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Platinum Compounds (1):
Recent article
Platinum Compounds
Abstract
A phase 2 trial was conducted to determine the toxicity and efficacy of combined weekly topotecan and biweekly bevacizumab in patients with primary or secondary platinum-resistant ovarian, peritoneal, or fallopian tube cancer (OC).
Patients were treated with bevacizum...
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PMID: 21815133
PDF is available here.
PDF is available here.
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Abstract
This is the first study evaluating the effect of the RAD51 G135C polymorphism in NSCLC patient survival. Our results suggest that RAD51 genotypes could be useful molecular markers for predicting the clinical outcome of NSCLC patients....
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PMID: 19960343
PDF is available here.
PDF is available here.
Journal of Chemotherapy (22)4 2010
Abstract
The aim of this study was to determine if in vitro extreme drug resistance (EDR) to platinum and/or taxane chemotherapy was predictive of patient response to intraperitoneal (I.P.) chemotherapy in patients with stage III or recurrent epithelial ovarian cancer (EOC). Fifty-six patients were retrospec...
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PMID: 20685633
PDF is available here.
PDF is available here.
British Journal of Cancer (102)12 2010
Abstract
Capecitabine seems to be an active, feasible and well-tolerated mode of palliative treatment for advanced HNC patients who have previously received PBT schedules....
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PMID: 20485287
PDF is available here.
PDF is available here.
Abstract
Darbepoetin alpha alleviated anemia caused by platinum-based chemotherapy, and the dosage of 2.25 microg/kg was the lowest dose that met the clinically effective dose criteria when administered once weekly....
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PMID: 20508073
PDF is available here.
PDF is available here.
Abstract
Metals are essential cellular components selected by nature to function in several indispensable biochemical processes for living organisms. Metals are endowed with unique characteristics that include redox activity, variable coordination modes, and reactivity towards organic substrates. Due to thei...
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PMID: 20337575
PDF is available here.
PDF is available here.
Abstract
The standard treatment for advanced ovarian cancer consist in complete surgical debulking and intravenous platin and taxane based chemotherapy. Despite research efforts, a lot of patients still die from peritoneal carcinomatosis. The aim of our work was to present the state of art about intraperiton...
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PMID: 20116179
PDF is available here.
PDF is available here.
Abstract
Picoplatin, a third-generation platinum agent, is efficacious against lung cancers that are otherwise resistant or become refractory during platinum treatment. This effort was aimed at the determination of the influence of organic cation transporters 1, 2, and 3 (OCT1, OCT2, and OCT3) and their gene...
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PMID: 20371711
PDF is available here.
PDF is available here.
Abstract
Our focus has been to study effects of generating electrochemical by-products at the electrode-electrolyte interface, using the pulse-clamp technique coupled with voltammetry to analyze charge transfer. The platinum-H(2)SO(4) system has been a standard for analyzing electrochemistry on platinum-stim...
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PMID: 20208126
PDF is available here.
PDF is available here.
Abstract
MoDCs populations generated from three healthy volunteers displayed the phenotype responsive to NiSO4 and non-responsive to sodium dodecyl sulfate (SDS). Clear up-regulation of IL-1beta mRNA as well as CD54, CD86 and HLA-DR expression in response to NiSO4 (250 microM) was detected after 48 hrs of ex...
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PMID: 19702435
PDF is available here.
PDF is available here.
Chemical Communications (46)8 2010
Abstract
Platinum(II) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.
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PMID: 20449253
PDF is available here.
PDF is available here.
Abstract
The potential energy surfaces of chiral tetraamine Pt(II) coordination complexes were computed at the B3LYP/LANL2DZ level of theory by a systematic variation of two dihedral angles: C12-C15-C34-C37 (theta) and C24-C17-C31-C48 (psi) employing a grid resolution of 30 degrees . Potential energy surface...
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PMID: 20333441
PDF is available here.
PDF is available here.
Abstract
Chemotherapy-induced peripheral neuropathy (CIN) is a common toxicity of anticancer treatment and its incidence is growing. It significantly affects quality of life and is a dose-limiting factor that interferes with treatment. Its diagnosis can be established in clinical terms but some complementary...
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PMID: 20156778
PDF is available here.
PDF is available here.
Abstract
We examined the association between chemotherapy-induced myelosuppression and prognosis in limited-stage disease small cell lung cancer (LD SCLC). We retrospectively analyzed 76 patients with LD SCLC who received combination cisplatin or carboplatin of etoposide or irinotecan. Patients were categori...
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PMID: 20154478
PDF is available here.
PDF is available here.
Oncology (Basel) (78)1 2010
Abstract
At relapse, 24% of the patients presented with an isolated elevation in serum tumor markers, 26% with pathologic radiologic confirmation with negative tumor markers, and 42% with elevated tumor markers and radiologically confirmed progression. Relapse was detected by clinical symptoms in 8%. 46% rel...
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PMID: 20215785
PDF is available here.
PDF is available here.
Voprosy onkologii (56)5 2010
Abstract
Two modalities of chemoradiotherapy for locally advanced squamous cell cancer of oro-hypopharynx and oral cavity were compared in the treatment of 34 patients. Five-year survival after cisplatin, 5-FU, taxotere, and carboplatin plus irradiation with TTD of 68-72 Gy (group 1) was 59.5% versus 13.8% w...
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PMID: 21137242
PDF is available here.
PDF is available here.
Abstract
Platinum-based chemotherapy has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it has high toxicity. In China, Shenqi Fuzheng, a newly developed injection concocted from Chinese medicinal herbs has been reported that may increase efficacy and reduce toxicity when combin...
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PMID: 20969765
PDF is available here.
PDF is available here.
Abstract
We studied 65,316 patients with breast cancer, 9242 with ovarian cancer, and 86,278 with non-small cell lung cancer from 1991 through 2002 identified from the 16 areas of Surveillance, Epidemiology and End Results. The incidence density of PN was 15.3, 21.5, and 18.3 per 1000 person-years for patien...
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PMID: 19417586
PDF is available here.
PDF is available here.
Abstract
DNA aptamers carrying Pt nanoparticles prepared with cisplatin showed peroxidase enzymatic activity while retaining the specific binding ability of the aptamers. Optimal preparation conditions of DNA-Pt complex prepared with cisplatin were investigated on the synthesis at pH 7-11, a reaction time of...
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PMID: 20040154
PDF is available here.
PDF is available here.
Abstract
The five platinum anticancer compounds currently in clinical use conform to structure-activity relationships formulated (M. J. Cleare and J. D. Hoeschele, Bioinorg. Chem., 1973, 2, 187-210) shortly after the discovery that cis-diamminedichloroplatinum(II), cisplatin, has antitumor activity in mice....
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PMID: 20023892
PDF is available here.
PDF is available here.
International Journal of Gynecological Cancer (19 Suppl 2) 2009
Abstract
We were better able to measure the benefit of palliative therapy and, in particular, ascertain whether cancer-related symptoms improve with treatment and how this impacts on quality of life. This paper reviews the management of patients with platinum-resistant/refractory ovarian cancer and highlight...
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PMID: 19955914
PDF is available here.
PDF is available here.
International Journal of Gynecological Cancer (19 Suppl 2) 2009
Abstract
Other mechanisms of variability, including epigenetic control of gene expression and copy number variation, may play important roles. In addition, nongenetic influences such as concurrent medications, and physiological and environmental factors could also affect individual responses to taxane and pl...
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PMID: 19955911
PDF is available here.
PDF is available here.
International Journal of Gynecological Cancer (19 Suppl 2) 2009
Abstract
The term platinum sensitive should probably be replaced by chemotherapy sensitive, particularly as new nonplatinum agents and combinations are identified as active in this setting. Nonplatinum doublets are effective in treating platinum-sensitive recurrent disease, and adding antiangiogenesis agents...
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PMID: 19955917
PDF is available here.
PDF is available here.
Oncology Reports (22)4 2009
Abstract
Platinating agents constitute the first line treatment for ovarian cancer but treatment failure is common because of intrinsic and acquired resistance. Cancer cells develop the RASP-phenotype (cross resistance against arsenite, antimonite and platinum) associated with decreased accumulation of cispl...
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PMID: 19724867
PDF is available here.
PDF is available here.
Radiation Research (172)3 2009
Abstract
We examined in vitro and in vivo whether monochromatic X rays are more efficient than high-energy photons in producing the PAT-Plat effect by measuring DNA double-strand breaks (DSBs) and survival of glioma-bearing rats and whether an increase in the platinum concentration in the tumor results in in...
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PMID: 19708784
PDF is available here.
PDF is available here.
Ginekologia polska (80)9 2009
[Safety of PLD in the treatment of the patients with recurrent ovarian cancer--clinical experience].
Abstract
Pegylated liposomal doxorubicin used in recurrent ovarian cancer as the second and subsequent lines of therapy drug of choice has good treatment tolerance and high rates of positive treatment responses....
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PMID: 19886242
PDF is available here.
PDF is available here.
Abstract
Abstract
The use of 2,2'-bipyridines (4,4'-R(2)-2,2'-bpy; R=H, Me, OMe, CF(3)) as non-leaving groups (L-L) in platinum-acridinylthiourea conjugates, [PtCl(L-L)(ACRAMTU)](NO(3))(2), has been investigated. All bpy-substituted complexes (2-5) show micromolar activity in HL-60 (leukemia) and H460...
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PMID: 19477643
PDF is available here.
PDF is available here.
Abstract
Three (15)N-labelled trans-Pt(ii) amine complexes with isopropylamine ((15)N-ipa), methylamine ((15)N-ma) and dimethylamine ((15)N-dma) have been prepared and characterized. 2D [(1)H,(15)N] HSQC NMR spectroscopy was used to obtain the rate and equilibrium constants for the aquation of trans-[PtCl(2)...
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PMID: 19381408
PDF is available here.
PDF is available here.
Abstract
No significant difference between the IC50 of the cells was observed among genotypes (P = 0.46) after exposure to camptothecin. No association was also observed for etoposide, carboplatin, cisplatin, and daunorubicin (ANOVA, P > 0.05). WRN expression also did not vary across genotypes (ANOVA, P = 0....
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PMID: 18677484
PDF is available here.
PDF is available here.
Abstract
PS and primary DFI are useful predictors of the response to third-line chemotherapy in women with recurrent ovarian, fallopian tube, and primary peritoneal cancer. In this setting, however, both of these variables are subject to several well-established potential biases and limitations; further pros...
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PMID: 18830625
PDF is available here.
PDF is available here.
Seminars in Oncology (36)2 2009
Abstract
The majority of patients who present with epithelial ovarian cancer respond well to the initial treatment, but will ultimately experience a recurrence of their disease. Chemotherapy can palliate symptoms of disease recurrence, and there is some evidence that it also can improve survival. Recurrent o...
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PMID: 19332246
PDF is available here.
PDF is available here.
Seminars in Oncology (36)2 2009
Abstract
Abstract
While some previous studies indicate that higher EGFR expression correlates with poor survival, our analyses provide statistically significant evidence that the combination of EGFR expression and growth pattern is a strong prognostic indicator for improved survival within this setting. The effects o...
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PMID: 18787840
PDF is available here.
PDF is available here.
Vojnosanitetski pregled (66)2 2009
Abstract
BECKGROUND/AIM: K-ras oncogene is mutated in about 20% of lung cancer. The purpose of this study was to investigate the predictive significance for therapeutic response of K-ras mutations in advanced non-small cell lung cancer (NSCLC) patients.
Bronchial aspirate samples were assessed prior to plati...
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PMID: 19281127
PDF is available here.
PDF is available here.
Inorganic Chemistry (48)3 2009
Abstract
The cyclometalated platinum(II) complex [Pt(L)Cl], where HL is a new cyclometalating ligand 2-phenyl-6-(1H-pyrazol-3-yl)pyridine containing C(phenyl), N(pyridyl), and N(pyrazolyl) donor moieties, was found to possess two-photon-induced luminescent properties. The two-photon-absorption cross section...
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PMID: 19128152
PDF is available here.
PDF is available here.
Prescrire international (18)99 2009
Abstract
The numerous adverse effects (especially life-threatening infections and bleeding) outweigh the at best only moderate efficacy.
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PMID: 19385126
PDF is available here.
PDF is available here.
Abstract
We present here a case of a BRCA1 mutation carrier with repeat responsiveness of recurrent EOC to paclitaxel/platinum. The patient had complete response to the combination of paclitaxel/platinum in the first line. Subsequent four recurrences also showed a complete response to this combination. The c...
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PMID: 19697632
PDF is available here.
PDF is available here.
Abstract
The series of complexes: cis-[Pd(PMSA)2X2], cis-[Pt(PMSA)2X2], trans-[Pt(PMSA)2I2] and [Pt(PMSA)4]Cl2 (PMSA = N-3-pyridinylmethanesulfonamide; X = Cl, Br, I), previously synthesized and characterized by us, as well as the free ligand PMSA, were tested for their cytotoxic activity without electropora...
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PMID: 19526709
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To construct a drug carrier and gene vector PEG-PEI-Pt. METHODS: Polyethyleneglycol (PEG) was coupled to polyethylenimine (PEI 600) and platinum tetrachloride; PEG-PEI-Pt complex was formed in ethanol. The complex was characterized by XRD, UV-VIS and FT-IR and the DNA condensation was tes...
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PMID: 19253430
PDF is available here.
PDF is available here.
Abstract
The permanent colouring of disfigured corneal scars is known for almost 200 years. Because of improvement in surgical reconstructive techniques, corneal tattoing is used today only with a restricted group on carefully chosen patients, and merely for esthetique reasons.
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PMID: 19697848
PDF is available here.
PDF is available here.
Abstract
I and phase II trials. Copper-chelating compounds have also shown promising results in both preclinical and clinical studies. This review provides a comprehensive overview of various non platinum metal complexes and metal-chelating compounds and discusses their potential molecular targets in tumor c...
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PMID: 19275642
PDF is available here.
PDF is available here.
Abstract
Measurement of CRP before initiation and during a platinum-based chemotherapy can provide prognostic information for the individual patient with advanced NSCLC and is able to support or even replace assessment of response by radiographic imaging in defined situations.
Copyright 2008 S. Karger AG, Ba...
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PMID: 19060504
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: Albeit transitional cell carcinoma of the urinary bladder is a chemosensitive neoplasm, metastatic disease is related with poor prognosis and short-term survival data. OBJECTIVE: Cisplatin-based combination chemotherapy is recognised as the golden standard therapy for patients with inope...
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PMID: 19012504
PDF is available here.
PDF is available here.
Abstract
Coordination-driven self-assembly that combines rigid ditopic Pt(II) metal acceptors and bis-pyridyl organic donors provides a facile means of synthesizing well-defined metallacycles of predetermined size and geometry. Functionalization of the component acceptor or donor building blocks allows for t...
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PMID: 19030534
PDF is available here.
PDF is available here.
Lancet Oncology (9)12 2008
Abstract
Abstract
A series of new mononuclear and dinuclear platinum(ii) compounds based on two bipyridyl systems, linked by an alkyl chain {1,2-bis[4-(4'-methyl-2,2'-bipyridinyl)]ethane, L2, (a), and 1,6-bis[4-(4'-methyl-2,2'-bipyridinyl)]hexane, L6, (b)} have been synthesized and characterized by IR and multinuclea...
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PMID: 19082047
PDF is available here.
PDF is available here.
Abstract
New Pt(ii) and Pd(ii) complexes with the metal center coordinated to two different chelating ligands, tropolone (trop) and dihexadecyl-2,2'-bipyridine-4,4'-dicarboxylate bipyridine (bipy), [(bipy)M(trop)][CF(3)SO(3)], have been synthesized and their biological evaluation has been per...
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PMID: 19082045
PDF is available here.
PDF is available here.
Abstract
We report a unique strategy to deliver cisplatin to prostate cancer cells by constructing Pt(IV)-encapsulated prostate-specific membrane antigen (PSMA) targeted nanoparticles (NPs) of poly(D,L-lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-functionalized controlled release polymers. By...
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PMID: 18978032
PDF is available here.
PDF is available here.
Abstract
Palladium(II) and platinum(II) complexes having the general composition [M(L)] X2 (where M=Pd(II) and Pt(II), L=3,4,12,13-tetraphenyl-2,5,11,14,19,20-hexaaza tricyclo [13.3.1.1.(6-10)] cosa-1(19), 2,4,6,8,10,(20),11,13,15,17-decaene (L1); 3,4,13,14-tetraphenyl-2,5,12,15-tetraaza tricyclo [11,0,0,(6-...
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PMID: 18343190
PDF is available here.
PDF is available here.
Abstract
We have used site-directed mutagenesis and functional analysis to identify positively charged amino acid residues in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel that interact with extracellular anions. Mutation of two positively charged arginine residues in the first...
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PMID: 18449561
PDF is available here.
PDF is available here.
Oncology Reports (20)5 2008
Abstract
Novel demethylcantharidin-platinum (DMC-Pt) complexes have been found to have superior in vitro anticancer activity against a number of human colon cancer cell lines when compared with oxaliplatin. One complex where the DMC-Pt moiety was integrated with trans-R,R-diamino-cyclohexane (DACH), exhibite...
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PMID: 18949432
PDF is available here.
PDF is available here.
Lung Cancer (62)2 2008
Abstract
We identified 7 gefitinib and 41 platinum-based doublets chemotherapy trials with nearly 3000 enrolled patients for planned comparison. The pooled response rate (95% confidence interval) to gefitinib for unselected chemonaïve population was 31% (23-38%), not substantially different from 34% (31-38%...
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PMID: 18423782
PDF is available here.
PDF is available here.
Abstract
We have developed highly emissive, synthetically versatile, and photostable platinum(II) complexes that make TREM a practicable reality. [PtLCl], {HL = 1,3-di(2-pyridyl)benzene and derivatives}, are charge-neutral, small molecules that have low cytotoxicity and accumulate intracellularly within a re...
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PMID: 18852476
PDF is available here.
PDF is available here.
Analytical Biochemistry (381)1 2008
Abstract
We compare the profiles of cellular O(2) consumption in the absence and presence of these agents. Oxygen measurements are made at 37 degrees C, using glucose as a substrate, with [O(2)] obtained from the phosphorescence decay rate of a palladium phosphor. The rate of respiration k is defined as -d[O...
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PMID: 18602881
PDF is available here.
PDF is available here.
Abstract
Abstract
DNA aptamers carrying Pt nanoparticles were prepared by the reaction of DNA aptamers (without functionalization with biotin, thiol, or other reactive groups) with K 2[PtCl 4] in solution at 60-90 degrees C. The DNA-Pt complexes possessed peroxidase enzymatic activity while retaining the specific bin...
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PMID: 18665606
PDF is available here.
PDF is available here.
Abstract
A method for noncovalent functionalization of DNA-wrapped single-walled carbon nanotubes (SWNTs) using platinum-based DNA cross-linkers is investigated. In particular, cisplatin and potassium tetrachloroplatinate are shown to bind to DNA that encapsulates SWNTs in aqueous solution. The bound platinu...
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PMID: 18646876
PDF is available here.
PDF is available here.
Abstract
Pd(II) and Pt(II) chloride complexes with LL = methyl cis-3,4-diamino-2,3,4,6-tetradeoxy-alpha-l-lyxo-hexopyranoside of the formulae [Pd(LL)Cl(2)] and [Pt(LL)Cl(2)], 1, were studied by (1)H, (2)H, (13)C, (15)N and (195)Pt NMR spectroscopy. These techniques were applied for characterization of the st...
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PMID: 18688431
PDF is available here.
PDF is available here.