.
Abstract
The performance of various density functional theory methods on the geometries and energetics of Au(2), Au(3), Au(4), and Au(5) has been systematically evaluated. The results were compared with those from experiments or high-level wave function theory methods. In the present study, spin-orbit (SO) c...
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PMID: 20806984
PDF is available here.
Abstract
A novel method for fabrication of 2D and 3D metal nanoparticle structures and arrays is proposed. This technique is based on laser-induced transfer of molten metal nanodroplets from thin metal films. Metal nanoparticles are produced by solidification of these nanodroplets. The size of the transferre...
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PMID: 20941016
PDF is available here.
Shutao Guo,
Yuanyu Huang,
Qiao Jiang,
Yun Sun,
Liandong Deng,
Zicai Liang,
Quan Du,
Jinfeng Xing,
Yuliang Zhao,
Paul C Wang,
Anjie Dong and
Xing-Jie Liang
Abstract
These results demonstrate the feasibility of using charge-reversal functional gold nanoparticles as a means of improving the nucleic acid delivery efficiency....
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PMID: 20707386
PDF is available here.
Abstract
We demonstrated enhanced localized surface plasmon resonance (SPR) biosensing based on subwavelength gold nanoarrays built on a thin gold film. Arrays of nanogratings (1D) and nanoholes (2D) with a period of 200 nm were fabricated by electron-beam lithography and used for the detection of avian infl...
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PMID: 20693616
PDF is available here.
Abstract
We show that long-range surface plasmons (LRSPs) are supported in a physically asymmetric thin film structure, consisting of a low refractive index medium on a metal slab, supported by a high refractive index dielectric layer (membrane) over air, as a suspended waveguide. For design purposes, an ana...
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PMID: 20940795
PDF is available here.
Abstract
The nonlinear optical (NLO) properties of induced transmission filters (ITFs) based on Ag are experimentally determined using white light continuum pump-probe measurements. The experimental results are supported using simulations based on the matrix transfer method. The magnitude of the NLO response...
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PMID: 20940805
PDF is available here.
Abstract
This paper reports the design analysis of a microfabricatable mid-infrared (mid-IR) surface plasmon resonance (SPR) sensor platform. The proposed platform has periodic heavily doped profiles implanted into intrinsic silicon and a thin gold layer deposited on top, making a physically flat grating SPR...
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PMID: 20940835
PDF is available here.
Abstract
A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900 nm) was als...
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PMID: 20940754
PDF is available here.
Abstract
The authors demonstrated that their integrated photoacoustic imaging and HIFU system has the potential for contrast imaging with gold nanorods with possible diagnosis and treatment of solid tumors....
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PMID: 20964197
PDF is available here.
Abstract
We compared the efficiencies of biosensors that use gold-coated single-crystal silicon and amorphous glass substrates. The reflectivity of light over a wide range of wavelengths was higher from gold layer coated single-crystal silicon substrates than from glass substrates. Furthermore, the efficienc...
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PMID: 20628872
PDF is available here.
Abstract
We investigated the covalent biofunctionalization of magnetic nanoparticles based on carbodiimide activation. An important aspect in the covalent biofunctionalization of nanoparticles has been neglected, namely pre-concentration. Exploiting the electrostatic attraction forces between a protein and t...
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PMID: 20683138
PDF is available here.
Abstract
We introduced a modification to the standard protocol exposing the Embryonic Stem Cells (ES-D3) to nanoparticles only during the first 5 days of the assay. Moreover, we proposed a method to discriminate and compare the embryotoxicity of the substances within the weakly embryotoxic range. Our ID(50)...
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PMID: 20566333
PDF is available here.
Abstract
DNA piezoelectric biosensors have become a promising tool in molecular medicine since they do not require any label or staining. Here, a DNA piezoelectric biosensor based on a quartz crystal microbalance (QCM) was created to identify abnormal genes causing α-thalassemia 1 (SEA deletion).
The functi...
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PMID: 20578968
PDF is available here.
Abstract
We report a novel aptamer-based capacitive label-free biosensor for monitoring transducing aptamer-protein recognition events, based on charge distribution under the applied frequency by non-Faradaic impedance spectroscopy (NFIS). This approach to capacitive biosensors is reported for the first time...
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PMID: 20648264
PDF is available here.
Abstract
In this study, an interface embedded in situ gold nanoparticles (AuNPs) and biotin in chitosan hydrogel was constructed by one-step electrochemical deposition in solution containing tetrachloroauric (III) acid, biotin and chitosan. This deposited interface acts as biosensing platform...
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PMID: 21133092
PDF is available here.
Abstract
We find that the use of enhanced nano-particles shows promise to be implemented quite easily in regular clinics on a physical level due to the advantageous properties in classical beams....
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PMID: 20668345
PDF is available here.
Abstract
We studied the growth of self-assembling monolayers of C(11)Eg(6)OMe on gold under aqueous conditions. With the help of polarisation modulation infrared reflection absorption spectroscopy (PMIRRAS) we monitored the evolution of characteristic absorption modes in the fingerprint region (1050-1500 cm(...
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PMID: 20532327
PDF is available here.