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Iodine Isotopes (1):
Recent article
Iodine Isotopes
Abstract
We evaluated 5-HT6 receptor expression and associated biochemical mechanisms in the hippocampus of rats that had been trained in the Morris water maze (MWM), a spatial learning task. Training in the MWM induces a down-regulation of 5-HT6 receptor protein and mRNA receptor expression. The learning pr...
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PMID: 19737440
PDF is available here.
PDF is available here.
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Abstract
Environmental 129I mainly released from reprocessing plants at La Hague (France) and Sellafield (U.K.) provides a unique atmospheric and environmental tracer. This study deals with 129I and 127I speciation in precipitation collected in Denmarkduring 2001-2006 that indicates many newfindings. The con...
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PMID: 19764211
PDF is available here.
PDF is available here.
Abstract
A facile synthesis of six 4-iodophenyl tagged sphingosine (SP) derivatives bearing alkyl chain lengths from 6 to 13 is described. The key steps for the assembly of these molecules, 5a-f, are Suzuki-Miyaura cross-coupling and cross-metathesis reactions. The feasibility of radiolabelin...
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PMID: 19467599
PDF is available here.
PDF is available here.
Journal of Neurochemistry (109)3 2009
Abstract
We tested whether nicotine is also beneficial when given to rats and monkeys with pre-existing nigrostriatal damage. Rats were administered nicotine before and after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle, and the results compared with those in which rats received nicot...
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PMID: 19250334
PDF is available here.
PDF is available here.
Neuroscience (159)2 2009
Abstract
With the use of a rabbit polyclonal antiserum against a conserved region (54-118) of C-peptide of human preproinsulin-like peptide 7, referred to herein as C-INSL7, neurons expressing C-INSL7-immunoreactivity (irC-INSL7) were detected in the pontine nucleus incertus, the lateral or ventrolateral per...
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PMID: 19373968
PDF is available here.
PDF is available here.
Abstract
A 64-year-old woman was admitted to our hospital for recurrent stroke and cognitive impairment and was diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Iodine-123 iodoamphetamine single photon emission computed tomography showed hyp...
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PMID: 19512965
PDF is available here.
PDF is available here.
Abstract
We measured the clearance of [125I]-Abeta(1-40) injected into the brains of liver-ligated rats that allowed peripheral Abeta levels to be maintained at elevated levels for approximately one hour with/without a single peripheral bolus of unlabeled Abeta(1-40). We found that elevating peripheral Abeta...
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PMID: 19221422
PDF is available here.
PDF is available here.
Lakartidningen (106)26-27 2009
Abstract
Neuropharmacology (55)5 2008
Abstract
Adaptive changes in serotonin2A (5-HT(2A)) receptor signaling are associated with the clinical response to a number of psychiatric drugs including atypical antipsychotics and selective serotonin reuptake inhibitors. The present study examined possible mechanisms of agonist-induced desensitization of...
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PMID: 18588902
PDF is available here.
PDF is available here.
Physiology & Behavior (95)1-2 2008
Abstract
We used immunohistochemical techniques to characterize the distribution of apo A-IV in brain areas involved in energy homeostasis. Dense apo A-IV staining was detected in the arcuate (ARC) and ventromedial hypothalamic nuclei with less staining in cells in the paraventricular and dorsomedial nuclei....
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PMID: 18577393
PDF is available here.
PDF is available here.
Abstract
We studied uptake of (125)I-amiodarone and (125)I-B2, an analog lacking the lateral group diethylamino-beta-ethoxy, and analyzed the effects of amiodarone on the distribution of endosomal markers and on the uptake of an acidotropic dye. Furthermore, using Vero cells, we tested the impact of amiodaro...
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PMID: 18314540
PDF is available here.
PDF is available here.
Neuroscience Letters (440)1 2008
Abstract
We studied the effects of concomitant chronic nicotine and chronic stress exposure on mouse striatal dopamine levels. C57Bl6/J mice were treated with nicotine in the drinking water or control solution for at least 6 weeks. Some mice were chronically stressed by daily exposure to cold, shaking or res...
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PMID: 18539390
PDF is available here.
PDF is available here.
Neurobiology of Disease (30)1 2008
Abstract
We developed an in vitro BBB-like model using Madin-Darby Canine Kidney (MDCK) cells seeded on filters separating apical (blood) and basolateral (brain) compartments. MDCK cells were stably transfected with Pgp or mLRP4, an LRP mini-receptor. When compared to empty vector-transfected cells, MDCK-Pgp...
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PMID: 18289866
PDF is available here.
PDF is available here.
Academic Radiology (15)3 2008
Abstract
DHOG yields a very good visualization of the liver and delineation of the surrounding structures with a long plateau. It is a very suitable contrast agent for liver imaging in mice for microCT imaging. The presented protocol provides a high reproducibility for lesion detection with a relatively low...
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PMID: 18280932
PDF is available here.
PDF is available here.
Abstract
We have evaluated microdialysis probes with two membrane materials (polycarbonate and polyarylethersulfone, both: molecular cut off 20,000 Da) in vitro, and adapted the method for in vivo hypothalamic sample collection in non-human primates. The results of in vitro experiments showed that the polyar...
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PMID: 17936911
PDF is available here.
PDF is available here.
Abstract
Specific cocaine-amphetamine regulated transcript (CART) receptor binding has been reported in AtT20 and PC12 cells. In this study, receptor binding has been examined in primary cell cultures of several rat brain regions. Utilizing (125)I-CART 61-102 as a ligand and CART 55-102 as a displacer, signi...
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PMID: 18000808
PDF is available here.
PDF is available here.
Abstract
The psychotherapy-related SERT elevation of atypically depressed subjects may be due to some unknown adaptive mechanisms inducing an increase in either the levels of SERT or serotonergic nerve terminals and therefore enhancing serotonergic activity and improving mood....
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PMID: 17884269
PDF is available here.
PDF is available here.
Abstract
These findings suggest that cigarette smoking may alter central dopamine functions in males, particularly at the pre-synaptic sites....
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PMID: 17900774
PDF is available here.
PDF is available here.
Abstract
Benzamide derivatives as radiotracers have played an important role in diagnosing malfunction in dopaminergic neurotransmission. A variety of halogenated and two unsubstituted benzamide derivatives were synthesised and their in vitro affinities to dopaminergic, serotonergic and adrenergic receptors...
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PMID: 17765546
PDF is available here.
PDF is available here.
Neuropsychopharmacology (32)11 2007
Abstract
Both clinical and animal studies have shown that adolescents undergo a late maturation of the central nervous system, which may underlie adolescent typical behaviors. In particular, decreased behavioral response to cocaine has been found in adolescents as compared to adults. In the present study, coc...
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PMID: 17299504
PDF is available here.
PDF is available here.
Abstract
Dementia with Lewy bodies (DLB) is a progressive dementia frequently accompanied by psychotic symptoms. Similar symptoms can occur in Alzheimer's disease (AD) to a lesser extent. The use of neuroleptic medication to treat psychosis in both diseases is of modest efficacy and can induce severe adverse...
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PMID: 17663455
PDF is available here.
PDF is available here.
Neuroscience Letters (425)1 2007
Abstract
DJ-1 is a multifunctional protein whose loss of function by gene mutations may play a causative role for familial Parkinson's disease (PD). A recent study has shown that the expression of this molecule is upregulated in both brains and cerebrospinal fluids (CSF) in various neurological disorders, in...
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PMID: 17720313
PDF is available here.
PDF is available here.
Abstract
We determined which part of chicken PrP(c) is required for its anterograde axonal transport within the optic nerve of embryonic chicken. We intraocularly injected radio-iodinated fragments of recombinant chicken PrP(c) and then examined their anterograde axonal transport from retina into optic tectu...
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PMID: 17335074
PDF is available here.
PDF is available here.
Abstract
We identified kinesin-I proteins as a motor participating in the anterograde axonal movement of vesicular structures containing radiolabeled neurotrophins along the optic nerve. RT-PCR analysis of purified murine RGCs showed that adult RGCs express all known members of the kinesin-I family. After in...
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PMID: 17243173
PDF is available here.
PDF is available here.
Abstract
Surface seawater samples collected from the North Sea and English Channel were analyzed for total 129I and 127I, as well as for iodide and iodate. Relatively high 129I concentrations (2-3 x 10(11) atoms/L) were observed in the northern part of the English Channel and in the southeastern North Sea. T...
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PMID: 17937272
PDF is available here.
PDF is available here.
Journal of Chromatography A (1159)1-2 2007
Abstract
We investigate the complexation behavior of HA and its influence on the migration or retardation of selected lanthanides (europium and gadolinium as homologues of the actinides americium and curium). Two independent speciation techniques, ultrafiltration and capillary electrophoresis coupled with in...
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PMID: 17459403
PDF is available here.
PDF is available here.
Abstract
The novel RFamide peptide 26RFa, the endogenous ligand of the orphan receptor GPR103, affects food intake, locomotion, and activity of the gonadotropic axis. However, little is known regarding the localization of 26RFa receptors. The present report provides the first detailed mapping...
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PMID: 17534937
PDF is available here.
PDF is available here.
Neurobiology of Aging (28)6 2007
Abstract
We report that the membrane-bound, but not cytosolic insulin degrading enzyme (IDE) protein concentration and IDE activity are significantly decreased in the hippocampal formation of cases affected by mild cognitive impairment (MCI) which are at high risk to develop Alzheimer's disease (AD), relativ...
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PMID: 16769157
PDF is available here.
PDF is available here.
Brain Research (1143) 2007
Abstract
Efforts to protect radiolabeled angiotensins from metabolism during receptor binding assays date back more than 30 years. However, this continues to be a problem. This study focused on the effects of a protease inhibitor, p-chloromercuribenzoate (PCMB), on the binding of (125)I-Ang II to rat brain m...
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PMID: 17306233
PDF is available here.
PDF is available here.
European Journal of Pharmacology (559)2-3 2007
Abstract
We report specific binding of 125I-CART(61-102) to the rat adrenal pheochromocytoma PC12 cell line, both intact cells and cell membranes. Saturation binding to intact plated cells resulted in Kd of 0.48+/-0.16 nM and Bmax of 2228+/-529 binding sites/cell. 125I-CART(61-102) was also bound to PC12 cel...
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PMID: 17292884
PDF is available here.
PDF is available here.
Abstract
We compared their L topologies and showed that both particle types exhibit the same amount of L with the following differences: 1--preS of intact virions was enzymatically digested with chymotrypsin, whereas in SVPs only half of preS was accessible, 2--phosphorylation of L at S118 was completely rem...
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PMID: 17045625
PDF is available here.
PDF is available here.
Abstract
Enzyme-mediated cancer imaging and therapy (EMCIT) is a novel approach in which radioactive water-soluble molecules are precipitated in vivo following their hydrolysis by extracellular enzymes overexpressed by cancer cells. AutoDock 3.0 was used to model the interaction-binding between a series of i...
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PMID: 17256924
PDF is available here.
PDF is available here.
Journal of Neurochemistry (100)2 2007
Abstract
We studied the role of the cytoplasmic regions adjacent to the M3 and M4 transmembrane segments of alpha7 nicotinic receptors in the expression of functional channels. For this purpose, a total of 50 amino acids were mutated throughout the mentioned regions. Mutants close to M3, from Arg294 to Leu32...
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PMID: 17076762
PDF is available here.
PDF is available here.
Abstract
No plasma CCK-like activity was detected by RIA or bioassay before or after ingestion of meals. Preprandial devazepide did not alter the gastric accommodation response but did significantly shorten the gastric half-emptying time and time to peak breath (13)CO(2) content with the glucose-enriched mea...
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PMID: 17144800
PDF is available here.
PDF is available here.
Neurotoxicology (27)6 2006
Abstract
We show that Nrf2, a transcription factor that regulates the expression of phase 2 and antioxidative enzymes, modulates MPTP neurotoxicity in rodents. Nrf2 knockout and wild-type mice were administered MPTP doses ranging from 20 to 60mg/kg. Seven days after MPTP administration dopamine transporter (...
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PMID: 16959318
PDF is available here.
PDF is available here.
Neuroscience (143)1 2006
Abstract
We previously reported that treatment and withdrawal from cocaine increases: (1) 5-HT2A receptor-mediated neuroendocrine responses, and (2) Galphaq and Galpha11 G-protein levels in the hypothalamic paraventricular nucleus (PVN) at 48 h post-treatment. This study investigates changes in the initial 2...
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PMID: 17055657
PDF is available here.
PDF is available here.
Neuroscience Research (56)3 2006
Abstract
We determined the apparent brain-to-blood [(125)I]hAbeta(1-40) efflux clearance in rats and found it to be 11.0 microL/(ming brain). There were no significant gender differences in the apparent brain-to-blood [(125)I]hAbeta(1-40) efflux clearance. The brain-to-blood [(125)I]hAbeta(1-40) efflux trans...
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PMID: 16926058
PDF is available here.
PDF is available here.
Abstract
Endocrine Journal (53)5 2006
Abstract
We compared serum FT4 levels at radioiodine uptake (RAIU) and therapy outcomes between a 2-day withdrawal group and 7-day withdrawal group. We prospectively recruited 43 patients for the 2-day withdrawal protocol and retrospectively reviewed 49 patients treated with radioiodine following the protoco...
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PMID: 16896267
PDF is available here.
PDF is available here.
Abstract
Changes of rCBF in right DLPFC, ACC, MPFC, PCC and precuneus were related to the AN recovery process and might be associated with improvement of IA following treatment....
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PMID: 16777310
PDF is available here.
PDF is available here.
Abstract
The association between atypical scores of HAM-D-29 and midbrain SERT densities suggests a relationship between serotonergic dysfunction and ATD....
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PMID: 16644083
PDF is available here.
PDF is available here.
Brain Research (1113)1 2006
Abstract
We determined if chronic nicotine treatment during a developmental period corresponding to the human third trimester regulates nAChR expression. Rat pups were intubated orally three times per day with or without nicotine (6 mg/kg/day) from postnatal day 1 to 8. Subunit mRNA expression was assessed b...
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PMID: 16942759
PDF is available here.
PDF is available here.
Biological Psychiatry (60)6 2006
Abstract
The present data are the first to confirm a significant correlation between frontal D(2/3) receptor BP values and positive symptoms in male schizophrenic patients. They are in agreement with the hypothesis that frontal D(2/3) receptor activity is significant for positive psychotic symptoms. Addition...
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PMID: 16580642
PDF is available here.
PDF is available here.
Abstract
We used metabolic labeling to directly assess leptin biosynthesis, secretion, and turnover in adipose tissue from 14 h-starved compared with fed 12-14 week old rats. Starvation decreased serum leptin (-47 +/- 7%), adipose tissue leptin content (-32 +/- 5%), and leptin secretion during 3 h of incubat...
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PMID: 16738357
PDF is available here.
PDF is available here.
Neuroscience (141)2 2006
Abstract
We hypothesized that oxytocin receptor in the nucleus accumbens facilitates the expression of "spontaneous" maternal behavior in prairie voles. Forty sexually-naive adult females were exposed to pups for the first time and tested for maternal behavior. Oxytocin receptor binding in the nucleus accumb...
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PMID: 16725274
PDF is available here.
PDF is available here.
Neuroscience (141)2 2006
Abstract
We therefore examined the effects of longer term morphine pretreatment and withdrawal on delta opioid receptor-mediated antinociception in the formalin test. Male adult rats were pretreated daily with morphine (10 mg/kg s.c.) or saline for 10 days, and were tested acutely with the delta opioid recep...
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PMID: 16716526
PDF is available here.
PDF is available here.
Abstract
Abstract
We examined the effects of low and high doses of estradiol administered to control and ovariectomized adult female rats and to pre-pubertal females. We demonstrate that estradiol administration to both intact adult and pre-pubertal females causes a significant increase in the relative thyroid weight...
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PMID: 16762383
PDF is available here.
PDF is available here.
Clinica Chimica Acta (369)2 2006
Abstract
Abstract
In cultured bovine adrenal chromaffin cells treated with nicotine (10 microm for 24 h), phosphorylation of Akt, glycogen synthase kinase-3beta (GSK-3beta) and extracellular signal-regulated kinase (ERK)1/2 induced by insulin (100 nm for 10 min) was enhanced by approximately 62%, without altering leve...
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PMID: 16805793
PDF is available here.
PDF is available here.
Abstract
In vitro receptor autoradiography requires unfixed tissue sections, but incubation and washing procedures often result in substantial tissue damage in sections from developing brain, hindering quantitative and qualitative analysis. Formaldehyde fixation greatly preserves morphology. However, fixatio...
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PMID: 16406107
PDF is available here.
PDF is available here.
Brain Research Bulletin (70)1 2006
Abstract
Our results suggest that impairment of Na+, K+-ATPase activity together with altered kinetic properties could be one of the underlying biochemical mechanism leading to central nervous system (CNS) dysfunctions as a consequence of thyroid hormone deprivation during critical stages of brain developmen...
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PMID: 16750483
PDF is available here.
PDF is available here.
Abstract
We showed that interaction of hAChE with Abeta affects the plasticity of the alpha7 nicotinic acetylcholine receptors (nAChRs) both in the brain and adrenal medulla. An age-related increase in the (125)I-alphabungarotoxin ((125)I-alphaBTX) binding (specific to alpha7 nAChRs) was observed in the adre...
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PMID: 16574369
PDF is available here.
PDF is available here.
Neuroscience (139)2 2006
Abstract
Insulin-like growth factors-I and -II and insulin are structurally related mitogenic growth factors with multiple actions in the developing nervous system and adult CNS. Previous studies have demonstrated acute induction of insulin-like growth factors and their receptors, over a time course of sever...
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PMID: 16448776
PDF is available here.
PDF is available here.
Matrix Biology (25)4 2006
Abstract
We evaluated the effect of perlecan isolated from the growth plate on the binding of FGF-2 to its low and high affinity receptors on resting and proliferating chondrocytes. Chondrocytes were isolated by pronase/collagenase digestion of 1 mm thick slices from the resting and proliferating zones of fe...
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PMID: 16481152
PDF is available here.
PDF is available here.
Movement Disorders (21)5 2006
Abstract
We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (GCH1) and a decrease in [123I]-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) nortropane (123I-FP-CIT) binding ratios indicative of Pa...
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PMID: 16267845
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (174)1-2 2006
Abstract
We initially showed that transport of LIF is mediated by its specific receptor LIFRalpha (gp190), using both adult mice and monolayers of mouse brain microvessel endothelial cells. Permeation of radioactively labeled LIF was inhibited not only by excess unlabeled LIF, but also by a blocking antibody...
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PMID: 16563523
PDF is available here.
PDF is available here.
Abstract
We used in vivo and in vitro techniques to examine the BBB permeation of the newly described satiety peptide obestatin. The fate of obestatin in blood and at the BBB was contrasted with that of adiponectin. By the sensitive multiple time-regression method, obestatin appeared to have an extremely fas...
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PMID: 16476508
PDF is available here.
PDF is available here.
Indian Pediatrics (43)4 2006
Abstract
Majority of patients was in the age group of 12-16 years. Common symptoms observed at presentation were weight loss (82.1%), excessive sweating (78.6%), heat intolerance (76.8%), increased appetite (73.2%) and diarrhea in 48.2%. In addition, accelerated linear growth was observed in 7.1% of patients...
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PMID: 16651668
PDF is available here.
PDF is available here.
Abstract
We conducted a phase 1/2 study in which targeted irradiation delivered by 131I-anti-CD45 antibody was combined with targeted busulfan (BU; area-under-curve, 600-900 ng/mL) and cyclophosphamide (CY; 120 mg/kg). Fifty-two (88%) of 59 patients receiving a trace 131I-labeled dose of 0.5 mg/kg anti-CD45...
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PMID: 16254140
PDF is available here.
PDF is available here.