Abstract
We lack however the results of large randomized phase III trials to define clearly the place of those interventional therapies in the management of colorectal cancer metastatic to the liver....
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PMID: 16673565
PDF is available here.
Abstract
I and II gene therapy trials using adenoviral vectors containing a wild-type or modified p53 have shown that the treatment is well tolerated. Phase II and III trials are ongoing with MAbs directed against CA-125 (MAb B43.13) and an antibody directed against HMFG1 (anti-HMFG1-yttrium-90-labeled antib...
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PMID: 12743131
PDF is available here.
Abstract
We compared the estimated absorbed doses to human organs, as well as to a CA20948 rat tumor, of 90Y- and 64Cu-labeled DOTA-Y3-OC and DOTA-Y3-octreotate (DOTA-Y3-TATE). Assuming that the radiopharmaceutical biodistributions are the same in rodents and humans, human absorbed dose estimates were obtain...
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PMID: 11190491
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Abstract
Yttrium-90 synovectomy resulted in complete resolution of chronic knee synovitis in 40% of a group of 15 patients. These patients would have otherwise required surgical synovectomy. The number of chromosomal aberrations detected in 30 patients after yttrium-90 synovectomy showed a statistically sign...
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PMID: 601431
PDF is available here.
Abstract
Experiments described in the literature lead to different formulae for saturation corrections in ionization chambers. To elucidate the differences, saturation curves of an extrapolation chamber irradiated with beta particles from 90Sr+90Y sources have been studied experimentally. The...
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PMID: 967924
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Abstract
The characteristics of three colloidal preparations of 90-Y currently used for the irradiation of chronic synovitis of the knee have been studied. One, 99-Y silicate, showed less leakage away from the joint than the other two preparations, 90-Y ferric hydroxide and 90-Y citrate. Comparable amounts o...
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PMID: 1139094
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Abstract
Intravesical Y-90 was used in 38 patients with multiple papillary T1 tumors considered beyond control by cystodiathermy. Of the 32 patients available for 3-year observation 19 (60 per cent) were alive after 3 years, 6 had died of progression of the tumor and 7 had died of other causes. Prolonged imp...
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PMID: 1117518
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Abstract
We report here the effects on symptoms, pituitary function and visual fields. On biopsy, about a third of the tumours showed some hormone granules. In the sixteen fully assessed at 1 year, pituitary function was improved in 25%, unchanged in 62-5%, and reduced in 12-5%. Improvement was confined to t...
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PMID: 165914
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Abstract
The results of a randomised trial of irradiation of the knee (synoviorthése), by intra-articular injection of yttrium-90, and surgical synovectomy have been compared in twenty knees in seventeen patients. The mean length of follow-up was 2 years. Relapse occurred in three out of ten irradiated kn...
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PMID: 46959
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Abstract
In human urinary concentrates and also in a urinary gonadotrophin standard (2nd IRP-HMG), gel-filtration analysis revealed three main peaks of immunoassayable luteinizing hormone (LH). A similar analysis of LH extracted from human pituitaries showed most of the activity in a peak of larger molecular...
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PMID: 166130
PDF is available here.
Abstract
Chromosomal damage to circulating lymphocytes occurs following injection of intra-articular radio-isotopes. Differences in the degree of chromosomal damage have been shown with various colloidal forms of yttrium 90, and the severity of these changes has been shown to correlate with the degree of lea...
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PMID: 1121639
PDF is available here.
Abstract
Two cases of acute rupture of the knee joint are reported after the intra-articular injection of radioactive yttrium 90. It is suggested that this may be a complication of intra-articular radioactive injections.
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PMID: 1124955
PDF is available here.
Abstract
A modification of the conventional extrapolation chamber to perform absolute dose measurements from surfaces of spherical beta applicators (type SIA.I, SIA.3, SIA.6) is described. A stack of Ilford N 550 films has been used in a spherical geometry to obtain the variation of surface dose, the depth d...
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PMID: 1119657
PDF is available here.