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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Skin (4):
Recent article
Skin
Abstract
A key to understanding the biological function(s) of the aryl hydrocarbon receptor (AHR) - a xenobiotic-activated receptor - is to identify its endogenous ligand(s). The discovery of a tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) as an endogenous, high affinity agonist of AHR filled...
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PMID: 21883026
PDF is available here.
PDF is available here.
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Biomacromolecules (12)9 2011
Abstract
The final goal of the present study was the development of a 3-D chitosan dressing that would shorten the healing time of skin wounds by stimulating migration, invasion, and proliferation of the relevant cutaneous resident cells. Three-dimensional chitosan nanofibrillar scaffolds pro...
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PMID: 21761871
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
I and elastin was significantly up-regulated when compared with TCPS control, whereas collagen III was down-regulated on PHBV fibers and 2-D film after 14 days in culture. The less ductile PHBV 2-D films showed higher levels of elastin expression. Furthermore, the PHBV fibers in the presence and abs...
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PMID: 21800891
PDF is available here.
PDF is available here.
Abstract
Natural biopolymers, such as collagen or chitosan, are considered ideal for biomedical scaffolds. However, low processability of the materials has hindered the fabrication of designed pore structures controlled by various solid freeform-fabrication methods. A new technique to fabrica...
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PMID: 21472408
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators and extrinsic support factors. hiN cells from unaffected individuals display morphological, el...
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PMID: 21816272
PDF is available here.
PDF is available here.
Abstract
We obtained and analysed samples of blood serum from 23 patients with MF, and 29 psoriasis patients and 22 healthy donors as controls. Protein profiling was carried out using SELDI TOF MS SELDI-TOF and also profiling of 27 cytokines with multiplex immunoassay technology was implemented....
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PMID: 21751413
PDF is available here.
PDF is available here.
Abstract
We found that UVB-induced tumors often had islands of phospho-Chk1 (Ser317) staining cells that were not present in nontumor areas of the epidermis. Treatment of mice with topical caffeine significantly diminished phospho-Chk1 (Ser317) staining and increased the number of mitotic cells that expresse...
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PMID: 21505179
PDF is available here.
PDF is available here.
Nature Immunology (12)5 2011
Abstract
We will discuss how the expression of IL-22 and IL-22R is regulated, the functions of the IL-22-IL-22R pathway in regulating immunity, inflammation and tissue homeostasis, and the therapeutic potential of targeting this pathway in human disease....
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PMID: 21502992
PDF is available here.
PDF is available here.
Abstract
Intravascular lymphomatosis (IVL) is a rare subtype of diffuse large B cell lymphoma, characterized by the presence of tumor cells only in the lumina of small vessels. Antemortem diagnosis of IVL is extremely difficult because of its varied clinical presentation and absence of lympha...
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PMID: 21515924
PDF is available here.
PDF is available here.
Abstract
PURPOSE. Topical biphasic vesicle delivery system encapsulating interferon alpha (IFN α) was developed as an alternative to injections used to treat human papillomavirus (HPV) infections. METHODS. Biphasic lipid vesicles encapsulating increasing doses of IFN α (biphasic IFN α) wer...
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PMID: 21291377
PDF is available here.
PDF is available here.
Abstract
The cytokine patterns in maculopapular exanthema have a Th1 or Th0 pattern, according to whether the reaction is induced by a drug or a virus, respectively. Additionally, the involvement of CD4 T-lymphocytes with cytotoxic capabilities has been shown in the former. Different chemokines and their rec...
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PMID: 19398898
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We discuss that the DNA delivery into skin can be greatly enhanced by topical electroporation of the DNA injection site in rabbits using a tweezer electrode. Furthermore, the immune responses following a DNA vaccine delivery by using electroporation have been explored. Electroporation shows great po...
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PMID: 18370202
PDF is available here.
PDF is available here.
Human Molecular Genetics (20)8 2011
Abstract
We generated transgenic mice expressing cDNA that encodes htt N118-82Q with the mouse prion promoter vector. In mice generated in this manner, we demonstrate robust inclusion pathology accompanied by early death and failure to gain weight. These phenotypes are the most robust abnormalities identifie...
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PMID: 21307087
PDF is available here.
PDF is available here.
Abstract
Severe burn injuries are a major health problem as they can compromise whole body function and result in extensive emotional trauma exacerbated by prolonged hospital stay. Burn injury treatment has improved dramatically to increase the probability of survival, but burn survivors stil...
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PMID: 21091393
PDF is available here.
PDF is available here.
Abstract
Hypoxia Inducible Factor-1 (HIF-1) is considered the major coordinator of the cellular adaptive response to hypoxia. Over recent years, its activity in the context of wound healing has been the object of increasing investigation. On the molecular level, HIF-1 transcriptional target p...
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PMID: 21375491
PDF is available here.
PDF is available here.
Abstract
We examined the inhibitive effect of ginsenoside Rh1 on oxazolone-induced atopic dermatitis-like skin lesions in hairless mice. Oral administration of ginsenoside Rh1 improved clinical symptoms, and it was confirmed by histophathological analysis. In ginsenoside Rh1 (20mg/kg) group, ear swellings an...
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PMID: 21238621
PDF is available here.
PDF is available here.
Abstract
We develop a simplified procedure that can be useful for large-scale screening of factors that can modulate the hair formation ability of candidate cells. Newborn mouse cells are used. Dissociated epidermal and dermal cells in high-density suspension are allowed to reconstitute in vitro to generate...
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PMID: 21034159
PDF is available here.
PDF is available here.
Abstract
We studied cutaneous melanomas from geographic regions with different levels of ambient UV radiation to delineate the relative effects of cumulative UV damage, age, and anatomic site on the frequency of BRAF mutations. We show that BRAF-mutated melanomas occur in a younger age group on skin without...
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PMID: 21324100
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)10 2011
Abstract
Abstract
We employed two-dimensional gel electrophoresis and mass spectrometry to generate a comparative proteome profile of control and mancozeb (200 mg/kg body weight) exposed mouse skin. Although many differentially expressed proteins were found, among them, two significantly upregulated proteins, namel...
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PMID: 21375462
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)5 2011
Abstract
Autoimmune and inflammatory phenomena are characteristically present in systemic sclerosis (SSc) and impact on dysregulated fibroblast extracellular matrix deposition, hallmark of the disease in conjunction with fibroproliferative vasculopathy. Oligoclonal T helper 2-like cells are p...
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PMID: 20863906
PDF is available here.
PDF is available here.
Autonomic Neuroscience (160)1-2 2011
Abstract
We hypothesized that vasoconstriction of skin microcirculatory bed should be altered following 7 days of simulated microgravity in order to maintain cardiovascular homeostasis during active standing. Eight healthy men were studied before and after 7 days of simulated microgravity modeled by dry imme...
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PMID: 21071283
PDF is available here.
PDF is available here.
Abstract
We focus on developing mouse skin, where progenitor cells execute a switch from symmetric to predominantly asymmetric divisions concomitant with stratification. Using in vivo skin-specific lentiviral RNA interference, we investigate spindle orientation regulation and provide direct evidence that LGN...
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PMID: 21331036
PDF is available here.
PDF is available here.
Abstract
We now confirm that GSPs do not inhibit UVB-induced immunosuppression in IL-12p40 knockout (IL-12 KO) mice and that treatment of these mice with recombinant IL-12 restores the inhibitory effect. To characterize the cell population responsible for the GSP-mediated inhibition of UVB-induced immunosupp...
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PMID: 21075976
PDF is available here.
PDF is available here.
Abstract
Skin, the largest organ of the human body, is organized into an elaborate layered structure consisting mainly of the outermost epidermis and the underlying dermis. A subcutaneous adipose-storing hypodermis layer and various appendages such as hair follicles, sweat glands, sebaceous g...
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PMID: 21029393
PDF is available here.
PDF is available here.
Abstract
We conclude this review by focusing on the most promising strategies suitable for inclusion into a cell-based in vitro alternative approach to hazard identification.
© 2010 Elsevier Inc. All rights reserved....
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PMID: 20950635
PDF is available here.
PDF is available here.
Abstract
We find that the background of Purkinje cell input provides a tonic inhibitory synaptic noise in the DCN cell. Under these conditions, individual Purkinje cells appear to have a near negligible influence on the DCN cell and clear-cut rebounds are difficult to induce. Peripheral input that drives the...
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PMID: 21552556
PDF is available here.
PDF is available here.
Abstract
We therefore analyzed the expression of these TNF cytokines in AE, seborrheic eczema (SE) and healthy controls (HC). The serum/plasma concentration of BAFF, APRIL and a close TNF member TWEAK (TNF-like weak inducer of apoptosis) was measured by ELISA. The expression of these cytokines and their rece...
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PMID: 21765951
PDF is available here.
PDF is available here.
Abstract
Our results indicated that while both acute and chronic UVR produced epidermal hyperplasia and a decrease in epidermal T-cell density, acute UVR increased T-cell proliferative response, while chronic UVR produced the opposite effect, shifting the cytokine production toward a Th2/Treg profile. Theref...
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PMID: 21598169
PDF is available here.
PDF is available here.
Abstract
We report an adult male with 22q11.2 deletion syndrome and a germline BRCA2 mutation who developed T-cell monoclonal lymphoid proliferation involving the skin and a polyclonal proliferation of a retroperitoneal lymph node without any identifiable infectious and inflammatory causes. This is the first...
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PMID: 20887823
PDF is available here.
PDF is available here.
Abstract
We describe the basic methodology for producing 3D tissue-engineered skin and oral mucosa based on de-epidermised acellular human dermis, and we give examples of how these models can be used for a variety of applications....
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PMID: 21042970
PDF is available here.
PDF is available here.
Abstract
We show the results of functional cutaneous microvascular experiments measured with photoacoustic microscopy, which provides high spatial resolution and multiparameter measurements. In a set of experiments, microvascular networks located in the palms of volunteers were perturbed by periodic ischemic...
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PMID: 21361688
PDF is available here.
PDF is available here.
Pharmaceutical Research (28)1 2011
Abstract
The purpose of this research was to examine the pharmacokinetics (PK) of drug uptake for microneedle-based intradermal (ID) delivery of several classes of protein drugs compared to standard subcutaneous (SC) administration.
Systemic absorption kinetics of various prot...
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PMID: 20354765
PDF is available here.
PDF is available here.
Abstract
Abstract
Expedited healing of skin wounds is essential regardless of surgical specialty. Any skin deficiency will thwart this basic intent, and an alternative must be sought. The autogenous skin graft or local flap has long had a major role in satisfying this objective. Various forms of autogenous skin graft...
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PMID: 21200192
PDF is available here.
PDF is available here.
Abstract
Closing Mohs' defects is a challenging undertaking for surgeons. There are many methods, including linear repair, local flaps, and skin grafts. Traditionally, geometric flaps have been a mainstay, particularly in the cheek and forehead. However, many flaps violate basic principles of following relax...
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PMID: 21200208
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to investigate the capabilities of a novel optical wide-field imaging technology known as spatial frequency domain imaging to quantitatively assess reconstructive tissue status.
Twenty-two cutaneous pedicle flaps were created on 11 rats based on the inferior epigastric...
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PMID: 21200206
PDF is available here.
PDF is available here.
Ugeskrift for laeger (173)1 2011
Abstract
Tattoos are very popular. Widely used standard industrial pigments are used. The field lacks basic knowledge concerning pigments, epidemiology and complications such as allergy, granulomas, skin cancer and foreign body reactions. The risks associated with laser treatment are unknown. Studies have su...
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PMID: 21199619
PDF is available here.
PDF is available here.
Abstract
Limitations associated with traditional skin-muscle flaps and later with transconjunctival fat resection combined with carbon dioxide laser resurfacing have led to newer concepts in lower blepharoplasty that emphasize fat preservation, blending of the lid-cheek junction, simplified skin excision, an...
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PMID: 21200234
PDF is available here.
PDF is available here.
Abstract
Necrosis with partial loss of mastectomy flaps is an all-too-common complication of otherwise advantageous skin-sparing mastectomies. Central to the problem of predictable flap viability is the thickness of the skin flaps. Seeking a balance between the preservation of adequate flap thickness and mai...
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PMID: 21200196
PDF is available here.
PDF is available here.
Abstract
Abstract
We reviewed the clinicopathologic features of 14 patients with syringotropic MF (male:female=10:4; median age, 59 years; mean age, 57.8; age range, 33 to 83 y). Six patients had variably large, solitary patches or plaques, located on the thigh (n=3), arm, trunk, or eyebrow (1 each). The other 8 pati...
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PMID: 21164293
PDF is available here.
PDF is available here.
Abstract
We studied their expression and localization in normal subjects and in genetically characterized UCMD and BM patients. We found that localization of α5, and to a lesser extent α6, is restricted to the papillary dermis, where the protein mainly colocalizes with collagen fibrils. In addition, both c...
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PMID: 20882040
PDF is available here.
PDF is available here.
Abstract
We hypothesized that PGI(2) has a dominant role in cathodal current-induced vasodilation (CIV) described in human skin. We thus aimed to study, in physiological conditions, the PGI(2) involvement in cathodal CIV in rats in order to use pharmacological blockers that could not be used in humans. CIV w...
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PMID: 20827283
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Fibromyalgia syndrome (FM) is a highly prevalent musculoskeletal disorder that is often accompanied by somatic hyperalgesia (enhanced pain from noxious stimuli). Neural mechanisms of somatic hyperalgesia have been analyzed via quantitative sensory testing of FM patients. Results of these studies sug...
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PMID: 20882373
PDF is available here.
PDF is available here.
Nature Immunology (11)12 2010
Abstract
Human CD4+ T cells that produce interleukin 22 are an essential component of skin defense and repair. New evidence shows that these T cells recognize CD1a-lipid complexes on Langerhans cells.
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PMID: 21079630
PDF is available here.
PDF is available here.
Nature Immunology (11)12 2010
Abstract
We show that polyclonal T cells responded at higher rates to cells expressing CD1a than to those expressing CD1b, CD1c or CD1d. Unlike the repertoire of invariant natural killer T (NKT) cells, the CD1a-autoreactive repertoire contained diverse T cell antigen receptors (TCRs). Functionally, many CD1a...
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PMID: 21037579
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The authors' purpose was to study the anatomy of the dorsum of the foot and determine the distribution and caliber of all vascular branches that nourish the skin and the extensor hallucis longus and extensor digitorum longus tendons.
The authors performed 20 cadaver dissections. The skin paddle was...
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PMID: 21124141
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The postmastectomy reconstruction of large and/or ptotic breasts poses a more difficult aesthetic challenge than the reconstruction of small or moderately sized breasts because of an excessively large skin envelope in both horizontal and vertical dimensions. The Wise-pattern skin excision best addre...
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PMID: 21124123
PDF is available here.
PDF is available here.
Abstract
That was a convergent-care study, carried out in a maternity ward in the Southern Region of Brazil from April to May 2009, with the purpose to comprehend the meanings of premature mother-child skin-to-skin contact and relevant nursing contributions. Data were collected through participant observation...
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PMID: 21308235
PDF is available here.
PDF is available here.
Abstract
We have reviewed clinically, morphologically, and immunophenotypically a series of 14 Epstein-Bar virus (EBV)+ cutaneous natural killer cell (NK)/T-cell lymphoma from Peru. Most (11 out of 14) of these cases fit well into the category of Hydroa vacciniforme-like lymphoma (HVLL), but 3 have a differe...
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PMID: 21107082
PDF is available here.
PDF is available here.